Click here to switch to the map view.

The map label for this gene is nadC [H]

Identifier: 150008696

GI number: 150008696

Start: 2467865

End: 2468704

Strand: Direct

Name: nadC [H]

Synonym: BDI_2086

Alternate gene names: 150008696

Gene position: 2467865-2468704 (Clockwise)

Preceding gene: 150008695

Following gene: 150008697

Centisome position: 51.29

GC content: 47.14

Gene sequence:

>840_bases
ATGGACAAACTTATTGACGACTTAATCAAATTAGCGTTTGCCGAGGATATTGGCGATGGCGATCATACCACCTTATGTTG
CATCCCCGAGACAGCGATGGGGAAAAGCCAGCTGATCATCAAGGAAGATGGCGTATTGGCCGGCGTGGAAATGGCTAAAC
GTATCTTCCACGACTTCGATCCGGAACTGAAAATGACGGTCTTTATACAAGACGGAGCCGAAGTGAAAAAAGGGGATATA
GCGTTCGTGGTGGAAGGTAAGATCCAATCCTTATTGCAGACCGAACGGTTGATGCTGAACGTTATGCAACGCATGAGCGG
TATCGCTACTACGACCCGTAAATACGCCAAGGCGTTGGAAGGTACCAAGACACACGTTTTGGATACTCGCAAGACAACTC
CCGGTATGCGTATGATCGAGAAAGAGGCCGTACGTATCGGTGGCGGCATGAACCATCGCATCGGTTTGTTCGATATGATC
TTATTGAAAGATAATCATGTGGATTTTGCTGGAGGCATCGAGCAAGCGATTACACGTGCGCAAAACTATCTGAAAGAAAA
AGGTAAGAACCTAAAGATCGAGATCGAGGTTCGTAACTTCGACGAGTTGGAACAAGCCATGAAAGTAGGCGGTATCGATC
GTATTATGTTGGATAATTTCAATATCGAGAATACAAAAGAAGCGGTTCGCCGCATCAACGGACGTTTCGAAGTAGAGTCT
TCCGGCGGTATCACGTTCGACACATTACGTGATTACGCGGAATGTGGCGTAGACTTCATCTCCGTAGGGGCATTGACTCA
CTCCGTGAAGAGCTTGGACATGAGCTTCAAAGCCTGCTAA

Upstream 100 bases:

>100_bases
CGGAAAGCTTCCGACGTCTTCCGGTGAGTATCGTGTAAACATCACGTACCGTGCCGAAGGGAATACAGCGATTATACAAT
CAATCAGAATAGAATAAAAG

Downstream 100 bases:

>100_bases
AACGAAAAACGATCATTCTATAAAAAAACAGCCTTGAGAAGATCAACTTCTTGAGGCTGTTTTTCCTATATCTACCCTAT
TATCTTGATTCACTATCATT

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MDKLIDDLIKLAFAEDIGDGDHTTLCCIPETAMGKSQLIIKEDGVLAGVEMAKRIFHDFDPELKMTVFIQDGAEVKKGDI
AFVVEGKIQSLLQTERLMLNVMQRMSGIATTTRKYAKALEGTKTHVLDTRKTTPGMRMIEKEAVRIGGGMNHRIGLFDMI
LLKDNHVDFAGGIEQAITRAQNYLKEKGKNLKIEIEVRNFDELEQAMKVGGIDRIMLDNFNIENTKEAVRRINGRFEVES
SGGITFDTLRDYAECGVDFISVGALTHSVKSLDMSFKAC

Sequences:

>Translated_279_residues
MDKLIDDLIKLAFAEDIGDGDHTTLCCIPETAMGKSQLIIKEDGVLAGVEMAKRIFHDFDPELKMTVFIQDGAEVKKGDI
AFVVEGKIQSLLQTERLMLNVMQRMSGIATTTRKYAKALEGTKTHVLDTRKTTPGMRMIEKEAVRIGGGMNHRIGLFDMI
LLKDNHVDFAGGIEQAITRAQNYLKEKGKNLKIEIEVRNFDELEQAMKVGGIDRIMLDNFNIENTKEAVRRINGRFEVES
SGGITFDTLRDYAECGVDFISVGALTHSVKSLDMSFKAC
>Mature_279_residues
MDKLIDDLIKLAFAEDIGDGDHTTLCCIPETAMGKSQLIIKEDGVLAGVEMAKRIFHDFDPELKMTVFIQDGAEVKKGDI
AFVVEGKIQSLLQTERLMLNVMQRMSGIATTTRKYAKALEGTKTHVLDTRKTTPGMRMIEKEAVRIGGGMNHRIGLFDMI
LLKDNHVDFAGGIEQAITRAQNYLKEKGKNLKIEIEVRNFDELEQAMKVGGIDRIMLDNFNIENTKEAVRRINGRFEVES
SGGITFDTLRDYAECGVDFISVGALTHSVKSLDMSFKAC

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=284, Percent_Identity=33.8028169014084, Blast_Score=144, Evalue=1e-34,
Organism=Escherichia coli, GI1786299, Length=278, Percent_Identity=39.2086330935252, Blast_Score=186, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6321162, Length=259, Percent_Identity=34.3629343629344, Blast_Score=132, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31112; Mature: 31112

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKLIDDLIKLAFAEDIGDGDHTTLCCIPETAMGKSQLIIKEDGVLAGVEMAKRIFHDFD
CHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHCCC
PELKMTVFIQDGAEVKKGDIAFVVEGKIQSLLQTERLMLNVMQRMSGIATTTRKYAKALE
CCEEEEEEEECCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GTKTHVLDTRKTTPGMRMIEKEAVRIGGGMNHRIGLFDMILLKDNHVDFAGGIEQAITRA
CCHHEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHH
QNYLKEKGKNLKIEIEVRNFDELEQAMKVGGIDRIMLDNFNIENTKEAVRRINGRFEVES
HHHHHHCCCCEEEEEEECCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCEEEEEC
SGGITFDTLRDYAECGVDFISVGALTHSVKSLDMSFKAC
CCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHCCC
>Mature Secondary Structure
MDKLIDDLIKLAFAEDIGDGDHTTLCCIPETAMGKSQLIIKEDGVLAGVEMAKRIFHDFD
CHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHCCC
PELKMTVFIQDGAEVKKGDIAFVVEGKIQSLLQTERLMLNVMQRMSGIATTTRKYAKALE
CCEEEEEEEECCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GTKTHVLDTRKTTPGMRMIEKEAVRIGGGMNHRIGLFDMILLKDNHVDFAGGIEQAITRA
CCHHEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHH
QNYLKEKGKNLKIEIEVRNFDELEQAMKVGGIDRIMLDNFNIENTKEAVRRINGRFEVES
HHHHHHCCCCEEEEEEECCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCEEEEEC
SGGITFDTLRDYAECGVDFISVGALTHSVKSLDMSFKAC
CCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]