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The map label for this gene is mscS [H]

Identifier: 150008667

GI number: 150008667

Start: 2427745

End: 2428590

Strand: Reverse

Name: mscS [H]

Synonym: BDI_2057

Alternate gene names: 150008667

Gene position: 2428590-2427745 (Counterclockwise)

Preceding gene: 150008669

Following gene: 150008666

Centisome position: 50.48

GC content: 45.51

Gene sequence:

>846_bases
ATGGTATTATTAGCAGCTGTAGAAGCTAGTTCTAAATTAGAGGAAGCTATCAGATCCTTGGTTGAGCATGGCTCCCAATT
GGGTTTTACGATTATTAAAGCCCTTATTGTCTTTTTGGTGGGACGATTGGTTATAAACTTACTAAATAAACTGGTTCGGA
AGATATTGAGCAAACGGGATATCGATCCTTCTGTCAAGACTTTTGTGGGTAGTTTGGTGAATGTCAGTTTAACCATTTTA
TTGATTATTTCAGTCGTAGGGGCGTTAGGCGTTCAAACTACGTCGTTTGCCGCCTTGTTGGCTTCCGCCGGTGTCGCTGT
CGGTATGGCATTGAGCGGTAACCTGTCAAACTTTGCCGGTGGATTGATCATCCTTCTTTTCAAGCCTTATAAGGTGGGTG
ATTATATTGAGGCGCAGGGTGTTGGCGGTACCGTGAAAGAGGTCCAGATGTTCCATACCGTATTAGGTACGGTTGATAAT
AAGGTCATTTATATACCGAACGGCTCTTTGAGCAGTGGCGTTGTGACTAATTTCAGTAACCAGACGACTCGCCGTGTAGA
CTGGACCTTTGGCGTGGAATACGGCAGCGATTATGAGAAAGTAAAGCAAGTGATAGAGTCTGTATTAGCGAAGGATTCCC
GCATCTTGTCCGAGCCGGCCGCTCCGTTTATCGCCTTGACAGCCTTGGCGGACAGCAGCGTAAACGTGGTGGTACGTGTT
TGGGTAAATAGTTCAGACTATTGGGGCGTGTATTTCGATATTAACAAGAATATCTACGCGACCTTCAATGAGGTAGGTAT
CGGTTTCCCATTCCCGCAACTAACCGTACACCAAGCGAAGGATTGA

Upstream 100 bases:

>100_bases
TTACCAGATTAAAAAAACTTTATACCTTTGCTACATTTCATAATATTTTTGGAAGATCAGATTGTTATATAATTAATAGA
TTAACTAAAATAGAAGAGAT

Downstream 100 bases:

>100_bases
AGTTCGTGATAATCTATGACTTGTCCTTAAAAGGAATCTTTTTGTTCAAAAATCTTTGAGTTTCGTTAGATGTGCGGTTA
TTTTATAGATGGTTGAACAA

Product: putative transport protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MVLLAAVEASSKLEEAIRSLVEHGSQLGFTIIKALIVFLVGRLVINLLNKLVRKILSKRDIDPSVKTFVGSLVNVSLTIL
LIISVVGALGVQTTSFAALLASAGVAVGMALSGNLSNFAGGLIILLFKPYKVGDYIEAQGVGGTVKEVQMFHTVLGTVDN
KVIYIPNGSLSSGVVTNFSNQTTRRVDWTFGVEYGSDYEKVKQVIESVLAKDSRILSEPAAPFIALTALADSSVNVVVRV
WVNSSDYWGVYFDINKNIYATFNEVGIGFPFPQLTVHQAKD

Sequences:

>Translated_281_residues
MVLLAAVEASSKLEEAIRSLVEHGSQLGFTIIKALIVFLVGRLVINLLNKLVRKILSKRDIDPSVKTFVGSLVNVSLTIL
LIISVVGALGVQTTSFAALLASAGVAVGMALSGNLSNFAGGLIILLFKPYKVGDYIEAQGVGGTVKEVQMFHTVLGTVDN
KVIYIPNGSLSSGVVTNFSNQTTRRVDWTFGVEYGSDYEKVKQVIESVLAKDSRILSEPAAPFIALTALADSSVNVVVRV
WVNSSDYWGVYFDINKNIYATFNEVGIGFPFPQLTVHQAKD
>Mature_281_residues
MVLLAAVEASSKLEEAIRSLVEHGSQLGFTIIKALIVFLVGRLVINLLNKLVRKILSKRDIDPSVKTFVGSLVNVSLTIL
LIISVVGALGVQTTSFAALLASAGVAVGMALSGNLSNFAGGLIILLFKPYKVGDYIEAQGVGGTVKEVQMFHTVLGTVDN
KVIYIPNGSLSSGVVTNFSNQTTRRVDWTFGVEYGSDYEKVKQVIESVLAKDSRILSEPAAPFIALTALADSSVNVVVRV
WVNSSDYWGVYFDINKNIYATFNEVGIGFPFPQLTVHQAKD

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=248, Percent_Identity=39.5161290322581, Blast_Score=204, Evalue=5e-54,
Organism=Escherichia coli, GI1786670, Length=264, Percent_Identity=29.9242424242424, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1787591, Length=243, Percent_Identity=26.7489711934156, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI2367355, Length=250, Percent_Identity=26.8, Blast_Score=83, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 30228; Mature: 30228

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: PS01246 UPF0003

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLLAAVEASSKLEEAIRSLVEHGSQLGFTIIKALIVFLVGRLVINLLNKLVRKILSKRD
CEEEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IDPSVKTFVGSLVNVSLTILLIISVVGALGVQTTSFAALLASAGVAVGMALSGNLSNFAG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEECCCCHHHCC
GLIILLFKPYKVGDYIEAQGVGGTVKEVQMFHTVLGTVDNKVIYIPNGSLSSGVVTNFSN
CEEEEEECCCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEECCCC
QTTRRVDWTFGVEYGSDYEKVKQVIESVLAKDSRILSEPAAPFIALTALADSSVNVVVRV
CCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHCCCCCCEEEEECCCCCCEEEEEE
WVNSSDYWGVYFDINKNIYATFNEVGIGFPFPQLTVHQAKD
EECCCCEEEEEEEECCCEEEEHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVLLAAVEASSKLEEAIRSLVEHGSQLGFTIIKALIVFLVGRLVINLLNKLVRKILSKRD
CEEEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IDPSVKTFVGSLVNVSLTILLIISVVGALGVQTTSFAALLASAGVAVGMALSGNLSNFAG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEECCCCHHHCC
GLIILLFKPYKVGDYIEAQGVGGTVKEVQMFHTVLGTVDNKVIYIPNGSLSSGVVTNFSN
CEEEEEECCCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEECCCC
QTTRRVDWTFGVEYGSDYEKVKQVIESVLAKDSRILSEPAAPFIALTALADSSVNVVVRV
CCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHCCCCCCEEEEECCCCCCEEEEEE
WVNSSDYWGVYFDINKNIYATFNEVGIGFPFPQLTVHQAKD
EECCCCEEEEEEEECCCEEEEHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12542086 [H]