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The map label for this gene is msrAB2 [H]

Identifier: 150008650

GI number: 150008650

Start: 2402933

End: 2404015

Strand: Direct

Name: msrAB2 [H]

Synonym: BDI_2038

Alternate gene names: 150008650

Gene position: 2402933-2404015 (Clockwise)

Preceding gene: 150008648

Following gene: 150008651

Centisome position: 49.94

GC content: 43.95

Gene sequence:

>1083_bases
ATGAAACATCTAATTTTATTTATAGCTTTGCTAGTATCAAACGGACTAGCAATCGCGAGAACGACAATGAGTGATCAACT
TTCAAAAACAACAAGAATGAATACCCAAAGTGAAATTTATTTTGCCGGTGGATGTTTCTGGGGAACAGAACATTTCATGA
AGCAAATCGATGGCGTTACGAATACCCGAGTAGGTTACGCGAACGGGAAGATGAGTATCAAAAACCCGACTTACGAACAA
GTGTGTAACGATAATACCGGATTCGCCGAGACAGTGGAAGTTAGCTACGATCCGCGACAAGCCGATTTGAAGTTATTGAT
CGAACTATTCTTCAAGACGATAGATCCGACAAGTATCAACCGGCAAGGCAACGATATCGGATCACAGTATCGTACCGGCA
TCTATTATACGAATACGGACGATCTGCCGATCATCAAAGAGACCGTGGAGGCATTGGCCAAGAATTATACCAAGCCCATC
GTCGTAGAGATTCAGCCATTAAGTAATTTCTATCCGGCAGAAGACTATCATCAGGATTATTTAGATAAACACCCGGACGG
TTATTGCCACATAAGCCCGGATCTATTCGATTTCGCCCGAAAGGCTAATAAGGGGAAAGCCTCGAACAAGCCTGTATCGC
AAAAGAAATTCCAGAAACCGGATGATCAGACATTGCGCTCTAAACTCACCGCCGAACAATATGCGGTAACACAGCAAAAC
GCTACGGAAAGAGCTTTCAAGAATGAATATTGGAATGAAAAGCGTGAAGGCATCTACGTAGATATCACGACTGGGGAACC
TTTGTTTATCTCTACCGATAAGTTTGATTCGGGTTGCGGATGGCCTAGTTTCTCCAAGCCGATAGACAAGAGCTTGGTGA
TGGAAAAAACGGATCTTTCCCACGGGATGAAACGGATTGAGATACGCAGCAAAACAGGAGATGCACATCTAGGGCACGTT
TTTAATGATGGCCCAGCCGACAAAGGTGGGTTACGATACTGCATCAACAGCGCGTCATTAAGATTTATCCCTAAAGCAAA
GATGGAAGAAGAGGGATATGCCGACTATCTCCCACTCCTATAA

Upstream 100 bases:

>100_bases
AGGCCGCCGGGATCAAGCCTTTGGTGGAGAACCATTTCCTGCTATTCTGGTTATATAATATAATGGATCTCATCCCTTCA
CGATAATAAAGAAAAAGTAT

Downstream 100 bases:

>100_bases
AAACAAATAAAAAAACATAGTTATGATTTGTTCAACTCATAACTATGTTTTGAAAATTTCATAACTATGATTTTTTAATA
GTATCTTCGCCGTATAAAAC

Product: putative peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MKHLILFIALLVSNGLAIARTTMSDQLSKTTRMNTQSEIYFAGGCFWGTEHFMKQIDGVTNTRVGYANGKMSIKNPTYEQ
VCNDNTGFAETVEVSYDPRQADLKLLIELFFKTIDPTSINRQGNDIGSQYRTGIYYTNTDDLPIIKETVEALAKNYTKPI
VVEIQPLSNFYPAEDYHQDYLDKHPDGYCHISPDLFDFARKANKGKASNKPVSQKKFQKPDDQTLRSKLTAEQYAVTQQN
ATERAFKNEYWNEKREGIYVDITTGEPLFISTDKFDSGCGWPSFSKPIDKSLVMEKTDLSHGMKRIEIRSKTGDAHLGHV
FNDGPADKGGLRYCINSASLRFIPKAKMEEEGYADYLPLL

Sequences:

>Translated_360_residues
MKHLILFIALLVSNGLAIARTTMSDQLSKTTRMNTQSEIYFAGGCFWGTEHFMKQIDGVTNTRVGYANGKMSIKNPTYEQ
VCNDNTGFAETVEVSYDPRQADLKLLIELFFKTIDPTSINRQGNDIGSQYRTGIYYTNTDDLPIIKETVEALAKNYTKPI
VVEIQPLSNFYPAEDYHQDYLDKHPDGYCHISPDLFDFARKANKGKASNKPVSQKKFQKPDDQTLRSKLTAEQYAVTQQN
ATERAFKNEYWNEKREGIYVDITTGEPLFISTDKFDSGCGWPSFSKPIDKSLVMEKTDLSHGMKRIEIRSKTGDAHLGHV
FNDGPADKGGLRYCINSASLRFIPKAKMEEEGYADYLPLL
>Mature_360_residues
MKHLILFIALLVSNGLAIARTTMSDQLSKTTRMNTQSEIYFAGGCFWGTEHFMKQIDGVTNTRVGYANGKMSIKNPTYEQ
VCNDNTGFAETVEVSYDPRQADLKLLIELFFKTIDPTSINRQGNDIGSQYRTGIYYTNTDDLPIIKETVEALAKNYTKPI
VVEIQPLSNFYPAEDYHQDYLDKHPDGYCHISPDLFDFARKANKGKASNKPVSQKKFQKPDDQTLRSKLTAEQYAVTQQN
ATERAFKNEYWNEKREGIYVDITTGEPLFISTDKFDSGCGWPSFSKPIDKSLVMEKTDLSHGMKRIEIRSKTGDAHLGHV
FNDGPADKGGLRYCINSASLRFIPKAKMEEEGYADYLPLL

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0229

COG function: function code O; Conserved domain frequently associated with peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=155, Percent_Identity=42.5806451612903, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI208609995, Length=156, Percent_Identity=42.3076923076923, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI301336164, Length=122, Percent_Identity=50.8196721311475, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI301336162, Length=122, Percent_Identity=50.8196721311475, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI73089054, Length=122, Percent_Identity=50.8196721311475, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI37620216, Length=122, Percent_Identity=50.8196721311475, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI117606353, Length=142, Percent_Identity=40.1408450704225, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI208609993, Length=110, Percent_Identity=40.9090909090909, Blast_Score=89, Evalue=4e-18,
Organism=Escherichia coli, GI1788077, Length=132, Percent_Identity=49.2424242424242, Blast_Score=131, Evalue=5e-32,
Organism=Escherichia coli, GI1790665, Length=150, Percent_Identity=40.6666666666667, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17553450, Length=121, Percent_Identity=44.6280991735537, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI115532676, Length=121, Percent_Identity=44.6280991735537, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17533973, Length=141, Percent_Identity=38.2978723404255, Blast_Score=88, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6320881, Length=174, Percent_Identity=41.3793103448276, Blast_Score=139, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6319816, Length=136, Percent_Identity=33.8235294117647, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221378664, Length=125, Percent_Identity=46.4, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI221378662, Length=134, Percent_Identity=43.2835820895522, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI45553335, Length=124, Percent_Identity=44.3548387096774, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI21356369, Length=124, Percent_Identity=44.3548387096774, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24645799, Length=124, Percent_Identity=44.3548387096774, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24645804, Length=135, Percent_Identity=40.7407407407407, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24645801, Length=135, Percent_Identity=40.7407407407407, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24664627, Length=208, Percent_Identity=31.25, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI45553131, Length=199, Percent_Identity=31.6582914572864, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24664631, Length=208, Percent_Identity=30.7692307692308, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 40779; Mature: 40779

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHLILFIALLVSNGLAIARTTMSDQLSKTTRMNTQSEIYFAGGCFWGTEHFMKQIDGVT
CHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHCCCCCEEEEECCEEHHHHHHHHHHCCCC
NTRVGYANGKMSIKNPTYEQVCNDNTGFAETVEVSYDPRQADLKLLIELFFKTIDPTSIN
CCEEEECCCEEEECCCCHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCC
RQGNDIGSQYRTGIYYTNTDDLPIIKETVEALAKNYTKPIVVEIQPLSNFYPAEDYHQDY
CCCCHHHHHHHCCEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHH
LDKHPDGYCHISPDLFDFARKANKGKASNKPVSQKKFQKPDDQTLRSKLTAEQYAVTQQN
HHCCCCCEEEECCHHHHHHHHHCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHCC
ATERAFKNEYWNEKREGIYVDITTGEPLFISTDKFDSGCGWPSFSKPIDKSLVMEKTDLS
HHHHHHHHHHCCHHHCCEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHH
HGMKRIEIRSKTGDAHLGHVFNDGPADKGGLRYCINSASLRFIPKAKMEEEGYADYLPLL
CCCEEEEEECCCCCCEECCCCCCCCCCCCCCEEEECCCCEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKHLILFIALLVSNGLAIARTTMSDQLSKTTRMNTQSEIYFAGGCFWGTEHFMKQIDGVT
CHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHCCCCCEEEEECCEEHHHHHHHHHHCCCC
NTRVGYANGKMSIKNPTYEQVCNDNTGFAETVEVSYDPRQADLKLLIELFFKTIDPTSIN
CCEEEECCCEEEECCCCHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCC
RQGNDIGSQYRTGIYYTNTDDLPIIKETVEALAKNYTKPIVVEIQPLSNFYPAEDYHQDY
CCCCHHHHHHHCCEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHH
LDKHPDGYCHISPDLFDFARKANKGKASNKPVSQKKFQKPDDQTLRSKLTAEQYAVTQQN
HHCCCCCEEEECCHHHHHHHHHCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHCC
ATERAFKNEYWNEKREGIYVDITTGEPLFISTDKFDSGCGWPSFSKPIDKSLVMEKTDLS
HHHHHHHHHHCCHHHCCEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHH
HGMKRIEIRSKTGDAHLGHVFNDGPADKGGLRYCINSASLRFIPKAKMEEEGYADYLPLL
CCCEEEEEECCCCCCEECCCCCCCCCCCCCCEEEECCCCEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]