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The map label for this gene is mutM [H]

Identifier: 150008625

GI number: 150008625

Start: 2380124

End: 2380957

Strand: Direct

Name: mutM [H]

Synonym: BDI_2011

Alternate gene names: 150008625

Gene position: 2380124-2380957 (Clockwise)

Preceding gene: 150008624

Following gene: 150008626

Centisome position: 49.47

GC content: 49.64

Gene sequence:

>834_bases
ATGATTGAGATTCCCGAATCCGCCACCATTGGCAAACAGGCTAGCGAAACGCTAAAGGGTAAACGGATAGCGCATGTTAT
CGAGTCGAACAGTCCTCACCGCTTCACGTTCTATAATGGCGATCCGGCGGAATACTCCAATAGGCTGGTAGGACGAACGG
TCCTAGGCGCCCAAGGCTATGGCGCATTCGTGGACATCTTTATGGACGCAGATACCCACCTCTTAATCGGAGACGGAACC
AATATGCGTTATTATACCTCCGCAGAAAAGGCCCCGAAGAAATATCAGCTTATGATCGTATTCGAGGACGATTCGTTCCT
AGCTTTCACGGTTTCGATGTATGGTTCCATCTACGCTTTCAAAGGCGAGTTTGACAATCCCTATTACCAAGGTAGCATCC
ATAAGCTATGTCCGTTGGACGAGAGATTCGATAAAACCTATTTTATCAGTCTCATCGGGAATCTCAAGAAAGATATATCC
GCAAAGGCGTTACTCGCCACCGAGCAACGTATTCCGGGCCTGGGCAACGGAGTCTGCCAAGATATCTTGTTCAATGCCCG
GATCTCCCCGAAACGAAAAATATCGACTTTATCAGAAGAGGATATAGACCGCCTCTTCAACACCGTGAAATCCACGCTGG
AAGAGATGACTCGCCGAGGAGGCCGGGATACGGAGAAGGATCTATACGGCGCCTTAGGCAATTACCGCACGATCCTATCG
AAGAACACCTACCATGACCCTTGCCCCGTCTGTGGCGAACGGATACAGAAAGAGGCTTACCTCGGAGGCAGCATTTACTA
TTGCCCGCATTGCCAGCCTAGTGCGGCAAATTAA

Upstream 100 bases:

>100_bases
GACCCAGAATTAAAGCCCGGTTCCTATTTTCCGTATCAATGAATATTGGTACGGAAAATATGCCTATATTTACCCTGTCA
CCTCTAAAAACAATACGAAT

Downstream 100 bases:

>100_bases
TAATAGATCCGCATAAGCAGGGATCGGAATACGTCCTATCGCAATGATACATAATATATTTATCTCCACCAGATAAAATA
TTACTCTATCAAACAAGCAT

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MIEIPESATIGKQASETLKGKRIAHVIESNSPHRFTFYNGDPAEYSNRLVGRTVLGAQGYGAFVDIFMDADTHLLIGDGT
NMRYYTSAEKAPKKYQLMIVFEDDSFLAFTVSMYGSIYAFKGEFDNPYYQGSIHKLCPLDERFDKTYFISLIGNLKKDIS
AKALLATEQRIPGLGNGVCQDILFNARISPKRKISTLSEEDIDRLFNTVKSTLEEMTRRGGRDTEKDLYGALGNYRTILS
KNTYHDPCPVCGERIQKEAYLGGSIYYCPHCQPSAAN

Sequences:

>Translated_277_residues
MIEIPESATIGKQASETLKGKRIAHVIESNSPHRFTFYNGDPAEYSNRLVGRTVLGAQGYGAFVDIFMDADTHLLIGDGT
NMRYYTSAEKAPKKYQLMIVFEDDSFLAFTVSMYGSIYAFKGEFDNPYYQGSIHKLCPLDERFDKTYFISLIGNLKKDIS
AKALLATEQRIPGLGNGVCQDILFNARISPKRKISTLSEEDIDRLFNTVKSTLEEMTRRGGRDTEKDLYGALGNYRTILS
KNTYHDPCPVCGERIQKEAYLGGSIYYCPHCQPSAAN
>Mature_277_residues
MIEIPESATIGKQASETLKGKRIAHVIESNSPHRFTFYNGDPAEYSNRLVGRTVLGAQGYGAFVDIFMDADTHLLIGDGT
NMRYYTSAEKAPKKYQLMIVFEDDSFLAFTVSMYGSIYAFKGEFDNPYYQGSIHKLCPLDERFDKTYFISLIGNLKKDIS
AKALLATEQRIPGLGNGVCQDILFNARISPKRKISTLSEEDIDRLFNTVKSTLEEMTRRGGRDTEKDLYGALGNYRTILS
KNTYHDPCPVCGERIQKEAYLGGSIYYCPHCQPSAAN

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 31090; Mature: 31090

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEIPESATIGKQASETLKGKRIAHVIESNSPHRFTFYNGDPAEYSNRLVGRTVLGAQGY
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHCHHHHHEEECCCCC
GAFVDIFMDADTHLLIGDGTNMRYYTSAEKAPKKYQLMIVFEDDSFLAFTVSMYGSIYAF
CEEEEEEECCCCEEEEECCCCEEEEECCCCCCCEEEEEEEEECCCEEEEEEEHHCEEEEE
KGEFDNPYYQGSIHKLCPLDERFDKTYFISLIGNLKKDISAKALLATEQRIPGLGNGVCQ
ECCCCCCEECCCCHHCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
DILFNARISPKRKISTLSEEDIDRLFNTVKSTLEEMTRRGGRDTEKDLYGALGNYRTILS
HHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHEECC
KNTYHDPCPVCGERIQKEAYLGGSIYYCPHCQPSAAN
CCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCC
>Mature Secondary Structure
MIEIPESATIGKQASETLKGKRIAHVIESNSPHRFTFYNGDPAEYSNRLVGRTVLGAQGY
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHCHHHHHEEECCCCC
GAFVDIFMDADTHLLIGDGTNMRYYTSAEKAPKKYQLMIVFEDDSFLAFTVSMYGSIYAF
CEEEEEEECCCCEEEEECCCCEEEEECCCCCCCEEEEEEEEECCCEEEEEEEHHCEEEEE
KGEFDNPYYQGSIHKLCPLDERFDKTYFISLIGNLKKDISAKALLATEQRIPGLGNGVCQ
ECCCCCCEECCCCHHCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
DILFNARISPKRKISTLSEEDIDRLFNTVKSTLEEMTRRGGRDTEKDLYGALGNYRTILS
HHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHEECC
KNTYHDPCPVCGERIQKEAYLGGSIYYCPHCQPSAAN
CCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA