Click here to switch to the map view.

The map label for this gene is bioF [C]

Identifier: 150008529

GI number: 150008529

Start: 2274734

End: 2275927

Strand: Direct

Name: bioF [C]

Synonym: BDI_1915

Alternate gene names: 150008529

Gene position: 2274734-2275927 (Clockwise)

Preceding gene: 150008528

Following gene: 150008530

Centisome position: 47.28

GC content: 51.17

Gene sequence:

>1194_bases
ATGAAATCATATAACGAGCAACTTACGGCTTTACGAGCCTCCGGGAATCTTAGGCACCTACCGGAAGTCGAGCATCAAGG
AATATGGATATTAAAAGAGGGAATGCGTATGCTGAATCTCTCTTCCAACGATTATCTTGGATTAGCCAGCCGGCAGGATT
TACAAGAGGAGTTTCAAGCATCCACACAAGACCGCTTCTATCCCTACTCCTCCTCATCATCCCGCTTGCTGACGGGTAAT
TTCTCCGTCTATACGAAACTGGAGAAACAGATCGCCCGCTCCTTCGACCGGGAAGCCGCATTGATCTTCAATAGCGGCTA
TCATGCCAACACCGGAATCCTCCCGGCCTTAACCGATAAACAGACCTTATTACTCGCCGACAAGCTGGTGCACGCCAGCA
TCATCGATGGCATCTTGTTGAGTGGCTCCCCATTCCTCCGTTACCGCCACAACGACTATGACCAACTGGAACGCCTCGTA
CAAAAGAACGCCTGTCAATACGAGACGATCATCATCTTGACCGAAAGCATTTTCAGCATGGACGGGGATGTAGCGGATTT
AAACCGCCTGATAGCTATCAAAAGGCAATATCCCAATATCCTATTGTACGTAGACGAGGCTCATGCCATCGGAGCCCGTG
GAAAGACGGGGCTAGGTATCGCCGAGGAACAAAGTTGTATCCAAGAGATCGATCTATTGGTCGGTACTTTCGGCAAGGCG
TTAGCGTCTATGGGGGCCTATTTGGTTTGTTCCCGTACGATACGGGAATATCTGGTCAATACGATGCGACCGCTCATATT
CAGTACGGCCCTGCCACCGTTCCAAATCGCATGGACTTCCTTCATCTGGGAGCAACTCCCCTCGTTCACGAAGGAACGGG
AGAATCTTCTAGCATATAGCCGATTGCTGGCGGAGGCTTTAACGGGCAAAGGAGGCGAGATCAGCCAAAGCCACATCATC
CCTTTCATTGTGGGAGAGAGCGAGGATTGCGTACGGAAAGCGGAAGAGCTACAACGAAAAGGCTTCTACTGCCTCCCCGT
TCGCCCGCCGACAGTGCCCAAAGGTACCTCCCGTATCCGCTTCTCCCTTACGGCAAACCTCACAATAAAAAATATTCATC
AACTGATTGTAGAGACGGGGCGTGCCTTGTCTCCCACCGGGACATGCCCCGTCTCTACACCCCCGGATAGATAA

Upstream 100 bases:

>100_bases
TTTCGTTATCTCCACGTATGAACTATCCAGACTAACCTCCGGATTATTGAGAGTATTAACGCATAATTAACATATCTACA
ACCGGGTAATATATAGATAT

Downstream 100 bases:

>100_bases
CTGGATAGATAGTATGTATATAGATAAGATAATAAATAAGCTATCCCCTAGTCTGATCCTCTGTCTCGCCGGCTGGTCCA
CCTCGCCGGAGCTTTTCCGC

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MKSYNEQLTALRASGNLRHLPEVEHQGIWILKEGMRMLNLSSNDYLGLASRQDLQEEFQASTQDRFYPYSSSSSRLLTGN
FSVYTKLEKQIARSFDREAALIFNSGYHANTGILPALTDKQTLLLADKLVHASIIDGILLSGSPFLRYRHNDYDQLERLV
QKNACQYETIIILTESIFSMDGDVADLNRLIAIKRQYPNILLYVDEAHAIGARGKTGLGIAEEQSCIQEIDLLVGTFGKA
LASMGAYLVCSRTIREYLVNTMRPLIFSTALPPFQIAWTSFIWEQLPSFTKERENLLAYSRLLAEALTGKGGEISQSHII
PFIVGESEDCVRKAEELQRKGFYCLPVRPPTVPKGTSRIRFSLTANLTIKNIHQLIVETGRALSPTGTCPVSTPPDR

Sequences:

>Translated_397_residues
MKSYNEQLTALRASGNLRHLPEVEHQGIWILKEGMRMLNLSSNDYLGLASRQDLQEEFQASTQDRFYPYSSSSSRLLTGN
FSVYTKLEKQIARSFDREAALIFNSGYHANTGILPALTDKQTLLLADKLVHASIIDGILLSGSPFLRYRHNDYDQLERLV
QKNACQYETIIILTESIFSMDGDVADLNRLIAIKRQYPNILLYVDEAHAIGARGKTGLGIAEEQSCIQEIDLLVGTFGKA
LASMGAYLVCSRTIREYLVNTMRPLIFSTALPPFQIAWTSFIWEQLPSFTKERENLLAYSRLLAEALTGKGGEISQSHII
PFIVGESEDCVRKAEELQRKGFYCLPVRPPTVPKGTSRIRFSLTANLTIKNIHQLIVETGRALSPTGTCPVSTPPDR
>Mature_397_residues
MKSYNEQLTALRASGNLRHLPEVEHQGIWILKEGMRMLNLSSNDYLGLASRQDLQEEFQASTQDRFYPYSSSSSRLLTGN
FSVYTKLEKQIARSFDREAALIFNSGYHANTGILPALTDKQTLLLADKLVHASIIDGILLSGSPFLRYRHNDYDQLERLV
QKNACQYETIIILTESIFSMDGDVADLNRLIAIKRQYPNILLYVDEAHAIGARGKTGLGIAEEQSCIQEIDLLVGTFGKA
LASMGAYLVCSRTIREYLVNTMRPLIFSTALPPFQIAWTSFIWEQLPSFTKERENLLAYSRLLAEALTGKGGEISQSHII
PFIVGESEDCVRKAEELQRKGFYCLPVRPPTVPKGTSRIRFSLTANLTIKNIHQLIVETGRALSPTGTCPVSTPPDR

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=385, Percent_Identity=31.9480519480519, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI284448556, Length=352, Percent_Identity=32.9545454545455, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI4758668, Length=353, Percent_Identity=30.3116147308782, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI83977442, Length=331, Percent_Identity=29.3051359516616, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI83977440, Length=331, Percent_Identity=30.2114803625378, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI83977444, Length=331, Percent_Identity=30.2114803625378, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI119220554, Length=352, Percent_Identity=28.9772727272727, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI4502025, Length=334, Percent_Identity=28.1437125748503, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI40316939, Length=334, Percent_Identity=28.1437125748503, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI5454084, Length=254, Percent_Identity=26.3779527559055, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI1786993, Length=364, Percent_Identity=34.3406593406593, Blast_Score=184, Evalue=7e-48,
Organism=Escherichia coli, GI1790046, Length=350, Percent_Identity=30.8571428571429, Blast_Score=182, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI71994529, Length=379, Percent_Identity=31.9261213720317, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI32566772, Length=372, Percent_Identity=30.6451612903226, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17560912, Length=375, Percent_Identity=30.4, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17560914, Length=375, Percent_Identity=30.4, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71982625, Length=296, Percent_Identity=25.6756756756757, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71982617, Length=296, Percent_Identity=25.6756756756757, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320267, Length=357, Percent_Identity=30.2521008403361, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6320438, Length=365, Percent_Identity=27.1232876712329, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323954, Length=282, Percent_Identity=25.886524822695, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24662918, Length=386, Percent_Identity=32.1243523316062, Blast_Score=191, Evalue=6e-49,
Organism=Drosophila melanogaster, GI17136286, Length=353, Percent_Identity=28.6118980169972, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI17137420, Length=347, Percent_Identity=27.3775216138329, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24653280, Length=310, Percent_Identity=29.0322580645161, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24653276, Length=310, Percent_Identity=29.0322580645161, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24653278, Length=310, Percent_Identity=29.0322580645161, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 44482; Mature: 44482

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSYNEQLTALRASGNLRHLPEVEHQGIWILKEGMRMLNLSSNDYLGLASRQDLQEEFQA
CCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCHHEECCCCCCCCCCCHHHHHHHHHC
STQDRFYPYSSSSSRLLTGNFSVYTKLEKQIARSFDREAALIFNSGYHANTGILPALTDK
CCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCC
QTLLLADKLVHASIIDGILLSGSPFLRYRHNDYDQLERLVQKNACQYETIIILTESIFSM
CHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCCCEEEEEEEEHHHHCC
DGDVADLNRLIAIKRQYPNILLYVDEAHAIGARGKTGLGIAEEQSCIQEIDLLVGTFGKA
CCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LASMGAYLVCSRTIREYLVNTMRPLIFSTALPPFQIAWTSFIWEQLPSFTKERENLLAYS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLLAEALTGKGGEISQSHIIPFIVGESEDCVRKAEELQRKGFYCLPVRPPTVPKGTSRIR
HHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEE
FSLTANLTIKNIHQLIVETGRALSPTGTCPVSTPPDR
EEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKSYNEQLTALRASGNLRHLPEVEHQGIWILKEGMRMLNLSSNDYLGLASRQDLQEEFQA
CCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCHHEECCCCCCCCCCCHHHHHHHHHC
STQDRFYPYSSSSSRLLTGNFSVYTKLEKQIARSFDREAALIFNSGYHANTGILPALTDK
CCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCC
QTLLLADKLVHASIIDGILLSGSPFLRYRHNDYDQLERLVQKNACQYETIIILTESIFSM
CHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCCCEEEEEEEEHHHHCC
DGDVADLNRLIAIKRQYPNILLYVDEAHAIGARGKTGLGIAEEQSCIQEIDLLVGTFGKA
CCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LASMGAYLVCSRTIREYLVNTMRPLIFSTALPPFQIAWTSFIWEQLPSFTKERENLLAYS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLLAEALTGKGGEISQSHIIPFIVGESEDCVRKAEELQRKGFYCLPVRPPTVPKGTSRIR
HHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEE
FSLTANLTIKNIHQLIVETGRALSPTGTCPVSTPPDR
EEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA