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The map label for this gene is kbl [C]

Identifier: 150008491

GI number: 150008491

Start: 2232071

End: 2233258

Strand: Direct

Name: kbl [C]

Synonym: BDI_1877

Alternate gene names: 150008491

Gene position: 2232071-2233258 (Clockwise)

Preceding gene: 150008489

Following gene: 150008492

Centisome position: 46.39

GC content: 44.44

Gene sequence:

>1188_bases
ATGAAACTTTTACAAGAGAAACTAGCAAAGTACGACGCTCCTCAAAGAGCCATGGCAATGGGAATCTATCCTTACTTCAG
GGAAATCCAGAGCGATCAGGACACGGAAGTTCTAATCAGCGGGAAGAAAGTCTTGATGTTTGGTTCTAATGCGTACTTAG
GATTAACCAATCATCCTAAAGTAAAAGAAGCAGCGATCGAGGCCATTAAAAAGTATGGTACAGGTTGTGCCGGCTCACGT
TTCTTAAACGGAACGTTGGACTTACACCTCCAGTTGGAAAAACGTTTAGCAGAATTTGTTGGTAAAGAAGACGCCATCGT
ATACTCTACAGGTTTCCAAGTTAATCTAGGTGTTGTATCCTGTATCACCGGACGTGAGGACTATATCCTTTGGGATGAGT
TGGATCATGCATCCATTATCGAAGGACATCGTCTTTCTTTCTCCACGAAATTGAAATTCAAGCATAACGATATGGACTCC
TTGGAGAAACAACTCCAGAAATGCGAGCCAGACAAGGTGAAACTTATCGTTATCGACGGTGTCTTCAGCATGGAAGGTGA
TGTCGCTAAATTACCGGAAATCGTAGCTCTCGCAAAGAAATATAACGCAAGTGTAATGGTTGACGAGGCTCATGGTATCG
GTGTATTCGGTGATCATGGCCGCGGTACTTGTAATCACTTCGGCGTTACGAACGATGTTGATTTGATCATGGGAACTTTC
AGTAAGTCTTTCGCTTCTATCGGTGGTTTTATCGCATCAGACGAACCGGTTATCAATTACTTACGTCACCACTCCCGTTC
CTATATCTTTAGCGCAAGCAATACGCCTGCCGCTACTGCCGCAGCGAACGCGGCATTAGATATTATGTTAAGCGAACCGG
AACGTATCCAACATTTATGGGATTTGACTCATTACGCATTGGATGGTTTCCGTAACATGGGTTGTGAGATCGGACATACT
TCTACCCCGATCATCCCGTTGTTTATCCGTGACAACGACTTGACATTCCTTATCGTAAAAGAATTATTTGAGGCCGGAAT
CTTCGTAAACCCGGTAGTAGCTCCCGCAGTTGCTTCCGAGGATACACTGATCCGCTTCTCCCTTATGGCTACCCACACGA
AAGAGCAACTAGATTACGCTTTGGAAACAATCCACAAGGTATTCAAGAGCCATGGGTTGGTAGACTAA

Upstream 100 bases:

>100_bases
CGGCTGGATTTGCCGAAACATGGGATTATGTATGCGGCGAACCTGTGTTCTTTATTAGAATAAATAAATAGCGAGATAAA
TCATTCTCTTTTATAATAAT

Downstream 100 bases:

>100_bases
TCGTGTAAATATATAAGAAAAGGCCCGAAGGTTAGGTATAACACCTATCTTCGGGTCTTTTTTTATAACTGAAAAAATCA
TAACTATGATTTTGAATGGG

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MKLLQEKLAKYDAPQRAMAMGIYPYFREIQSDQDTEVLISGKKVLMFGSNAYLGLTNHPKVKEAAIEAIKKYGTGCAGSR
FLNGTLDLHLQLEKRLAEFVGKEDAIVYSTGFQVNLGVVSCITGREDYILWDELDHASIIEGHRLSFSTKLKFKHNDMDS
LEKQLQKCEPDKVKLIVIDGVFSMEGDVAKLPEIVALAKKYNASVMVDEAHGIGVFGDHGRGTCNHFGVTNDVDLIMGTF
SKSFASIGGFIASDEPVINYLRHHSRSYIFSASNTPAATAAANAALDIMLSEPERIQHLWDLTHYALDGFRNMGCEIGHT
STPIIPLFIRDNDLTFLIVKELFEAGIFVNPVVAPAVASEDTLIRFSLMATHTKEQLDYALETIHKVFKSHGLVD

Sequences:

>Translated_395_residues
MKLLQEKLAKYDAPQRAMAMGIYPYFREIQSDQDTEVLISGKKVLMFGSNAYLGLTNHPKVKEAAIEAIKKYGTGCAGSR
FLNGTLDLHLQLEKRLAEFVGKEDAIVYSTGFQVNLGVVSCITGREDYILWDELDHASIIEGHRLSFSTKLKFKHNDMDS
LEKQLQKCEPDKVKLIVIDGVFSMEGDVAKLPEIVALAKKYNASVMVDEAHGIGVFGDHGRGTCNHFGVTNDVDLIMGTF
SKSFASIGGFIASDEPVINYLRHHSRSYIFSASNTPAATAAANAALDIMLSEPERIQHLWDLTHYALDGFRNMGCEIGHT
STPIIPLFIRDNDLTFLIVKELFEAGIFVNPVVAPAVASEDTLIRFSLMATHTKEQLDYALETIHKVFKSHGLVD
>Mature_395_residues
MKLLQEKLAKYDAPQRAMAMGIYPYFREIQSDQDTEVLISGKKVLMFGSNAYLGLTNHPKVKEAAIEAIKKYGTGCAGSR
FLNGTLDLHLQLEKRLAEFVGKEDAIVYSTGFQVNLGVVSCITGREDYILWDELDHASIIEGHRLSFSTKLKFKHNDMDS
LEKQLQKCEPDKVKLIVIDGVFSMEGDVAKLPEIVALAKKYNASVMVDEAHGIGVFGDHGRGTCNHFGVTNDVDLIMGTF
SKSFASIGGFIASDEPVINYLRHHSRSYIFSASNTPAATAAANAALDIMLSEPERIQHLWDLTHYALDGFRNMGCEIGHT
STPIIPLFIRDNDLTFLIVKELFEAGIFVNPVVAPAVASEDTLIRFSLMATHTKEQLDYALETIHKVFKSHGLVD

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=375, Percent_Identity=35.2, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI284448556, Length=350, Percent_Identity=36, Blast_Score=241, Evalue=6e-64,
Organism=Homo sapiens, GI4758668, Length=364, Percent_Identity=37.9120879120879, Blast_Score=229, Evalue=2e-60,
Organism=Homo sapiens, GI119220554, Length=361, Percent_Identity=35.7340720221607, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI4502025, Length=371, Percent_Identity=31.8059299191375, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI40316939, Length=371, Percent_Identity=31.8059299191375, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI5454084, Length=382, Percent_Identity=33.7696335078534, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI83977442, Length=379, Percent_Identity=29.023746701847, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI83977444, Length=379, Percent_Identity=29.023746701847, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI83977440, Length=379, Percent_Identity=29.023746701847, Blast_Score=182, Evalue=4e-46,
Organism=Escherichia coli, GI1790046, Length=384, Percent_Identity=36.4583333333333, Blast_Score=244, Evalue=5e-66,
Organism=Escherichia coli, GI1786993, Length=346, Percent_Identity=33.2369942196532, Blast_Score=191, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI71994529, Length=377, Percent_Identity=38.4615384615385, Blast_Score=258, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI17560912, Length=360, Percent_Identity=33.8888888888889, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17560914, Length=360, Percent_Identity=33.8888888888889, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI32566772, Length=369, Percent_Identity=33.8753387533875, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71982617, Length=289, Percent_Identity=34.9480968858132, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71982625, Length=289, Percent_Identity=34.9480968858132, Blast_Score=170, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6320267, Length=359, Percent_Identity=35.3760445682451, Blast_Score=205, Evalue=9e-54,
Organism=Saccharomyces cerevisiae, GI6320438, Length=375, Percent_Identity=32.8, Blast_Score=179, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6323954, Length=278, Percent_Identity=33.0935251798561, Blast_Score=146, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24662918, Length=373, Percent_Identity=38.0697050938338, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI17136286, Length=371, Percent_Identity=34.7708894878706, Blast_Score=201, Evalue=5e-52,
Organism=Drosophila melanogaster, GI17137420, Length=382, Percent_Identity=30.6282722513089, Blast_Score=178, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24653280, Length=284, Percent_Identity=36.6197183098592, Blast_Score=174, Evalue=7e-44,
Organism=Drosophila melanogaster, GI24653276, Length=284, Percent_Identity=36.6197183098592, Blast_Score=174, Evalue=7e-44,
Organism=Drosophila melanogaster, GI24653278, Length=284, Percent_Identity=36.6197183098592, Blast_Score=174, Evalue=7e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 43763; Mature: 43763

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLQEKLAKYDAPQRAMAMGIYPYFREIQSDQDTEVLISGKKVLMFGSNAYLGLTNHPK
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCEEEEECCCEEEECCCCCC
VKEAAIEAIKKYGTGCAGSRFLNGTLDLHLQLEKRLAEFVGKEDAIVYSTGFQVNLGVVS
HHHHHHHHHHHHCCCCCCCEEECCEEEEEEEHHHHHHHHCCCCCEEEEECCCEEECCEEE
CITGREDYILWDELDHASIIEGHRLSFSTKLKFKHNDMDSLEKQLQKCEPDKVKLIVIDG
EECCCCCEEEEECCCCCHHCCCCEEEEEEEEEEECCCHHHHHHHHHHCCCCCEEEEEEEC
VFSMEGDVAKLPEIVALAKKYNASVMVDEAHGIGVFGDHGRGTCNHFGVTNDVDLIMGTF
EECCCCCHHHHHHHHHHHHHCCCEEEEECCCCCEEECCCCCCCCCCCCCCCCHHHHHHHH
SKSFASIGGFIASDEPVINYLRHHSRSYIFSASNTPAATAAANAALDIMLSEPERIQHLW
HHHHHHHCCCCCCCCHHHHHHHHCCCCEEEECCCCCCHHHHCCCEEEEEECCHHHHHHHH
DLTHYALDGFRNMGCEIGHTSTPIIPLFIRDNDLTFLIVKELFEAGIFVNPVVAPAVASE
HHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCEEEHHHHHHHHCCCEECCCCCCCCCCC
DTLIRFSLMATHTKEQLDYALETIHKVFKSHGLVD
CCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKLLQEKLAKYDAPQRAMAMGIYPYFREIQSDQDTEVLISGKKVLMFGSNAYLGLTNHPK
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCEEEEECCCEEEECCCCCC
VKEAAIEAIKKYGTGCAGSRFLNGTLDLHLQLEKRLAEFVGKEDAIVYSTGFQVNLGVVS
HHHHHHHHHHHHCCCCCCCEEECCEEEEEEEHHHHHHHHCCCCCEEEEECCCEEECCEEE
CITGREDYILWDELDHASIIEGHRLSFSTKLKFKHNDMDSLEKQLQKCEPDKVKLIVIDG
EECCCCCEEEEECCCCCHHCCCCEEEEEEEEEEECCCHHHHHHHHHHCCCCCEEEEEEEC
VFSMEGDVAKLPEIVALAKKYNASVMVDEAHGIGVFGDHGRGTCNHFGVTNDVDLIMGTF
EECCCCCHHHHHHHHHHHHHCCCEEEEECCCCCEEECCCCCCCCCCCCCCCCHHHHHHHH
SKSFASIGGFIASDEPVINYLRHHSRSYIFSASNTPAATAAANAALDIMLSEPERIQHLW
HHHHHHHCCCCCCCCHHHHHHHHCCCCEEEECCCCCCHHHHCCCEEEEEECCHHHHHHHH
DLTHYALDGFRNMGCEIGHTSTPIIPLFIRDNDLTFLIVKELFEAGIFVNPVVAPAVASE
HHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCEEEHHHHHHHHCCCEECCCCCCCCCCC
DTLIRFSLMATHTKEQLDYALETIHKVFKSHGLVD
CCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA