Click here to switch to the map view.

The map label for this gene is capD [H]

Identifier: 150008452

GI number: 150008452

Start: 2187744

End: 2189657

Strand: Reverse

Name: capD [H]

Synonym: BDI_1836

Alternate gene names: 150008452

Gene position: 2189657-2187744 (Counterclockwise)

Preceding gene: 150008453

Following gene: 150008451

Centisome position: 45.51

GC content: 50.21

Gene sequence:

>1914_bases
ATGAGGGATCCTTTTTCTCGACTATCTACCTGGTACTTTTCCAAGAAATCCTTACCCTATTGGGGTATTATCTTGCTGGA
TTGCTGCTTGATCTTATTTTCCGGCTTGTTGGTGTATACCTTGAATAATGGCGTATTATCAACCTTGGATATCTTGGGGC
ACCTGCTGGTCACGCTATTGGTATGCCTGATTCCTTATCTGGTAGGCTTTCGCCTGTTCCATACCTATTCGGGGATTATA
CGTTATTCCTCTTTCGTGGACTTGCAAAAGGTGGGATTCGCCGTCTTGTTTGGCTTGATTTGCGTGGTCGTGTTTCAGGC
GTTGACGGACTTTTCTCCTTATTTGGTGTATATCCGTAAACGGGATCTGATCCTCTCTGCGTTGTTGGCTATGAGCTTGA
TGTGGATGATGCGTGTGTTCGTGAAATATTTTTATGTAAGTACTTTTCGTGTGGCTAAGGCGGAACGAGCCTTTATCTAT
GGCGTGAAGCAAGGTGGGGTGAGTTTGGCGAAGAGTATCCAGAATCAGGATCCGGCCCGGTTTGTGCTGGCTGGATTTAT
CTCGGACATGGCTGAGATTGGGAATCGGTATTTAATGGGAGTCAAGGTTTATCCGAATAACGAGGATTTGATTGGTGTGA
TGAGAAGGCTGCAAGCCGATGTCTTGCTGGTGTCTCCATTGAAAGTTGAGGCGATCCGGAATAATCAGGAGATGGTGGAC
AGGCTGATCAAGGCGAATATAAAGATCTATATGACTCCTGCCGCCCAAGAGTGGGACGGGAAGAGCGACTTGAGCCATAC
CCAGCTGAGGGAGGTGAATATAGAGGATTTACTGCCCCGTGATAAGATCGAGATAGACTTGGAGGCTGTGAGGAAGCAGC
TTACCGGTAAGCGGATTCTGATAACAGGAGCCGCCGGGAGTATCGGTAGCGAGATCGTGCGGCAGGTAGCCCAGTTCGCC
CCGGAACGTATGGTCTTGATAGATCAGGCGGAGACCCCCTTACACGATGTCCGCTTGATGATGGCTCGTCAGTGGTCGAA
TATAGAATCCTATACGGTTGTGAGCGATATTTGTGTGCGTGAACGCATGGAGGAGCTGTTCGAGGAGCATCGTCCGGATT
ACGTGTTTCATGCCGCGGCCTACAAGCATGTACCTATGATGGAGGATAATCCGGAGGAGAGTGTCCGTAACAACGTGGAC
GGTACCCGGGTGATCGCAGACTTGTCGGTGAAATACGGCACGAGGAAGTTTGTGATGGTATCGACTGACAAGGCGGTGAA
TCCCACGAACGTGATGGGCTGCTCGAAACGTATTTGCGAGATCTACGTGCAGAGCTTGGATCAGGCTATCAAGGATGGGA
AGGTGAGGGGGCGTACGCAATTCGTGACGACTCGTTTCGGTAATGTGCTGGGATCGAACGGTTCCGTGATCCCGTTATTC
AAGGAACAGATCAAGCGGGGCGGTCCGGTTACGGTGACGCACAAGGATATCATTCGTTTCTTCATGCTGATACCGGAGGC
TTGTAAGCTGGTCCTAGAGGCCGGTACGATGGGTAATGGGGGAGAGATCTTCGTGTTCGATATGGGTAAACCTGTACGGA
TCGTGGATCTGGCTGAGCGTATGATCCGTCTGAGCGGGGTGAAGGGAATCGAGATCCGGTTCACGGGATTGCGAGACGGG
GAGAAGTTGTATGAGGAGGTACTCAATGAGGAGGAGACCTCCAAGCCTACTTTTCATCCGAAGATCAAGATCGCCCAAGT
CCGTGCGTATGACTATGCTGACGCCAATCTGCGGATTGATGCCTTGGTACATGCTTGTGCCGTGGAGGGGGATATGCAGA
TCGTGAAGCGGATGAAGGAGATTGTTCCTGAGTTCAAGAGCCAGCATTCTAAATACGAGGTTCTGGATAAATAA

Upstream 100 bases:

>100_bases
AAGATTGATATTTCAAACATTTAGAGCTATTGTATCGGAATAGCCCAAAAGAGCTTTTATTCTATAGATTATTCGTGTAA
CTATATAAACAAGAATTGAT

Downstream 100 bases:

>100_bases
ATTGTAGAAAAATAAATAAGATACAAAAAGAAGGTCTCTCATTGCGGGGGACCTTTTTTTATGAGATAAGCGTTGTCTTT
GGGATAGTATTTCGTATTTT

Product: putative nucleotide-diphosphate sugar epimerase

Products: dTDP-4-dehydro-6-deoxy-D-glucose; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 637; Mature: 637

Protein sequence:

>637_residues
MRDPFSRLSTWYFSKKSLPYWGIILLDCCLILFSGLLVYTLNNGVLSTLDILGHLLVTLLVCLIPYLVGFRLFHTYSGII
RYSSFVDLQKVGFAVLFGLICVVVFQALTDFSPYLVYIRKRDLILSALLAMSLMWMMRVFVKYFYVSTFRVAKAERAFIY
GVKQGGVSLAKSIQNQDPARFVLAGFISDMAEIGNRYLMGVKVYPNNEDLIGVMRRLQADVLLVSPLKVEAIRNNQEMVD
RLIKANIKIYMTPAAQEWDGKSDLSHTQLREVNIEDLLPRDKIEIDLEAVRKQLTGKRILITGAAGSIGSEIVRQVAQFA
PERMVLIDQAETPLHDVRLMMARQWSNIESYTVVSDICVRERMEELFEEHRPDYVFHAAAYKHVPMMEDNPEESVRNNVD
GTRVIADLSVKYGTRKFVMVSTDKAVNPTNVMGCSKRICEIYVQSLDQAIKDGKVRGRTQFVTTRFGNVLGSNGSVIPLF
KEQIKRGGPVTVTHKDIIRFFMLIPEACKLVLEAGTMGNGGEIFVFDMGKPVRIVDLAERMIRLSGVKGIEIRFTGLRDG
EKLYEEVLNEEETSKPTFHPKIKIAQVRAYDYADANLRIDALVHACAVEGDMQIVKRMKEIVPEFKSQHSKYEVLDK

Sequences:

>Translated_637_residues
MRDPFSRLSTWYFSKKSLPYWGIILLDCCLILFSGLLVYTLNNGVLSTLDILGHLLVTLLVCLIPYLVGFRLFHTYSGII
RYSSFVDLQKVGFAVLFGLICVVVFQALTDFSPYLVYIRKRDLILSALLAMSLMWMMRVFVKYFYVSTFRVAKAERAFIY
GVKQGGVSLAKSIQNQDPARFVLAGFISDMAEIGNRYLMGVKVYPNNEDLIGVMRRLQADVLLVSPLKVEAIRNNQEMVD
RLIKANIKIYMTPAAQEWDGKSDLSHTQLREVNIEDLLPRDKIEIDLEAVRKQLTGKRILITGAAGSIGSEIVRQVAQFA
PERMVLIDQAETPLHDVRLMMARQWSNIESYTVVSDICVRERMEELFEEHRPDYVFHAAAYKHVPMMEDNPEESVRNNVD
GTRVIADLSVKYGTRKFVMVSTDKAVNPTNVMGCSKRICEIYVQSLDQAIKDGKVRGRTQFVTTRFGNVLGSNGSVIPLF
KEQIKRGGPVTVTHKDIIRFFMLIPEACKLVLEAGTMGNGGEIFVFDMGKPVRIVDLAERMIRLSGVKGIEIRFTGLRDG
EKLYEEVLNEEETSKPTFHPKIKIAQVRAYDYADANLRIDALVHACAVEGDMQIVKRMKEIVPEFKSQHSKYEVLDK
>Mature_637_residues
MRDPFSRLSTWYFSKKSLPYWGIILLDCCLILFSGLLVYTLNNGVLSTLDILGHLLVTLLVCLIPYLVGFRLFHTYSGII
RYSSFVDLQKVGFAVLFGLICVVVFQALTDFSPYLVYIRKRDLILSALLAMSLMWMMRVFVKYFYVSTFRVAKAERAFIY
GVKQGGVSLAKSIQNQDPARFVLAGFISDMAEIGNRYLMGVKVYPNNEDLIGVMRRLQADVLLVSPLKVEAIRNNQEMVD
RLIKANIKIYMTPAAQEWDGKSDLSHTQLREVNIEDLLPRDKIEIDLEAVRKQLTGKRILITGAAGSIGSEIVRQVAQFA
PERMVLIDQAETPLHDVRLMMARQWSNIESYTVVSDICVRERMEELFEEHRPDYVFHAAAYKHVPMMEDNPEESVRNNVD
GTRVIADLSVKYGTRKFVMVSTDKAVNPTNVMGCSKRICEIYVQSLDQAIKDGKVRGRTQFVTTRFGNVLGSNGSVIPLF
KEQIKRGGPVTVTHKDIIRFFMLIPEACKLVLEAGTMGNGGEIFVFDMGKPVRIVDLAERMIRLSGVKGIEIRFTGLRDG
EKLYEEVLNEEETSKPTFHPKIKIAQVRAYDYADANLRIDALVHACAVEGDMQIVKRMKEIVPEFKSQHSKYEVLDK

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG1086

COG function: function code MG; Predicted nucleoside-diphosphate sugar epimerases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the polysaccharide synthase family [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=269, Percent_Identity=27.1375464684015, Blast_Score=74, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR003869 [H]

Pfam domain/function: PF02719 Polysacc_synt_2 [H]

EC number: 4.2.1.46 [C]

Molecular weight: Translated: 72327; Mature: 72327

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDPFSRLSTWYFSKKSLPYWGIILLDCCLILFSGLLVYTLNNGVLSTLDILGHLLVTLL
CCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEHCCCCHHHHHHHHHHHHHHHH
VCLIPYLVGFRLFHTYSGIIRYSSFVDLQKVGFAVLFGLICVVVFQALTDFSPYLVYIRK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEH
RDLILSALLAMSLMWMMRVFVKYFYVSTFRVAKAERAFIYGVKQGGVSLAKSIQNQDPAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHCCCCHHH
FVLAGFISDMAEIGNRYLMGVKVYPNNEDLIGVMRRLQADVLLVSPLKVEAIRNNQEMVD
HHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHCCEEEECCCCHHHHCCCHHHHH
RLIKANIKIYMTPAAQEWDGKSDLSHTQLREVNIEDLLPRDKIEIDLEAVRKQLTGKRIL
HHHHCCCEEEECCCCCCCCCCCCCCHHHHHCCCHHHCCCCCCEEEEHHHHHHHHCCCEEE
ITGAAGSIGSEIVRQVAQFAPERMVLIDQAETPLHDVRLMMARQWSNIESYTVVSDICVR
EEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHH
ERMEELFEEHRPDYVFHAAAYKHVPMMEDNPEESVRNNVDGTRVIADLSVKYGTRKFVMV
HHHHHHHHHCCCCEEEEHHHHHCCCCCCCCCHHHHHCCCCCCEEEEEEEEECCCEEEEEE
STDKAVNPTNVMGCSKRICEIYVQSLDQAIKDGKVRGRTQFVTTRFGNVLGSNGSVIPLF
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEHHH
KEQIKRGGPVTVTHKDIIRFFMLIPEACKLVLEAGTMGNGGEIFVFDMGKPVRIVDLAER
HHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHH
MIRLSGVKGIEIRFTGLRDGEKLYEEVLNEEETSKPTFHPKIKIAQVRAYDYADANLRID
HHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCCEEHH
ALVHACAVEGDMQIVKRMKEIVPEFKSQHSKYEVLDK
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHCCCC
>Mature Secondary Structure
MRDPFSRLSTWYFSKKSLPYWGIILLDCCLILFSGLLVYTLNNGVLSTLDILGHLLVTLL
CCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEHCCCCHHHHHHHHHHHHHHHH
VCLIPYLVGFRLFHTYSGIIRYSSFVDLQKVGFAVLFGLICVVVFQALTDFSPYLVYIRK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEH
RDLILSALLAMSLMWMMRVFVKYFYVSTFRVAKAERAFIYGVKQGGVSLAKSIQNQDPAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHCCCCHHH
FVLAGFISDMAEIGNRYLMGVKVYPNNEDLIGVMRRLQADVLLVSPLKVEAIRNNQEMVD
HHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHCCEEEECCCCHHHHCCCHHHHH
RLIKANIKIYMTPAAQEWDGKSDLSHTQLREVNIEDLLPRDKIEIDLEAVRKQLTGKRIL
HHHHCCCEEEECCCCCCCCCCCCCCHHHHHCCCHHHCCCCCCEEEEHHHHHHHHCCCEEE
ITGAAGSIGSEIVRQVAQFAPERMVLIDQAETPLHDVRLMMARQWSNIESYTVVSDICVR
EEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHH
ERMEELFEEHRPDYVFHAAAYKHVPMMEDNPEESVRNNVDGTRVIADLSVKYGTRKFVMV
HHHHHHHHHCCCCEEEEHHHHHCCCCCCCCCHHHHHCCCCCCEEEEEEEEECCCEEEEEE
STDKAVNPTNVMGCSKRICEIYVQSLDQAIKDGKVRGRTQFVTTRFGNVLGSNGSVIPLF
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEHHH
KEQIKRGGPVTVTHKDIIRFFMLIPEACKLVLEAGTMGNGGEIFVFDMGKPVRIVDLAER
HHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHH
MIRLSGVKGIEIRFTGLRDGEKLYEEVLNEEETSKPTFHPKIKIAQVRAYDYADANLRID
HHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCCEEHH
ALVHACAVEGDMQIVKRMKEIVPEFKSQHSKYEVLDK
HHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.093 {dTDPglucose}} [C]

Substrates: dTDPglucose [C]

Specific reaction: dTDPglucose --> dTDP-4-dehydro-6-deoxy-D-glucose + H2O [C]

General reaction: Elimination (of H2O C-O bond cleavage [C]

Inhibitor: p-Chloromercuribenzoate; TMP [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]