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The map label for this gene is rcsC [H]

Identifier: 150008441

GI number: 150008441

Start: 2174651

End: 2175259

Strand: Direct

Name: rcsC [H]

Synonym: BDI_1823

Alternate gene names: 150008441

Gene position: 2174651-2175259 (Clockwise)

Preceding gene: 150008440

Following gene: 150008442

Centisome position: 45.2

GC content: 40.89

Gene sequence:

>609_bases
ATGAACACAGACATCGAGCTCAGTAAGGCAGAACGGGAAAACTTTACCGAGTTAATCAATACGAACAGCGATCTGTTATT
GAACCTTATCAATGATATCTTAGATCTTTCCCGTATCGAATCGGGCCGTATGTCATTCTCTTTCCAGCAATATTCTCTAA
ATGAATTAATAAGCACGATTTACCAGACTTTCCAAGTTTTAATGCCGGAGAACGTAGAACTTCGTATGCAAATACCGGAA
AAAAGCATATCCATTCCCACGGATAAGTTTCGGTTGACACAAGTGATTACCAACTTTCTTAGCAACGCTATTAAATTCAC
GCAAAAGGGATATATATTGATTGGTTATGAATACCGAGAGGAAGAGCGGCATGTACATATTTTCGTAGAAGATACCGGCA
TTGGTATCCCGAAAGAAAAGCAAGACGCCGTTTTCAATCGTTTCACGAAACTGGATGAATTCGCCAAAGGTACCGGCTTG
GGACTATCCATTTGCAAAGTGATAGCCGAACGTTTCGATGGGTATATCGCCGTAGAGTCCGAAATAGGAAAAGGAAGCCG
TTTTTCCATTATCCTTCCCCTTAACCCCAAACACACTGAAAGTGATTAA

Upstream 100 bases:

>100_bases
GAGCAAAAGAAAGATACCTACCCGATTTTTAATGAAACACTGAAACGAACATTCGATAAACCGGACTCCATTGAACGCTA
TTGTCGGATTCTCGAATCTT

Downstream 100 bases:

>100_bases
TCACATTTATTCGCAATAATCCCGAAAATAATATTACTTTTGCTTTTGTATACAATTTTAAATTTCAGATCTGTGAGTAC
AAGAATAAAATTAAGGGTTC

Product: putative two-component regulator sensor kinase

Products: NA

Alternate protein names: Capsular synthesis regulator component C [H]

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MNTDIELSKAERENFTELINTNSDLLLNLINDILDLSRIESGRMSFSFQQYSLNELISTIYQTFQVLMPENVELRMQIPE
KSISIPTDKFRLTQVITNFLSNAIKFTQKGYILIGYEYREEERHVHIFVEDTGIGIPKEKQDAVFNRFTKLDEFAKGTGL
GLSICKVIAERFDGYIAVESEIGKGSRFSIILPLNPKHTESD

Sequences:

>Translated_202_residues
MNTDIELSKAERENFTELINTNSDLLLNLINDILDLSRIESGRMSFSFQQYSLNELISTIYQTFQVLMPENVELRMQIPE
KSISIPTDKFRLTQVITNFLSNAIKFTQKGYILIGYEYREEERHVHIFVEDTGIGIPKEKQDAVFNRFTKLDEFAKGTGL
GLSICKVIAERFDGYIAVESEIGKGSRFSIILPLNPKHTESD
>Mature_202_residues
MNTDIELSKAERENFTELINTNSDLLLNLINDILDLSRIESGRMSFSFQQYSLNELISTIYQTFQVLMPENVELRMQIPE
KSISIPTDKFRLTQVITNFLSNAIKFTQKGYILIGYEYREEERHVHIFVEDTGIGIPKEKQDAVFNRFTKLDEFAKGTGL
GLSICKVIAERFDGYIAVESEIGKGSRFSIILPLNPKHTESD

Specific function: Member of the two-component regulatory system RcsC/RcsB involved in the regulation of the expression of genes involved in colanic acid capsule synthesis. Together with RcsF, RcsC probably functions as a membrane-associated protein kinase that phosphorylat

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=187, Percent_Identity=37.4331550802139, Blast_Score=115, Evalue=1e-27,
Organism=Escherichia coli, GI48994928, Length=198, Percent_Identity=32.3232323232323, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1789149, Length=205, Percent_Identity=32.6829268292683, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1788713, Length=196, Percent_Identity=29.5918367346939, Blast_Score=87, Evalue=6e-19,
Organism=Escherichia coli, GI87081816, Length=193, Percent_Identity=32.6424870466321, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1790436, Length=192, Percent_Identity=32.2916666666667, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786912, Length=167, Percent_Identity=27.5449101796407, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1788549, Length=186, Percent_Identity=31.1827956989247, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786783, Length=173, Percent_Identity=27.1676300578035, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1787374, Length=140, Percent_Identity=29.2857142857143, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1786600, Length=197, Percent_Identity=24.3654822335025, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1788393, Length=175, Percent_Identity=26.8571428571429, Blast_Score=61, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=75, Percent_Identity=45.3333333333333, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR000014
- InterPro:   IPR004358
- InterPro:   IPR019017
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09456 RcsC; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 23181; Mature: 23181

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTDIELSKAERENFTELINTNSDLLLNLINDILDLSRIESGRMSFSFQQYSLNELISTI
CCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHH
YQTFQVLMPENVELRMQIPEKSISIPTDKFRLTQVITNFLSNAIKFTQKGYILIGYEYRE
HHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECC
EERHVHIFVEDTGIGIPKEKQDAVFNRFTKLDEFAKGTGLGLSICKVIAERFDGYIAVES
CCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEC
EIGKGSRFSIILPLNPKHTESD
CCCCCCEEEEEEECCCCCCCCC
>Mature Secondary Structure
MNTDIELSKAERENFTELINTNSDLLLNLINDILDLSRIESGRMSFSFQQYSLNELISTI
CCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHH
YQTFQVLMPENVELRMQIPEKSISIPTDKFRLTQVITNFLSNAIKFTQKGYILIGYEYRE
HHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECC
EERHVHIFVEDTGIGIPKEKQDAVFNRFTKLDEFAKGTGLGLSICKVIAERFDGYIAVES
CCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEC
EIGKGSRFSIILPLNPKHTESD
CCCCCCEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2404948; 8366025; 9097040; 9278503; 11758943; 11309126; 13129944 [H]