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The map label for this gene is clcA [H]

Identifier: 150008405

GI number: 150008405

Start: 2122284

End: 2123855

Strand: Direct

Name: clcA [H]

Synonym: BDI_1781

Alternate gene names: 150008405

Gene position: 2122284-2123855 (Clockwise)

Preceding gene: 150008404

Following gene: 150008407

Centisome position: 44.11

GC content: 49.81

Gene sequence:

>1572_bases
ATGGATAATGATCTCTTAGATATAACAAAATTGAGGCGCTGGCGGATCTGGAAATTGAAACTTATTGACGCCAGGCTTTA
TTTTGTAAGCATTTTCGTGGGATTGCTGACCGGGTTGGTAGCGGTACCTTATCACTATCTGCTCCAGCAGTTATTCAATA
GCCGGAAACTTTTTTTCGACGGTCATTACCCTTGGTATTTCCATGTCTTGTTCTTCTTCACGCTATGGGGTATATTGCTT
TGTGTGAATTGGATGGTCAAGAAGATGCCGCTGATTACCGGTGGGGGCATTCCCCAGACACGGGCGGTTATCAATGGCAG
GATCACTTATAAGAACCCGTTGACACAATTAATCGCCAAGTTCACGGGAGGGATATTAGCAATCAGCGCCGGCCTGTCCC
TTGGTCGTGAGGGGCCGTGCGTACAGATCGGATCTTACGTGGGGAATATCATTTCCAAATGGGGACACGTATTGGCTGGA
GAGCGCAAGCAACTTTTGGCCGCCGGCGCAGGTGCCGGATTGGCCGCCGCTTTCGCCGCTCCCCTCGCTTCCTCACTTTT
GGTGATCGAGTCCATCGAACGGTTCGACGCTCCCAAGACCGCCATTACCACCTTGCTGGCAGGGGTCGTGGCGGGAGGCG
TAGCGAGCTTGATTTTTCCCTTCAACCCCTACTCGCAGATTAGCGCTATTGCCCCGCAGGCTACTTTTATAGATCAACTG
AAGTTGTTCTTATTTCTGGCCGTGGTTATTTCCGTCTTCGGGAAAATTTACTCGATGTTTACCCTTTGGTGCAAGGATTT
CTTTACCAGACTGAAGCATCCTCCTTATATGAAGATGTTGTACCTGCTTATCATAGCGTATACGATCTCATTGACGGAGA
TCGACTTGACAGGAGGAGGCGAGCAATTCCTTATCATGCAAGCGATGCATGGATATCACCCCGTTTTATGGATAGCGGCG
ATGATGCTCATCCACTTGATATTCACGTCTCTCTCTTTCTCCTCCGGACTGCCGGGAGGGAATTTCATCCCTACACTAGT
TACCGGGGGATTGTTCGGGCAGATCATCGCCTTATTATTGGTGAAGTATGGTTTCATTGAGACGGAGAGCATCAGCTATA
TCATGTTAATCAGCATGGTAGGTTTCTTGGTGGCGGTAGTCCGGACACCACTGACGGGTATCGTCTTGATTACGGAGATA
ACCGGGCATCTGGATGTATTCTACCCCTCTATCATTGTCGGCGGGCTTACGTATTACTTCACGGAAATGCTACAGATAAA
GCCCTTTAACGTGGTTCTCTATGACGAGATGATCTCGACTCCAGCCTTCCGTGCCGAAGGGCGTTCCAGCCTGTTCGTCG
AGATCATGACAGGTGCCTATTTCGACGGGAAGGAGGTAGATCACCTCACCCTCCCCCAACGTTGTATCATCAAGACTATT
CACCGGGATCGCAAGGACTTGGCTCCTGCTGGACAGACCCTTATCCCCGGCGATCAGGTAGAGATCGAGATCGATTCGCA
GGATATCGAGAAGCTGTATGAGCCGCTGGTTAGCATGGCGAACATCTATTAA

Upstream 100 bases:

>100_bases
TTAATAACAAGGCTTTTAAAAAAAGGTTCAATGGAATGAGATTTTAAACCTCTTATTTACCTTGGTTGTTGTAACAGGAA
ACGAAAACAAGGTGAGTCCG

Downstream 100 bases:

>100_bases
TCGCTGATCTGCCAATCGCCTCGAAAAGAAATGCCACACCAAGAATCCCCCGGTGTGGCACATTTACAAAACGCTACATT
ATCAGAAGTTATATTGAGCG

Product: putative transporter periplasmic binding protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MDNDLLDITKLRRWRIWKLKLIDARLYFVSIFVGLLTGLVAVPYHYLLQQLFNSRKLFFDGHYPWYFHVLFFFTLWGILL
CVNWMVKKMPLITGGGIPQTRAVINGRITYKNPLTQLIAKFTGGILAISAGLSLGREGPCVQIGSYVGNIISKWGHVLAG
ERKQLLAAGAGAGLAAAFAAPLASSLLVIESIERFDAPKTAITTLLAGVVAGGVASLIFPFNPYSQISAIAPQATFIDQL
KLFLFLAVVISVFGKIYSMFTLWCKDFFTRLKHPPYMKMLYLLIIAYTISLTEIDLTGGGEQFLIMQAMHGYHPVLWIAA
MMLIHLIFTSLSFSSGLPGGNFIPTLVTGGLFGQIIALLLVKYGFIETESISYIMLISMVGFLVAVVRTPLTGIVLITEI
TGHLDVFYPSIIVGGLTYYFTEMLQIKPFNVVLYDEMISTPAFRAEGRSSLFVEIMTGAYFDGKEVDHLTLPQRCIIKTI
HRDRKDLAPAGQTLIPGDQVEIEIDSQDIEKLYEPLVSMANIY

Sequences:

>Translated_523_residues
MDNDLLDITKLRRWRIWKLKLIDARLYFVSIFVGLLTGLVAVPYHYLLQQLFNSRKLFFDGHYPWYFHVLFFFTLWGILL
CVNWMVKKMPLITGGGIPQTRAVINGRITYKNPLTQLIAKFTGGILAISAGLSLGREGPCVQIGSYVGNIISKWGHVLAG
ERKQLLAAGAGAGLAAAFAAPLASSLLVIESIERFDAPKTAITTLLAGVVAGGVASLIFPFNPYSQISAIAPQATFIDQL
KLFLFLAVVISVFGKIYSMFTLWCKDFFTRLKHPPYMKMLYLLIIAYTISLTEIDLTGGGEQFLIMQAMHGYHPVLWIAA
MMLIHLIFTSLSFSSGLPGGNFIPTLVTGGLFGQIIALLLVKYGFIETESISYIMLISMVGFLVAVVRTPLTGIVLITEI
TGHLDVFYPSIIVGGLTYYFTEMLQIKPFNVVLYDEMISTPAFRAEGRSSLFVEIMTGAYFDGKEVDHLTLPQRCIIKTI
HRDRKDLAPAGQTLIPGDQVEIEIDSQDIEKLYEPLVSMANIY
>Mature_523_residues
MDNDLLDITKLRRWRIWKLKLIDARLYFVSIFVGLLTGLVAVPYHYLLQQLFNSRKLFFDGHYPWYFHVLFFFTLWGILL
CVNWMVKKMPLITGGGIPQTRAVINGRITYKNPLTQLIAKFTGGILAISAGLSLGREGPCVQIGSYVGNIISKWGHVLAG
ERKQLLAAGAGAGLAAAFAAPLASSLLVIESIERFDAPKTAITTLLAGVVAGGVASLIFPFNPYSQISAIAPQATFIDQL
KLFLFLAVVISVFGKIYSMFTLWCKDFFTRLKHPPYMKMLYLLIIAYTISLTEIDLTGGGEQFLIMQAMHGYHPVLWIAA
MMLIHLIFTSLSFSSGLPGGNFIPTLVTGGLFGQIIALLLVKYGFIETESISYIMLISMVGFLVAVVRTPLTGIVLITEI
TGHLDVFYPSIIVGGLTYYFTEMLQIKPFNVVLYDEMISTPAFRAEGRSSLFVEIMTGAYFDGKEVDHLTLPQRCIIKTI
HRDRKDLAPAGQTLIPGDQVEIEIDSQDIEKLYEPLVSMANIY

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557473, Length=402, Percent_Identity=24.8756218905473, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI189217923, Length=402, Percent_Identity=24.8756218905473, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI189217921, Length=402, Percent_Identity=24.8756218905473, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI153252026, Length=398, Percent_Identity=25.1256281407035, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI55770840, Length=380, Percent_Identity=24.2105263157895, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI55770838, Length=380, Percent_Identity=24.2105263157895, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1786350, Length=401, Percent_Identity=30.4239401496259, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71980828, Length=258, Percent_Identity=25.5813953488372, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71980820, Length=258, Percent_Identity=25.5813953488372, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71980824, Length=258, Percent_Identity=25.5813953488372, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71996455, Length=459, Percent_Identity=22.6579520697168, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71996452, Length=459, Percent_Identity=22.8758169934641, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71985148, Length=461, Percent_Identity=21.4750542299349, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71985141, Length=462, Percent_Identity=21.4285714285714, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17532615, Length=377, Percent_Identity=25.4641909814324, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI45551566, Length=346, Percent_Identity=26.878612716763, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24665008, Length=346, Percent_Identity=26.878612716763, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 58101; Mature: 58101

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNDLLDITKLRRWRIWKLKLIDARLYFVSIFVGLLTGLVAVPYHYLLQQLFNSRKLFFD
CCCCHHHHHHHHHHEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEC
GHYPWYFHVLFFFTLWGILLCVNWMVKKMPLITGGGIPQTRAVINGRITYKNPLTQLIAK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHCCEEEECCHHHHHHHH
FTGGILAISAGLSLGREGPCVQIGSYVGNIISKWGHVLAGERKQLLAAGAGAGLAAAFAA
HCCCCEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHH
PLASSLLVIESIERFDAPKTAITTLLAGVVAGGVASLIFPFNPYSQISAIAPQATFIDQL
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHH
KLFLFLAVVISVFGKIYSMFTLWCKDFFTRLKHPPYMKMLYLLIIAYTISLTEIDLTGGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHEEEEECCCC
EQFLIMQAMHGYHPVLWIAAMMLIHLIFTSLSFSSGLPGGNFIPTLVTGGLFGQIIALLL
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
VKYGFIETESISYIMLISMVGFLVAVVRTPLTGIVLITEITGHLDVFYPSIIVGGLTYYF
HHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCHHHHHHHHHHHHHHHHHH
TEMLQIKPFNVVLYDEMISTPAFRAEGRSSLFVEIMTGAYFDGKEVDHLTLPQRCIIKTI
HHHHHCCCCEEEEEHHHHCCCCCCCCCCCCEEEEEHHCCCCCCCCCCCCCCCHHHHHHHH
HRDRKDLAPAGQTLIPGDQVEIEIDSQDIEKLYEPLVSMANIY
HHHHHHCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDNDLLDITKLRRWRIWKLKLIDARLYFVSIFVGLLTGLVAVPYHYLLQQLFNSRKLFFD
CCCCHHHHHHHHHHEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEC
GHYPWYFHVLFFFTLWGILLCVNWMVKKMPLITGGGIPQTRAVINGRITYKNPLTQLIAK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHCCEEEECCHHHHHHHH
FTGGILAISAGLSLGREGPCVQIGSYVGNIISKWGHVLAGERKQLLAAGAGAGLAAAFAA
HCCCCEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHH
PLASSLLVIESIERFDAPKTAITTLLAGVVAGGVASLIFPFNPYSQISAIAPQATFIDQL
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHH
KLFLFLAVVISVFGKIYSMFTLWCKDFFTRLKHPPYMKMLYLLIIAYTISLTEIDLTGGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHEEEEECCCC
EQFLIMQAMHGYHPVLWIAAMMLIHLIFTSLSFSSGLPGGNFIPTLVTGGLFGQIIALLL
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
VKYGFIETESISYIMLISMVGFLVAVVRTPLTGIVLITEITGHLDVFYPSIIVGGLTYYF
HHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCHHHHHHHHHHHHHHHHHH
TEMLQIKPFNVVLYDEMISTPAFRAEGRSSLFVEIMTGAYFDGKEVDHLTLPQRCIIKTI
HHHHHCCCCEEEEEHHHHCCCCCCCCCCCCEEEEEHHCCCCCCCCCCCCCCCHHHHHHHH
HRDRKDLAPAGQTLIPGDQVEIEIDSQDIEKLYEPLVSMANIY
HHHHHHCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA