Click here to switch to the map view.

The map label for this gene is norM [H]

Identifier: 150008403

GI number: 150008403

Start: 2119673

End: 2120995

Strand: Reverse

Name: norM [H]

Synonym: BDI_1779

Alternate gene names: 150008403

Gene position: 2120995-2119673 (Counterclockwise)

Preceding gene: 150008406

Following gene: 150008400

Centisome position: 44.08

GC content: 49.13

Gene sequence:

>1323_bases
ATGCGATATACGAACAAACAAATTCTAAAGATCACGTATCCGGTATTAATCAGCTTGCTCATGGAGCATATGATCGGATT
GACGGACACCGCTTATCTGGGACGTGTCGGCGAGGTTGAGCTAGGTGCCTCCGCCTTGGCAGGAGTCTATTATCTCGTGA
TTTATATGCTGGGCTTTGGTTTCAGTGTAGGAGCTCAGGTGCTGATGGCACGTCGTAATGGTGAGGGGGAGTATAAGCGG
ATCGGCGAGGTTTTCACGCAAGGCGGGCTATTCCTTTTTCTGCTGGCGGCGGTGTTGTTTACGGCCTCTAATCTGCTTAC
GCCCTATCTGCTCCACCGGATGATCGGCTCAGAAGAGGTGTATCGGGCGACGATGAGCTATCTGGACTGGCGGGTGTACG
GGTTCTTCTTCTCTTTTATAGCGGTGATGTTCCGTGCGTTTTACGTGAGTACGACGAATACGAAGATCTTGACGGCCAAT
TCGGTGGTGATGGTGCTTACCAACGTGGTCTTGAACTATATCTTGATATTCGGTAAGTTCGGGTTCCCCGCTTTGGGGAT
AGCGGGTGCCGCTATCGCTTCCTCGATCTCGGAAGCTGTTTCCGTATTGTTCTTCGTGATTTATACTTGGAAGAAGATAG
ATTATAAAAAATATGGTCTGTTCCGTTTTACGAGAGTGGATTTTAGGATGCTGGGACAAATACTGAGTGTCTCTATCTGG
GTGATGATCCAGCATGGGATCGCTTTTGGGGGATGGTTTATCTTCTTCATCGCTATGGAGCATCTGGGCGAGCGGCCGTT
GGCGATTACGAATGTGGTACGTAGCATCTCCTCGTTCCTGTTTATGTTCGTGAATGCTTTCGCCTCCACGAACAGCTCGC
TGGTAAGTAACTTGATCGGCGCCGGGGAGTCGGACCGGGTGCTTCCGCTTTGCCGGAGGATGATCGGGCTATGCTATGCG
TTCGTGCTACCGATCGGTATCTTGATCGCTATGTTCCCGTCTACCGTATTGCGTATTTATACGGATAACCCGGATCTGAT
CGCTAGCTCGATCCCCTCGCTGTGGGTGATGCTGTCCTCTTATCTTTTCGCCGTTCCCGGTTTTATTTATTTCTTTAGCG
TATCGGGGACAGGCAATACCCGCCGTGCGCTGGAAATCGATATGGCTAGCATATTCGTGTACGTATTATATATATTGTAT
GTCGCCGTATGGTTGCGTGCGGACGTGGCGGTTTGCTGGACTACGGAGTATGTATATAATATCATGATCCTTTCTTCTTT
CTTCTATCTATGGAAAGGAAATTGGCGTAACAAGAAAATCTGA

Upstream 100 bases:

>100_bases
GTATAATAATGTAATATGATAAGAAACGGATCGCATGGGGTAATATTGTGTGACTGGCATCTTATTACTACCTTTGCCTC
CCTTTTATTTAAGATTCATC

Downstream 100 bases:

>100_bases
AGACTTATCTTTTGATTAGTACGGTAATTCGTAAGGATAAATCAAAAAAGACCATCTTGGCATTCACGTTCTGTGTGATA
TGGCGTTCCGCTTTCGCCAA

Product: multidrug efflux pump BexA

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MRYTNKQILKITYPVLISLLMEHMIGLTDTAYLGRVGEVELGASALAGVYYLVIYMLGFGFSVGAQVLMARRNGEGEYKR
IGEVFTQGGLFLFLLAAVLFTASNLLTPYLLHRMIGSEEVYRATMSYLDWRVYGFFFSFIAVMFRAFYVSTTNTKILTAN
SVVMVLTNVVLNYILIFGKFGFPALGIAGAAIASSISEAVSVLFFVIYTWKKIDYKKYGLFRFTRVDFRMLGQILSVSIW
VMIQHGIAFGGWFIFFIAMEHLGERPLAITNVVRSISSFLFMFVNAFASTNSSLVSNLIGAGESDRVLPLCRRMIGLCYA
FVLPIGILIAMFPSTVLRIYTDNPDLIASSIPSLWVMLSSYLFAVPGFIYFFSVSGTGNTRRALEIDMASIFVYVLYILY
VAVWLRADVAVCWTTEYVYNIMILSSFFYLWKGNWRNKKI

Sequences:

>Translated_440_residues
MRYTNKQILKITYPVLISLLMEHMIGLTDTAYLGRVGEVELGASALAGVYYLVIYMLGFGFSVGAQVLMARRNGEGEYKR
IGEVFTQGGLFLFLLAAVLFTASNLLTPYLLHRMIGSEEVYRATMSYLDWRVYGFFFSFIAVMFRAFYVSTTNTKILTAN
SVVMVLTNVVLNYILIFGKFGFPALGIAGAAIASSISEAVSVLFFVIYTWKKIDYKKYGLFRFTRVDFRMLGQILSVSIW
VMIQHGIAFGGWFIFFIAMEHLGERPLAITNVVRSISSFLFMFVNAFASTNSSLVSNLIGAGESDRVLPLCRRMIGLCYA
FVLPIGILIAMFPSTVLRIYTDNPDLIASSIPSLWVMLSSYLFAVPGFIYFFSVSGTGNTRRALEIDMASIFVYVLYILY
VAVWLRADVAVCWTTEYVYNIMILSSFFYLWKGNWRNKKI
>Mature_440_residues
MRYTNKQILKITYPVLISLLMEHMIGLTDTAYLGRVGEVELGASALAGVYYLVIYMLGFGFSVGAQVLMARRNGEGEYKR
IGEVFTQGGLFLFLLAAVLFTASNLLTPYLLHRMIGSEEVYRATMSYLDWRVYGFFFSFIAVMFRAFYVSTTNTKILTAN
SVVMVLTNVVLNYILIFGKFGFPALGIAGAAIASSISEAVSVLFFVIYTWKKIDYKKYGLFRFTRVDFRMLGQILSVSIW
VMIQHGIAFGGWFIFFIAMEHLGERPLAITNVVRSISSFLFMFVNAFASTNSSLVSNLIGAGESDRVLPLCRRMIGLCYA
FVLPIGILIAMFPSTVLRIYTDNPDLIASSIPSLWVMLSSYLFAVPGFIYFFSVSGTGNTRRALEIDMASIFVYVLYILY
VAVWLRADVAVCWTTEYVYNIMILSSFFYLWKGNWRNKKI

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI48994890, Length=355, Percent_Identity=21.4084507042254, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49692; Mature: 49692

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYTNKQILKITYPVLISLLMEHMIGLTDTAYLGRVGEVELGASALAGVYYLVIYMLGFG
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCC
FSVGAQVLMARRNGEGEYKRIGEVFTQGGLFLFLLAAVLFTASNLLTPYLLHRMIGSEEV
HHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
YRATMSYLDWRVYGFFFSFIAVMFRAFYVSTTNTKILTANSVVMVLTNVVLNYILIFGKF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHCC
GFPALGIAGAAIASSISEAVSVLFFVIYTWKKIDYKKYGLFRFTRVDFRMLGQILSVSIW
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHH
VMIQHGIAFGGWFIFFIAMEHLGERPLAITNVVRSISSFLFMFVNAFASTNSSLVSNLIG
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHC
AGESDRVLPLCRRMIGLCYAFVLPIGILIAMFPSTVLRIYTDNPDLIASSIPSLWVMLSS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHH
YLFAVPGFIYFFSVSGTGNTRRALEIDMASIFVYVLYILYVAVWLRADVAVCWTTEYVYN
HHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEHHHHHHH
IMILSSFFYLWKGNWRNKKI
HHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]