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The map label for this gene is mip [H]

Identifier: 150008365

GI number: 150008365

Start: 2061393

End: 2061794

Strand: Reverse

Name: mip [H]

Synonym: BDI_1739

Alternate gene names: 150008365

Gene position: 2061794-2061393 (Counterclockwise)

Preceding gene: 150008367

Following gene: 150008361

Centisome position: 42.85

GC content: 44.03

Gene sequence:

>402_bases
ATGAGTAGAAAAGAGGAGTACAAAGAGAAGAATCTATTGTATTTGGACGAGATCGCTTCGGAAGAGGGAACCCAGACATT
ACCGTGCGGTATATTATATAAGGTAATACAAGCGGGTACAGGCCAGGTATCGCCTAATAGGGAAAACGTCGTTTCCGTAC
ATTATAAGGGAACGTTGATTAACGGAAGGGAATTTGATAACTCATGGAAACGGGGTTGCCCGGAAGCCTTTCGCTTGAAT
CAAGTGATTGAAGGCTGGCAATTGGCTCTTCAAGAAATGCGGGTAGGAGATAGATGGATAATCTATATCCCTTACAGTTT
GGGTTATGGTAATCGTGCCTCGGGTCCGATCCCTGCTTTCTCCACATTAATATTTGAGGTAGAGTTGTTGGGAATCGCCT
AA

Upstream 100 bases:

>100_bases
GTATTTGAACGTTTGGCATGTCTATTGTGTTACTATGCCATTGCATTTCTATTTCTATTTGCTACATTTGCGGAGCTAAA
TGTAAGATAATGTAATATAT

Downstream 100 bases:

>100_bases
TTCCAATCATAGAATATATAATAATGTATCCGAAGGGAGTAAAAAAGAATAGCCATGGCTAAACCCATGGCTATTCTCTT
TTTGCCTCATTAGAGGATTG

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: Macrophage infectivity potentiator; Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase [H]

Number of amino acids: Translated: 133; Mature: 132

Protein sequence:

>133_residues
MSRKEEYKEKNLLYLDEIASEEGTQTLPCGILYKVIQAGTGQVSPNRENVVSVHYKGTLINGREFDNSWKRGCPEAFRLN
QVIEGWQLALQEMRVGDRWIIYIPYSLGYGNRASGPIPAFSTLIFEVELLGIA

Sequences:

>Translated_133_residues
MSRKEEYKEKNLLYLDEIASEEGTQTLPCGILYKVIQAGTGQVSPNRENVVSVHYKGTLINGREFDNSWKRGCPEAFRLN
QVIEGWQLALQEMRVGDRWIIYIPYSLGYGNRASGPIPAFSTLIFEVELLGIA
>Mature_132_residues
SRKEEYKEKNLLYLDEIASEEGTQTLPCGILYKVIQAGTGQVSPNRENVVSVHYKGTLINGREFDNSWKRGCPEAFRLNQ
VIEGWQLALQEMRVGDRWIIYIPYSLGYGNRASGPIPAFSTLIFEVELLGIA

Specific function: Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI206725530, Length=114, Percent_Identity=39.4736842105263, Blast_Score=73, Evalue=7e-14,
Organism=Homo sapiens, GI17149844, Length=114, Percent_Identity=39.4736842105263, Blast_Score=73, Evalue=7e-14,
Organism=Homo sapiens, GI17149842, Length=114, Percent_Identity=39.4736842105263, Blast_Score=73, Evalue=7e-14,
Organism=Homo sapiens, GI17149836, Length=104, Percent_Identity=38.4615384615385, Blast_Score=71, Evalue=3e-13,
Organism=Homo sapiens, GI4503725, Length=104, Percent_Identity=38.4615384615385, Blast_Score=71, Evalue=3e-13,
Organism=Homo sapiens, GI224809331, Length=104, Percent_Identity=39.4230769230769, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI224809329, Length=104, Percent_Identity=39.4230769230769, Blast_Score=68, Evalue=2e-12,
Organism=Homo sapiens, GI224809327, Length=104, Percent_Identity=39.4230769230769, Blast_Score=68, Evalue=2e-12,
Organism=Homo sapiens, GI4758384, Length=104, Percent_Identity=39.4230769230769, Blast_Score=68, Evalue=2e-12,
Organism=Homo sapiens, GI4758380, Length=106, Percent_Identity=35.8490566037736, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI4503729, Length=128, Percent_Identity=35.15625, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082390, Length=131, Percent_Identity=45.8015267175573, Blast_Score=108, Evalue=1e-25,
Organism=Escherichia coli, GI1789745, Length=119, Percent_Identity=44.5378151260504, Blast_Score=105, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=39.622641509434, Blast_Score=79, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17561782, Length=104, Percent_Identity=43.2692307692308, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17540882, Length=85, Percent_Identity=48.2352941176471, Blast_Score=73, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324194, Length=102, Percent_Identity=42.156862745098, Blast_Score=78, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320727, Length=86, Percent_Identity=44.1860465116279, Blast_Score=68, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24583150, Length=105, Percent_Identity=38.0952380952381, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281363946, Length=88, Percent_Identity=43.1818181818182, Blast_Score=72, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17352457, Length=88, Percent_Identity=43.1818181818182, Blast_Score=72, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24655568, Length=106, Percent_Identity=37.7358490566038, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008104
- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 15056; Mature: 14925

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKEEYKEKNLLYLDEIASEEGTQTLPCGILYKVIQAGTGQVSPNRENVVSVHYKGTLI
CCCHHHHHHCCCEEEHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCEEE
NGREFDNSWKRGCPEAFRLNQVIEGWQLALQEMRVGDRWIIYIPYSLGYGNRASGPIPAF
CCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCHH
STLIFEVELLGIA
HHHHHEEEEEECC
>Mature Secondary Structure 
SRKEEYKEKNLLYLDEIASEEGTQTLPCGILYKVIQAGTGQVSPNRENVVSVHYKGTLI
CCHHHHHHCCCEEEHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCEEE
NGREFDNSWKRGCPEAFRLNQVIEGWQLALQEMRVGDRWIIYIPYSLGYGNRASGPIPAF
CCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCHH
STLIFEVELLGIA
HHHHHEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1840577 [H]