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The map label for this gene is gyaR [H]

Identifier: 150008360

GI number: 150008360

Start: 2054055

End: 2054948

Strand: Reverse

Name: gyaR [H]

Synonym: BDI_1734

Alternate gene names: 150008360

Gene position: 2054948-2054055 (Counterclockwise)

Preceding gene: 150008361

Following gene: 150008358

Centisome position: 42.71

GC content: 50.0

Gene sequence:

>894_bases
ATGTTTGAGAAAATTGTAGTGGTAGATTCTACCGGGTTGAATACATGGGGAGTGGAGCGTTTGAAGGCGCTTGGAAAAGA
GGTTGTTTTTTATACCGGCATTCCGGAAACGGATGAGGAGATTGTGAACCGGATCGGGGACGCAGATTGCGTACTCGTCT
CTTATAATACACAGATCCGGAGGAACGTGATCGAGGCTTGCCCGAATATCAAATACATCGGGATGTGCTGTACCCTCTAT
AGCGAGTCTAGCGCGAATGTGGATATAGCCGCCGCACGTGAGCGGGGGATAACGGTCTTGGGTATCCGCGACTATGGCGA
TGAGGGAGTCGTGGAGTATGTCATTAGCGAGCTAGTCCGTCTGTTGCATGGTTTCGGCGGGAAACAATGGAAGCATAAGG
CGTATGAGCTGGGCGGGCAAAAAGTAGGCATTGTGGGATTGGGTCGCACCGGGAGAATGATCGCTGACGCTCTTCGTTTT
TTTGGGGCGGAGGTTTATTATTTCAGCCGTACCCGTAAGCCGGATGCCGAGGCCGCCGGTATCGCTTACCTGCCTTTGCG
GGAGTTGCTGCCGGAGGTGGATATTTTATGTACTTGCTTGCCTCGTAATACGATTCTTCTGGGGGCGGGTGAGTTTCGTT
TGTTCGGTAATCTGAAGATATTGATCAATACGTCGGTAGGGCCGACTTTCCGTGTCCCGGATTTACAACGTTGGCTTAGC
GCACATAAGCGGAATTTCTTCTTATGCGATGCGGTAGGTATCGGGAATTATGCGGATACCTTGACGCAATTCGATAATGT
CATATATACCCCGAAAGTCTCCGGCCACTCGGAGCAATGTATGGAGCGATTGTCGCAAAAGGTAATAGCGAATATCGAAA
GCTATCTAAATTGA

Upstream 100 bases:

>100_bases
TTTATTAAGTGTCGTGCTGAAGGTTACCCTTTGCGGCTATTTTATTTATAGTTTTGTGAGAGGGATAATTAATTGAAGAT
GGTAATTAATAAAGTAAGAT

Downstream 100 bases:

>100_bases
CATGACCCTGTATCAAAACTCTTGGTGGTCTATCTTTTAGACGCAGATGACGCAGATGACACGGATGACACGGATTTATT
TTATTCTTATCCGTGTTATC

Product: putative D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MFEKIVVVDSTGLNTWGVERLKALGKEVVFYTGIPETDEEIVNRIGDADCVLVSYNTQIRRNVIEACPNIKYIGMCCTLY
SESSANVDIAAARERGITVLGIRDYGDEGVVEYVISELVRLLHGFGGKQWKHKAYELGGQKVGIVGLGRTGRMIADALRF
FGAEVYYFSRTRKPDAEAAGIAYLPLRELLPEVDILCTCLPRNTILLGAGEFRLFGNLKILINTSVGPTFRVPDLQRWLS
AHKRNFFLCDAVGIGNYADTLTQFDNVIYTPKVSGHSEQCMERLSQKVIANIESYLN

Sequences:

>Translated_297_residues
MFEKIVVVDSTGLNTWGVERLKALGKEVVFYTGIPETDEEIVNRIGDADCVLVSYNTQIRRNVIEACPNIKYIGMCCTLY
SESSANVDIAAARERGITVLGIRDYGDEGVVEYVISELVRLLHGFGGKQWKHKAYELGGQKVGIVGLGRTGRMIADALRF
FGAEVYYFSRTRKPDAEAAGIAYLPLRELLPEVDILCTCLPRNTILLGAGEFRLFGNLKILINTSVGPTFRVPDLQRWLS
AHKRNFFLCDAVGIGNYADTLTQFDNVIYTPKVSGHSEQCMERLSQKVIANIESYLN
>Mature_297_residues
MFEKIVVVDSTGLNTWGVERLKALGKEVVFYTGIPETDEEIVNRIGDADCVLVSYNTQIRRNVIEACPNIKYIGMCCTLY
SESSANVDIAAARERGITVLGIRDYGDEGVVEYVISELVRLLHGFGGKQWKHKAYELGGQKVGIVGLGRTGRMIADALRF
FGAEVYYFSRTRKPDAEAAGIAYLPLRELLPEVDILCTCLPRNTILLGAGEFRLFGNLKILINTSVGPTFRVPDLQRWLS
AHKRNFFLCDAVGIGNYADTLTQFDNVIYTPKVSGHSEQCMERLSQKVIANIESYLN

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=273, Percent_Identity=23.0769230769231, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1789279, Length=314, Percent_Identity=27.0700636942675, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787645, Length=284, Percent_Identity=23.5915492957746, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320925, Length=324, Percent_Identity=24.6913580246914, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6322116, Length=315, Percent_Identity=23.4920634920635, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 33074; Mature: 33074

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEKIVVVDSTGLNTWGVERLKALGKEVVFYTGIPETDEEIVNRIGDADCVLVSYNTQIR
CCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCCCEEEEECCHHHH
RNVIEACPNIKYIGMCCTLYSESSANVDIAAARERGITVLGIRDYGDEGVVEYVISELVR
HHHHHHCCCCEEEEEEEEEECCCCCCEEEEEHHHCCEEEEEEECCCCCHHHHHHHHHHHH
LLHGFGGKQWKHKAYELGGQKVGIVGLGRTGRMIADALRFFGAEVYYFSRTRKPDAEAAG
HHHCCCCCCHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCEEEEEECCCCCCCCCCC
IAYLPLRELLPEVDILCTCLPRNTILLGAGEFRLFGNLKILINTSVGPTFRVPDLQRWLS
EEEECHHHHCCHHHEEEEECCCCEEEEECCCEEEEECEEEEEECCCCCEECCCHHHHHHH
AHKRNFFLCDAVGIGNYADTLTQFDNVIYTPKVSGHSEQCMERLSQKVIANIESYLN
HHCCCEEEEEECCCCHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFEKIVVVDSTGLNTWGVERLKALGKEVVFYTGIPETDEEIVNRIGDADCVLVSYNTQIR
CCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCCCEEEEECCHHHH
RNVIEACPNIKYIGMCCTLYSESSANVDIAAARERGITVLGIRDYGDEGVVEYVISELVR
HHHHHHCCCCEEEEEEEEEECCCCCCEEEEEHHHCCEEEEEEECCCCCHHHHHHHHHHHH
LLHGFGGKQWKHKAYELGGQKVGIVGLGRTGRMIADALRFFGAEVYYFSRTRKPDAEAAG
HHHCCCCCCHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCEEEEEECCCCCCCCCCC
IAYLPLRELLPEVDILCTCLPRNTILLGAGEFRLFGNLKILINTSVGPTFRVPDLQRWLS
EEEECHHHHCCHHHEEEEECCCCEEEEECCCEEEEECEEEEEECCCCCEECCCHHHHHHH
AHKRNFFLCDAVGIGNYADTLTQFDNVIYTPKVSGHSEQCMERLSQKVIANIESYLN
HHCCCEEEEEECCCCHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA