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The map label for this gene is galK [H]

Identifier: 150008297

GI number: 150008297

Start: 1969521

End: 1970666

Strand: Direct

Name: galK [H]

Synonym: BDI_1666

Alternate gene names: 150008297

Gene position: 1969521-1970666 (Clockwise)

Preceding gene: 150008296

Following gene: 150008298

Centisome position: 40.93

GC content: 45.9

Gene sequence:

>1146_bases
ATGCAACAAAAAATCAGAACTAAATTTAAAGAGTTATTTAATACCGAAGGTAGCTTATACACATCCCCGGGACGTATTAA
CTTGATCGGTGAACACACTGATTATAATGGAGGTTTCGTTTTTCCGGGTGCTGTAGATAAAGGGATGATCGCCGAGATCA
AACCGAATGGGACGGGCAAAGTCCGGGCGTTCTCCATCGACTTAAATGATTACGCTGAATTTGGCTTGACCGAGGAGGAC
GCTCCTTCCGCAAGCTGGGCAAGATATATCTTTGGCGTATGCCGGGAGATTATTAAACGAGGTGGTAATATCCAAGGTTT
CGATACCGTATTCGCTGGAGACGTACCTCTGGGCGCTGGAATGTCTTCTTCCGCCGCATTGGAAAGTACTTATGCTTTCG
CATTGAATGACTTATTCTCATTGAATATCGATAAATTCGAGTTGGCTAAGATCGGTCAAGCTACAGAACATAATTATTGT
GGCGTGAATTGCGGTATCATGGACCAATTCGCTTCCGTATTCGGCAAGGCCGGAAGTTTGATCCGCTTGGATTGCCGTTC
TTTGGAATATAAATATTATCCGTTTAATCCGGTTGGTTACAAACTCGTGTTATTGGATTCGGTCGTTAAGCATGAGTTGG
CATCCTCAGCCTACAACAAACGCCGTAAATCCTGCGAGAACGTGGTAGCCGCCATTCGCCGCAACCATCCGGAAGTAGAG
TTCTTACGTGACGCTACGATGGAGATGCTGAACGAGGTAAAAGCGGATGTCAGCGCAGAGGATTACATGCGTGCCGAATA
TGTTATCGAGGAAATCCAACGTGTACTCGACGTATGTGCCGCTTTGGAGAAAGGCGACTATGAGACTGTCGGCGAAAAGA
TGTACGGCACGCATCAAGGTATGAGCAAGCTTTATGAAGTTAGCTGCGAGGAACTGGATTTCTTGAACGATATCGCCAAG
GAATGTGGTGTAACGGGTTCTCGTGTCATGGGTGGAGGATTCGGCGGTTGTACGATCAACTTGGTTAAGGATGAGTTGTA
CGACGATTTCGTGAAGAAAGCCTTCTCCGCTTATAAAGAGAAGTTTGGCCGTGAACCTAAATTATATAATGTAGTAATCA
GCGACGGAGCACGCAAGCTCTGTTAA

Upstream 100 bases:

>100_bases
AGGACATAATATGATAAAGAAGAAATTATCCGGCAGAGTTATCTGAATGGGTAATTTCTTCTTGTTTATTCAATTATTTA
CCTTAATCAAATTAAGTATC

Downstream 100 bases:

>100_bases
TCTTTAAAATCCATAAAACGATGTCAGCAGCTTTTTATCAAGACGAAGTAAAATTCTATGTTGCCGTAGATTGTATCATT
CTAGGGTTTAACAATAAGGA

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MQQKIRTKFKELFNTEGSLYTSPGRINLIGEHTDYNGGFVFPGAVDKGMIAEIKPNGTGKVRAFSIDLNDYAEFGLTEED
APSASWARYIFGVCREIIKRGGNIQGFDTVFAGDVPLGAGMSSSAALESTYAFALNDLFSLNIDKFELAKIGQATEHNYC
GVNCGIMDQFASVFGKAGSLIRLDCRSLEYKYYPFNPVGYKLVLLDSVVKHELASSAYNKRRKSCENVVAAIRRNHPEVE
FLRDATMEMLNEVKADVSAEDYMRAEYVIEEIQRVLDVCAALEKGDYETVGEKMYGTHQGMSKLYEVSCEELDFLNDIAK
ECGVTGSRVMGGGFGGCTINLVKDELYDDFVKKAFSAYKEKFGREPKLYNVVISDGARKLC

Sequences:

>Translated_381_residues
MQQKIRTKFKELFNTEGSLYTSPGRINLIGEHTDYNGGFVFPGAVDKGMIAEIKPNGTGKVRAFSIDLNDYAEFGLTEED
APSASWARYIFGVCREIIKRGGNIQGFDTVFAGDVPLGAGMSSSAALESTYAFALNDLFSLNIDKFELAKIGQATEHNYC
GVNCGIMDQFASVFGKAGSLIRLDCRSLEYKYYPFNPVGYKLVLLDSVVKHELASSAYNKRRKSCENVVAAIRRNHPEVE
FLRDATMEMLNEVKADVSAEDYMRAEYVIEEIQRVLDVCAALEKGDYETVGEKMYGTHQGMSKLYEVSCEELDFLNDIAK
ECGVTGSRVMGGGFGGCTINLVKDELYDDFVKKAFSAYKEKFGREPKLYNVVISDGARKLC
>Mature_381_residues
MQQKIRTKFKELFNTEGSLYTSPGRINLIGEHTDYNGGFVFPGAVDKGMIAEIKPNGTGKVRAFSIDLNDYAEFGLTEED
APSASWARYIFGVCREIIKRGGNIQGFDTVFAGDVPLGAGMSSSAALESTYAFALNDLFSLNIDKFELAKIGQATEHNYC
GVNCGIMDQFASVFGKAGSLIRLDCRSLEYKYYPFNPVGYKLVLLDSVVKHELASSAYNKRRKSCENVVAAIRRNHPEVE
FLRDATMEMLNEVKADVSAEDYMRAEYVIEEIQRVLDVCAALEKGDYETVGEKMYGTHQGMSKLYEVSCEELDFLNDIAK
ECGVTGSRVMGGGFGGCTINLVKDELYDDFVKKAFSAYKEKFGREPKLYNVVISDGARKLC

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=387, Percent_Identity=37.984496124031, Blast_Score=234, Evalue=8e-62,
Organism=Homo sapiens, GI4503897, Length=422, Percent_Identity=27.9620853080569, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI48527957, Length=422, Percent_Identity=27.9620853080569, Blast_Score=122, Evalue=5e-28,
Organism=Escherichia coli, GI1786972, Length=386, Percent_Identity=36.0103626943005, Blast_Score=228, Evalue=5e-61,
Organism=Caenorhabditis elegans, GI71989053, Length=422, Percent_Identity=26.0663507109005, Blast_Score=88, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6319494, Length=246, Percent_Identity=31.3008130081301, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6320212, Length=236, Percent_Identity=31.3559322033898, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24661292, Length=422, Percent_Identity=26.5402843601896, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21355577, Length=422, Percent_Identity=26.5402843601896, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24661285, Length=422, Percent_Identity=26.5402843601896, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 42296; Mature: 42296

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP ; PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQKIRTKFKELFNTEGSLYTSPGRINLIGEHTDYNGGFVFPGAVDKGMIAEIKPNGTGK
CCHHHHHHHHHHHCCCCCEEECCCEEEEEECCCCCCCCEEECCCCCCCCEEEECCCCCCE
VRAFSIDLNDYAEFGLTEEDAPSASWARYIFGVCREIIKRGGNIQGFDTVFAGDVPLGAG
EEEEEEEHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCC
MSSSAALESTYAFALNDLFSLNIDKFELAKIGQATEHNYCGVNCGIMDQFASVFGKAGSL
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCE
IRLDCRSLEYKYYPFNPVGYKLVLLDSVVKHELASSAYNKRRKSCENVVAAIRRNHPEVE
EEEEHHHCEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
FLRDATMEMLNEVKADVSAEDYMRAEYVIEEIQRVLDVCAALEKGDYETVGEKMYGTHQG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
MSKLYEVSCEELDFLNDIAKECGVTGSRVMGGGFGGCTINLVKDELYDDFVKKAFSAYKE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHH
KFGREPKLYNVVISDGARKLC
HHCCCCCEEEEEEECCCCCCC
>Mature Secondary Structure
MQQKIRTKFKELFNTEGSLYTSPGRINLIGEHTDYNGGFVFPGAVDKGMIAEIKPNGTGK
CCHHHHHHHHHHHCCCCCEEECCCEEEEEECCCCCCCCEEECCCCCCCCEEEECCCCCCE
VRAFSIDLNDYAEFGLTEEDAPSASWARYIFGVCREIIKRGGNIQGFDTVFAGDVPLGAG
EEEEEEEHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCC
MSSSAALESTYAFALNDLFSLNIDKFELAKIGQATEHNYCGVNCGIMDQFASVFGKAGSL
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCE
IRLDCRSLEYKYYPFNPVGYKLVLLDSVVKHELASSAYNKRRKSCENVVAAIRRNHPEVE
EEEEHHHCEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
FLRDATMEMLNEVKADVSAEDYMRAEYVIEEIQRVLDVCAALEKGDYETVGEKMYGTHQG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
MSKLYEVSCEELDFLNDIAKECGVTGSRVMGGGFGGCTINLVKDELYDDFVKKAFSAYKE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHH
KFGREPKLYNVVISDGARKLC
HHCCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA