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The map label for this gene is mepA [H]

Identifier: 150008018

GI number: 150008018

Start: 1601170

End: 1602549

Strand: Reverse

Name: mepA [H]

Synonym: BDI_1381

Alternate gene names: 150008018

Gene position: 1602549-1601170 (Counterclockwise)

Preceding gene: 150008019

Following gene: 150008011

Centisome position: 33.31

GC content: 44.35

Gene sequence:

>1380_bases
ATGAAAATGAGTGGAGAAAAGGCGATCCATCGCCAAGAGTTGGAGCGTGGTTTACTAACTCAAAAGATTTCAAGACTATT
TCTGAAATATACGATACCGGGAGTAGCCGGCCTATTATTCCTCGGGATTCAGTCGGTGATCGATGGTGTGATATTAGGGC
GGTTTGTCGGGGCGAACGCTTTGGCCAGCGTGAATCTGATCTTACCTTGCTATAGTTTGATGACGGCTTTGTCTATCGTG
ATAGGAGTAGGGTGTCAGACCTTGATCGGTATAAACCTCGGACGTTCGGATCGGCAAGAGGCGAATAACGCTATAACTAC
TTCGTTCTTGTTTCTTGGAGGAATATCCGTTTTGATTAGCGGGTTGATTTATATATTCGCCGGAGATATCGCCCGTATGT
TAGGTGCGAATGACGTATTGGTTACGGGAGCCGTGGACTATATTCGTTCCCTTGTCCCGTTTTTCCCTTTATTATCATTG
ATGTTCTTAGGAGATTATATGATTAAGGCGATGGGGCATCCGCTTTATGCCATGATCGTAATGGGAAGTACGGTGTTGAT
TAATATCGGTCTGGATCTTTTGTTTATCCCGGTAATGGGTTTAGGGATTAAGGGGGCGGGATTGGCTACAGGTTTGGCCT
TTACCTTGGGAGCGCTGTTCAATATTCCCCGGATGTTCCAGCGAGGGCAAGTCGTAGTGGTACAAAGAGGACGTTTCCGT
TGGCCTTTGGTCTGGAATGCGTTATACAATGGCTCTTCGGAAGGAATATCCGAGCTATCTGCCGGAATCACGATTTTTTT
GTTCAATATAACGATGATGCGATATTTAGGAGAGGATGGAGTCGCCGCCTTTACGGCGATTAACTATATCTTGTTTATCG
CCACCACGGTATTCTTAGGGATATCCGATGGAATTATACCGATTATCAGTTATAATTTCGGGGCGGGAAGATTGGACCGG
ATCGAGAAAGTGCTGAGATTAGCAGGGCGTGTTAATTTTATGATAGGTATAACGTTATTCGCCATCTTATTCTTTTTCGG
GCAACAGATCACGTCCTTTTTCTTTAAGGGAGGAGAGGCTTTGGACGCTTTGGCGATCGCTAATTACGGCATAACGATTT
ATTGCTTCACCTTCTTGATGAGTGGGCTGAATATATTGGCCTCCAGTTATTTCACGGCTATCGGCAACGCTAAGCTGTCG
GTTGTTATCTCTATGCTGCGTAGCTTGGTATTCGTAACCTTTGGTATTATCGTTTATCCTTCTTTATTCGGCATCCAAAG
TATTTGGTATAATGTACCGGTGGCGGAGTTGTGTACGTTATTTATCTCCTTTATGTTGGTAAGGAGAGAACTTTTAAAAG
AGGCCGTGCTGAAAAATTAA

Upstream 100 bases:

>100_bases
TCCGTAAAAAAATAGGGAAAAGTCATTATTTATCATAGGGTAATTTTTCTTGTTTTCAATAGCCATATCTTCGCGTCGTT
AAAAACGTGAAGTGGATAAT

Downstream 100 bases:

>100_bases
TCAGCACAACCTTCTTAATTTCTTATTCGATATTCTTCCGTATCTTGGTCAGATACTCTTTCATCTTCTCGGAATCCTTA
TCCTTGATGATTTCTTGCAA

Product: putative transmembrane cation efflux pump

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MKMSGEKAIHRQELERGLLTQKISRLFLKYTIPGVAGLLFLGIQSVIDGVILGRFVGANALASVNLILPCYSLMTALSIV
IGVGCQTLIGINLGRSDRQEANNAITTSFLFLGGISVLISGLIYIFAGDIARMLGANDVLVTGAVDYIRSLVPFFPLLSL
MFLGDYMIKAMGHPLYAMIVMGSTVLINIGLDLLFIPVMGLGIKGAGLATGLAFTLGALFNIPRMFQRGQVVVVQRGRFR
WPLVWNALYNGSSEGISELSAGITIFLFNITMMRYLGEDGVAAFTAINYILFIATTVFLGISDGIIPIISYNFGAGRLDR
IEKVLRLAGRVNFMIGITLFAILFFFGQQITSFFFKGGEALDALAIANYGITIYCFTFLMSGLNILASSYFTAIGNAKLS
VVISMLRSLVFVTFGIIVYPSLFGIQSIWYNVPVAELCTLFISFMLVRRELLKEAVLKN

Sequences:

>Translated_459_residues
MKMSGEKAIHRQELERGLLTQKISRLFLKYTIPGVAGLLFLGIQSVIDGVILGRFVGANALASVNLILPCYSLMTALSIV
IGVGCQTLIGINLGRSDRQEANNAITTSFLFLGGISVLISGLIYIFAGDIARMLGANDVLVTGAVDYIRSLVPFFPLLSL
MFLGDYMIKAMGHPLYAMIVMGSTVLINIGLDLLFIPVMGLGIKGAGLATGLAFTLGALFNIPRMFQRGQVVVVQRGRFR
WPLVWNALYNGSSEGISELSAGITIFLFNITMMRYLGEDGVAAFTAINYILFIATTVFLGISDGIIPIISYNFGAGRLDR
IEKVLRLAGRVNFMIGITLFAILFFFGQQITSFFFKGGEALDALAIANYGITIYCFTFLMSGLNILASSYFTAIGNAKLS
VVISMLRSLVFVTFGIIVYPSLFGIQSIWYNVPVAELCTLFISFMLVRRELLKEAVLKN
>Mature_459_residues
MKMSGEKAIHRQELERGLLTQKISRLFLKYTIPGVAGLLFLGIQSVIDGVILGRFVGANALASVNLILPCYSLMTALSIV
IGVGCQTLIGINLGRSDRQEANNAITTSFLFLGGISVLISGLIYIFAGDIARMLGANDVLVTGAVDYIRSLVPFFPLLSL
MFLGDYMIKAMGHPLYAMIVMGSTVLINIGLDLLFIPVMGLGIKGAGLATGLAFTLGALFNIPRMFQRGQVVVVQRGRFR
WPLVWNALYNGSSEGISELSAGITIFLFNITMMRYLGEDGVAAFTAINYILFIATTVFLGISDGIIPIISYNFGAGRLDR
IEKVLRLAGRVNFMIGITLFAILFFFGQQITSFFFKGGEALDALAIANYGITIYCFTFLMSGLNILASSYFTAIGNAKLS
VVISMLRSLVFVTFGIIVYPSLFGIQSIWYNVPVAELCTLFISFMLVRRELLKEAVLKN

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 50007; Mature: 50007

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMSGEKAIHRQELERGLLTQKISRLFLKYTIPGVAGLLFLGIQSVIDGVILGRFVGANA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LASVNLILPCYSLMTALSIVIGVGCQTLIGINLGRSDRQEANNAITTSFLFLGGISVLIS
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHH
GLIYIFAGDIARMLGANDVLVTGAVDYIRSLVPFFPLLSLMFLGDYMIKAMGHPLYAMIV
HHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
MGSTVLINIGLDLLFIPVMGLGIKGAGLATGLAFTLGALFNIPRMFQRGQVVVVQRGRFR
HCCHHEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCEEEEECCCCC
WPLVWNALYNGSSEGISELSAGITIFLFNITMMRYLGEDGVAAFTAINYILFIATTVFLG
CCHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ISDGIIPIISYNFGAGRLDRIEKVLRLAGRVNFMIGITLFAILFFFGQQITSFFFKGGEA
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
LDALAIANYGITIYCFTFLMSGLNILASSYFTAIGNAKLSVVISMLRSLVFVTFGIIVYP
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
SLFGIQSIWYNVPVAELCTLFISFMLVRRELLKEAVLKN
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKMSGEKAIHRQELERGLLTQKISRLFLKYTIPGVAGLLFLGIQSVIDGVILGRFVGANA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LASVNLILPCYSLMTALSIVIGVGCQTLIGINLGRSDRQEANNAITTSFLFLGGISVLIS
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHH
GLIYIFAGDIARMLGANDVLVTGAVDYIRSLVPFFPLLSLMFLGDYMIKAMGHPLYAMIV
HHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
MGSTVLINIGLDLLFIPVMGLGIKGAGLATGLAFTLGALFNIPRMFQRGQVVVVQRGRFR
HCCHHEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCEEEEECCCCC
WPLVWNALYNGSSEGISELSAGITIFLFNITMMRYLGEDGVAAFTAINYILFIATTVFLG
CCHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ISDGIIPIISYNFGAGRLDRIEKVLRLAGRVNFMIGITLFAILFFFGQQITSFFFKGGEA
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
LDALAIANYGITIYCFTFLMSGLNILASSYFTAIGNAKLSVVISMLRSLVFVTFGIIVYP
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
SLFGIQSIWYNVPVAELCTLFISFMLVRRELLKEAVLKN
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA