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The map label for this gene is putP1 [H]

Identifier: 150008005

GI number: 150008005

Start: 1586501

End: 1588054

Strand: Direct

Name: putP1 [H]

Synonym: BDI_1368

Alternate gene names: 150008005

Gene position: 1586501-1588054 (Clockwise)

Preceding gene: 150008004

Following gene: 150008006

Centisome position: 32.97

GC content: 48.58

Gene sequence:

>1554_bases
ATGAGTACGCTAACATTAGGCATTATTGTCATTATTTACATGTTTGTAATCGCTTGGTTAGGGTATCTCGGATACAGGCA
GACGAAAAACGCCAGTGATTATTTATTAGGCGGACGAAAAGTAAACCCCATTATCATGGCCCTGTCTTACGGGGCGACCT
TTATCTCGGCATCGGCGATCGTTGGTTTCGGTGGCGTAGCCGCTACGTTCGGCATGGGTATTCAATGGCTTTGCTTATTG
AACATGTTCATGGGCGTAGTGGTAGCCTTTATCTTTTTCGGACGAAGGACCCGGAAGTTAGGCGAGGCACATAACGCACG
GACTTTCCCGCAATTATTGGGATTACACTATAAGTCCCGGTCTATACAGATCTTCATCGCCTCGATCATTTTCATCGGCA
TGCCCCTCTACACCGCCGTGGTGATGAAGGGAGGAGCCGTCTTCATCGAACAGATGTTTCACATCGACCTTCATCTGGCC
TTGTTGATCTTCACCTTGATCGTAGCGGCCTACGTGATTACGGGCGGAATCAAGGGAGTACTTTATACGGATGCGTTGCA
AGCGGTTATCATGTTCGCTTGTATGCTATTCCTGCTATTTTGGTTTTACCATATCATGGACATGGGCTTTATCGAGGCAA
ACCAGAAGTTGACGGATATCGCCCCCATGGTGCCCGAACGCTTCAAGGCCTTGGGACATCAAGGATGGACAGCTATGCCC
ATCTCAGGCTCTTCACAATGGTATACATTGGTTACCTCATTGATCCTTGGCGTAGGAATCGGTTGCTTAGCGCAGCCACA
ACTAGTCGTACGCTTCATGATGGTGGAAAGTACCAAGCAACTCAACAGGGGCGTATTGATCGGTTGCGTGTTCTTGATTG
TCACGGTAGGGGCGATTTATCACGTGGGAGCCTTGTCTAATTTGTTTTTCCTCAAGACGGAAGGTGTAGTCGCCTCCGAG
GCGGTAAAAGATATGGACAAGATCATCCCCCTATTTATCAATAAAGCGATGCCGGAGTGGTTCGGGGCGGTTTTCATGCT
TTGTATTCTCTCTGCCAGTATGTCTACCCTTAGCGCACAATTTCATACCATGGGAGCGGCTTTCGGGGCAGACGCATTCC
CCAAACTAGGACGTAGCAAAAATCCGAACTCTACATTAGGTGTACGTATCGGCGTGCTATGCTCTATCTTGGTCAGCTAC
GTTATCTGCTATACGCTAAGCGCGAGTATTATCGCACGAGGCACCGCCTTGTTCATGGGTATTTGCGCGGCTACATTCCT
ACCTACCTATTTCTGCTCGTTATATTGGAAAGGGGCTACCCGGCAAGGGGCCTTGGCCAGCTTATGGGTAGGAGGCTTGG
CCAGTTTATTCGCCATGTTGTTCCTTCATAAGGCGGAAGCGGCTCCGGTAGGACTTTGCAAGGCTTTATTCGGACAAGAC
GTCTTGATCGATGTATATCCGTGGCATGCGATAGATCCGATCTTATTTGCTTTGCCATTATCGGCGATAACGATTGTTTT
GGTTAGCCTAGCGACTCAAAAGAAGGCTTTTTAG

Upstream 100 bases:

>100_bases
TTCTAGCGTTCGCCTGCCTCCTATTTTCTATTTGGTTCGGGATAACCACTTGGAATAAAGAAGACGACGAAAAAACAAAC
CCTACTAAAGAATCACGAAA

Downstream 100 bases:

>100_bases
CTTTTCTTATGAACCTCAAAACACTAATTAGCATTTATTCTATTGACAGATATATAGAAAACAGTACATTTGCACTGTGG
TTTTTTCATAATAGTATTAG

Product: osmo-regulated proline transporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Proline permease 1 [H]

Number of amino acids: Translated: 517; Mature: 516

Protein sequence:

>517_residues
MSTLTLGIIVIIYMFVIAWLGYLGYRQTKNASDYLLGGRKVNPIIMALSYGATFISASAIVGFGGVAATFGMGIQWLCLL
NMFMGVVVAFIFFGRRTRKLGEAHNARTFPQLLGLHYKSRSIQIFIASIIFIGMPLYTAVVMKGGAVFIEQMFHIDLHLA
LLIFTLIVAAYVITGGIKGVLYTDALQAVIMFACMLFLLFWFYHIMDMGFIEANQKLTDIAPMVPERFKALGHQGWTAMP
ISGSSQWYTLVTSLILGVGIGCLAQPQLVVRFMMVESTKQLNRGVLIGCVFLIVTVGAIYHVGALSNLFFLKTEGVVASE
AVKDMDKIIPLFINKAMPEWFGAVFMLCILSASMSTLSAQFHTMGAAFGADAFPKLGRSKNPNSTLGVRIGVLCSILVSY
VICYTLSASIIARGTALFMGICAATFLPTYFCSLYWKGATRQGALASLWVGGLASLFAMLFLHKAEAAPVGLCKALFGQD
VLIDVYPWHAIDPILFALPLSAITIVLVSLATQKKAF

Sequences:

>Translated_517_residues
MSTLTLGIIVIIYMFVIAWLGYLGYRQTKNASDYLLGGRKVNPIIMALSYGATFISASAIVGFGGVAATFGMGIQWLCLL
NMFMGVVVAFIFFGRRTRKLGEAHNARTFPQLLGLHYKSRSIQIFIASIIFIGMPLYTAVVMKGGAVFIEQMFHIDLHLA
LLIFTLIVAAYVITGGIKGVLYTDALQAVIMFACMLFLLFWFYHIMDMGFIEANQKLTDIAPMVPERFKALGHQGWTAMP
ISGSSQWYTLVTSLILGVGIGCLAQPQLVVRFMMVESTKQLNRGVLIGCVFLIVTVGAIYHVGALSNLFFLKTEGVVASE
AVKDMDKIIPLFINKAMPEWFGAVFMLCILSASMSTLSAQFHTMGAAFGADAFPKLGRSKNPNSTLGVRIGVLCSILVSY
VICYTLSASIIARGTALFMGICAATFLPTYFCSLYWKGATRQGALASLWVGGLASLFAMLFLHKAEAAPVGLCKALFGQD
VLIDVYPWHAIDPILFALPLSAITIVLVSLATQKKAF
>Mature_516_residues
STLTLGIIVIIYMFVIAWLGYLGYRQTKNASDYLLGGRKVNPIIMALSYGATFISASAIVGFGGVAATFGMGIQWLCLLN
MFMGVVVAFIFFGRRTRKLGEAHNARTFPQLLGLHYKSRSIQIFIASIIFIGMPLYTAVVMKGGAVFIEQMFHIDLHLAL
LIFTLIVAAYVITGGIKGVLYTDALQAVIMFACMLFLLFWFYHIMDMGFIEANQKLTDIAPMVPERFKALGHQGWTAMPI
SGSSQWYTLVTSLILGVGIGCLAQPQLVVRFMMVESTKQLNRGVLIGCVFLIVTVGAIYHVGALSNLFFLKTEGVVASEA
VKDMDKIIPLFINKAMPEWFGAVFMLCILSASMSTLSAQFHTMGAAFGADAFPKLGRSKNPNSTLGVRIGVLCSILVSYV
ICYTLSASIIARGTALFMGICAATFLPTYFCSLYWKGATRQGALASLWVGGLASLFAMLFLHKAEAAPVGLCKALFGQDV
LIDVYPWHAIDPILFALPLSAITIVLVSLATQKKAF

Specific function: Catalyzes the sodium-dependent uptake of extracellular L-proline [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=517, Percent_Identity=27.4661508704062, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI4507035, Length=368, Percent_Identity=23.0978260869565, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI206597483, Length=436, Percent_Identity=24.5412844036697, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI206597487, Length=436, Percent_Identity=24.5412844036697, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI14140236, Length=491, Percent_Identity=23.4215885947047, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI17941285, Length=197, Percent_Identity=29.4416243654822, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI87082237, Length=435, Percent_Identity=26.4367816091954, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1787251, Length=448, Percent_Identity=25.2232142857143, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1790503, Length=482, Percent_Identity=21.5767634854772, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI115533094, Length=357, Percent_Identity=27.1708683473389, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 56280; Mature: 56149

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STLTLGIIVIIYMFVIAWLGYLGYRQTKNASDYLLGGRKVNPIIMALSYGATFISASAI
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCEEEEEHHCHHHHHHHHH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EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA