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The map label for this gene is mdtA [H]

Identifier: 150007950

GI number: 150007950

Start: 1523949

End: 1524998

Strand: Reverse

Name: mdtA [H]

Synonym: BDI_1311

Alternate gene names: 150007950

Gene position: 1524998-1523949 (Counterclockwise)

Preceding gene: 150007951

Following gene: 150007949

Centisome position: 31.7

GC content: 47.52

Gene sequence:

>1050_bases
ATGAAAGGAAAATTAATCCCTGTGTTTGTTTTGGCAGCATTGGTTTCCTGTAGTCAACCACCCGTTAAGGAGCAAGGTCC
TCGTCCAGTTAAATTGGCGGACGTTACTTCGCTGAACATGGTTGAGAAATCATTCAGTGGAGTGGTATCGCCCGATCAAT
TCAGTGATTTGGCGTTTAAGATGTCCGGCCCGCTGATCTCATTAAACGTGGACGAAGGCCAGAAGGTCCGTACGGGACAG
ATCGTGGCCGAGATCGATCCGCTGGACTTTAAATGGGAATATGAGGCGAAGAAAGCGTCTTTCCAGACCGCTGAGGCGCA
ATTGCAACGTGCGAAGAAGTTATTGTCCAAGCAAGCTATCTCCAAGCAAGAGTATGAGTCTACGGAAGCCTCTTACTCAA
ATGCCAAGGCGGCTTTCGAGTATGCGCAAAACACATTGAACCAGACAAAGCTTCGTGCGCCGTTCGATGGATTTATCCAG
AAGAAATATGTGGAGAATTACCAGAAGGTACAGGCCGGACAAGGAATCGTTTGCTTGATCAACCCGAATAAGTTACAGGT
CGTGTTTACGATGCCGGAGAGTAATATCAATTACTTCTCTTCTCCTTATTCTGTTTATGTGGAATTCGATAATTACAAGG
GCGTTCGCTTCAAGGCGAAGGTGAAAGAATACGTGGAAGCCTCTCCGGATGGTTCCGGCGTTCCCGTATATCTGTATATC
GACGATCCGAACTTTAATTTAGAGAAATATAAGGTAGCCGTAGGTTTCTCTTGCCGTGTGATCTTGAACGTGGATAGCGA
GAGTTTCACGCAAGGCGCCGTATTGGTTCCGCTAGCCGCTGTCGTGGCTGACGATGCCAATAGCGATAAGTATGTGTTTG
TTTATAATGGGCAGTCTCAAAAGGTTGAGCGTCGCAAGATTACCGAGTCTATGCTGATCGGCAAGGATGGCGTGATCGTA
ACGGATGGCTTGCGACCCGGCGAACAGGTTGTCTCAGCCGGAGCCACTCGTTTGGTGGATGGACAACAGGTAAAAGTATT
AACAGATTAA

Upstream 100 bases:

>100_bases
TTTTTAAGGCACGTTATGCTCAACAATCTCTAGGCGAGAATGTTTTATATTTACTGTGAAGAAAAAGAAATCATAATTAA
ATAACAAAATGCAAGTTATC

Downstream 100 bases:

>100_bases
GAGATAAACAATGAATATTCCAAAATATTCCTTAGAGAATCAGAAGATTATATACTTTTTCCTAGCGGTCATGCTGATAG
GAGGTATATATTCTTTCTTT

Product: periplasmic linker protein multidrug resistance protein

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MKGKLIPVFVLAALVSCSQPPVKEQGPRPVKLADVTSLNMVEKSFSGVVSPDQFSDLAFKMSGPLISLNVDEGQKVRTGQ
IVAEIDPLDFKWEYEAKKASFQTAEAQLQRAKKLLSKQAISKQEYESTEASYSNAKAAFEYAQNTLNQTKLRAPFDGFIQ
KKYVENYQKVQAGQGIVCLINPNKLQVVFTMPESNINYFSSPYSVYVEFDNYKGVRFKAKVKEYVEASPDGSGVPVYLYI
DDPNFNLEKYKVAVGFSCRVILNVDSESFTQGAVLVPLAAVVADDANSDKYVFVYNGQSQKVERRKITESMLIGKDGVIV
TDGLRPGEQVVSAGATRLVDGQQVKVLTD

Sequences:

>Translated_349_residues
MKGKLIPVFVLAALVSCSQPPVKEQGPRPVKLADVTSLNMVEKSFSGVVSPDQFSDLAFKMSGPLISLNVDEGQKVRTGQ
IVAEIDPLDFKWEYEAKKASFQTAEAQLQRAKKLLSKQAISKQEYESTEASYSNAKAAFEYAQNTLNQTKLRAPFDGFIQ
KKYVENYQKVQAGQGIVCLINPNKLQVVFTMPESNINYFSSPYSVYVEFDNYKGVRFKAKVKEYVEASPDGSGVPVYLYI
DDPNFNLEKYKVAVGFSCRVILNVDSESFTQGAVLVPLAAVVADDANSDKYVFVYNGQSQKVERRKITESMLIGKDGVIV
TDGLRPGEQVVSAGATRLVDGQQVKVLTD
>Mature_349_residues
MKGKLIPVFVLAALVSCSQPPVKEQGPRPVKLADVTSLNMVEKSFSGVVSPDQFSDLAFKMSGPLISLNVDEGQKVRTGQ
IVAEIDPLDFKWEYEAKKASFQTAEAQLQRAKKLLSKQAISKQEYESTEASYSNAKAAFEYAQNTLNQTKLRAPFDGFIQ
KKYVENYQKVQAGQGIVCLINPNKLQVVFTMPESNINYFSSPYSVYVEFDNYKGVRFKAKVKEYVEASPDGSGVPVYLYI
DDPNFNLEKYKVAVGFSCRVILNVDSESFTQGAVLVPLAAVVADDANSDKYVFVYNGQSQKVERRKITESMLIGKDGVIV
TDGLRPGEQVVSAGATRLVDGQQVKVLTD

Specific function: The mdtABC tripartite complex confers resistance against novobiocin and deoxycholate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=355, Percent_Identity=25.3521126760563, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1789665, Length=379, Percent_Identity=25.065963060686, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1786668, Length=333, Percent_Identity=27.027027027027, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 38556; Mature: 38556

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGKLIPVFVLAALVSCSQPPVKEQGPRPVKLADVTSLNMVEKSFSGVVSPDQFSDLAFK
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCHHHHHHHHHCCCCCCCCCCCEEEE
MSGPLISLNVDEGQKVRTGQIVAEIDPLDFKWEYEAKKASFQTAEAQLQRAKKLLSKQAI
ECCCEEEEECCCCCEEECCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
SKQEYESTEASYSNAKAAFEYAQNTLNQTKLRAPFDGFIQKKYVENYQKVQAGQGIVCLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHCCCCEEEEE
NPNKLQVVFTMPESNINYFSSPYSVYVEFDNYKGVRFKAKVKEYVEASPDGSGVPVYLYI
CCCEEEEEEECCCCCCCEECCCEEEEEEECCCCCEEEEHHHHHHHHCCCCCCCCEEEEEE
DDPNFNLEKYKVAVGFSCRVILNVDSESFTQGAVLVPLAAVVADDANSDKYVFVYNGQSQ
ECCCCCCEEEEEEECCEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCC
KVERRKITESMLIGKDGVIVTDGLRPGEQVVSAGATRLVDGQQVKVLTD
HHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHCCCCEEECCCEEEEEEC
>Mature Secondary Structure
MKGKLIPVFVLAALVSCSQPPVKEQGPRPVKLADVTSLNMVEKSFSGVVSPDQFSDLAFK
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCHHHHHHHHHCCCCCCCCCCCEEEE
MSGPLISLNVDEGQKVRTGQIVAEIDPLDFKWEYEAKKASFQTAEAQLQRAKKLLSKQAI
ECCCEEEEECCCCCEEECCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
SKQEYESTEASYSNAKAAFEYAQNTLNQTKLRAPFDGFIQKKYVENYQKVQAGQGIVCLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHCCCCEEEEE
NPNKLQVVFTMPESNINYFSSPYSVYVEFDNYKGVRFKAKVKEYVEASPDGSGVPVYLYI
CCCEEEEEEECCCCCCCEECCCEEEEEEECCCCCEEEEHHHHHHHHCCCCCCCCEEEEEE
DDPNFNLEKYKVAVGFSCRVILNVDSESFTQGAVLVPLAAVVADDANSDKYVFVYNGQSQ
ECCCCCCEEEEEEECCEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCC
KVERRKITESMLIGKDGVIVTDGLRPGEQVVSAGATRLVDGQQVKVLTD
HHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHCCCCEEECCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA