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The map label for this gene is pyrC [H]

Identifier: 150007940

GI number: 150007940

Start: 1510187

End: 1511533

Strand: Reverse

Name: pyrC [H]

Synonym: BDI_1301

Alternate gene names: 150007940

Gene position: 1511533-1510187 (Counterclockwise)

Preceding gene: 150007941

Following gene: 150007933

Centisome position: 31.42

GC content: 54.42

Gene sequence:

>1347_bases
ATGAATAAAATATTAATCCAAAATCCGAGAATCATCAACGAGGGCCGTTCTTTTATCGGCTCGGTGTTGGTGGAGGGGGA
TAAGATCGCGGCGGTGTTCGAGGGGGAGGTTCCCGGGAACGTGCGTGCCGAGGCGAACCAAGTGATCGACGCTACGGGGA
AATGGTTGATACCGGGCGTTATCGACGATCAGGTGCATTTCCGGGACCCCGGGCTTACCCATAAGGGGGATATCGGGACC
GAGAGCCGTGCGGCCGTGGCCGGTGGCGTGACGACCTTCATGGATATGCCGAACACGAAGCCACAGACCACGACGATCGC
CGATCTGGAATGGAAATTCAACCGTGCCGCCGAGGTCTCCCGTGCGAATTACTCCTTCTTCTTCGGTGGGACAAACGATA
ATATGGACGAGATCCGCAGGCTGGATCGTAGCCGTGTGCCGGGACTGAAACTCTTTCTCGGCTCGTCTACGGGAAATATG
CTGGTGGACAAGAAAGACTCGTTGGAGCGTATCTTTGGCGAGGCCGGTATGCTGATCGCCATCCATGCGGAGAAAGAGGA
GGTGATCCGGCGTAATATCCAGTATTACACGAACCTGCATGGCGAGGATCTGGATATCTCTTTCCATAGCAAGATCCGTA
GCGAGGAGGCCTGCTACCAATGCTCGGCCGAGGCGGTTGAACTGGCTACCCGCTTGGATTCCCGTTTGCATATCCTGCAT
CTCTCCACGGAGAAGGAATTATCGTTGCTCAGTAACCATCTTCCCTTGAGCGAGAAAAAGATAACCGGCGAGGTCTGCGT
GCACCATCTGTGGTTTCATGACGGCGACTACGCCCAATTCGGTAATCGTATCAAGTGGAATCCTTCTATCAAGACGATCG
AGGATCGCGCGGCGCTGCGTGAGGCGGTCAATAACAATACGATCGATATCGTGGCTACCGACCATGCCCCGCATCTACCG
GAGGAGAAGCAAGGCTCTTGCTTGAAGGCGGCTTCCGGAGGACCGCTTATCCAGCACTCCTTGATCACGATGTTGGAGCT
GGCGATGGAAGGCCGTTTCACGTACGAGAAGGTGGTCGAGAAGATGGCGCATATGCCGGCGGAGCTGTTCCGTATCGATA
GGAGGGGATACATCCGTCCCGGATACTACGCCGATATCGTATTGATCGATCCGGAGAGGACTTGGACGGTATCGAAGGAG
AATATCTTGTACAAATGCGGTTGGTCTCCTTTCGAGGGCTATACGTTCCACCATGGTGTATGGAAGACTTTCGTGAATGG
CGAGTTGGCCTATGGCGATGGAGAGGTGAATGACGCCGTGAGAGGTAAAGAAGTCCGTTATCTATAG

Upstream 100 bases:

>100_bases
TCAATTGAAATGGTGGAGTTTCTTCAGGAAGTATCCGAGGAAACATGCGAGCCATGCCTAATGAAAACAGAGTTTGACAA
TTTATAATAGGATAAGAAAG

Downstream 100 bases:

>100_bases
CAGTAGAGACGGGGCATGCCCCCGTCTCATCCTATCTATTGGATATCGATCAGTTTATGGGTTTGCAGACTTAGTCTCCA
CCGGGGATGCCGGAGGATGT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MNKILIQNPRIINEGRSFIGSVLVEGDKIAAVFEGEVPGNVRAEANQVIDATGKWLIPGVIDDQVHFRDPGLTHKGDIGT
ESRAAVAGGVTTFMDMPNTKPQTTTIADLEWKFNRAAEVSRANYSFFFGGTNDNMDEIRRLDRSRVPGLKLFLGSSTGNM
LVDKKDSLERIFGEAGMLIAIHAEKEEVIRRNIQYYTNLHGEDLDISFHSKIRSEEACYQCSAEAVELATRLDSRLHILH
LSTEKELSLLSNHLPLSEKKITGEVCVHHLWFHDGDYAQFGNRIKWNPSIKTIEDRAALREAVNNNTIDIVATDHAPHLP
EEKQGSCLKAASGGPLIQHSLITMLELAMEGRFTYEKVVEKMAHMPAELFRIDRRGYIRPGYYADIVLIDPERTWTVSKE
NILYKCGWSPFEGYTFHHGVWKTFVNGELAYGDGEVNDAVRGKEVRYL

Sequences:

>Translated_448_residues
MNKILIQNPRIINEGRSFIGSVLVEGDKIAAVFEGEVPGNVRAEANQVIDATGKWLIPGVIDDQVHFRDPGLTHKGDIGT
ESRAAVAGGVTTFMDMPNTKPQTTTIADLEWKFNRAAEVSRANYSFFFGGTNDNMDEIRRLDRSRVPGLKLFLGSSTGNM
LVDKKDSLERIFGEAGMLIAIHAEKEEVIRRNIQYYTNLHGEDLDISFHSKIRSEEACYQCSAEAVELATRLDSRLHILH
LSTEKELSLLSNHLPLSEKKITGEVCVHHLWFHDGDYAQFGNRIKWNPSIKTIEDRAALREAVNNNTIDIVATDHAPHLP
EEKQGSCLKAASGGPLIQHSLITMLELAMEGRFTYEKVVEKMAHMPAELFRIDRRGYIRPGYYADIVLIDPERTWTVSKE
NILYKCGWSPFEGYTFHHGVWKTFVNGELAYGDGEVNDAVRGKEVRYL
>Mature_448_residues
MNKILIQNPRIINEGRSFIGSVLVEGDKIAAVFEGEVPGNVRAEANQVIDATGKWLIPGVIDDQVHFRDPGLTHKGDIGT
ESRAAVAGGVTTFMDMPNTKPQTTTIADLEWKFNRAAEVSRANYSFFFGGTNDNMDEIRRLDRSRVPGLKLFLGSSTGNM
LVDKKDSLERIFGEAGMLIAIHAEKEEVIRRNIQYYTNLHGEDLDISFHSKIRSEEACYQCSAEAVELATRLDSRLHILH
LSTEKELSLLSNHLPLSEKKITGEVCVHHLWFHDGDYAQFGNRIKWNPSIKTIEDRAALREAVNNNTIDIVATDHAPHLP
EEKQGSCLKAASGGPLIQHSLITMLELAMEGRFTYEKVVEKMAHMPAELFRIDRRGYIRPGYYADIVLIDPERTWTVSKE
NILYKCGWSPFEGYTFHHGVWKTFVNGELAYGDGEVNDAVRGKEVRYL

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=388, Percent_Identity=28.6082474226804, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI4503375, Length=456, Percent_Identity=21.9298245614035, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI4503051, Length=463, Percent_Identity=22.0302375809935, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI62422571, Length=463, Percent_Identity=22.0302375809935, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI4503379, Length=455, Percent_Identity=21.3186813186813, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1786722, Length=441, Percent_Identity=27.437641723356, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI87082175, Length=469, Percent_Identity=26.226012793177, Blast_Score=125, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI193204318, Length=405, Percent_Identity=28.3950617283951, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6322218, Length=393, Percent_Identity=25.1908396946565, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24642586, Length=389, Percent_Identity=30.8483290488432, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI18859883, Length=419, Percent_Identity=26.0143198090692, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 50430; Mature: 50430

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKILIQNPRIINEGRSFIGSVLVEGDKIAAVFEGEVPGNVRAEANQVIDATGKWLIPGV
CCCEEECCCEEHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHCCCCEEECCE
IDDQVHFRDPGLTHKGDIGTESRAAVAGGVTTFMDMPNTKPQTTTIADLEWKFNRAAEVS
ECCCEEECCCCCCCCCCCCCCCCHHHHCCHHHEECCCCCCCCCEEEEEEEECCCCHHHHC
RANYSFFFGGTNDNMDEIRRLDRSRVPGLKLFLGSSTGNMLVDKKDSLERIFGEAGMLIA
CCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEECHHHHHHHHCCCCEEEE
IHAEKEEVIRRNIQYYTNLHGEDLDISFHSKIRSEEACYQCSAEAVELATRLDSRLHILH
EECCHHHHHHHHHHHHCCCCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEE
LSTEKELSLLSNHLPLSEKKITGEVCVHHLWFHDGDYAQFGNRIKWNPSIKTIEDRAALR
ECCHHHHHHHHHCCCCCHHHCCHHHHHEEHEECCCCHHHHCCEEEECCCCCCHHHHHHHH
EAVNNNTIDIVATDHAPHLPEEKQGSCLKAASGGPLIQHSLITMLELAMEGRFTYEKVVE
HHHCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHH
KMAHMPAELFRIDRRGYIRPGYYADIVLIDPERTWTVSKENILYKCGWSPFEGYTFHHGV
HHHCCCHHHHHCCCCCCCCCCCEEEEEEECCCCEEEECCCCEEEEECCCCCCCCEEECHH
WKTFVNGELAYGDGEVNDAVRGKEVRYL
HHHHCCCEEEECCCCCCCCCCCCEECCC
>Mature Secondary Structure
MNKILIQNPRIINEGRSFIGSVLVEGDKIAAVFEGEVPGNVRAEANQVIDATGKWLIPGV
CCCEEECCCEEHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHCCCCEEECCE
IDDQVHFRDPGLTHKGDIGTESRAAVAGGVTTFMDMPNTKPQTTTIADLEWKFNRAAEVS
ECCCEEECCCCCCCCCCCCCCCCHHHHCCHHHEECCCCCCCCCEEEEEEEECCCCHHHHC
RANYSFFFGGTNDNMDEIRRLDRSRVPGLKLFLGSSTGNMLVDKKDSLERIFGEAGMLIA
CCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEECHHHHHHHHCCCCEEEE
IHAEKEEVIRRNIQYYTNLHGEDLDISFHSKIRSEEACYQCSAEAVELATRLDSRLHILH
EECCHHHHHHHHHHHHCCCCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEE
LSTEKELSLLSNHLPLSEKKITGEVCVHHLWFHDGDYAQFGNRIKWNPSIKTIEDRAALR
ECCHHHHHHHHHCCCCCHHHCCHHHHHEEHEECCCCHHHHCCEEEECCCCCCHHHHHHHH
EAVNNNTIDIVATDHAPHLPEEKQGSCLKAASGGPLIQHSLITMLELAMEGRFTYEKVVE
HHHCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHH
KMAHMPAELFRIDRRGYIRPGYYADIVLIDPERTWTVSKENILYKCGWSPFEGYTFHHGV
HHHCCCHHHHHCCCCCCCCCCCEEEEEEECCCCEEEECCCCEEEEECCCCCCCCEEECHH
WKTFVNGELAYGDGEVNDAVRGKEVRYL
HHHHCCCEEEECCCCCCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]