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The map label for this gene is pyrD

Identifier: 150007754

GI number: 150007754

Start: 1286885

End: 1287802

Strand: Reverse

Name: pyrD

Synonym: BDI_1112

Alternate gene names: 150007754

Gene position: 1287802-1286885 (Counterclockwise)

Preceding gene: 150007755

Following gene: 150007752

Centisome position: 26.77

GC content: 42.37

Gene sequence:

>918_bases
ATGGCTGAATTAAATGTAAACATTGGGAATTTACCGTTGAAAAATCCGGTAATGACAGCATCCGGCACGTTCGGATATGG
TATAGAATATGCTGATTTCATGGATATTTCACGTTTGGGGGGTATTTTCGTGAAAGGTACCACTATCCAACCTCGTGAAG
GTAATGATTATCCAAGAATGGCGGAGACTCCTTCCGGAATGTTGAATGCCGTGGGGCTTCAGAATAAGGGCGCCGATTAT
TTCGCTGAGCATATTTATCCGAAGATCAAGGACATCAATACGAATATGATCGTAAACGTGAGTGGGTCTTCGGTTGAAAC
GTATGTCGAGTGTGCGGAAAAGATCGCAGAGTTGGATAGGATTCCCGCTATCGAACTGAACATTTCTTGTCCGAACGTAA
AGCAAGGTGGTATGGCTTTCGGCGTTACTACGTGTGGTGCGGGAGAGGTTGTTAAGGCTGTTCGTAGGGTTTATCCAAAG
ATACTTATTGTAAAACTTTCTCCTAATGTAACTGATATTACGGAGATCGCTAAAGCTGTTGAAGCGGAGGGTGCGGATTC
TGTTTCGTTAATTAATACGATGCTTGGAATGGCCATCGACGCAGAGAAACGTAAACCTATATTATCTACAATAACTGGAG
GTCTTTCCGGGCCTTGCGTAAAACCTGTAGCTCTACGTATGGTATGGCAAACGTATCATGCGGTAAAGATTCCAATTATA
GGTTTGGGAGGTATTTCAAATTGGAAAGATGCCGTGGAGTTCATGTTAGCTGGGGCTAGTGCTATCCAGATCGGAACTTA
TAACTTTGTAGATCCAACTGTTTCTATCAAGGTTATTGATGGATTGAATGACTATTGTGACCGACATGGTTTTAAATCAG
TAAAAGAGTTGATCGGAGCATTGGATATTCAGAGATAA

Upstream 100 bases:

>100_bases
GTGGCATAGGTGCTTGTTTGTGCTGCGTAGAGAAAAACAAGGAAGGTCATAATGTGTGTGTATGTACAGAAGGTCCCGTA
TTTAATATTGAGAAATTGTC

Downstream 100 bases:

>100_bases
TCTAAGTTCATTTATAGACTTTATTTCCATTTTTTCAATAATAAAAAAGGATGTGTTCGCTTACGCAAAAAGAACACATC
CTTTCTTTTTATTATGAAAA

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MAELNVNIGNLPLKNPVMTASGTFGYGIEYADFMDISRLGGIFVKGTTIQPREGNDYPRMAETPSGMLNAVGLQNKGADY
FAEHIYPKIKDINTNMIVNVSGSSVETYVECAEKIAELDRIPAIELNISCPNVKQGGMAFGVTTCGAGEVVKAVRRVYPK
ILIVKLSPNVTDITEIAKAVEAEGADSVSLINTMLGMAIDAEKRKPILSTITGGLSGPCVKPVALRMVWQTYHAVKIPII
GLGGISNWKDAVEFMLAGASAIQIGTYNFVDPTVSIKVIDGLNDYCDRHGFKSVKELIGALDIQR

Sequences:

>Translated_305_residues
MAELNVNIGNLPLKNPVMTASGTFGYGIEYADFMDISRLGGIFVKGTTIQPREGNDYPRMAETPSGMLNAVGLQNKGADY
FAEHIYPKIKDINTNMIVNVSGSSVETYVECAEKIAELDRIPAIELNISCPNVKQGGMAFGVTTCGAGEVVKAVRRVYPK
ILIVKLSPNVTDITEIAKAVEAEGADSVSLINTMLGMAIDAEKRKPILSTITGGLSGPCVKPVALRMVWQTYHAVKIPII
GLGGISNWKDAVEFMLAGASAIQIGTYNFVDPTVSIKVIDGLNDYCDRHGFKSVKELIGALDIQR
>Mature_304_residues
AELNVNIGNLPLKNPVMTASGTFGYGIEYADFMDISRLGGIFVKGTTIQPREGNDYPRMAETPSGMLNAVGLQNKGADYF
AEHIYPKIKDINTNMIVNVSGSSVETYVECAEKIAELDRIPAIELNISCPNVKQGGMAFGVTTCGAGEVVKAVRRVYPKI
LIVKLSPNVTDITEIAKAVEAEGADSVSLINTMLGMAIDAEKRKPILSTITGGLSGPCVKPVALRMVWQTYHAVKIPIIG
LGGISNWKDAVEFMLAGASAIQIGTYNFVDPTVSIKVIDGLNDYCDRHGFKSVKELIGALDIQR

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=318, Percent_Identity=27.6729559748428, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI119943098, Length=339, Percent_Identity=25.3687315634218, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI87082059, Length=223, Percent_Identity=33.6322869955157, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1787177, Length=285, Percent_Identity=28.0701754385965, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71984108, Length=273, Percent_Identity=27.1062271062271, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322633, Length=315, Percent_Identity=31.7460317460317, Blast_Score=119, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24640763, Length=237, Percent_Identity=30.8016877637131, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI18858217, Length=237, Percent_Identity=30.8016877637131, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI281361352, Length=310, Percent_Identity=27.4193548387097, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17137316, Length=310, Percent_Identity=27.4193548387097, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_PARD8 (A6LB11)

Other databases:

- EMBL:   CP000140
- RefSeq:   YP_001302497.1
- ProteinModelPortal:   A6LB11
- SMR:   A6LB11
- STRING:   A6LB11
- GeneID:   5306265
- GenomeReviews:   CP000140_GR
- KEGG:   pdi:BDI_1112
- eggNOG:   COG0167
- HOGENOM:   HBG472415
- OMA:   NSIGLQN
- ProtClustDB:   PRK07259
- BioCyc:   PDIS435591:BDI_1112-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00224_B
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01037

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.3.1

Molecular weight: Translated: 32773; Mature: 32642

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 130-130

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELNVNIGNLPLKNPVMTASGTFGYGIEYADFMDISRLGGIFVKGTTIQPREGNDYPRM
CCEEEEECCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCEEEECCEECCCCCCCCCCC
AETPSGMLNAVGLQNKGADYFAEHIYPKIKDINTNMIVNVSGSSVETYVECAEKIAELDR
CCCCCCHHHHCCCCCCCHHHHHHHHCCHHEECCCCEEEEECCCCHHHHHHHHHHHHHHHC
IPAIELNISCPNVKQGGMAFGVTTCGAGEVVKAVRRVYPKILIVKLSPNVTDITEIAKAV
CCEEEEEECCCCCCCCCEEEEEEECCHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHH
EAEGADSVSLINTMLGMAIDAEKRKPILSTITGGLSGPCVKPVALRMVWQTYHAVKIPII
HCCCCCHHHHHHHHHHHHCCCHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHHCEEEEEEE
GLGGISNWKDAVEFMLAGASAIQIGTYNFVDPTVSIKVIDGLNDYCDRHGFKSVKELIGA
EECCCCCHHHHHHHHHCCCCEEEECCEEECCCEEEEEEECCCHHHHHHCCHHHHHHHHHH
LDIQR
HCCCC
>Mature Secondary Structure 
AELNVNIGNLPLKNPVMTASGTFGYGIEYADFMDISRLGGIFVKGTTIQPREGNDYPRM
CEEEEECCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCEEEECCEECCCCCCCCCCC
AETPSGMLNAVGLQNKGADYFAEHIYPKIKDINTNMIVNVSGSSVETYVECAEKIAELDR
CCCCCCHHHHCCCCCCCHHHHHHHHCCHHEECCCCEEEEECCCCHHHHHHHHHHHHHHHC
IPAIELNISCPNVKQGGMAFGVTTCGAGEVVKAVRRVYPKILIVKLSPNVTDITEIAKAV
CCEEEEEECCCCCCCCCEEEEEEECCHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHH
EAEGADSVSLINTMLGMAIDAEKRKPILSTITGGLSGPCVKPVALRMVWQTYHAVKIPII
HCCCCCHHHHHHHHHHHHCCCHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHHCEEEEEEE
GLGGISNWKDAVEFMLAGASAIQIGTYNFVDPTVSIKVIDGLNDYCDRHGFKSVKELIGA
EECCCCCHHHHHHHHHCCCCEEEECCEEECCCEEEEEEECCCHHHHHHCCHHHHHHHHHH
LDIQR
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA