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The map label for this gene is thiD [H]

Identifier: 150007707

GI number: 150007707

Start: 1231540

End: 1232388

Strand: Reverse

Name: thiD [H]

Synonym: BDI_1062

Alternate gene names: 150007707

Gene position: 1232388-1231540 (Counterclockwise)

Preceding gene: 150007708

Following gene: 150007706

Centisome position: 25.61

GC content: 46.53

Gene sequence:

>849_bases
ATGGATAAAAATGAAATGTACCGTTATCCGGTAGCTTTAACGATCGCGGGCTCTGATAGTGGCGGTGGTGCCGGAATACA
AGCGGATATTAAGACTTTTTCCTCGCTGGGGGTTTTTGGAGCCTCGGCGATAACGGCTATAACCGCTCAAAACACACAGG
GAGTGCGAGGGATCCAAGCGATCTCTCCCGAGATTTTGAGAGGACAAATCGAAGCTATTCTTGAGGATTTCATCGTAGAT
GCCGTAAAAATAGGGATGCTACATAACAAGGATGCCGTAAAGGTTGTATCTGAGACTTTACCTTCCTTCCGACGAACTTC
TATCATTTTAGATCCAGTGATGATATCCACGAGCGGAAGTAAATTATTGGAGGATGACGCCATCCGAACCATCATGGATG
AGTTGTTCCCTAAAGCGACACTGCTTACTCCGAATATTCCCGAGACGGAATATCTTTCCGGTATAAAAATCAATAACGAG
GCGGATATCTTATGTGCCGCCCGGAAATTGCAGGAAAAAGGATGTAACGCTATATTGATCAAAGGGGGGCATATTCCCGG
AGTAGAAACGGTGGATCGGTTATTTATCAATGAGAATAATCCGATTTGTCTGGCCTCGCCAACAGTGGAGACCTTCAATA
CCCATGGAACGGGCTGTACGCTATCGTCCGCCATCGCCGCTTATATGGCACTCGGCCATTCATTGGTGGAAGCCGTACGA
TTAGCCAAGGAATATATGAATAACGCGCTCGTTCACGGGGCAAATGTATGCATGGGAAAAGGGCACGGACCTGTAAACCA
CTTCTTCTCACCCTCTGCCCTTCATAAAATCCGATGGAATCATGAATAA

Upstream 100 bases:

>100_bases
CTAAGTTTGCGTCGTCGAAGGGGTGCCATACTATATGGGCTGAGATCATACCCTTACTACTTGATGCGGGTAATGCCGCC
GTAAGAAAAACGAATGTTAG

Downstream 100 bases:

>100_bases
GCTGGTCGTAATTACTACACCTTATTTTTTCGCGGATGAAGCTTCTTTGATCGAACTTCTATTCGCGGAAGGAATGTCTC
GTTTACATCTACGTAAACCG

Product: hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MDKNEMYRYPVALTIAGSDSGGGAGIQADIKTFSSLGVFGASAITAITAQNTQGVRGIQAISPEILRGQIEAILEDFIVD
AVKIGMLHNKDAVKVVSETLPSFRRTSIILDPVMISTSGSKLLEDDAIRTIMDELFPKATLLTPNIPETEYLSGIKINNE
ADILCAARKLQEKGCNAILIKGGHIPGVETVDRLFINENNPICLASPTVETFNTHGTGCTLSSAIAAYMALGHSLVEAVR
LAKEYMNNALVHGANVCMGKGHGPVNHFFSPSALHKIRWNHE

Sequences:

>Translated_282_residues
MDKNEMYRYPVALTIAGSDSGGGAGIQADIKTFSSLGVFGASAITAITAQNTQGVRGIQAISPEILRGQIEAILEDFIVD
AVKIGMLHNKDAVKVVSETLPSFRRTSIILDPVMISTSGSKLLEDDAIRTIMDELFPKATLLTPNIPETEYLSGIKINNE
ADILCAARKLQEKGCNAILIKGGHIPGVETVDRLFINENNPICLASPTVETFNTHGTGCTLSSAIAAYMALGHSLVEAVR
LAKEYMNNALVHGANVCMGKGHGPVNHFFSPSALHKIRWNHE
>Mature_282_residues
MDKNEMYRYPVALTIAGSDSGGGAGIQADIKTFSSLGVFGASAITAITAQNTQGVRGIQAISPEILRGQIEAILEDFIVD
AVKIGMLHNKDAVKVVSETLPSFRRTSIILDPVMISTSGSKLLEDDAIRTIMDELFPKATLLTPNIPETEYLSGIKINNE
ADILCAARKLQEKGCNAILIKGGHIPGVETVDRLFINENNPICLASPTVETFNTHGTGCTLSSAIAAYMALGHSLVEAVR
LAKEYMNNALVHGANVCMGKGHGPVNHFFSPSALHKIRWNHE

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=258, Percent_Identity=42.2480620155039, Blast_Score=214, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6325378, Length=275, Percent_Identity=36, Blast_Score=151, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6324517, Length=276, Percent_Identity=38.4057971014493, Blast_Score=145, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6324997, Length=276, Percent_Identity=38.0434782608696, Blast_Score=142, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 30240; Mature: 30240

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKNEMYRYPVALTIAGSDSGGGAGIQADIKTFSSLGVFGASAITAITAQNTQGVRGIQA
CCCCCEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHCHHHHHHHEEEEECCCCCCCHHHH
ISPEILRGQIEAILEDFIVDAVKIGMLHNKDAVKVVSETLPSFRRTSIILDPVMISTSGS
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCEEEECCEEEECCCC
KLLEDDAIRTIMDELFPKATLLTPNIPETEYLSGIKINNEADILCAARKLQEKGCNAILI
HHHHHHHHHHHHHHHCCCEEEECCCCCCHHHCCCEEECCCCHHHHHHHHHHHCCCCEEEE
KGGHIPGVETVDRLFINENNPICLASPTVETFNTHGTGCTLSSAIAAYMALGHSLVEAVR
ECCCCCCHHHHHHHEECCCCCEEEECCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LAKEYMNNALVHGANVCMGKGHGPVNHFFSPSALHKIRWNHE
HHHHHHHHHHHCCCCEEEECCCCCHHHCCCHHHHHHCCCCCC
>Mature Secondary Structure
MDKNEMYRYPVALTIAGSDSGGGAGIQADIKTFSSLGVFGASAITAITAQNTQGVRGIQA
CCCCCEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHCHHHHHHHEEEEECCCCCCCHHHH
ISPEILRGQIEAILEDFIVDAVKIGMLHNKDAVKVVSETLPSFRRTSIILDPVMISTSGS
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCEEEECCEEEECCCC
KLLEDDAIRTIMDELFPKATLLTPNIPETEYLSGIKINNEADILCAARKLQEKGCNAILI
HHHHHHHHHHHHHHHCCCEEEECCCCCCHHHCCCEEECCCCHHHHHHHHHHHCCCCEEEE
KGGHIPGVETVDRLFINENNPICLASPTVETFNTHGTGCTLSSAIAAYMALGHSLVEAVR
ECCCCCCHHHHHHHEECCCCCEEEECCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LAKEYMNNALVHGANVCMGKGHGPVNHFFSPSALHKIRWNHE
HHHHHHHHHHHCCCCEEEECCCCCHHHCCCHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481431; 8246891 [H]