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The map label for this gene is fhs

Identifier: 150007659

GI number: 150007659

Start: 1173123

End: 1174790

Strand: Reverse

Name: fhs

Synonym: BDI_1014

Alternate gene names: 150007659

Gene position: 1174790-1173123 (Counterclockwise)

Preceding gene: 150007661

Following gene: 150007653

Centisome position: 24.42

GC content: 45.86

Gene sequence:

>1668_bases
ATGAAATCGGACATTGAGATAGCAAGAGAAACAGACTTGCGTAAAATTAAGGAAGTTGCGACAACGTTAGGTATCCCTCG
TGAGGAAGTACAAAATTATGGCAGGTATATTGCCAAGGTTCCTATCCATTTGATCGATAAAAAGCAAATGGACCAGCATA
ATTTAATTTTAGTGACCGCTATCACTCCCACTAAAGCGGGAATCGGAAAGACTACGGTTTCGATCGGTCTGGCTTTAGGG
CTGAATAAAATAGGGAAGAAAGCGGTGGTCGCTTTACGTGAGCCGTCTCTTGGCCCGTGTTTCGGCATGAAAGGTGGTGC
TGCCGGAGGTGGATATGCCCAAGTGCTTCCCATGGAAAACATCAACTTGCATTTTACAGGGGATTTTCATGCGGTTACTT
CCGCCCACAATATGATTACCGCTTTATTGGATAACTATATTTATCAGACCCGCAACACCTGCGAGGGATTGAAGGAGATC
AAATGGAAACGGGTTCTTGACGTAAACGACCGTAGCTTACGTAACATCGTATCGGGTCTAGGCGGCTCGGCGAACGGTGT
CCCTACCGAGACCGGATTTGACATCACTCCCGCTTCAGAGATCATGGCGATCCTTTGCTTGGCTACGGATATAGAGGATT
TGAAACGACGTGTCGGAAATATTTTATTGGGTTATACAAACGAAGATAAGCCTTTCACGGTAAATGATCTTGGCATAGCC
GGAGCTATTACCGTATTGCTAAAAGACGCATTACTGCCGAACCTTGTACAAACAACGGAGAATACTCCCGCATTTGTACA
TGGAGGTCCTTTCGCTAATATCGCCCATGGATGTAATTCCATATCGGCCACCCAAATGGCTCTTACTTATGGAGATTATG
TGATTACGGAGGCTGGTTTCGGCGCTGATCTGGGCGCAGAGAAATTCTTTAATATCAAATGTAGAAAAGCGGGGCTTTCA
CCGAAACTGACAGTCATCGTAGCGACTGCCCAGAGCTTGAAACTTCATGGTGGCGTTCCGGAGAAAGAAATCAAGGAACC
GAATATCGAAGGATTAAAGAACGGATTCGCTAACTTAGATAAACACATTGAGAATATGAAGAGCTTCGGCCAGCAAGTAA
TCGTTACTTTCAACCGTTTCGCTACCGATACGGACGAGGAGATTGCGTTAGTGGCTGAGCATTGCGAGGAGAAAGGGGTT
GGATTCGCCATGAATAACGTTTTCGCCGAAGGCGGTGAAGGGGGTACGGAGCTTGCCCGCTTAGTGGTTGATACGATCGA
AAATCATCCTTCCGCTCCTTTACAATATACATATGATCTGAATGATCCGATCCGTACGAAGGTACAAAAAGTGGCCCAGA
AGATATACGGAGCTTCTTCGATTGTTTATACGACTTTGGCCGATAAAAAATTGCGTCAGATCGAAAGCTTGGGTATTTCC
CATTATCCGATCTGTATCGCCAAGACTCAATATTCATTCTCTTCCGATCCGAAAGCTTATGGGGTCGCCAAAGATTTCGA
ACTAAAAGTACGAGATGTAATCATCAATAACGGAGCCGAGATGATCGTTGTCGTCATGGGCGAGATCATGCGTATGCCGG
GACTCCCGAAAGAGCCGCAAGCCCGAAAGATCGATATCGTGGATGGCATGATTGAGGGATTGAGTTAA

Upstream 100 bases:

>100_bases
TTATTATTCCATAAAGGGGGAAAACCTTGTTCCGTATCATTTTGTTATTATAATAAATTAGATTTACTTTGTTCAAACTA
TATAAACTTACATAAAGCAC

Downstream 100 bases:

>100_bases
TAGACAGTAAAACGATTCAAATAAAAAAGGTGCGCCTCACACATTCAGTAAGGCGCACCTTACTTTTGCTTATTTATGAA
TAAACTTTATAGAACCTCTA

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MKSDIEIARETDLRKIKEVATTLGIPREEVQNYGRYIAKVPIHLIDKKQMDQHNLILVTAITPTKAGIGKTTVSIGLALG
LNKIGKKAVVALREPSLGPCFGMKGGAAGGGYAQVLPMENINLHFTGDFHAVTSAHNMITALLDNYIYQTRNTCEGLKEI
KWKRVLDVNDRSLRNIVSGLGGSANGVPTETGFDITPASEIMAILCLATDIEDLKRRVGNILLGYTNEDKPFTVNDLGIA
GAITVLLKDALLPNLVQTTENTPAFVHGGPFANIAHGCNSISATQMALTYGDYVITEAGFGADLGAEKFFNIKCRKAGLS
PKLTVIVATAQSLKLHGGVPEKEIKEPNIEGLKNGFANLDKHIENMKSFGQQVIVTFNRFATDTDEEIALVAEHCEEKGV
GFAMNNVFAEGGEGGTELARLVVDTIENHPSAPLQYTYDLNDPIRTKVQKVAQKIYGASSIVYTTLADKKLRQIESLGIS
HYPICIAKTQYSFSSDPKAYGVAKDFELKVRDVIINNGAEMIVVVMGEIMRMPGLPKEPQARKIDIVDGMIEGLS

Sequences:

>Translated_555_residues
MKSDIEIARETDLRKIKEVATTLGIPREEVQNYGRYIAKVPIHLIDKKQMDQHNLILVTAITPTKAGIGKTTVSIGLALG
LNKIGKKAVVALREPSLGPCFGMKGGAAGGGYAQVLPMENINLHFTGDFHAVTSAHNMITALLDNYIYQTRNTCEGLKEI
KWKRVLDVNDRSLRNIVSGLGGSANGVPTETGFDITPASEIMAILCLATDIEDLKRRVGNILLGYTNEDKPFTVNDLGIA
GAITVLLKDALLPNLVQTTENTPAFVHGGPFANIAHGCNSISATQMALTYGDYVITEAGFGADLGAEKFFNIKCRKAGLS
PKLTVIVATAQSLKLHGGVPEKEIKEPNIEGLKNGFANLDKHIENMKSFGQQVIVTFNRFATDTDEEIALVAEHCEEKGV
GFAMNNVFAEGGEGGTELARLVVDTIENHPSAPLQYTYDLNDPIRTKVQKVAQKIYGASSIVYTTLADKKLRQIESLGIS
HYPICIAKTQYSFSSDPKAYGVAKDFELKVRDVIINNGAEMIVVVMGEIMRMPGLPKEPQARKIDIVDGMIEGLS
>Mature_555_residues
MKSDIEIARETDLRKIKEVATTLGIPREEVQNYGRYIAKVPIHLIDKKQMDQHNLILVTAITPTKAGIGKTTVSIGLALG
LNKIGKKAVVALREPSLGPCFGMKGGAAGGGYAQVLPMENINLHFTGDFHAVTSAHNMITALLDNYIYQTRNTCEGLKEI
KWKRVLDVNDRSLRNIVSGLGGSANGVPTETGFDITPASEIMAILCLATDIEDLKRRVGNILLGYTNEDKPFTVNDLGIA
GAITVLLKDALLPNLVQTTENTPAFVHGGPFANIAHGCNSISATQMALTYGDYVITEAGFGADLGAEKFFNIKCRKAGLS
PKLTVIVATAQSLKLHGGVPEKEIKEPNIEGLKNGFANLDKHIENMKSFGQQVIVTFNRFATDTDEEIALVAEHCEEKGV
GFAMNNVFAEGGEGGTELARLVVDTIENHPSAPLQYTYDLNDPIRTKVQKVAQKIYGASSIVYTTLADKKLRQIESLGIS
HYPICIAKTQYSFSSDPKAYGVAKDFELKVRDVIINNGAEMIVVVMGEIMRMPGLPKEPQARKIDIVDGMIEGLS

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=610, Percent_Identity=39.672131147541, Blast_Score=398, Evalue=1e-111,
Organism=Homo sapiens, GI36796743, Length=609, Percent_Identity=40.2298850574713, Blast_Score=394, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17568737, Length=622, Percent_Identity=40.9967845659164, Blast_Score=404, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17568739, Length=622, Percent_Identity=40.9967845659164, Blast_Score=404, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=39.1373801916933, Blast_Score=390, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6319558, Length=631, Percent_Identity=38.6687797147385, Blast_Score=389, Evalue=1e-109,
Organism=Drosophila melanogaster, GI62472483, Length=620, Percent_Identity=39.8387096774194, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI45551871, Length=620, Percent_Identity=39.8387096774194, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24645718, Length=620, Percent_Identity=40, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI17137370, Length=620, Percent_Identity=40, Blast_Score=401, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_PARD8 (A6LAR6)

Other databases:

- EMBL:   CP000140
- RefSeq:   YP_001302402.1
- ProteinModelPortal:   A6LAR6
- SMR:   A6LAR6
- STRING:   A6LAR6
- GeneID:   5306167
- GenomeReviews:   CP000140_GR
- KEGG:   pdi:BDI_1014
- eggNOG:   COG2759
- HOGENOM:   HBG677721
- OMA:   EIMAVLC
- ProtClustDB:   PRK13505
- BioCyc:   PDIS435591:BDI_1014-MONOMER
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 60157; Mature: 60157

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSDIEIARETDLRKIKEVATTLGIPREEVQNYGRYIAKVPIHLIDKKQMDQHNLILVTA
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHEEHHCCHHEECCCCCCCCCEEEEEE
ITPTKAGIGKTTVSIGLALGLNKIGKKAVVALREPSLGPCFGMKGGAAGGGYAQVLPMEN
ECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECC
INLHFTGDFHAVTSAHNMITALLDNYIYQTRNTCEGLKEIKWKRVLDVNDRSLRNIVSGL
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCHHHHHHHHHHC
GGSANGVPTETGFDITPASEIMAILCLATDIEDLKRRVGNILLGYTNEDKPFTVNDLGIA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCEEEEECCCCCCEEEECCCHH
GAITVLLKDALLPNLVQTTENTPAFVHGGPFANIAHGCNSISATQMALTYGDYVITEAGF
HHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHCCCCCCHHHEEEEECCEEEEECCC
GADLGAEKFFNIKCRKAGLSPKLTVIVATAQSLKLHGGVPEKEIKEPNIEGLKNGFANLD
CCCCCCCCEEEEEEECCCCCCCEEEEEEECCHHEECCCCCHHHCCCCCHHHHHHHHHHHH
KHIENMKSFGQQVIVTFNRFATDTDEEIALVAEHCEEKGVGFAMNNVFAEGGEGGTELAR
HHHHHHHHHCHHEEEEHHHHCCCCCHHHHHHHHHHHHCCCCEEEHHHHHCCCCCHHHHHH
LVVDTIENHPSAPLQYTYDLNDPIRTKVQKVAQKIYGASSIVYTTLADKKLRQIESLGIS
HHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCC
HYPICIAKTQYSFSSDPKAYGVAKDFELKVRDVIINNGAEMIVVVMGEIMRMPGLPKEPQ
CCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEHHHHHHHHHCCCCCCCCC
ARKIDIVDGMIEGLS
CCEEEHHHHHHHCCC
>Mature Secondary Structure
MKSDIEIARETDLRKIKEVATTLGIPREEVQNYGRYIAKVPIHLIDKKQMDQHNLILVTA
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHEEHHCCHHEECCCCCCCCCEEEEEE
ITPTKAGIGKTTVSIGLALGLNKIGKKAVVALREPSLGPCFGMKGGAAGGGYAQVLPMEN
ECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECC
INLHFTGDFHAVTSAHNMITALLDNYIYQTRNTCEGLKEIKWKRVLDVNDRSLRNIVSGL
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCHHHHHHHHHHC
GGSANGVPTETGFDITPASEIMAILCLATDIEDLKRRVGNILLGYTNEDKPFTVNDLGIA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCEEEEECCCCCCEEEECCCHH
GAITVLLKDALLPNLVQTTENTPAFVHGGPFANIAHGCNSISATQMALTYGDYVITEAGF
HHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHCCCCCCHHHEEEEECCEEEEECCC
GADLGAEKFFNIKCRKAGLSPKLTVIVATAQSLKLHGGVPEKEIKEPNIEGLKNGFANLD
CCCCCCCCEEEEEEECCCCCCCEEEEEEECCHHEECCCCCHHHCCCCCHHHHHHHHHHHH
KHIENMKSFGQQVIVTFNRFATDTDEEIALVAEHCEEKGVGFAMNNVFAEGGEGGTELAR
HHHHHHHHHCHHEEEEHHHHCCCCCHHHHHHHHHHHHCCCCEEEHHHHHCCCCCHHHHHH
LVVDTIENHPSAPLQYTYDLNDPIRTKVQKVAQKIYGASSIVYTTLADKKLRQIESLGIS
HHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCC
HYPICIAKTQYSFSSDPKAYGVAKDFELKVRDVIINNGAEMIVVVMGEIMRMPGLPKEPQ
CCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEHHHHHHHHHCCCCCCCCC
ARKIDIVDGMIEGLS
CCEEEHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA