Click here to switch to the map view.

The map label for this gene is poxB [H]

Identifier: 150007634

GI number: 150007634

Start: 1148990

End: 1150729

Strand: Direct

Name: poxB [H]

Synonym: BDI_0987

Alternate gene names: 150007634

Gene position: 1148990-1150729 (Clockwise)

Preceding gene: 150007633

Following gene: 150007636

Centisome position: 23.88

GC content: 50.52

Gene sequence:

>1740_bases
ATGGCGAAGAAAGTTGCGGACCAGTTAGTGGATACGCTGGAAAAAGCAGGCGTACGACGTATATACGCCGTGACAGGCGA
TAGCCTGAATGAGGTGAACGAGGCTGTTCGGAAAAACGGCAGATTGCGGTGGATTCATGTCCGTCATGAGGAAACGGGGG
CTTATGCCGCTGCGGCGGAGGCCCAGTTGACAGGCGAGTTGGCTTGTTGCGCAGGTAGTAGTGGCCCCGGGCATGTACAT
TTAATTAATGGGCTGTATGATGCCCAACGATCCGGAGCACGGGTCTTGGCGATCGCTTCCACGATCCCTTCCCGGGAGTT
TGGTACGGAATATTTCCAAGAGACAAATACGATCAAATTATTCGATGATTGTAGCTATTATAACCAAGTAGCCACTACGC
CGGAACAATTTCCCCGGATGCTTCAAGGCGCTATGCAAGCGGCGATCTCATCACGTGGGGTCGGGGTGATCGGACTTCCC
GGTGACTTGGCGGCAGAGAATGCTACAGCGGGTTTGTCCTCTACCTTTTCTTTTCCTACGCGACAACGGGTTTGTCCCGC
CGAACAGGAAATCCGGGAATTAGCGGATTTGTTGAATAACGCAAAGAAAGTGACACTTTATTGTGGAATAGGTGCGAAAG
ATGCCCATCCGGAATTGGTGCAGTTGGCTAAATTACTGAATGCTCCGGTAGCCTATTCTTTCAAGGGTAAGATGGAGATC
CAATACGATAATCCGAACGAGGTGGGGATGACCGGTCTATTGGGCATGCCTTCCGGCTATTATAGTATGCATGAGGCAGA
GGTGTTGGTGTTGTTGGGAACCGATTTTCCATACGAGGCATTCATGCCAGAGAGCAACACGATCGTACAGGTGGATATCA
ATCCGAATCGTCTGGGGCGTCGTGCCAAGATACAAATGGGGCTTTGTGGCGATGTGAAGGATACTTTGGATGAGTTGATT
CCGTTGATTCACCAGAAAGAAGATAATAGTTTCTTGCGGGAACAGTTGGCTAAATATGAGAAAGTTCGGGAAAATCTCCG
TTCTGCCGCCACTGTCCGGGGGAAAGAAGAGAAGATACAGCCAGAGTACGTGATCTCGGTCGTAGACGAGCTTAGCTCGG
ACGACGCCATATTTACCGTGGATACGGGTATGACTTGTGTATGGGGTGCCCGCTATTTGCAAGCTACGGGTATGCGGAAG
ATGTTGGGATCATTCAATCATGGCTCGATGGCGAACGCCATGCCGCAAGCGATAGGGGCGGCATTGGCTTATCCCGGCAG
GCAAGTCGTGGCGTTGTGTGGTGATGGAGGTATCTCAATGTTGTTGGGCGACCTTGCTACGATCGTGCAATACCATTTGC
CGATTAAATTAATCGTATTTAATAACCGTTCCCTAGGAATGGTAAAACTTGAGATGGAGGTGGCCGGACTGCCGGATTGG
CAGACCACGATGCTGAACCCGGATTTCGCCCGGGTCGCCCTTTCAATGGGAATGGCGGGCTACAACGTGATCAACCCCGA
CGATGTATTCCCCACTTTGCAGAAAGTGTTTAACGCTGACGGACCGGCCTTGGTTAACATCATGACCGATCCGAACGCAT
TAGCGATGCCTCCCAAGATTGAGTTCTCCCAAATGCTTGGTTTTGCCCAGACCATGTATAAGTTAATGATGGAGGGGCGA
AGCAAGGAGGTCTTGGATACCATCGATACGAATCTAAAACATTGGAAAGAGGTGTTTTAA

Upstream 100 bases:

>100_bases
ACGAACATTGACGGATTGCATCAAATAAAAATCAGTCTTTCCAAAAACTTTCTCCAGCCCTTGATAGTTTTCTTATAAAA
TAAAAAGAAGAGTTTAAACT

Downstream 100 bases:

>100_bases
ACTCTCAAAAGAGCTGGATAACCGCTTTAGATTTCGCGCTTTGAATGGCAGCGTCCAATATCCGCACTACCATTAGGTTA
TTCTCCAACGAGGAAAGGTC

Product: pyruvate dehydrogenase

Products: NA

Alternate protein names: Pyruvate oxidase; POX [H]

Number of amino acids: Translated: 579; Mature: 578

Protein sequence:

>579_residues
MAKKVADQLVDTLEKAGVRRIYAVTGDSLNEVNEAVRKNGRLRWIHVRHEETGAYAAAAEAQLTGELACCAGSSGPGHVH
LINGLYDAQRSGARVLAIASTIPSREFGTEYFQETNTIKLFDDCSYYNQVATTPEQFPRMLQGAMQAAISSRGVGVIGLP
GDLAAENATAGLSSTFSFPTRQRVCPAEQEIRELADLLNNAKKVTLYCGIGAKDAHPELVQLAKLLNAPVAYSFKGKMEI
QYDNPNEVGMTGLLGMPSGYYSMHEAEVLVLLGTDFPYEAFMPESNTIVQVDINPNRLGRRAKIQMGLCGDVKDTLDELI
PLIHQKEDNSFLREQLAKYEKVRENLRSAATVRGKEEKIQPEYVISVVDELSSDDAIFTVDTGMTCVWGARYLQATGMRK
MLGSFNHGSMANAMPQAIGAALAYPGRQVVALCGDGGISMLLGDLATIVQYHLPIKLIVFNNRSLGMVKLEMEVAGLPDW
QTTMLNPDFARVALSMGMAGYNVINPDDVFPTLQKVFNADGPALVNIMTDPNALAMPPKIEFSQMLGFAQTMYKLMMEGR
SKEVLDTIDTNLKHWKEVF

Sequences:

>Translated_579_residues
MAKKVADQLVDTLEKAGVRRIYAVTGDSLNEVNEAVRKNGRLRWIHVRHEETGAYAAAAEAQLTGELACCAGSSGPGHVH
LINGLYDAQRSGARVLAIASTIPSREFGTEYFQETNTIKLFDDCSYYNQVATTPEQFPRMLQGAMQAAISSRGVGVIGLP
GDLAAENATAGLSSTFSFPTRQRVCPAEQEIRELADLLNNAKKVTLYCGIGAKDAHPELVQLAKLLNAPVAYSFKGKMEI
QYDNPNEVGMTGLLGMPSGYYSMHEAEVLVLLGTDFPYEAFMPESNTIVQVDINPNRLGRRAKIQMGLCGDVKDTLDELI
PLIHQKEDNSFLREQLAKYEKVRENLRSAATVRGKEEKIQPEYVISVVDELSSDDAIFTVDTGMTCVWGARYLQATGMRK
MLGSFNHGSMANAMPQAIGAALAYPGRQVVALCGDGGISMLLGDLATIVQYHLPIKLIVFNNRSLGMVKLEMEVAGLPDW
QTTMLNPDFARVALSMGMAGYNVINPDDVFPTLQKVFNADGPALVNIMTDPNALAMPPKIEFSQMLGFAQTMYKLMMEGR
SKEVLDTIDTNLKHWKEVF
>Mature_578_residues
AKKVADQLVDTLEKAGVRRIYAVTGDSLNEVNEAVRKNGRLRWIHVRHEETGAYAAAAEAQLTGELACCAGSSGPGHVHL
INGLYDAQRSGARVLAIASTIPSREFGTEYFQETNTIKLFDDCSYYNQVATTPEQFPRMLQGAMQAAISSRGVGVIGLPG
DLAAENATAGLSSTFSFPTRQRVCPAEQEIRELADLLNNAKKVTLYCGIGAKDAHPELVQLAKLLNAPVAYSFKGKMEIQ
YDNPNEVGMTGLLGMPSGYYSMHEAEVLVLLGTDFPYEAFMPESNTIVQVDINPNRLGRRAKIQMGLCGDVKDTLDELIP
LIHQKEDNSFLREQLAKYEKVRENLRSAATVRGKEEKIQPEYVISVVDELSSDDAIFTVDTGMTCVWGARYLQATGMRKM
LGSFNHGSMANAMPQAIGAALAYPGRQVVALCGDGGISMLLGDLATIVQYHLPIKLIVFNNRSLGMVKLEMEVAGLPDWQ
TTMLNPDFARVALSMGMAGYNVINPDDVFPTLQKVFNADGPALVNIMTDPNALAMPPKIEFSQMLGFAQTMYKLMMEGRS
KEVLDTIDTNLKHWKEVF

Specific function: Unknown

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=572, Percent_Identity=24.8251748251748, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1787096, Length=571, Percent_Identity=46.9352014010508, Blast_Score=541, Evalue=1e-155,
Organism=Escherichia coli, GI1790104, Length=569, Percent_Identity=26.8892794376098, Blast_Score=206, Evalue=4e-54,
Organism=Escherichia coli, GI87081685, Length=529, Percent_Identity=26.2759924385633, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1786717, Length=541, Percent_Identity=23.6598890942699, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1788716, Length=566, Percent_Identity=21.2014134275618, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17531299, Length=557, Percent_Identity=23.6983842010772, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17531301, Length=557, Percent_Identity=23.6983842010772, Blast_Score=99, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6323755, Length=566, Percent_Identity=23.6749116607774, Blast_Score=179, Evalue=9e-46,
Organism=Saccharomyces cerevisiae, GI6320816, Length=499, Percent_Identity=21.0420841683367, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19922626, Length=485, Percent_Identity=23.7113402061856, Blast_Score=113, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =1.2.5.1 [H]

Molecular weight: Translated: 63426; Mature: 63294

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKKVADQLVDTLEKAGVRRIYAVTGDSLNEVNEAVRKNGRLRWIHVRHEETGAYAAAAE
CCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHH
AQLTGELACCAGSSGPGHVHLINGLYDAQRSGARVLAIASTIPSREFGTEYFQETNTIKL
HHHCCCEEEECCCCCCCEEEEECCHHHHCCCCCEEEEEEECCCCHHHCHHHHHCCCCEEE
FDDCSYYNQVATTPEQFPRMLQGAMQAAISSRGVGVIGLPGDLAAENATAGLSSTFSFPT
EECCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCC
RQRVCPAEQEIRELADLLNNAKKVTLYCGIGAKDAHPELVQLAKLLNAPVAYSFKGKMEI
CCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCEEEEECCEEEE
QYDNPNEVGMTGLLGMPSGYYSMHEAEVLVLLGTDFPYEAFMPESNTIVQVDINPNRLGR
EECCCCCCCCEEEECCCCCCCCCCCCEEEEEEECCCCCHHCCCCCCCEEEEECCHHHCCC
RAKIQMGLCGDVKDTLDELIPLIHQKEDNSFLREQLAKYEKVRENLRSAATVRGKEEKIQ
EEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCC
PEYVISVVDELSSDDAIFTVDTGMTCVWGARYLQATGMRKMLGSFNHGSMANAMPQAIGA
HHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
ALAYPGRQVVALCGDGGISMLLGDLATIVQYHLPIKLIVFNNRSLGMVKLEMEVAGLPDW
HHCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEEEECCCCCC
QTTMLNPDFARVALSMGMAGYNVINPDDVFPTLQKVFNADGPALVNIMTDPNALAMPPKI
HHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCC
EFSQMLGFAQTMYKLMMEGRSKEVLDTIDTNLKHWKEVF
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKKVADQLVDTLEKAGVRRIYAVTGDSLNEVNEAVRKNGRLRWIHVRHEETGAYAAAAE
CHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHH
AQLTGELACCAGSSGPGHVHLINGLYDAQRSGARVLAIASTIPSREFGTEYFQETNTIKL
HHHCCCEEEECCCCCCCEEEEECCHHHHCCCCCEEEEEEECCCCHHHCHHHHHCCCCEEE
FDDCSYYNQVATTPEQFPRMLQGAMQAAISSRGVGVIGLPGDLAAENATAGLSSTFSFPT
EECCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCC
RQRVCPAEQEIRELADLLNNAKKVTLYCGIGAKDAHPELVQLAKLLNAPVAYSFKGKMEI
CCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCEEEEECCEEEE
QYDNPNEVGMTGLLGMPSGYYSMHEAEVLVLLGTDFPYEAFMPESNTIVQVDINPNRLGR
EECCCCCCCCEEEECCCCCCCCCCCCEEEEEEECCCCCHHCCCCCCCEEEEECCHHHCCC
RAKIQMGLCGDVKDTLDELIPLIHQKEDNSFLREQLAKYEKVRENLRSAATVRGKEEKIQ
EEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCC
PEYVISVVDELSSDDAIFTVDTGMTCVWGARYLQATGMRKMLGSFNHGSMANAMPQAIGA
HHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
ALAYPGRQVVALCGDGGISMLLGDLATIVQYHLPIKLIVFNNRSLGMVKLEMEVAGLPDW
HHCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEEEECCCCCC
QTTMLNPDFARVALSMGMAGYNVINPDDVFPTLQKVFNADGPALVNIMTDPNALAMPPKI
HHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCC
EFSQMLGFAQTMYKLMMEGRSKEVLDTIDTNLKHWKEVF
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3016647; 8905232; 9278503; 2663858; 3902830; 8022274 [H]