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The map label for this gene is thrC [H]

Identifier: 150006923

GI number: 150006923

Start: 284808

End: 286121

Strand: Reverse

Name: thrC [H]

Synonym: BDI_0259

Alternate gene names: 150006923

Gene position: 286121-284808 (Counterclockwise)

Preceding gene: 150006924

Following gene: 150006920

Centisome position: 5.95

GC content: 50.76

Gene sequence:

>1314_bases
ATGAAATATTACAGCACAAACAAACAAGCCCCTGTAGCCAGCCTAGAAGAGGCCGTCGTAAAAGGTCTGGCCGGCGATAA
GGGATTATATATGCCCGAGTATATCGACTCCTTGGACGAGGAGGTGATAGCCAACATGAAGAACCAGTCCTTCCACGAGA
TCGCCTGCACGGTAGCTCAGATGTTCTTCGGGGAAGACATCGAGCCGGAGGTATTGGACGGTATCGTAAAAGATACGCTC
TCCTTCGAGACCCCGGTGGTACCCGTAAAGGATAATATCTATAGCTTGGAGTTATTTCACGGGCCTACATTGGCCTTTAA
GGATGTAGGAGGGCGCTTCATGGCTCGTCTGCTCGGTTATTTCATAAAGAAAGAGGGATTGAAGCAAGTAAACGTATTGG
TAGCTACTTCCGGCGATACGGGAAGCGCCGTCGCCAACGGATTCCTAGGTGTCCCGGGCATTCACGTGTATGTGCTTTAT
CCCAAGGGAAAGGTCAGCCCGATACAGGAATGCCAGTTCACGACATTAGGACAGAACATCACGGCATTGGAGATAGACGG
CACGTTCGACGATTGCCAAGCGCTGGTTAAATCCGCCTTTATGGACGAGGAATTAAACCGTCATATGAAACTGACCTCGG
CGAACTCCATCAACGTAGCCCGTTTCTTGCCCCAATCGTTCTACTATTTCAACGCTTACGCTCAGCTGGACAAGCTGGGA
AAAGCGGACGAGCTGGTCGTTTGCGTGCCGAGCGGTAATTTCGGAAACATCACCGCCGGATTGTTCGCCTATTGGATGGG
GCTCCCTATCAAGCGTTTCGTAGCGGCAAACAACCGTAACGACGTATTCTTGGAATACCTAAATACAGGAACTTATACAC
CCCGCCCATCAGTCGCCACCCTAGCGAACGCCATGGATGTAGGCGATCCGAGTAATTTCGCCCGTATCATCGACCTATTC
GGCGCATTCAATGATCCCCATAAAGAAATATGCGCACTGATCTCCGGACATCGCTATACGGACGAGGAAATCGCCTCTAC
GATGCGAGCCGTCTATAAAGAGACGGGATATATCCTCGACCCACACGGAGCCTGTGGCTACCAAGGATTACTAGACAGCG
ACCTAAGCGAGACCGAGACGGGTCTATTCCTCGAGACCGCCCATCCCGCCAAATTCAAAGGAACGGTCGATAAGATATTG
GAGGCAGATATCGAGATCCCGGCGAAACTGAAAGCCTTCATGGAAGGAACCAAGCAAAGCATCGAGCTGGCAAAAGATTT
CGAGGGATTCAAATCTTTCTTGATGAGCCGGTAA

Upstream 100 bases:

>100_bases
CGACTCCGTTACCACATTTGATGAGTTCTCCGTATCAAACGGCAAATATGGCATACTGGAAAAAGATCAATTTATAAAAG
AATTTCTAAACGATTAGAGC

Downstream 100 bases:

>100_bases
AAAGAAGAATAGTTTTCGTAATTGATATAAAATGGAAGGTGTAGCAAATTGATATTATCGATATTTGCCACACCTTCCAT
TTTTATCACCTAGGACATAC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MKYYSTNKQAPVASLEEAVVKGLAGDKGLYMPEYIDSLDEEVIANMKNQSFHEIACTVAQMFFGEDIEPEVLDGIVKDTL
SFETPVVPVKDNIYSLELFHGPTLAFKDVGGRFMARLLGYFIKKEGLKQVNVLVATSGDTGSAVANGFLGVPGIHVYVLY
PKGKVSPIQECQFTTLGQNITALEIDGTFDDCQALVKSAFMDEELNRHMKLTSANSINVARFLPQSFYYFNAYAQLDKLG
KADELVVCVPSGNFGNITAGLFAYWMGLPIKRFVAANNRNDVFLEYLNTGTYTPRPSVATLANAMDVGDPSNFARIIDLF
GAFNDPHKEICALISGHRYTDEEIASTMRAVYKETGYILDPHGACGYQGLLDSDLSETETGLFLETAHPAKFKGTVDKIL
EADIEIPAKLKAFMEGTKQSIELAKDFEGFKSFLMSR

Sequences:

>Translated_437_residues
MKYYSTNKQAPVASLEEAVVKGLAGDKGLYMPEYIDSLDEEVIANMKNQSFHEIACTVAQMFFGEDIEPEVLDGIVKDTL
SFETPVVPVKDNIYSLELFHGPTLAFKDVGGRFMARLLGYFIKKEGLKQVNVLVATSGDTGSAVANGFLGVPGIHVYVLY
PKGKVSPIQECQFTTLGQNITALEIDGTFDDCQALVKSAFMDEELNRHMKLTSANSINVARFLPQSFYYFNAYAQLDKLG
KADELVVCVPSGNFGNITAGLFAYWMGLPIKRFVAANNRNDVFLEYLNTGTYTPRPSVATLANAMDVGDPSNFARIIDLF
GAFNDPHKEICALISGHRYTDEEIASTMRAVYKETGYILDPHGACGYQGLLDSDLSETETGLFLETAHPAKFKGTVDKIL
EADIEIPAKLKAFMEGTKQSIELAKDFEGFKSFLMSR
>Mature_437_residues
MKYYSTNKQAPVASLEEAVVKGLAGDKGLYMPEYIDSLDEEVIANMKNQSFHEIACTVAQMFFGEDIEPEVLDGIVKDTL
SFETPVVPVKDNIYSLELFHGPTLAFKDVGGRFMARLLGYFIKKEGLKQVNVLVATSGDTGSAVANGFLGVPGIHVYVLY
PKGKVSPIQECQFTTLGQNITALEIDGTFDDCQALVKSAFMDEELNRHMKLTSANSINVARFLPQSFYYFNAYAQLDKLG
KADELVVCVPSGNFGNITAGLFAYWMGLPIKRFVAANNRNDVFLEYLNTGTYTPRPSVATLANAMDVGDPSNFARIIDLF
GAFNDPHKEICALISGHRYTDEEIASTMRAVYKETGYILDPHGACGYQGLLDSDLSETETGLFLETAHPAKFKGTVDKIL
EADIEIPAKLKAFMEGTKQSIELAKDFEGFKSFLMSR

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=452, Percent_Identity=32.7433628318584, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI153792148, Length=436, Percent_Identity=29.8165137614679, Blast_Score=167, Evalue=2e-41,
Organism=Escherichia coli, GI1786185, Length=439, Percent_Identity=44.4191343963554, Blast_Score=341, Evalue=4e-95,
Organism=Saccharomyces cerevisiae, GI6319901, Length=459, Percent_Identity=36.8191721132898, Blast_Score=259, Evalue=5e-70,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 48134; Mature: 48134

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYYSTNKQAPVASLEEAVVKGLAGDKGLYMPEYIDSLDEEVIANMKNQSFHEIACTVAQ
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
MFFGEDIEPEVLDGIVKDTLSFETPVVPVKDNIYSLELFHGPTLAFKDVGGRFMARLLGY
HHHCCCCCHHHHHHHHHHHHCCCCCEEEECCCEEEEEEECCCCEEHHHCCHHHHHHHHHH
FIKKEGLKQVNVLVATSGDTGSAVANGFLGVPGIHVYVLYPKGKVSPIQECQFTTLGQNI
HHHHCCCCEEEEEEEECCCCCHHHHCCCCCCCCEEEEEEECCCCCCHHHHCCHHCCCCCE
TALEIDGTFDDCQALVKSAFMDEELNRHMKLTSANSINVARFLPQSFYYFNAYAQLDKLG
EEEEECCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCC
KADELVVCVPSGNFGNITAGLFAYWMGLPIKRFVAANNRNDVFLEYLNTGTYTPRPSVAT
CCCCEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHCCCCCCEEEEEECCCCCCCCCCHHH
LANAMDVGDPSNFARIIDLFGAFNDPHKEICALISGHRYTDEEIASTMRAVYKETGYILD
HHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEC
PHGACGYQGLLDSDLSETETGLFLETAHPAKFKGTVDKILEADIEIPAKLKAFMEGTKQS
CCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHH
IELAKDFEGFKSFLMSR
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKYYSTNKQAPVASLEEAVVKGLAGDKGLYMPEYIDSLDEEVIANMKNQSFHEIACTVAQ
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
MFFGEDIEPEVLDGIVKDTLSFETPVVPVKDNIYSLELFHGPTLAFKDVGGRFMARLLGY
HHHCCCCCHHHHHHHHHHHHCCCCCEEEECCCEEEEEEECCCCEEHHHCCHHHHHHHHHH
FIKKEGLKQVNVLVATSGDTGSAVANGFLGVPGIHVYVLYPKGKVSPIQECQFTTLGQNI
HHHHCCCCEEEEEEEECCCCCHHHHCCCCCCCCEEEEEEECCCCCCHHHHCCHHCCCCCE
TALEIDGTFDDCQALVKSAFMDEELNRHMKLTSANSINVARFLPQSFYYFNAYAQLDKLG
EEEEECCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCC
KADELVVCVPSGNFGNITAGLFAYWMGLPIKRFVAANNRNDVFLEYLNTGTYTPRPSVAT
CCCCEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHCCCCCCEEEEEECCCCCCCCCCHHH
LANAMDVGDPSNFARIIDLFGAFNDPHKEICALISGHRYTDEEIASTMRAVYKETGYILD
HHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEC
PHGACGYQGLLDSDLSETETGLFLETAHPAKFKGTVDKILEADIEIPAKLKAFMEGTKQS
CCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHH
IELAKDFEGFKSFLMSR
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]