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The map label for this gene is guaB [H]

Identifier: 150006764

GI number: 150006764

Start: 99765

End: 101258

Strand: Reverse

Name: guaB [H]

Synonym: BDI_0090

Alternate gene names: 150006764

Gene position: 101258-99765 (Counterclockwise)

Preceding gene: 150006766

Following gene: 150006763

Centisome position: 2.1

GC content: 48.26

Gene sequence:

>1494_bases
ATGGCAATCTACTTAAACGATGTATCGAGAACATTTGGTGAGTATTTACTTATTCCCGGTTTAACCACCAAAGAATGTAT
TCCCGCAAACGTTTCATTGAAAACGCCGCTTGTGAAATTCAAGTCTGGCGAGAAATCCGCTATTGAATTAAATATTCCTT
TCGTTTCCGCGATCATGCAATCGGTTTCCGGCCCTAAACTGGCAATCGAGTTGGCTCGCAACGGAGGACTTTCCTTCATC
TTCGGCTCGCAACCGATCGAGAGCCAAGCGGATATGGTTCGCAAAGTAAAGAAATTCAAGGCCGGATTTGTTATCAGCGA
CTCTAACCTTACGCCCGAGAATACCTTGGCCGACGTGCTTGAGCTAGTCCGCCGGACAGAACATTCTACGATTGGTGTGA
CAGATGATGGTACGCCTAACGGCAAATTGCTAGGTATGGTAACCAGTCGCGATTACCGTGAAGGCAAAGACCCGATCGAC
ATGAAAGTGAAAGATTTCATGACCCCGTTCGCTAAACTAATCGTTGGCGAGCTAGGCATGACCTTGAAAGAGGCGAACCA
GATTATCTGGGATCATAAGTTGAATACATTGCCAATCATCGACAAGGATCAGAAGCTTCAATACTTCGTATTCCGCAAGG
ACTACGATAGCCACCGTGAGAATCCGAAAGAGTTATCCGGCGGAGATAAGAAATTATTAGTAGGTGCCGGTATCAACACC
CGCGACTATAAGGAACGTGTTCCGGCATTGGTAGAGGCTGGCGTTGACGTATTGTGTATCGACTCTTCCGACGGCTATTC
CGAATGGCAGTACGAGACCTTGCACTGGATCAAGGATACCTACGGAGACAAGGTACTGGTTGGTGCCGGAAACGTGGTTG
ACCAAGATGGTTTCAACTACTTGGCTGACGCCGGAGCGGATTTCATCAAGGTAGGTATCGGTGGTGGTTCCATCTGTATC
ACCCGTGAGCAGAAAGGTATCGGTCGCGGACAGGCTACCGCCTTGATCGACGTAGCGAAAGCTCGTGACGAGTATTTCAA
GAGACACGGCGTTTATATCCCTATCTGTAGCGATGGTGGCTTGGTACACGATTACCATATGGTATTAGCGTTGGCTATGG
GTGCCGACTTCCTGATGATGGGCCGTTATTTCGCCCGCTTCGACGAGTCTCCTACGAAGAAGATGAAAATCGGAAACAAC
TTCGTGAAGGAGTATTGGGGTGAGGGATCTAACCGTGCGAAGAACTGGCAGCGCTATGACATGGGTGGAAACGAGTCCTT
GAAATTCGAGGAAGGCGTGGACAGCTATGTACCGTATGCCGGAAAATTGAAAGATAATTTAAACGTAACATTGGGTAAGA
TGATCGCTACGATGTGTAGCTGCGGTTCCATCTCTATCCAAGAGTTGCAGCAGCATGCCAAGATCACGCTTGTCTCCTCT
ACAAGTATCGTTGAGGGTGGCGCTCACGACGTGATCCTGAAAGAGCAGAATTAA

Upstream 100 bases:

>100_bases
GCATATTTCGAACATTTCATGTAAACATGTGATTCATATATGAACAGAAATCGCTACTTTTGCGCAATTAAAAAAACTCA
TCCTGTAAATATAAAATCTT

Downstream 100 bases:

>100_bases
TTACAATATGTATTCTAGTAGAGGCGTGGCACGCTACGTCTCTACTATTTACACATTCAAATAATTTACCATGAAAAATC
TATTACTTACAGTTATCCTT

Product: inosine 5-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MAIYLNDVSRTFGEYLLIPGLTTKECIPANVSLKTPLVKFKSGEKSAIELNIPFVSAIMQSVSGPKLAIELARNGGLSFI
FGSQPIESQADMVRKVKKFKAGFVISDSNLTPENTLADVLELVRRTEHSTIGVTDDGTPNGKLLGMVTSRDYREGKDPID
MKVKDFMTPFAKLIVGELGMTLKEANQIIWDHKLNTLPIIDKDQKLQYFVFRKDYDSHRENPKELSGGDKKLLVGAGINT
RDYKERVPALVEAGVDVLCIDSSDGYSEWQYETLHWIKDTYGDKVLVGAGNVVDQDGFNYLADAGADFIKVGIGGGSICI
TREQKGIGRGQATALIDVAKARDEYFKRHGVYIPICSDGGLVHDYHMVLALAMGADFLMMGRYFARFDESPTKKMKIGNN
FVKEYWGEGSNRAKNWQRYDMGGNESLKFEEGVDSYVPYAGKLKDNLNVTLGKMIATMCSCGSISIQELQQHAKITLVSS
TSIVEGGAHDVILKEQN

Sequences:

>Translated_497_residues
MAIYLNDVSRTFGEYLLIPGLTTKECIPANVSLKTPLVKFKSGEKSAIELNIPFVSAIMQSVSGPKLAIELARNGGLSFI
FGSQPIESQADMVRKVKKFKAGFVISDSNLTPENTLADVLELVRRTEHSTIGVTDDGTPNGKLLGMVTSRDYREGKDPID
MKVKDFMTPFAKLIVGELGMTLKEANQIIWDHKLNTLPIIDKDQKLQYFVFRKDYDSHRENPKELSGGDKKLLVGAGINT
RDYKERVPALVEAGVDVLCIDSSDGYSEWQYETLHWIKDTYGDKVLVGAGNVVDQDGFNYLADAGADFIKVGIGGGSICI
TREQKGIGRGQATALIDVAKARDEYFKRHGVYIPICSDGGLVHDYHMVLALAMGADFLMMGRYFARFDESPTKKMKIGNN
FVKEYWGEGSNRAKNWQRYDMGGNESLKFEEGVDSYVPYAGKLKDNLNVTLGKMIATMCSCGSISIQELQQHAKITLVSS
TSIVEGGAHDVILKEQN
>Mature_496_residues
AIYLNDVSRTFGEYLLIPGLTTKECIPANVSLKTPLVKFKSGEKSAIELNIPFVSAIMQSVSGPKLAIELARNGGLSFIF
GSQPIESQADMVRKVKKFKAGFVISDSNLTPENTLADVLELVRRTEHSTIGVTDDGTPNGKLLGMVTSRDYREGKDPIDM
KVKDFMTPFAKLIVGELGMTLKEANQIIWDHKLNTLPIIDKDQKLQYFVFRKDYDSHRENPKELSGGDKKLLVGAGINTR
DYKERVPALVEAGVDVLCIDSSDGYSEWQYETLHWIKDTYGDKVLVGAGNVVDQDGFNYLADAGADFIKVGIGGGSICIT
REQKGIGRGQATALIDVAKARDEYFKRHGVYIPICSDGGLVHDYHMVLALAMGADFLMMGRYFARFDESPTKKMKIGNNF
VKEYWGEGSNRAKNWQRYDMGGNESLKFEEGVDSYVPYAGKLKDNLNVTLGKMIATMCSCGSISIQELQQHAKITLVSST
SIVEGGAHDVILKEQN

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=441, Percent_Identity=37.18820861678, Blast_Score=246, Evalue=5e-65,
Organism=Homo sapiens, GI34328930, Length=441, Percent_Identity=37.18820861678, Blast_Score=246, Evalue=5e-65,
Organism=Homo sapiens, GI156616279, Length=441, Percent_Identity=37.18820861678, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI34328928, Length=441, Percent_Identity=37.18820861678, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI217035152, Length=445, Percent_Identity=37.0786516853933, Blast_Score=244, Evalue=2e-64,
Organism=Homo sapiens, GI66933016, Length=496, Percent_Identity=34.0725806451613, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI217035148, Length=441, Percent_Identity=36.0544217687075, Blast_Score=232, Evalue=7e-61,
Organism=Homo sapiens, GI217035150, Length=441, Percent_Identity=34.4671201814059, Blast_Score=216, Evalue=5e-56,
Organism=Homo sapiens, GI156104880, Length=237, Percent_Identity=30.8016877637131, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI50541956, Length=262, Percent_Identity=30.1526717557252, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI50541954, Length=262, Percent_Identity=30.1526717557252, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI50541952, Length=262, Percent_Identity=30.1526717557252, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI50541948, Length=262, Percent_Identity=30.1526717557252, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1788855, Length=496, Percent_Identity=33.2661290322581, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI1786293, Length=250, Percent_Identity=28.4, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71994385, Length=510, Percent_Identity=30.9803921568627, Blast_Score=205, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI71994389, Length=425, Percent_Identity=32.9411764705882, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17560440, Length=249, Percent_Identity=29.3172690763052, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6323585, Length=497, Percent_Identity=33.1991951710262, Blast_Score=224, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6323464, Length=498, Percent_Identity=34.136546184739, Blast_Score=220, Evalue=4e-58,
Organism=Saccharomyces cerevisiae, GI6322012, Length=499, Percent_Identity=32.6653306613226, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6319352, Length=352, Percent_Identity=36.0795454545455, Blast_Score=185, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24641071, Length=459, Percent_Identity=35.5119825708061, Blast_Score=231, Evalue=6e-61,
Organism=Drosophila melanogaster, GI24641073, Length=459, Percent_Identity=35.5119825708061, Blast_Score=231, Evalue=6e-61,
Organism=Drosophila melanogaster, GI28571163, Length=400, Percent_Identity=36.75, Blast_Score=214, Evalue=2e-55,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 54893; Mature: 54762

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIYLNDVSRTFGEYLLIPGLTTKECIPANVSLKTPLVKFKSGEKSAIELNIPFVSAIMQ
CEEEEECHHHHCCCEEEECCCCCCCCCCCCCEECCCEEEECCCCCCEEEEECHHHHHHHH
SVSGPKLAIELARNGGLSFIFGSQPIESQADMVRKVKKFKAGFVISDSNLTPENTLADVL
HCCCCEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHH
ELVRRTEHSTIGVTDDGTPNGKLLGMVTSRDYREGKDPIDMKVKDFMTPFAKLIVGELGM
HHHHHCCCCEEECCCCCCCCCEEEEEEECCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCC
TLKEANQIIWDHKLNTLPIIDKDQKLQYFVFRKDYDSHRENPKELSGGDKKLLVGAGINT
HHHHHHHEEEECCCCCCCCCCCCCCEEEEEEECCCHHHCCCCHHCCCCCCEEEEECCCCC
RDYKERVPALVEAGVDVLCIDSSDGYSEWQYETLHWIKDTYGDKVLVGAGNVVDQDGFNY
HHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCCEECCCCCHH
LADAGADFIKVGIGGGSICITREQKGIGRGQATALIDVAKARDEYFKRHGVYIPICSDGG
HHHCCCCEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCC
LVHDYHMVLALAMGADFLMMGRYFARFDESPTKKMKIGNNFVKEYWGEGSNRAKNWQRYD
EEHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHEECCCHHHHHHCCCCCCCCCCCEEEC
MGGNESLKFEEGVDSYVPYAGKLKDNLNVTLGKMIATMCSCGSISIQELQQHAKITLVSS
CCCCCCEEHHCCCHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHCCEEEEEEC
TSIVEGGAHDVILKEQN
CCEECCCCCEEEEECCC
>Mature Secondary Structure 
AIYLNDVSRTFGEYLLIPGLTTKECIPANVSLKTPLVKFKSGEKSAIELNIPFVSAIMQ
EEEEECHHHHCCCEEEECCCCCCCCCCCCCEECCCEEEECCCCCCEEEEECHHHHHHHH
SVSGPKLAIELARNGGLSFIFGSQPIESQADMVRKVKKFKAGFVISDSNLTPENTLADVL
HCCCCEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHH
ELVRRTEHSTIGVTDDGTPNGKLLGMVTSRDYREGKDPIDMKVKDFMTPFAKLIVGELGM
HHHHHCCCCEEECCCCCCCCCEEEEEEECCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCC
TLKEANQIIWDHKLNTLPIIDKDQKLQYFVFRKDYDSHRENPKELSGGDKKLLVGAGINT
HHHHHHHEEEECCCCCCCCCCCCCCEEEEEEECCCHHHCCCCHHCCCCCCEEEEECCCCC
RDYKERVPALVEAGVDVLCIDSSDGYSEWQYETLHWIKDTYGDKVLVGAGNVVDQDGFNY
HHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCCEECCCCCHH
LADAGADFIKVGIGGGSICITREQKGIGRGQATALIDVAKARDEYFKRHGVYIPICSDGG
HHHCCCCEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCC
LVHDYHMVLALAMGADFLMMGRYFARFDESPTKKMKIGNNFVKEYWGEGSNRAKNWQRYD
EEHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHEECCCHHHHHHCCCCCCCCCCCEEEC
MGGNESLKFEEGVDSYVPYAGKLKDNLNVTLGKMIATMCSCGSISIQELQQHAKITLVSS
CCCCCCEEHHCCCHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHCCEEEEEEC
TSIVEGGAHDVILKEQN
CCEECCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]