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The map label for this gene is arsA [H]

Identifier: 150006665

GI number: 150006665

Start: 5153055

End: 5154767

Strand: Direct

Name: arsA [H]

Synonym: BVU_4186

Alternate gene names: 150006665

Gene position: 5153055-5154767 (Clockwise)

Preceding gene: 150006664

Following gene: 150006666

Centisome position: 99.8

GC content: 42.91

Gene sequence:

>1713_bases
ATGAGAACATTCAATTTATCAGATATAGAATTGACAAAATACCTTTTCTTCACCGGAAAAGGCGGTGTGGGCAAAACTTC
TATTGCCTGTGCTACTGCGGTAGGTTTGGCAGATAATGGTAAGAAAATACTTCTTATCAGCACAGCCCCGGCTTCAAACC
TGCAAGATGTCTTTAATCAAACTTTAAACGGACACGGCACGGATATTCAGGAAGTACCCGGCTTAACTGTAGTTAATCTC
GACCCGGAACAAGCTGCTGCCGAATACAGGGAAAGCGTTATTGCGCCTTTCCGAGGAAAACTGCCCGATAGTGTTATCCA
AAATATGGAAGAACAACTTTCAGGTTCTTGCACGGTAGAAATTGCTGCTTTCAATCAATTTTCCGATTTTATCACGGATG
CTGATAAAGCAAAAGAATATGACCATATCATCTTTGATACAGCCCCAACGGGACATACATTGCGAATGCTACAACTACCA
TCGGCTTGGAGTACGTTTATTAGCGAAAGTACGCACGGTGCATCATGCTTAGGGCAATTATCCGGTTTGGAAGAAAGGAA
AGGCATCTATAAGCAAGCGGTTGAAACACTCTCGGATGCAAATGCAACTCGCTTAGTGTTGGTAAGTCGTCCCGAAATCG
CACCTTTGAAAGAAGCTGCCCGTTCTTCGCATGAATTACAATTACTGGGAATTAATAACCAGCTATTAGTAATCAACGGA
CTTTTGCTGCAATTAGATGAAGCCGATAGCGTATCGAAACAAATATATGACAGACAGCAAACCGCCCTGAAACAAACCCC
TGCGGAACTGCTGGATTACCCCTCTTATTCTGTTCCTTTACGGTCGTATAATCTATCTAACATTGCAAATATCCGCCGGA
TGCTATACGATGATAATTTAACAGACAATGCGGATTATCAACGGATTACTGATGCAAAAGGTATAGACGAATTGGTTAAT
GACCTCTATCAGTCAGGGAAAAGAGTTGTATTTACTATGGGAAAGGGTGGCGTAGGTAAAACAACGTTAGCCACGGAAAT
AGCCCTGAAATTAACTAAACTGGGTGCAAAGGTGCATCTAACCACCACTGACCCGGCAAACCACCTGAATTACAACCTTG
CAGTTCAGGCAGGTATTACAGTAAGCCGCATTGATGAAGCGGAAGTACTGGAAGCCTATAAAAACGAAGTTCGTAGTAAA
GCTGCGGAAACAATGACTGCCGAAGATATGGAATACATAGAGGAAGATTTGCGTTCACCGTGTACGCAAGAAATCGCAGT
GTTCCGGGCTTTTGCCGAAATCGTAGACAAAGCGGAAAATGAAATTGTTGTGATTGATACCGCACCTACCGGACACACCT
TGTTACTGCTGGATGCAACGGAAAGCTACCACAAGGAAGTACAACGCACGCATGGCGATTCTCCTGCTTCGGTAAGAAAA
TTATTACCACGTTTAAGAAACCAGCAAGAAACGGAAGTTGTTATTGTGACCTTGCCCGAAGCAACCCCCGTCTTTGAAGC
CGAACGTTTGCAAAAGGATTTACAGCGTGCGGGAATTAATAACAAATGGTGGGTTGTAAACGCTTGTTTATCATTAACCG
ATACGGAAAATTCTTTTTTGCGGGCAAAGGCACAAAATGAATTGACTTGGATTAAGAAAGTAGAAGAATTGTCAAAGGGA
AACGCTGCCCTGATAGCTTGGAAAAATAATTGA

Upstream 100 bases:

>100_bases
CAAACCTATCCTACCACCAAACAAATGAGTGAATGGACGGGGGTCAATTTAGATTTTATGCCAGTTAAATAAGTATTCAC
CAATTAATTATTTAAGAAAA

Downstream 100 bases:

>100_bases
GAATATGAGAATTTTAATCCTTTGTACTGGAAATAGTTGCCGTAGCCAAATGGCACACGGCTTATTACAATCATTTGACA
GTAAACTGGAAGTCTTTTCA

Product: arsenical pump-driving ATPase

Products: NA

Alternate protein names: Arsenical resistance ATPase; Arsenite-translocating ATPase; Arsenite-transporting ATPase [H]

Number of amino acids: Translated: 570; Mature: 570

Protein sequence:

>570_residues
MRTFNLSDIELTKYLFFTGKGGVGKTSIACATAVGLADNGKKILLISTAPASNLQDVFNQTLNGHGTDIQEVPGLTVVNL
DPEQAAAEYRESVIAPFRGKLPDSVIQNMEEQLSGSCTVEIAAFNQFSDFITDADKAKEYDHIIFDTAPTGHTLRMLQLP
SAWSTFISESTHGASCLGQLSGLEERKGIYKQAVETLSDANATRLVLVSRPEIAPLKEAARSSHELQLLGINNQLLVING
LLLQLDEADSVSKQIYDRQQTALKQTPAELLDYPSYSVPLRSYNLSNIANIRRMLYDDNLTDNADYQRITDAKGIDELVN
DLYQSGKRVVFTMGKGGVGKTTLATEIALKLTKLGAKVHLTTTDPANHLNYNLAVQAGITVSRIDEAEVLEAYKNEVRSK
AAETMTAEDMEYIEEDLRSPCTQEIAVFRAFAEIVDKAENEIVVIDTAPTGHTLLLLDATESYHKEVQRTHGDSPASVRK
LLPRLRNQQETEVVIVTLPEATPVFEAERLQKDLQRAGINNKWWVVNACLSLTDTENSFLRAKAQNELTWIKKVEELSKG
NAALIAWKNN

Sequences:

>Translated_570_residues
MRTFNLSDIELTKYLFFTGKGGVGKTSIACATAVGLADNGKKILLISTAPASNLQDVFNQTLNGHGTDIQEVPGLTVVNL
DPEQAAAEYRESVIAPFRGKLPDSVIQNMEEQLSGSCTVEIAAFNQFSDFITDADKAKEYDHIIFDTAPTGHTLRMLQLP
SAWSTFISESTHGASCLGQLSGLEERKGIYKQAVETLSDANATRLVLVSRPEIAPLKEAARSSHELQLLGINNQLLVING
LLLQLDEADSVSKQIYDRQQTALKQTPAELLDYPSYSVPLRSYNLSNIANIRRMLYDDNLTDNADYQRITDAKGIDELVN
DLYQSGKRVVFTMGKGGVGKTTLATEIALKLTKLGAKVHLTTTDPANHLNYNLAVQAGITVSRIDEAEVLEAYKNEVRSK
AAETMTAEDMEYIEEDLRSPCTQEIAVFRAFAEIVDKAENEIVVIDTAPTGHTLLLLDATESYHKEVQRTHGDSPASVRK
LLPRLRNQQETEVVIVTLPEATPVFEAERLQKDLQRAGINNKWWVVNACLSLTDTENSFLRAKAQNELTWIKKVEELSKG
NAALIAWKNN
>Mature_570_residues
MRTFNLSDIELTKYLFFTGKGGVGKTSIACATAVGLADNGKKILLISTAPASNLQDVFNQTLNGHGTDIQEVPGLTVVNL
DPEQAAAEYRESVIAPFRGKLPDSVIQNMEEQLSGSCTVEIAAFNQFSDFITDADKAKEYDHIIFDTAPTGHTLRMLQLP
SAWSTFISESTHGASCLGQLSGLEERKGIYKQAVETLSDANATRLVLVSRPEIAPLKEAARSSHELQLLGINNQLLVING
LLLQLDEADSVSKQIYDRQQTALKQTPAELLDYPSYSVPLRSYNLSNIANIRRMLYDDNLTDNADYQRITDAKGIDELVN
DLYQSGKRVVFTMGKGGVGKTTLATEIALKLTKLGAKVHLTTTDPANHLNYNLAVQAGITVSRIDEAEVLEAYKNEVRSK
AAETMTAEDMEYIEEDLRSPCTQEIAVFRAFAEIVDKAENEIVVIDTAPTGHTLLLLDATESYHKEVQRTHGDSPASVRK
LLPRLRNQQETEVVIVTLPEATPVFEAERLQKDLQRAGINNKWWVVNACLSLTDTENSFLRAKAQNELTWIKKVEELSKG
NAALIAWKNN

Specific function: Anion-transporting ATPase. Catalyzes the extrusion of the oxyanions arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents [H]

COG id: COG0003

COG function: function code P; Oxyanion-translocating ATPase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arsA ATPase family [H]

Homologues:

Organism=Homo sapiens, GI50428938, Length=258, Percent_Identity=29.0697674418605, Blast_Score=80, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17557003, Length=266, Percent_Identity=27.0676691729323, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320103, Length=327, Percent_Identity=26.605504587156, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24586297, Length=324, Percent_Identity=26.5432098765432, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016300
- InterPro:   IPR003593
- InterPro:   IPR003348 [H]

Pfam domain/function: NA

EC number: =3.6.3.16 [H]

Molecular weight: Translated: 62899; Mature: 62899

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTFNLSDIELTKYLFFTGKGGVGKTSIACATAVGLADNGKKILLISTAPASNLQDVFNQ
CCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHH
TLNGHGTDIQEVPGLTVVNLDPEQAAAEYRESVIAPFRGKLPDSVIQNMEEQLSGSCTVE
HCCCCCCCHHHCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEE
IAAFNQFSDFITDADKAKEYDHIIFDTAPTGHTLRMLQLPSAWSTFISESTHGASCLGQL
EEECHHHHHHHCCCHHHCCCCEEEEECCCCCCEEEEEECCHHHHHHHCCCCCCHHHHHHH
SGLEERKGIYKQAVETLSDANATRLVLVSRPEIAPLKEAARSSHELQLLGINNQLLVING
CCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHCCCCCEEEEECCCCEEEEEC
LLLQLDEADSVSKQIYDRQQTALKQTPAELLDYPSYSVPLRSYNLSNIANIRRMLYDDNL
EEEEECCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
TDNADYQRITDAKGIDELVNDLYQSGKRVVFTMGKGGVGKTTLATEIALKLTKLGAKVHL
CCCCCHHHHHCCCCHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEE
TTTDPANHLNYNLAVQAGITVSRIDEAEVLEAYKNEVRSKAAETMTAEDMEYIEEDLRSP
EECCCHHHCCEEEEEEECCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
CTQEIAVFRAFAEIVDKAENEIVVIDTAPTGHTLLLLDATESYHKEVQRTHGDSPASVRK
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHH
LLPRLRNQQETEVVIVTLPEATPVFEAERLQKDLQRAGINNKWWVVNACLSLTDTENSFL
HHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCHHH
RAKAQNELTWIKKVEELSKGNAALIAWKNN
HHHHHHHHHHHHHHHHHCCCCEEEEEEECC
>Mature Secondary Structure
MRTFNLSDIELTKYLFFTGKGGVGKTSIACATAVGLADNGKKILLISTAPASNLQDVFNQ
CCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHH
TLNGHGTDIQEVPGLTVVNLDPEQAAAEYRESVIAPFRGKLPDSVIQNMEEQLSGSCTVE
HCCCCCCCHHHCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEE
IAAFNQFSDFITDADKAKEYDHIIFDTAPTGHTLRMLQLPSAWSTFISESTHGASCLGQL
EEECHHHHHHHCCCHHHCCCCEEEEECCCCCCEEEEEECCHHHHHHHCCCCCCHHHHHHH
SGLEERKGIYKQAVETLSDANATRLVLVSRPEIAPLKEAARSSHELQLLGINNQLLVING
CCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHCCCCCEEEEECCCCEEEEEC
LLLQLDEADSVSKQIYDRQQTALKQTPAELLDYPSYSVPLRSYNLSNIANIRRMLYDDNL
EEEEECCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
TDNADYQRITDAKGIDELVNDLYQSGKRVVFTMGKGGVGKTTLATEIALKLTKLGAKVHL
CCCCCHHHHHCCCCHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEE
TTTDPANHLNYNLAVQAGITVSRIDEAEVLEAYKNEVRSKAAETMTAEDMEYIEEDLRSP
EECCCHHHCCEEEEEEECCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
CTQEIAVFRAFAEIVDKAENEIVVIDTAPTGHTLLLLDATESYHKEVQRTHGDSPASVRK
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHH
LLPRLRNQQETEVVIVTLPEATPVFEAERLQKDLQRAGINNKWWVVNACLSLTDTENSFL
HHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCHHH
RAKAQNELTWIKKVEELSKGNAALIAWKNN
HHHHHHHHHHHHHHHHHCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3021763; 1704144 [H]