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The map label for this gene is ung

Identifier: 150006627

GI number: 150006627

Start: 5110659

End: 5111321

Strand: Direct

Name: ung

Synonym: BVU_4148

Alternate gene names: 150006627

Gene position: 5110659-5111321 (Clockwise)

Preceding gene: 150006626

Following gene: 150006630

Centisome position: 98.98

GC content: 48.27

Gene sequence:

>663_bases
ATGAACGTACAAATAGAAGAAAGCTGGAAACAACATCTGGCACCCGAATTTGAAAAAGATTACTTTATCAGACTCACTGA
GTTTGTAAGAAGCGAATACCAGACTGCCACTATTTACCCACCGGGCAGATTTATATTCAACGCCTTCAATCTGTGCCCGT
TTGACAAAGTGAAAGTCGTCATTATCGGCCAAGATCCCTACCATGGTCCCGGCCAGGCGCACGGACTCTGCTTCTCTGTT
AATGACGGAGTACCTTTTCCTCCTTCCCTACAAAATATTTTCAAAGAAATACAAAGCGATTTGGGTGCTCCCATCCCTAC
TTCAGGCAACCTGACCCGCTGGGCGAATCAAGGAGTTTTATTACTCAATGCCACACTGACGGTCCGTGCCCACCAGGCAG
GCTCTCATCAACGACGGGGCTGGGAGGAATTTACAGATGCCGCCATCCGTGTACTGGCAGAACAACGTGAAAATATTGTA
TTCATCTTATGGGGATCTTATGCACAGAAAAAAGGCGCCTTCATAGACCGCAACAAGCACCTGGTACTGGCTTCCGCACA
TCCGTCCCCCCTGTCAGCCTATAACGGTTTCTTTGGCAACAAGCACTTCAGCCGTACCAACGAATATTTGCAAGCGCACG
GGCAAACACCGATTGAGTGGTAG

Upstream 100 bases:

>100_bases
TGAAAGAAGAGGATGATTATAAAAAGTCATCCTCTTTTTATTTGTCATTTTTACAAATTACCCCTATCTTTAACGCACAT
TTTATAATAAAAGAAATGCC

Downstream 100 bases:

>100_bases
ACATAAATAAAAAAATGAGAAATGGTTTCTGATAACAACACGCAACCATTTCTCATTTTTTTATTCCCAACTTCTTCCTA
GTACCAATTCACCGCACTAC

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MNVQIEESWKQHLAPEFEKDYFIRLTEFVRSEYQTATIYPPGRFIFNAFNLCPFDKVKVVIIGQDPYHGPGQAHGLCFSV
NDGVPFPPSLQNIFKEIQSDLGAPIPTSGNLTRWANQGVLLLNATLTVRAHQAGSHQRRGWEEFTDAAIRVLAEQRENIV
FILWGSYAQKKGAFIDRNKHLVLASAHPSPLSAYNGFFGNKHFSRTNEYLQAHGQTPIEW

Sequences:

>Translated_220_residues
MNVQIEESWKQHLAPEFEKDYFIRLTEFVRSEYQTATIYPPGRFIFNAFNLCPFDKVKVVIIGQDPYHGPGQAHGLCFSV
NDGVPFPPSLQNIFKEIQSDLGAPIPTSGNLTRWANQGVLLLNATLTVRAHQAGSHQRRGWEEFTDAAIRVLAEQRENIV
FILWGSYAQKKGAFIDRNKHLVLASAHPSPLSAYNGFFGNKHFSRTNEYLQAHGQTPIEW
>Mature_220_residues
MNVQIEESWKQHLAPEFEKDYFIRLTEFVRSEYQTATIYPPGRFIFNAFNLCPFDKVKVVIIGQDPYHGPGQAHGLCFSV
NDGVPFPPSLQNIFKEIQSDLGAPIPTSGNLTRWANQGVLLLNATLTVRAHQAGSHQRRGWEEFTDAAIRVLAEQRENIV
FILWGSYAQKKGAFIDRNKHLVLASAHPSPLSAYNGFFGNKHFSRTNEYLQAHGQTPIEW

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=219, Percent_Identity=59.3607305936073, Blast_Score=271, Evalue=3e-73,
Organism=Homo sapiens, GI6224979, Length=219, Percent_Identity=59.3607305936073, Blast_Score=271, Evalue=4e-73,
Organism=Escherichia coli, GI1788934, Length=217, Percent_Identity=54.3778801843318, Blast_Score=239, Evalue=8e-65,
Organism=Caenorhabditis elegans, GI17556304, Length=217, Percent_Identity=52.5345622119816, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6323620, Length=233, Percent_Identity=46.3519313304721, Blast_Score=207, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_BACV8 (A6L7T5)

Other databases:

- EMBL:   CP000139
- RefSeq:   YP_001301371.1
- ProteinModelPortal:   A6L7T5
- SMR:   A6L7T5
- STRING:   A6L7T5
- GeneID:   5305107
- GenomeReviews:   CP000139_GR
- KEGG:   bvu:BVU_4148
- NMPDR:   fig|435590.6.peg.3858
- eggNOG:   COG0692
- HOGENOM:   HBG605450
- OMA:   GAHAQKK
- ProtClustDB:   PRK05254
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 24956; Mature: 24956

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 65-65

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVQIEESWKQHLAPEFEKDYFIRLTEFVRSEYQTATIYPPGRFIFNAFNLCPFDKVKVV
CCCEEHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCCCEEEE
IIGQDPYHGPGQAHGLCFSVNDGVPFPPSLQNIFKEIQSDLGAPIPTSGNLTRWANQGVL
EEECCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEE
LLNATLTVRAHQAGSHQRRGWEEFTDAAIRVLAEQRENIVFILWGSYAQKKGAFIDRNKH
EEEEEEEEEECCCCCCHHCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEECCCE
LVLASAHPSPLSAYNGFFGNKHFSRTNEYLQAHGQTPIEW
EEEEECCCCCHHHHCCCCCCCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNVQIEESWKQHLAPEFEKDYFIRLTEFVRSEYQTATIYPPGRFIFNAFNLCPFDKVKVV
CCCEEHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCCCEEEE
IIGQDPYHGPGQAHGLCFSVNDGVPFPPSLQNIFKEIQSDLGAPIPTSGNLTRWANQGVL
EEECCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEE
LLNATLTVRAHQAGSHQRRGWEEFTDAAIRVLAEQRENIVFILWGSYAQKKGAFIDRNKH
EEEEEEEEEECCCCCCHHCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEECCCE
LVLASAHPSPLSAYNGFFGNKHFSRTNEYLQAHGQTPIEW
EEEEECCCCCHHHHCCCCCCCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA