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The map label for this gene is nagB

Identifier: 150006600

GI number: 150006600

Start: 5067644

End: 5068435

Strand: Direct

Name: nagB

Synonym: BVU_4120

Alternate gene names: 150006600

Gene position: 5067644-5068435 (Clockwise)

Preceding gene: 150006599

Following gene: 150006601

Centisome position: 98.15

GC content: 42.17

Gene sequence:

>792_bases
ATGAGAGTAATTATTGAATCTGATTACCAAGCGCTGTCACAATGGGCGGCAAACTATGTAGCTAGTAAAATCAATGCGGC
AAATCCGACTCCTGAAAAACCTTTTGTTTTAGGTTGTCCCACAGGATCTTCACCGCTAGGCATGTACAAAGCGCTGATAG
AACTGAACAAGCAGGGAAAAGTATCTTTCCAGAATGTCGTTACTTTCAATATGGACGAATATGTAGGCTTGCCTGAAGAT
CATCCAGAAAGCTACCATACATTTATGTGGAAAAACTTTTTTAACCATATTGATATAAAGAAAGAAAATGTACATATCCT
GAACGGAAATGCCGAAGACCTGGAAGCAGAATGCGCCAACTACGAAAAACAAATAGCCGAAATCGGAGGCATCGACCTGT
TTATGGGAGGTATCGGTCCCGACGGACATATCGCATTCAACGAGCCGGGCTCATCTTTGTCTTCACGCACACGTATCAAA
ACACTGACTACAGACACAATCATTGCAAACTCACGTTTCTTTGACAATGACGTGAACAAAGTACCTAAAACTGCGTTAAC
AGTAGGTGTAGGGACTGTCCTTTCAGCCAAAGAAGTTCTGATTATCTGCAACGGGCACAACAAAGCACGTGCTTTGCAAC
ATGCCGTTGAAGGTGGTATTACACAAATGTGGACTATCAGCGCATTACAAATGCACCAGCATGGCATCATTGTTTGTGAC
GAAGCCGCTACAGACGAACTGAAAGTCGGTACCTACAAATATTTCAAAGACATCGAAAAAGCTAATTTGTAA

Upstream 100 bases:

>100_bases
CGCACTGGTAGTACAATTGACATTCCTCCGTCCCAAAACGGATAATATGGAATAACCCGTATAGTTAACTTAACACTTAA
AACTTAAAAAAGAAAGAACC

Downstream 100 bases:

>100_bases
TTTATGAGAACAAACTTAAGTTCGCAGATTTCTCTGAACAGAGTATCTCCGAAATATTATAAACCCGAAAATGCGGTGGA
ACGTTCTGTCTTGACCCGCT

Product: glucosamine-6-phosphate deaminase

Products: NA

Alternate protein names: GlcN6P deaminase; GNPDA; Glucosamine-6-phosphate isomerase

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MRVIIESDYQALSQWAANYVASKINAANPTPEKPFVLGCPTGSSPLGMYKALIELNKQGKVSFQNVVTFNMDEYVGLPED
HPESYHTFMWKNFFNHIDIKKENVHILNGNAEDLEAECANYEKQIAEIGGIDLFMGGIGPDGHIAFNEPGSSLSSRTRIK
TLTTDTIIANSRFFDNDVNKVPKTALTVGVGTVLSAKEVLIICNGHNKARALQHAVEGGITQMWTISALQMHQHGIIVCD
EAATDELKVGTYKYFKDIEKANL

Sequences:

>Translated_263_residues
MRVIIESDYQALSQWAANYVASKINAANPTPEKPFVLGCPTGSSPLGMYKALIELNKQGKVSFQNVVTFNMDEYVGLPED
HPESYHTFMWKNFFNHIDIKKENVHILNGNAEDLEAECANYEKQIAEIGGIDLFMGGIGPDGHIAFNEPGSSLSSRTRIK
TLTTDTIIANSRFFDNDVNKVPKTALTVGVGTVLSAKEVLIICNGHNKARALQHAVEGGITQMWTISALQMHQHGIIVCD
EAATDELKVGTYKYFKDIEKANL
>Mature_263_residues
MRVIIESDYQALSQWAANYVASKINAANPTPEKPFVLGCPTGSSPLGMYKALIELNKQGKVSFQNVVTFNMDEYVGLPED
HPESYHTFMWKNFFNHIDIKKENVHILNGNAEDLEAECANYEKQIAEIGGIDLFMGGIGPDGHIAFNEPGSSLSSRTRIK
TLTTDTIIANSRFFDNDVNKVPKTALTVGVGTVLSAKEVLIICNGHNKARALQHAVEGGITQMWTISALQMHQHGIIVCD
EAATDELKVGTYKYFKDIEKANL

Specific function: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily

Homologues:

Organism=Homo sapiens, GI13027378, Length=258, Percent_Identity=63.1782945736434, Blast_Score=348, Evalue=3e-96,
Organism=Homo sapiens, GI19923881, Length=258, Percent_Identity=60.8527131782946, Blast_Score=339, Evalue=2e-93,
Organism=Escherichia coli, GI1786893, Length=263, Percent_Identity=61.2167300380228, Blast_Score=352, Evalue=2e-98,
Organism=Escherichia coli, GI1789530, Length=233, Percent_Identity=27.8969957081545, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI48994958, Length=245, Percent_Identity=29.7959183673469, Blast_Score=92, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17554876, Length=258, Percent_Identity=60.8527131782946, Blast_Score=324, Evalue=3e-89,
Organism=Drosophila melanogaster, GI24581960, Length=258, Percent_Identity=63.953488372093, Blast_Score=354, Evalue=4e-98,
Organism=Drosophila melanogaster, GI19920764, Length=258, Percent_Identity=63.953488372093, Blast_Score=354, Evalue=4e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NAGB_BACV8 (A6L7Q8)

Other databases:

- EMBL:   CP000139
- RefSeq:   YP_001301344.1
- ProteinModelPortal:   A6L7Q8
- SMR:   A6L7Q8
- STRING:   A6L7Q8
- GeneID:   5305079
- GenomeReviews:   CP000139_GR
- KEGG:   bvu:BVU_4120
- NMPDR:   fig|435590.6.peg.3832
- eggNOG:   COG0363
- HOGENOM:   HBG725991
- OMA:   CATFVAD
- ProtClustDB:   PRK00443
- HAMAP:   MF_01241
- InterPro:   IPR006148
- InterPro:   IPR004547
- InterPro:   IPR018321
- PANTHER:   PTHR11280
- TIGRFAMs:   TIGR00502

Pfam domain/function: PF01182 Glucosamine_iso

EC number: =3.5.99.6

Molecular weight: Translated: 29020; Mature: 29020

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS01161 GLC_GALNAC_ISOMERASE

Important sites: ACT_SITE 72-72 ACT_SITE 141-141 ACT_SITE 143-143 ACT_SITE 148-148

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVIIESDYQALSQWAANYVASKINAANPTPEKPFVLGCPTGSSPLGMYKALIELNKQGK
CEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCC
VSFQNVVTFNMDEYVGLPEDHPESYHTFMWKNFFNHIDIKKENVHILNGNAEDLEAECAN
EEEEEEEEECHHHHCCCCCCCCCHHHHHHHHHHHHHCCEECCCEEEECCCHHHHHHHHHH
YEKQIAEIGGIDLFMGGIGPDGHIAFNEPGSSLSSRTRIKTLTTDTIIANSRFFDNDVNK
HHHHHHHHCCEEEEECCCCCCCCEEECCCCCCCHHCCEEEEEECCEEEECCCCCCCHHHH
VPKTALTVGVGTVLSAKEVLIICNGHNKARALQHAVEGGITQMWTISALQMHQHGIIVCD
CCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCHHEEHHHHHHHHCCCEEEEC
EAATDELKVGTYKYFKDIEKANL
CCCCCCEECCHHHHHHHHHHCCC
>Mature Secondary Structure
MRVIIESDYQALSQWAANYVASKINAANPTPEKPFVLGCPTGSSPLGMYKALIELNKQGK
CEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCC
VSFQNVVTFNMDEYVGLPEDHPESYHTFMWKNFFNHIDIKKENVHILNGNAEDLEAECAN
EEEEEEEEECHHHHCCCCCCCCCHHHHHHHHHHHHHCCEECCCEEEECCCHHHHHHHHHH
YEKQIAEIGGIDLFMGGIGPDGHIAFNEPGSSLSSRTRIKTLTTDTIIANSRFFDNDVNK
HHHHHHHHCCEEEEECCCCCCCCEEECCCCCCCHHCCEEEEEECCEEEECCCCCCCHHHH
VPKTALTVGVGTVLSAKEVLIICNGHNKARALQHAVEGGITQMWTISALQMHQHGIIVCD
CCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCHHEEHHHHHHHHCCCEEEEC
EAATDELKVGTYKYFKDIEKANL
CCCCCCEECCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA