Click here to switch to the map view.

The map label for this gene is yfhQ [H]

Identifier: 150006581

GI number: 150006581

Start: 5043014

End: 5044072

Strand: Reverse

Name: yfhQ [H]

Synonym: BVU_4101

Alternate gene names: 150006581

Gene position: 5044072-5043014 (Counterclockwise)

Preceding gene: 150006584

Following gene: 150006580

Centisome position: 97.69

GC content: 46.93

Gene sequence:

>1059_bases
ATGGAGAATTTTAGCAGAAAATTGATAGATTGGTATAGGGAAAACGGGCGTGATTTGCCGTGGAGAAGGACAAAAAATCC
TTATTTGATATGGATCTCGGAGATTATTCTACAACAAACTCGTGTGGTTCAGGGATATGATTACTATCAACGTTTTGTGG
CCCGTTTTCCTGATGTGTTCGCACTGGCGGCAGCCGATGAGGATGAGGTGATGAAATATTGGCAGGGGCTGGGGTATTAT
TCCCGTGCGAGAAATTTGCATGCTGCGGCCAGAAGGATGGCAGAGGCAGGAGGATTTCCTGTAACATACACTGGGGTGCG
TGCTTTGAAAGGAGTGGGAGAATATACAGCAGCGGCTATTTGTTCATTTGCTTACGGTATGCCATACGCAGTGGTGGACG
GTAATGTGTATCGGGTGCTGTCCCGTTGGTTAGGCATTGATACCCCCATTGATTCGGCGGAAGGAAAGAAACTGTTTGTC
CGGGTTGCCGATGAGTTGCTGGACCGTGAGCGCCCTGGTCTCTACAACCAGGCTATCATGGATTTTGGAGCTTTGCAGTG
TACTCCGGTAGCGCCCGACTGCCTGTTTTGTCCGCTAAACGATTCTTGTGTGGCGCGTCTGAAGGGGATTGCCGGCTCTT
TGCCTGTGAAGCAACATAAAAACAAGGTGACTAATCGTTATTTTAATTATATATATGTACGCATGGGCGCGTATACCTTT
ATACATAAGCGCAGCGGAAATGATATATGGAAAAATTTGTATGAACCGCCTTTGATAGAAACGGATCGTGAGTGGACGGA
AGAGGAACTGTATGCATCGCCACAGTTTCGCGAGATGCTGGCCGGAGGAGAGGAGCCCATAGTGCGGCTGGTGCGGAAAG
GGGTGAAGCACGTGTTATCCCACCGGGTGATTTACGCAAATTTTTATGAAGTGATTCTCCCTGAGAATTCGGCTTCTTTT
GCGAAGTATCAGAGAATAAGCGTGGAAGATTTGCATAAATTTGCCGTATCGCGTTTGGTGAATCAGTTTTTTTCGCTAAT
TTTGGAGCCTAATAATTAA

Upstream 100 bases:

>100_bases
TATATTCAGAATAAATTTCCTAAAAAAAGCATCTTCTTCCATTTTCTTGGTTTACTTTTGCGGAAATATTGCATAGAATG
CACTTTTATATAATACTGAT

Downstream 100 bases:

>100_bases
AAAGGAATAATAGAATGTCAGTAAATAAAGTCATTTTGATTGGAAATGTAGGAAAGGACCCTGATGTGAGATATTTGGAT
ACCGGCATTGCCGTTGCCAC

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MENFSRKLIDWYRENGRDLPWRRTKNPYLIWISEIILQQTRVVQGYDYYQRFVARFPDVFALAAADEDEVMKYWQGLGYY
SRARNLHAAARRMAEAGGFPVTYTGVRALKGVGEYTAAAICSFAYGMPYAVVDGNVYRVLSRWLGIDTPIDSAEGKKLFV
RVADELLDRERPGLYNQAIMDFGALQCTPVAPDCLFCPLNDSCVARLKGIAGSLPVKQHKNKVTNRYFNYIYVRMGAYTF
IHKRSGNDIWKNLYEPPLIETDREWTEEELYASPQFREMLAGGEEPIVRLVRKGVKHVLSHRVIYANFYEVILPENSASF
AKYQRISVEDLHKFAVSRLVNQFFSLILEPNN

Sequences:

>Translated_352_residues
MENFSRKLIDWYRENGRDLPWRRTKNPYLIWISEIILQQTRVVQGYDYYQRFVARFPDVFALAAADEDEVMKYWQGLGYY
SRARNLHAAARRMAEAGGFPVTYTGVRALKGVGEYTAAAICSFAYGMPYAVVDGNVYRVLSRWLGIDTPIDSAEGKKLFV
RVADELLDRERPGLYNQAIMDFGALQCTPVAPDCLFCPLNDSCVARLKGIAGSLPVKQHKNKVTNRYFNYIYVRMGAYTF
IHKRSGNDIWKNLYEPPLIETDREWTEEELYASPQFREMLAGGEEPIVRLVRKGVKHVLSHRVIYANFYEVILPENSASF
AKYQRISVEDLHKFAVSRLVNQFFSLILEPNN
>Mature_352_residues
MENFSRKLIDWYRENGRDLPWRRTKNPYLIWISEIILQQTRVVQGYDYYQRFVARFPDVFALAAADEDEVMKYWQGLGYY
SRARNLHAAARRMAEAGGFPVTYTGVRALKGVGEYTAAAICSFAYGMPYAVVDGNVYRVLSRWLGIDTPIDSAEGKKLFV
RVADELLDRERPGLYNQAIMDFGALQCTPVAPDCLFCPLNDSCVARLKGIAGSLPVKQHKNKVTNRYFNYIYVRMGAYTF
IHKRSGNDIWKNLYEPPLIETDREWTEEELYASPQFREMLAGGEEPIVRLVRKGVKHVLSHRVIYANFYEVILPENSASF
AKYQRISVEDLHKFAVSRLVNQFFSLILEPNN

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298654, Length=216, Percent_Identity=41.6666666666667, Blast_Score=165, Evalue=4e-41,
Organism=Homo sapiens, GI115298652, Length=216, Percent_Identity=41.6666666666667, Blast_Score=165, Evalue=4e-41,
Organism=Homo sapiens, GI115298650, Length=216, Percent_Identity=41.6666666666667, Blast_Score=165, Evalue=5e-41,
Organism=Homo sapiens, GI115298648, Length=216, Percent_Identity=41.6666666666667, Blast_Score=165, Evalue=5e-41,
Organism=Homo sapiens, GI190358497, Length=216, Percent_Identity=41.6666666666667, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI6912520, Length=216, Percent_Identity=41.6666666666667, Blast_Score=165, Evalue=7e-41,
Organism=Escherichia coli, GI1789331, Length=286, Percent_Identity=36.7132867132867, Blast_Score=193, Evalue=1e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 40625; Mature: 40625

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENFSRKLIDWYRENGRDLPWRRTKNPYLIWISEIILQQTRVVQGYDYYQRFVARFPDVF
CCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCHHHHHHHHHHCCCCE
ALAAADEDEVMKYWQGLGYYSRARNLHAAARRMAEAGGFPVTYTGVRALKGVGEYTAAAI
EEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCHHHHHHHH
CSFAYGMPYAVVDGNVYRVLSRWLGIDTPIDSAEGKKLFVRVADELLDRERPGLYNQAIM
HHHHHCCCEEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
DFGALQCTPVAPDCLFCPLNDSCVARLKGIAGSLPVKQHKNKVTNRYFNYIYVRMGAYTF
HCCCCEECCCCCCCEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEECCEEE
IHKRSGNDIWKNLYEPPLIETDREWTEEELYASPQFREMLAGGEEPIVRLVRKGVKHVLS
EEECCCCHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHH
HRVIYANFYEVILPENSASFAKYQRISVEDLHKFAVSRLVNQFFSLILEPNN
CCCCEEEHEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MENFSRKLIDWYRENGRDLPWRRTKNPYLIWISEIILQQTRVVQGYDYYQRFVARFPDVF
CCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCHHHHHHHHHHCCCCE
ALAAADEDEVMKYWQGLGYYSRARNLHAAARRMAEAGGFPVTYTGVRALKGVGEYTAAAI
EEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCHHHHHHHH
CSFAYGMPYAVVDGNVYRVLSRWLGIDTPIDSAEGKKLFVRVADELLDRERPGLYNQAIM
HHHHHCCCEEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
DFGALQCTPVAPDCLFCPLNDSCVARLKGIAGSLPVKQHKNKVTNRYFNYIYVRMGAYTF
HCCCCEECCCCCCCEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEECCEEE
IHKRSGNDIWKNLYEPPLIETDREWTEEELYASPQFREMLAGGEEPIVRLVRKGVKHVLS
EEECCCCHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHH
HRVIYANFYEVILPENSASFAKYQRISVEDLHKFAVSRLVNQFFSLILEPNN
CCCCEEEHEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]