Click here to switch to the map view.

The map label for this gene is trpE [H]

Identifier: 150006568

GI number: 150006568

Start: 5030780

End: 5032180

Strand: Direct

Name: trpE [H]

Synonym: BVU_4088

Alternate gene names: 150006568

Gene position: 5030780-5032180 (Clockwise)

Preceding gene: 150006567

Following gene: 150006569

Centisome position: 97.44

GC content: 47.18

Gene sequence:

>1401_bases
ATGAAAACTTTTACCTATACCACCCGATGCAAAACCATACTGGGTGACCTGCATACACCGGTCAGTACCTATCTGAAAGT
GCGCGACATTTTCCCACAGAGTGCACTGATGGAAAGTTCCGACTATCATGGAAGTGAGAACAACCGTTCTTTCATCGGAC
TGAATCCTGTAGCCAGCATCGGAATCAATCATGGCACAGCCACTGCCACCTACCCTGACGGCAGCATAGAAGAACATCCC
ATCAGCGAACATTTCCGGGCAGACCATGCGATCTCCGATTTTCTGAATCGTTTCAAGGTAAGCGGAGAATACAACAACTA
CTGCGGACTGTATGGCTATACCACTTTCAATGCCGTACGCTATTTCGAACATATCAATGTAAAAGACAGCCGTGATCCTA
AGAACGATGCTCCGGATATGTTGTATATCTTATATAAATACCTGATTGTCTTCAATGACTTCCGCAACGAAATGTTATTA
CTGGAAATGTTGCAGGACGGTGAGGACAGCCATCTGGATTATGTGGAAAAAGCGATCCACAACCGTAACTATACTACTTA
CGACTTCCGTGCCGTGGGCGAAACCACCAGTACCCTGACCGATGAAGAACATAAGGCGAACATCCGCAAAGGCATTGCCC
ACTGTATGCGCGGCGATGTTTTCCAAATCGTCCTTTCACGCCGTTTTATCCAACGTTACGAAGGAGATGATTTCAAACTT
TACCGTGCTTTACGCAGCATCAACCCGTCCCCCTACTTATTTTACTTCGATTTCGGAGGCTTCCGTATTTTTGGTTCCTC
TCCCGAAACCCATTGTAAAATAGAAAACGGGCGTGCCACCATTGACCCTATCGCCGGAACCACCCGCCGCAACGGAGACA
AGAAAATAGATGCTGAACTCACCGCCAACCTATTGGCTGATCCCAAAGAAAATGCGGAACATGTAATGCTGGTAGATCTG
GCACGCAATGACTTGAGCCGCAACTGTCACGATGTACAAGTAGAATTTTACAAAGAAGCTCAATATTACAGCCACGTCAT
TCATCTGGTAAGCCGGGTCAGCGGCGAACTGAACCCCAAAGCCAATCCCATCAAAGCATTTATTGATACTTTCCCGGCCG
GAACCCTGAGTGGCGCTCCGAAGGTAAAAGCCATGCAGCTGATCAGCGAATACGAACCTCACAGCCGTGGAGCCTATGGA
GGTTGCATCGGATTTATCGGGCTGAACGGCACATTGAACCAAGCTATCACCATTCGTACATTCGTCAGCCGCAACAACGA
ACTATGGTTTCAAGCCGGTGGCGGCATCGTAGCTAAGAGCAATGAAGAGTACGAATTACAAGAAGTAAACAACAAACTGG
GAGCACTTAAAAAAGCAATCATCCTGGCAGAACAAATGTAA

Upstream 100 bases:

>100_bases
CTACTTGAAAGAATCCGGCACAAGGACCTCCTTGCAATAACACATAGAAACCCATGAGAGCAAAAACCCTATACGGACAA
CTATAAACAGAAAAGAAACA

Downstream 100 bases:

>100_bases
AAACGAATCATCATGAAAACAGTAATTATAGACAACTATGACTCATTTACCTACAATTTGAGTCATTTGGTAAAAGAACT
GGGAGCCGAAGTTACCGTAT

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MKTFTYTTRCKTILGDLHTPVSTYLKVRDIFPQSALMESSDYHGSENNRSFIGLNPVASIGINHGTATATYPDGSIEEHP
ISEHFRADHAISDFLNRFKVSGEYNNYCGLYGYTTFNAVRYFEHINVKDSRDPKNDAPDMLYILYKYLIVFNDFRNEMLL
LEMLQDGEDSHLDYVEKAIHNRNYTTYDFRAVGETTSTLTDEEHKANIRKGIAHCMRGDVFQIVLSRRFIQRYEGDDFKL
YRALRSINPSPYLFYFDFGGFRIFGSSPETHCKIENGRATIDPIAGTTRRNGDKKIDAELTANLLADPKENAEHVMLVDL
ARNDLSRNCHDVQVEFYKEAQYYSHVIHLVSRVSGELNPKANPIKAFIDTFPAGTLSGAPKVKAMQLISEYEPHSRGAYG
GCIGFIGLNGTLNQAITIRTFVSRNNELWFQAGGGIVAKSNEEYELQEVNNKLGALKKAIILAEQM

Sequences:

>Translated_466_residues
MKTFTYTTRCKTILGDLHTPVSTYLKVRDIFPQSALMESSDYHGSENNRSFIGLNPVASIGINHGTATATYPDGSIEEHP
ISEHFRADHAISDFLNRFKVSGEYNNYCGLYGYTTFNAVRYFEHINVKDSRDPKNDAPDMLYILYKYLIVFNDFRNEMLL
LEMLQDGEDSHLDYVEKAIHNRNYTTYDFRAVGETTSTLTDEEHKANIRKGIAHCMRGDVFQIVLSRRFIQRYEGDDFKL
YRALRSINPSPYLFYFDFGGFRIFGSSPETHCKIENGRATIDPIAGTTRRNGDKKIDAELTANLLADPKENAEHVMLVDL
ARNDLSRNCHDVQVEFYKEAQYYSHVIHLVSRVSGELNPKANPIKAFIDTFPAGTLSGAPKVKAMQLISEYEPHSRGAYG
GCIGFIGLNGTLNQAITIRTFVSRNNELWFQAGGGIVAKSNEEYELQEVNNKLGALKKAIILAEQM
>Mature_466_residues
MKTFTYTTRCKTILGDLHTPVSTYLKVRDIFPQSALMESSDYHGSENNRSFIGLNPVASIGINHGTATATYPDGSIEEHP
ISEHFRADHAISDFLNRFKVSGEYNNYCGLYGYTTFNAVRYFEHINVKDSRDPKNDAPDMLYILYKYLIVFNDFRNEMLL
LEMLQDGEDSHLDYVEKAIHNRNYTTYDFRAVGETTSTLTDEEHKANIRKGIAHCMRGDVFQIVLSRRFIQRYEGDDFKL
YRALRSINPSPYLFYFDFGGFRIFGSSPETHCKIENGRATIDPIAGTTRRNGDKKIDAELTANLLADPKENAEHVMLVDL
ARNDLSRNCHDVQVEFYKEAQYYSHVIHLVSRVSGELNPKANPIKAFIDTFPAGTLSGAPKVKAMQLISEYEPHSRGAYG
GCIGFIGLNGTLNQAITIRTFVSRNNELWFQAGGGIVAKSNEEYELQEVNNKLGALKKAIILAEQM

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=274, Percent_Identity=39.7810218978102, Blast_Score=178, Evalue=8e-46,
Organism=Escherichia coli, GI1788114, Length=357, Percent_Identity=30.5322128851541, Blast_Score=169, Evalue=5e-43,
Organism=Escherichia coli, GI1786809, Length=284, Percent_Identity=27.112676056338, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI87082077, Length=214, Percent_Identity=29.4392523364486, Blast_Score=86, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6320935, Length=480, Percent_Identity=34.5833333333333, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6324361, Length=267, Percent_Identity=27.7153558052434, Blast_Score=102, Evalue=1e-22,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 52810; Mature: 52810

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00636 DNAJ_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTFTYTTRCKTILGDLHTPVSTYLKVRDIFPQSALMESSDYHGSENNRSFIGLNPVASI
CCCEEEHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHCCCCCCCCCCCCEEEECCCHHHC
GINHGTATATYPDGSIEEHPISEHFRADHAISDFLNRFKVSGEYNNYCGLYGYTTFNAVR
CCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHH
YFEHINVKDSRDPKNDAPDMLYILYKYLIVFNDFRNEMLLLEMLQDGEDSHLDYVEKAIH
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
NRNYTTYDFRAVGETTSTLTDEEHKANIRKGIAHCMRGDVFQIVLSRRFIQRYEGDDFKL
CCCCCEEEEEECCCCHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHH
YRALRSINPSPYLFYFDFGGFRIFGSSPETHCKIENGRATIDPIAGTTRRNGDKKIDAEL
HHHHHHCCCCCEEEEEECCCEEEECCCCCCEEEEECCCEEECCCCCCCCCCCCCEECHHH
TANLLADPKENAEHVMLVDLARNDLSRNCHDVQVEFYKEAQYYSHVIHLVSRVSGELNPK
HHHHHCCCCCCCCEEEEEEEHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCC
ANPIKAFIDTFPAGTLSGAPKVKAMQLISEYEPHSRGAYGGCIGFIGLNGTLNQAITIRT
CCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCEEEEEE
FVSRNNELWFQAGGGIVAKSNEEYELQEVNNKLGALKKAIILAEQM
EECCCCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKTFTYTTRCKTILGDLHTPVSTYLKVRDIFPQSALMESSDYHGSENNRSFIGLNPVASI
CCCEEEHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHCCCCCCCCCCCCEEEECCCHHHC
GINHGTATATYPDGSIEEHPISEHFRADHAISDFLNRFKVSGEYNNYCGLYGYTTFNAVR
CCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHH
YFEHINVKDSRDPKNDAPDMLYILYKYLIVFNDFRNEMLLLEMLQDGEDSHLDYVEKAIH
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
NRNYTTYDFRAVGETTSTLTDEEHKANIRKGIAHCMRGDVFQIVLSRRFIQRYEGDDFKL
CCCCCEEEEEECCCCHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHH
YRALRSINPSPYLFYFDFGGFRIFGSSPETHCKIENGRATIDPIAGTTRRNGDKKIDAEL
HHHHHHCCCCCEEEEEECCCEEEECCCCCCEEEEECCCEEECCCCCCCCCCCCCEECHHH
TANLLADPKENAEHVMLVDLARNDLSRNCHDVQVEFYKEAQYYSHVIHLVSRVSGELNPK
HHHHHCCCCCCCCEEEEEEEHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCC
ANPIKAFIDTFPAGTLSGAPKVKAMQLISEYEPHSRGAYGGCIGFIGLNGTLNQAITIRT
CCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCEEEEEE
FVSRNNELWFQAGGGIVAKSNEEYELQEVNNKLGALKKAIILAEQM
EECCCCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7685830; 10360571 [H]