Click here to switch to the map view.

The map label for this gene is algA [H]

Identifier: 150006428

GI number: 150006428

Start: 4861488

End: 4862552

Strand: Reverse

Name: algA [H]

Synonym: BVU_3947

Alternate gene names: 150006428

Gene position: 4862552-4861488 (Counterclockwise)

Preceding gene: 150006432

Following gene: 150006427

Centisome position: 94.18

GC content: 46.67

Gene sequence:

>1065_bases
ATGAACATCAAGAATAATCACCTCGTTATAATGGCCGGAGGTGTTGGAAGCCGTTTCTGGCCGATGAGTACTCCTGATTA
TCCTAAGCAATTTATTGATGTACTGGGTTGCGGCCGTACATTGATCCAACTTACGGCTGACCGTTTTCAGGGGATCTGTC
CTCCGGAAAATATTTGGGTGGTGACATCAGAGAAGTATGCGGACACTGTAAAGGAGCAGTTGCCCGATATTGCTGATGAT
CATATCCTGCGTGAGCCTTGCCGTCGCAATACGGCTCCTTGTATAGCATACGTCAGTTGGAAAATAAAGGCACGTAATCC
TAAGGCCAATATGGTGGTGACCCCCAGCGACCACATTGTGATGAATATCGCGGAGTTTCAGCGGGTGATTAATTCGGCGA
TGAATTTTACGGCCGATTCGGACGCTATCCTTACCCTGGGCATGAAACCTACCCGTCCTGAGACGGGCTACGGTTACATT
GAAGCTGATCTCAGTGTACCTTCTACCGCCAATAAGGAGGTATTCCGGGTGTATTCTTTTAAAGAGAAACCCGATCTGGA
AACAGCCCGGCGCTATATTCAAAAAAATAATTTCTTCTGGAATGCCGGTATTTTTGTGTGGAATGTAAATACGGTGGTGA
ACGCCCTGCGCGTATATCAGCCTGCCATTTCGAAGGTGTTCGAGCGTTTGCTTCCTTATTATTATACGGACAAGGAGCAG
GAAATGATTGACCGGAATTTCCCTTTGTGCGAGAACATTTCGGTGGATTATGCCATTATGGAGAAGGCGGATGAGATTTT
TGTCCTTCCTGCCAGCTTTGGGTGGAGTGATCTGGGTACTTGGGGATCATTGCACGAGAATTTGCCGAAAGATGCCCATA
ATAATACGCAGATAGGTGAGAATATAAAGTTGTATGAAACCCGTAACTGTGTGATTCACACTACACAGGAAAAGAGGGTG
GTGGTACAGGGACTGGACGGATATATCGTTGCTGAGAAGAATAACACATTGCTGATCTGCCGGTTGAGCGAGGAACAGCG
CATCAAAGAATTTTCGGCGGAGTAA

Upstream 100 bases:

>100_bases
TTAGTCGTATGCAAATATAGGACATATAAATTAAAACGCAATACTTTTTTTAAAAAATAATACTTATCTTTGCGGTCATA
CAACGTAAAAAATGAATCAT

Downstream 100 bases:

>100_bases
ATATTCTTTCTTGTATATATTTTATTTCTGCATACATGGAGTGTATGCTGTCTGTCATCTGCTGTTCTGTTGGGTCATTC
CGCCCTTTGCCATGCCGAAA

Product: mannose-1-phosphate guanylyltransferase

Products: NA

Alternate protein names: Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; Mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; GMP; GMPP; GTP--mannose-1-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MNIKNNHLVIMAGGVGSRFWPMSTPDYPKQFIDVLGCGRTLIQLTADRFQGICPPENIWVVTSEKYADTVKEQLPDIADD
HILREPCRRNTAPCIAYVSWKIKARNPKANMVVTPSDHIVMNIAEFQRVINSAMNFTADSDAILTLGMKPTRPETGYGYI
EADLSVPSTANKEVFRVYSFKEKPDLETARRYIQKNNFFWNAGIFVWNVNTVVNALRVYQPAISKVFERLLPYYYTDKEQ
EMIDRNFPLCENISVDYAIMEKADEIFVLPASFGWSDLGTWGSLHENLPKDAHNNTQIGENIKLYETRNCVIHTTQEKRV
VVQGLDGYIVAEKNNTLLICRLSEEQRIKEFSAE

Sequences:

>Translated_354_residues
MNIKNNHLVIMAGGVGSRFWPMSTPDYPKQFIDVLGCGRTLIQLTADRFQGICPPENIWVVTSEKYADTVKEQLPDIADD
HILREPCRRNTAPCIAYVSWKIKARNPKANMVVTPSDHIVMNIAEFQRVINSAMNFTADSDAILTLGMKPTRPETGYGYI
EADLSVPSTANKEVFRVYSFKEKPDLETARRYIQKNNFFWNAGIFVWNVNTVVNALRVYQPAISKVFERLLPYYYTDKEQ
EMIDRNFPLCENISVDYAIMEKADEIFVLPASFGWSDLGTWGSLHENLPKDAHNNTQIGENIKLYETRNCVIHTTQEKRV
VVQGLDGYIVAEKNNTLLICRLSEEQRIKEFSAE
>Mature_354_residues
MNIKNNHLVIMAGGVGSRFWPMSTPDYPKQFIDVLGCGRTLIQLTADRFQGICPPENIWVVTSEKYADTVKEQLPDIADD
HILREPCRRNTAPCIAYVSWKIKARNPKANMVVTPSDHIVMNIAEFQRVINSAMNFTADSDAILTLGMKPTRPETGYGYI
EADLSVPSTANKEVFRVYSFKEKPDLETARRYIQKNNFFWNAGIFVWNVNTVVNALRVYQPAISKVFERLLPYYYTDKEQ
EMIDRNFPLCENISVDYAIMEKADEIFVLPASFGWSDLGTWGSLHENLPKDAHNNTQIGENIKLYETRNCVIHTTQEKRV
VVQGLDGYIVAEKNNTLLICRLSEEQRIKEFSAE

Specific function: Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=350, Percent_Identity=33.7142857142857, Blast_Score=179, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =5.3.1.8; =2.7.7.13 [H]

Molecular weight: Translated: 40505; Mature: 40505

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIKNNHLVIMAGGVGSRFWPMSTPDYPKQFIDVLGCGRTLIQLTADRFQGICPPENIWV
CCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEE
VTSEKYADTVKEQLPDIADDHILREPCRRNTAPCIAYVSWKIKARNPKANMVVTPSDHIV
EECHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCCEEECCCCCEE
MNIAEFQRVINSAMNFTADSDAILTLGMKPTRPETGYGYIEADLSVPSTANKEVFRVYSF
EEHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEEC
KEKPDLETARRYIQKNNFFWNAGIFVWNVNTVVNALRVYQPAISKVFERLLPYYYTDKEQ
CCCCCHHHHHHHHHHCCEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHH
EMIDRNFPLCENISVDYAIMEKADEIFVLPASFGWSDLGTWGSLHENLPKDAHNNTQIGE
HHHHCCCCCCCCCCCCHHEECCCCEEEEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCC
NIKLYETRNCVIHTTQEKRVVVQGLDGYIVAEKNNTLLICRLSEEQRIKEFSAE
CEEEEEECCEEEEECCCCEEEEECCCCEEEEECCCEEEEEECCCHHHHHHHCCC
>Mature Secondary Structure
MNIKNNHLVIMAGGVGSRFWPMSTPDYPKQFIDVLGCGRTLIQLTADRFQGICPPENIWV
CCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEE
VTSEKYADTVKEQLPDIADDHILREPCRRNTAPCIAYVSWKIKARNPKANMVVTPSDHIV
EECHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCCEEECCCCCEE
MNIAEFQRVINSAMNFTADSDAILTLGMKPTRPETGYGYIEADLSVPSTANKEVFRVYSF
EEHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEEC
KEKPDLETARRYIQKNNFFWNAGIFVWNVNTVVNALRVYQPAISKVFERLLPYYYTDKEQ
CCCCCHHHHHHHHHHCCEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHH
EMIDRNFPLCENISVDYAIMEKADEIFVLPASFGWSDLGTWGSLHENLPKDAHNNTQIGE
HHHHCCCCCCCCCCCCHHEECCCCEEEEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCC
NIKLYETRNCVIHTTQEKRVVVQGLDGYIVAEKNNTLLICRLSEEQRIKEFSAE
CEEEEEECCEEEEECCCCEEEEECCCCEEEEECCCEEEEEECCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]