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The map label for this gene is xasA [C]

Identifier: 150006382

GI number: 150006382

Start: 4809599

End: 4811176

Strand: Direct

Name: xasA [C]

Synonym: BVU_3901

Alternate gene names: 150006382

Gene position: 4809599-4811176 (Clockwise)

Preceding gene: 150006378

Following gene: 150006383

Centisome position: 93.15

GC content: 53.55

Gene sequence:

>1578_bases
ATGGCAAACATTAGTAAATCAGTCAAGCTAGGGGTATTTACCCTCGCTATTATGAACGTGACTGCGGTAGTATCCCTGCG
CGGGCTGCCTGCTGAAGCCGAATACGGACTGAGTTCGGCATTTTATTATTTATTCGCGGCCATCGTCTTCCTGATACCTA
CCTCGTTGGTAGCGGCGGAACTGGCGGCCATGTTCCAGGACAAGCAAGGCGGTGTGTTCCGATGGGTGGGTGAAGCCTAC
GGAAAGAAATTCGGCTTCCTCGCCATCTTCCTGCAATGGGTGGAAAGCACCATCTGGTATCCCACCGTCCTGACTTTCGG
AGCCGTGGCACTGGCATTTATCGGCATGAGTGACACCCATGATATGGCCTTGGCATCCAACCGCTATTACTCACTGGCGG
TGGTCTTGATTATCTACTGGCTGGCCACCTTCATTTCGCTGAAAGGCATGGGCTGGGTAGGCAAAGTGGCCAAAGTAGGC
GGTATGGTAGGTACGATCATTCCTGCCGGCCTGCTGATGGTGCTGGCGGTGATTTACCTTGCTTCCGGCGGACAGAGCCA
GATGAACTTTGACGGCAACTTCTTCCCCGATTTCAGCAACTTCGACAACCTGGTACTGGCTTCCAGCATCTTCCTGTTCT
ATGCCGGTATGGAAATGGGCGGTATCCATGTAAAAGACATGGAAAATCCTGCCAAGAACTATCCGAAAGCCGTATTCATC
GGTGCGGCTATCACCGTGATCATCTTCGTGCTAGGCACCTTCGCACTGGGGATCATCATTCCCGAAAAGGACATCAACCT
GACTCAGAGTCTGCTGGTAGGCTTTGATAATTACTTCAAGTATGTCCATGCTTCGTGGTTGTCGCCTATCATCGCCGTGG
CTTTGGCATTCGGTGTGCTGGCAGGCGTGTTGACCTGGGTGGCAGGTCCGTCCAAAGGTATCTTCGCAGTGGGCAAAGCA
GGTTATCTGCCTCCCTTCTTCCAGAAGACCAACGCCAACGGCGTACAGAAAAACATTCTGCTGATCCAAGGCCTTGCCGT
AACCTTGCTCAGCCTGCTGTTCGTTGTGATGCCTTCCGTACAGAGTTTCTACCAAATCCTGTCACAGCTCACCGTATTGC
TTTACCTCATCATGTATCTGCTGATGTTCAGCGGCGCCATCTATCTGCGTTACAATATGAAAAAGGCCCCGCGCCCGTTC
CGCATCGGCAGCAAAGGCAACGGACTGATGTGGCTCATCGGCGGTCTGGGTTTCTGCGGTTCGCTGCTGGCATTCGTGCT
CAGCTTCATTCCGCCCAGCCAGATTGCGGTAGGCAGCAACACCGTATGGTTTGCCGTTTTGATTATCGGCTGCGTCGTGG
TAGTCGCAGCTCCGTTCATTATCTATGCATCGCGCAAACCGTCATGGGTAGACAAGGATACACAGTTCGAACCGTTCCAC
TGGGAAGAACAGGCCACAACGGCACAGACAGCGGCTCCGGTTTCCGGCGCGGCTAAAAGTTCCGCTTCAAGCGCCTCTAC
AAACGCTGCCGCCGGACCGGCCTCTCAAAGTACCCCGTCTCCGGAGCAACACAAATAA

Upstream 100 bases:

>100_bases
ACCTTCCGGGTTAATAAACCTAAACGGATAAACATCATTTCCAGGGAGTTGTTATAAACTCCGTAAACAAAAAACATACA
TTTTTTAAAACCTAAACTTT

Downstream 100 bases:

>100_bases
CCCCCGCTGACGGGTTGGCCCATTCCTTTTTATCACAGGCAATTCCGGTTCCTTGAAAAGCAAGAAGCATGTTTTTCAAG
AAGCCGGAATTGCTGTTTTC

Product: glutamate/gamma-aminobutyrate anti-porter

Products: L-glutamate [Cytoplasm]; 4-aminobutyrate [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MANISKSVKLGVFTLAIMNVTAVVSLRGLPAEAEYGLSSAFYYLFAAIVFLIPTSLVAAELAAMFQDKQGGVFRWVGEAY
GKKFGFLAIFLQWVESTIWYPTVLTFGAVALAFIGMSDTHDMALASNRYYSLAVVLIIYWLATFISLKGMGWVGKVAKVG
GMVGTIIPAGLLMVLAVIYLASGGQSQMNFDGNFFPDFSNFDNLVLASSIFLFYAGMEMGGIHVKDMENPAKNYPKAVFI
GAAITVIIFVLGTFALGIIIPEKDINLTQSLLVGFDNYFKYVHASWLSPIIAVALAFGVLAGVLTWVAGPSKGIFAVGKA
GYLPPFFQKTNANGVQKNILLIQGLAVTLLSLLFVVMPSVQSFYQILSQLTVLLYLIMYLLMFSGAIYLRYNMKKAPRPF
RIGSKGNGLMWLIGGLGFCGSLLAFVLSFIPPSQIAVGSNTVWFAVLIIGCVVVVAAPFIIYASRKPSWVDKDTQFEPFH
WEEQATTAQTAAPVSGAAKSSASSASTNAAAGPASQSTPSPEQHK

Sequences:

>Translated_525_residues
MANISKSVKLGVFTLAIMNVTAVVSLRGLPAEAEYGLSSAFYYLFAAIVFLIPTSLVAAELAAMFQDKQGGVFRWVGEAY
GKKFGFLAIFLQWVESTIWYPTVLTFGAVALAFIGMSDTHDMALASNRYYSLAVVLIIYWLATFISLKGMGWVGKVAKVG
GMVGTIIPAGLLMVLAVIYLASGGQSQMNFDGNFFPDFSNFDNLVLASSIFLFYAGMEMGGIHVKDMENPAKNYPKAVFI
GAAITVIIFVLGTFALGIIIPEKDINLTQSLLVGFDNYFKYVHASWLSPIIAVALAFGVLAGVLTWVAGPSKGIFAVGKA
GYLPPFFQKTNANGVQKNILLIQGLAVTLLSLLFVVMPSVQSFYQILSQLTVLLYLIMYLLMFSGAIYLRYNMKKAPRPF
RIGSKGNGLMWLIGGLGFCGSLLAFVLSFIPPSQIAVGSNTVWFAVLIIGCVVVVAAPFIIYASRKPSWVDKDTQFEPFH
WEEQATTAQTAAPVSGAAKSSASSASTNAAAGPASQSTPSPEQHK
>Mature_524_residues
ANISKSVKLGVFTLAIMNVTAVVSLRGLPAEAEYGLSSAFYYLFAAIVFLIPTSLVAAELAAMFQDKQGGVFRWVGEAYG
KKFGFLAIFLQWVESTIWYPTVLTFGAVALAFIGMSDTHDMALASNRYYSLAVVLIIYWLATFISLKGMGWVGKVAKVGG
MVGTIIPAGLLMVLAVIYLASGGQSQMNFDGNFFPDFSNFDNLVLASSIFLFYAGMEMGGIHVKDMENPAKNYPKAVFIG
AAITVIIFVLGTFALGIIIPEKDINLTQSLLVGFDNYFKYVHASWLSPIIAVALAFGVLAGVLTWVAGPSKGIFAVGKAG
YLPPFFQKTNANGVQKNILLIQGLAVTLLSLLFVVMPSVQSFYQILSQLTVLLYLIMYLLMFSGAIYLRYNMKKAPRPFR
IGSKGNGLMWLIGGLGFCGSLLAFVLSFIPPSQIAVGSNTVWFAVLIIGCVVVVAAPFIIYASRKPSWVDKDTQFEPFHW
EEQATTAQTAAPVSGAAKSSASSASTNAAAGPASQSTPSPEQHK

Specific function: Probable Amino Acid Transporter. Involved In Extreme Acid Resistance. [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI1787768, Length=485, Percent_Identity=30.7216494845361, Blast_Score=206, Evalue=4e-54,
Organism=Escherichia coli, GI87082380, Length=261, Percent_Identity=27.9693486590038, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI48994921, Length=432, Percent_Identity=21.2962962962963, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI87081798, Length=387, Percent_Identity=23.2558139534884, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI221331183, Length=360, Percent_Identity=23.0555555555556, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17647653, Length=360, Percent_Identity=23.0555555555556, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24664379, Length=360, Percent_Identity=23.0555555555556, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45550968, Length=363, Percent_Identity=24.2424242424242, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI19921172, Length=363, Percent_Identity=24.2424242424242, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 56474; Mature: 56343

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCHHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ANISKSVKLGVFTLAIMNVTAVVSLRGLPAEAEYGLSSAFYYLFAAIVFLIPTSLVAAE
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHH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CCHHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-aminobutyrate [Cytoplasm]; L-glutamate [Periplasm] [C]

Specific reaction: 4-aminobutyrate [Cytoplasm] + L-glutamate [Periplasm] = L-glutamate [Cytoplasm] + 4-aminobutyrate [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8366052 [H]