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The map label for this gene is tdcB [H]

Identifier: 150006373

GI number: 150006373

Start: 4796730

End: 4797926

Strand: Reverse

Name: tdcB [H]

Synonym: BVU_3892

Alternate gene names: 150006373

Gene position: 4797926-4796730 (Counterclockwise)

Preceding gene: 150006374

Following gene: 150006372

Centisome position: 92.93

GC content: 47.28

Gene sequence:

>1197_bases
ATGCTACAATTAGATGCAATATACAAAGCGGCTCATGTCCTGAAAGAGGTTGTCCGTCGCACTGATTTGATTTATGCTCC
TCAGATAAATCCTGAGAGTACAGTTTATCTGAAGCCCGAAAACCTGCAACTCACAGGATCGTTTAAAGTGCGTGGTGCTT
ATTACAAGATTTCCCAATTGTCCGATGAAGAAAAGGCGAGAGGCGTGATAGCCTGTTCTGCCGGTAATCATGCGCAAGGG
GTGGCATTGGCTGCCACTAAGTGCGGTATCAAGTCGTTGATTTGTCTTCCGGAAGGAGCGCCTATATCTAAAGTTGAGGC
TACGAAGCATTATGGGGCGGAAGTTTGTTTGGTTCCGGGAGTCTATGATGATGCTTATCAGAAAGCCCTGCAATTGCGTG
ATGAAAAGGGATATACTTTTGTTCATCCCTTTGATGACGAGAACGTGATAGCCGGACAAGGTACTATCGGTTTGGAATTA
TTGGAGGAAATGCCGGATGTGGAGGTAGTCATTGTTCCCATTGGTGGGGGAGGACTGATTTCGGGAGTGGCTTATGCGTT
GAAGGCTTTGAAACCATCTGTCAAGGTATATGGCGTACAGGCGTTGGGTGCGGCCAGTATGGCAAATTCTATTCTTCATT
CGCGTATTGAGCGTCTTCACTCTGTTTCCACTTTTGCCGATGGAATCGCGGTGAAAGAGCCGGGAACAAATACTTTTGAC
TTGGTAAATCAGTATGTGGACGGAGTTGTAACTGTGACTGAGGACGAGATTGCCGCAGCTATTCTGGCATTGATAGAACG
CCAGCGGATTGTTGCAGAGGGGGCGGGAGCTGTGTCCGTTGCCGCAGCCATGTTCAATAAAGTACCGGTAAAGGGTAAGA
AAACTGTCTGCCTGGTGTCCGGAGGCAATATTGATGTGACGATATTGAGCCGTGTCATCAGTCGCGGTATGGCGAAGTCG
GGACGTACCTATGCAGTAACTTTGGACTTGATAGACAAGCCGGGGCAGCTGTTGGGAGTCAGCAAAATTGTTGCAGAGCA
GGGAGGAAATGTAATTTCTGTACATCATGAGCGAAATAGTGAGAGTGCAGATGTCACCGGATGTGCCCTTCGTGTCGTTA
TGGAAACCAGAAACGAGGAACATATAGCATCCATTCGTCAAAAACTGTTGGATGCAGGCTATGTGATAATGAAATAA

Upstream 100 bases:

>100_bases
AACAAAGAGAAAAGAATACAATTTTACGTTGTATGTGAGTGTAAGGAATCAATTTTATTTGTAGCTTTGCACCCAATTTA
AAAACAAGAGTGTTATACCT

Downstream 100 bases:

>100_bases
ATTATATACCTTACAAGTAGAAAGGAGGAAAATTAAATATTTCTTCCTTTTCTTGCTTCTAATTTTAATTTCTCCACACA
AAAAATCGATTTTTATAGTG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MLQLDAIYKAAHVLKEVVRRTDLIYAPQINPESTVYLKPENLQLTGSFKVRGAYYKISQLSDEEKARGVIACSAGNHAQG
VALAATKCGIKSLICLPEGAPISKVEATKHYGAEVCLVPGVYDDAYQKALQLRDEKGYTFVHPFDDENVIAGQGTIGLEL
LEEMPDVEVVIVPIGGGGLISGVAYALKALKPSVKVYGVQALGAASMANSILHSRIERLHSVSTFADGIAVKEPGTNTFD
LVNQYVDGVVTVTEDEIAAAILALIERQRIVAEGAGAVSVAAAMFNKVPVKGKKTVCLVSGGNIDVTILSRVISRGMAKS
GRTYAVTLDLIDKPGQLLGVSKIVAEQGGNVISVHHERNSESADVTGCALRVVMETRNEEHIASIRQKLLDAGYVIMK

Sequences:

>Translated_398_residues
MLQLDAIYKAAHVLKEVVRRTDLIYAPQINPESTVYLKPENLQLTGSFKVRGAYYKISQLSDEEKARGVIACSAGNHAQG
VALAATKCGIKSLICLPEGAPISKVEATKHYGAEVCLVPGVYDDAYQKALQLRDEKGYTFVHPFDDENVIAGQGTIGLEL
LEEMPDVEVVIVPIGGGGLISGVAYALKALKPSVKVYGVQALGAASMANSILHSRIERLHSVSTFADGIAVKEPGTNTFD
LVNQYVDGVVTVTEDEIAAAILALIERQRIVAEGAGAVSVAAAMFNKVPVKGKKTVCLVSGGNIDVTILSRVISRGMAKS
GRTYAVTLDLIDKPGQLLGVSKIVAEQGGNVISVHHERNSESADVTGCALRVVMETRNEEHIASIRQKLLDAGYVIMK
>Mature_398_residues
MLQLDAIYKAAHVLKEVVRRTDLIYAPQINPESTVYLKPENLQLTGSFKVRGAYYKISQLSDEEKARGVIACSAGNHAQG
VALAATKCGIKSLICLPEGAPISKVEATKHYGAEVCLVPGVYDDAYQKALQLRDEKGYTFVHPFDDENVIAGQGTIGLEL
LEEMPDVEVVIVPIGGGGLISGVAYALKALKPSVKVYGVQALGAASMANSILHSRIERLHSVSTFADGIAVKEPGTNTFD
LVNQYVDGVVTVTEDEIAAAILALIERQRIVAEGAGAVSVAAAMFNKVPVKGKKTVCLVSGGNIDVTILSRVISRGMAKS
GRTYAVTLDLIDKPGQLLGVSKIVAEQGGNVISVHHERNSESADVTGCALRVVMETRNEEHIASIRQKLLDAGYVIMK

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=280, Percent_Identity=37.8571428571429, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI33469958, Length=256, Percent_Identity=25.390625, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI19923959, Length=280, Percent_Identity=26.7857142857143, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1789505, Length=280, Percent_Identity=47.8571428571429, Blast_Score=231, Evalue=5e-62,
Organism=Escherichia coli, GI1790207, Length=372, Percent_Identity=36.8279569892473, Blast_Score=201, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI71991565, Length=391, Percent_Identity=39.1304347826087, Blast_Score=244, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI17537387, Length=392, Percent_Identity=36.2244897959184, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17508781, Length=275, Percent_Identity=32, Blast_Score=142, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6322631, Length=310, Percent_Identity=37.0967741935484, Blast_Score=189, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6320930, Length=374, Percent_Identity=35.0267379679144, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6319788, Length=261, Percent_Identity=22.6053639846743, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21355833, Length=361, Percent_Identity=37.6731301939058, Blast_Score=198, Evalue=5e-51,
Organism=Drosophila melanogaster, GI24645328, Length=300, Percent_Identity=36, Blast_Score=147, Evalue=9e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 42408; Mature: 42408

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQLDAIYKAAHVLKEVVRRTDLIYAPQINPESTVYLKPENLQLTGSFKVRGAYYKISQL
CCCHHHHHHHHHHHHHHHHHHCEEECCCCCCCCEEEECCCCEEEEEEEEEEEEEEEECCC
SDEEKARGVIACSAGNHAQGVALAATKCGIKSLICLPEGAPISKVEATKHYGAEVCLVPG
CCHHHCCEEEEECCCCCCCCEEEEEHHCCCEEEEECCCCCCCCHHHHHHHCCCCEEEECC
VYDDAYQKALQLRDEKGYTFVHPFDDENVIAGQGTIGLELLEEMPDVEVVIVPIGGGGLI
CCHHHHHHHHHHHCCCCEEEEECCCCCCEEECCCCHHHHHHHHCCCCEEEEEEECCCHHH
SGVAYALKALKPSVKVYGVQALGAASMANSILHSRIERLHSVSTFADGIAVKEPGTNTFD
HHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHH
LVNQYVDGVVTVTEDEIAAAILALIERQRIVAEGAGAVSVAAAMFNKVPVKGKKTVCLVS
HHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEEE
GGNIDVTILSRVISRGMAKSGRTYAVTLDLIDKPGQLLGVSKIVAEQGGNVISVHHERNS
CCCEEHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCC
ESADVTGCALRVVMETRNEEHIASIRQKLLDAGYVIMK
CCCCHHHHHHEEEHHCCCHHHHHHHHHHHHHCCCEEEC
>Mature Secondary Structure
MLQLDAIYKAAHVLKEVVRRTDLIYAPQINPESTVYLKPENLQLTGSFKVRGAYYKISQL
CCCHHHHHHHHHHHHHHHHHHCEEECCCCCCCCEEEECCCCEEEEEEEEEEEEEEEECCC
SDEEKARGVIACSAGNHAQGVALAATKCGIKSLICLPEGAPISKVEATKHYGAEVCLVPG
CCHHHCCEEEEECCCCCCCCEEEEEHHCCCEEEEECCCCCCCCHHHHHHHCCCCEEEECC
VYDDAYQKALQLRDEKGYTFVHPFDDENVIAGQGTIGLELLEEMPDVEVVIVPIGGGGLI
CCHHHHHHHHHHHCCCCEEEEECCCCCCEEECCCCHHHHHHHHCCCCEEEEEEECCCHHH
SGVAYALKALKPSVKVYGVQALGAASMANSILHSRIERLHSVSTFADGIAVKEPGTNTFD
HHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHH
LVNQYVDGVVTVTEDEIAAAILALIERQRIVAEGAGAVSVAAAMFNKVPVKGKKTVCLVS
HHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEEE
GGNIDVTILSRVISRGMAKSGRTYAVTLDLIDKPGQLLGVSKIVAEQGGNVISVHHERNS
CCCEEHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCC
ESADVTGCALRVVMETRNEEHIASIRQKLLDAGYVIMK
CCCCHHHHHHEEEHHCCCHHHHHHHHHHHHHCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA