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The map label for this gene is hisI [H]

Identifier: 150006335

GI number: 150006335

Start: 4754615

End: 4755226

Strand: Direct

Name: hisI [H]

Synonym: BVU_3854

Alternate gene names: 150006335

Gene position: 4754615-4755226 (Clockwise)

Preceding gene: 150006334

Following gene: 150006336

Centisome position: 92.09

GC content: 44.93

Gene sequence:

>612_bases
ATGGATTTGAATTTCGAAAAAATGAACGGGTTGATCCCCGCCATCATACAAGACAACAGCACCAGCAAAGTACTGATGTT
AGGGTTTATGAATGAAGAAGCATACCGAAAGACAGTGGAAACCGGTAAAGTAACCTTCTTCAGCCGTACCAAGAACCGTC
TGTGGACAAAAGGTGAAGAAAGCGGGAATTTCCTGAATGTTGTTTCTATAAAAGAAGACTGTGACAAGGATACCCTGCTG
ATCAAAGTAAATCCGGCAGGTCCTGTATGTCACACCGGAACAGATACTTGCTGGGGAGAAGAAAACAAAGAAGACATCAT
GTTCCTGAAGGAATTACAAGATTTCATTGACAAACGTCACGAGGAAATGCCCGCAGGCTCTTACACCACCAGCCTGTTCG
AATCCGGTATCAACAAAATGGCACAGAAAGTAGGCGAGGAAGCCGTGGAAACGGTTATCGAAGCTTGTAACGGAACCGAC
GAACGCCTCATCTACGAAGGAGCCGATCTGATATACCACATGATTGTACTGCTCACCTCAAAAGGCTATCGCATCGAAGA
CCTTGCCCGTGAATTGAAAGAACGTCATAGCGCTACGTGGAAAAAACATTAA

Upstream 100 bases:

>100_bases
AACGACCTTCAGATCCTCATTCCACTCTGAATGACGATGCTGATGAAATTTTAAACAAGTTCTATACAACACCGATAATA
TAACAATAAAATATAGAAAA

Downstream 100 bases:

>100_bases
AAATGATGGACGAAGCTCTCATTCGATATAAAAACGTATATATCAACCAACAAGAGTTAGGCGTATTGGAAGATGTAAAC
CTGGAACTGAACAAGGGTGA

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MDLNFEKMNGLIPAIIQDNSTSKVLMLGFMNEEAYRKTVETGKVTFFSRTKNRLWTKGEESGNFLNVVSIKEDCDKDTLL
IKVNPAGPVCHTGTDTCWGEENKEDIMFLKELQDFIDKRHEEMPAGSYTTSLFESGINKMAQKVGEEAVETVIEACNGTD
ERLIYEGADLIYHMIVLLTSKGYRIEDLARELKERHSATWKKH

Sequences:

>Translated_203_residues
MDLNFEKMNGLIPAIIQDNSTSKVLMLGFMNEEAYRKTVETGKVTFFSRTKNRLWTKGEESGNFLNVVSIKEDCDKDTLL
IKVNPAGPVCHTGTDTCWGEENKEDIMFLKELQDFIDKRHEEMPAGSYTTSLFESGINKMAQKVGEEAVETVIEACNGTD
ERLIYEGADLIYHMIVLLTSKGYRIEDLARELKERHSATWKKH
>Mature_203_residues
MDLNFEKMNGLIPAIIQDNSTSKVLMLGFMNEEAYRKTVETGKVTFFSRTKNRLWTKGEESGNFLNVVSIKEDCDKDTLL
IKVNPAGPVCHTGTDTCWGEENKEDIMFLKELQDFIDKRHEEMPAGSYTTSLFESGINKMAQKVGEEAVETVIEACNGTD
ERLIYEGADLIYHMIVLLTSKGYRIEDLARELKERHSATWKKH

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=195, Percent_Identity=50.7692307692308, Blast_Score=207, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6319819, Length=194, Percent_Identity=30.4123711340206, Blast_Score=79, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 23137; Mature: 23137

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLNFEKMNGLIPAIIQDNSTSKVLMLGFMNEEAYRKTVETGKVTFFSRTKNRLWTKGEE
CCCCHHHHCCCCCEEEECCCCCEEEEEEECCHHHHHHHHHCCCEEEEECCCHHCCCCCCC
SGNFLNVVSIKEDCDKDTLLIKVNPAGPVCHTGTDTCWGEENKEDIMFLKELQDFIDKRH
CCCEEEEEEECCCCCCCEEEEEECCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
EEMPAGSYTTSLFESGINKMAQKVGEEAVETVIEACNGTDERLIYEGADLIYHMIVLLTS
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHC
KGYRIEDLARELKERHSATWKKH
CCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDLNFEKMNGLIPAIIQDNSTSKVLMLGFMNEEAYRKTVETGKVTFFSRTKNRLWTKGEE
CCCCHHHHCCCCCEEEECCCCCEEEEEEECCHHHHHHHHHCCCEEEEECCCHHCCCCCCC
SGNFLNVVSIKEDCDKDTLLIKVNPAGPVCHTGTDTCWGEENKEDIMFLKELQDFIDKRH
CCCEEEEEEECCCCCCCEEEEEECCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
EEMPAGSYTTSLFESGINKMAQKVGEEAVETVIEACNGTDERLIYEGADLIYHMIVLLTS
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHC
KGYRIEDLARELKERHSATWKKH
CCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]