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The map label for this gene is ygcA [C]

Identifier: 150005861

GI number: 150005861

Start: 4196430

End: 4197851

Strand: Reverse

Name: ygcA [C]

Synonym: BVU_3357

Alternate gene names: 150005861

Gene position: 4197851-4196430 (Counterclockwise)

Preceding gene: 150005865

Following gene: 150005860

Centisome position: 81.3

GC content: 42.26

Gene sequence:

>1422_bases
GTGGCTAGAAAGAAGAAAGAACTTCCATTATTAGAGAAGATAACCATAATAGATGTAGCTGCCGAAGGAAAAGCTTTGGC
GAAAGTGAATGACCTGGTAGTATTTGTGCCTTATGTAGTGCCCGGTGATGTGGTGGATTTACAAGTGAAGCGTAAGAAAA
ATCATTATGCAGAAGCTGTGGCTGTGAAATTCCATGAGTATTCTCCTGTGCGTGCAGTACCCTTCTGCCAGCATTATGGT
ATATGTGGTGGTTGTAAGTGGCAGTGTCTGCCATATACAGAACAAATAAAGTATAAGCAAAAGCAGGTGACGGATAATCT
GACCCGTATCGGCAAGATCGAATTGCCGGAAATTTCACCTATCATGGGGTCGGAAAAAACGGAGTTTTACCGTAATAAGT
TGGAATTTACGTTTTCTAACAAACGTTGGCTGACAGAGGAAGAGGTAAAGGAAGATGTGAAGTACGATCAGATGAACGCC
GTAGGTTTCCACATTCCCGGTGCATTTGACAAGGTACTGGCTATAGAAAAGTGCTGGTTACAGGATGATATCAGCAACCA
GATACGCAATGCGATTCGTGACTATGCATACGAACACAATTATTCTTTCTTTAATCTGCGTTCTCAAGAAGGAATGCTTC
GCAACTTGATGATCCGTACTTCGAGTACGGGTGAGCTTATGGTGTTGCTGCAATGCAAGATTGTGGAAGAGAGCGAAATG
GATCTGATGAAGCAACTGCTGGCTTTCGTGGCAGAACATTTTCCGCAGATTACTTCCTTATTATATGTAGTCAATAACAA
ATGCAATGATACCATTAACGATCTGGAGGTAATGGTGTTCAAAGGCAACGATCATATTTTCGAGGAAATGGAGGGGTTGC
GCTTCAAGATAGGAGCAAAATCATTTTATCAGACTAATTCCGGACAGGCGTATAATCTTTATAAGGTGGCCCGTAATTTT
GCCGGATTGACCGGTAAAGAATTGGTGTATGATCTTTATACAGGGACTGGAACCATAGCCAACTTTGTTTCACGCCAGGC
AAAGAAAGTGATTGGTATCGAATATGTGCCTGAAGCAATAGAAGATGCTAAAGTGAATTCGGCAATTAATGGCATTGACA
ATACCTTATTTTATGCCGGTGACATGAAGGATATCCTCACTCAGGAGTTTATCAACCAACATGGTCGTCCTGATGTTATA
ATCACTGATCCTCCGCGTGCCGGAATGCACAATGATGTGATTAATACAATTCTTTTTGCTGAACCTCAGCGGATTGTGTA
TGTTAGCTGTAATCCTGCCACCCAGGCACGTGATTTGTCTTTGTTAGATGCCAAATACAAGGTGATGGCCGTGCAACCCG
TAGATATGTTCCCTCATACGCATCATGTGGAAAATGTGGTGTTGCTGGAAAAAAGAGGATAA

Upstream 100 bases:

>100_bases
AATTGCAATTTCTACTTTGCAATTTTAATATCTTACGATTTATGAGGCAATATTCAGGGAAAATGCTTAAATTTGTCCCC
AAATTAACTTATTCAGAAAA

Downstream 100 bases:

>100_bases
TCCGGATAGTTCAATTATAAATTGTTTAAACAGTAAATAGAATTATGTCAAGAGGTAAGAATAGTGATTCCGGCAGGCCA
AAGGCGAGAAGTGTTGCCCG

Product: RNA methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MARKKKELPLLEKITIIDVAAEGKALAKVNDLVVFVPYVVPGDVVDLQVKRKKNHYAEAVAVKFHEYSPVRAVPFCQHYG
ICGGCKWQCLPYTEQIKYKQKQVTDNLTRIGKIELPEISPIMGSEKTEFYRNKLEFTFSNKRWLTEEEVKEDVKYDQMNA
VGFHIPGAFDKVLAIEKCWLQDDISNQIRNAIRDYAYEHNYSFFNLRSQEGMLRNLMIRTSSTGELMVLLQCKIVEESEM
DLMKQLLAFVAEHFPQITSLLYVVNNKCNDTINDLEVMVFKGNDHIFEEMEGLRFKIGAKSFYQTNSGQAYNLYKVARNF
AGLTGKELVYDLYTGTGTIANFVSRQAKKVIGIEYVPEAIEDAKVNSAINGIDNTLFYAGDMKDILTQEFINQHGRPDVI
ITDPPRAGMHNDVINTILFAEPQRIVYVSCNPATQARDLSLLDAKYKVMAVQPVDMFPHTHHVENVVLLEKRG

Sequences:

>Translated_473_residues
MARKKKELPLLEKITIIDVAAEGKALAKVNDLVVFVPYVVPGDVVDLQVKRKKNHYAEAVAVKFHEYSPVRAVPFCQHYG
ICGGCKWQCLPYTEQIKYKQKQVTDNLTRIGKIELPEISPIMGSEKTEFYRNKLEFTFSNKRWLTEEEVKEDVKYDQMNA
VGFHIPGAFDKVLAIEKCWLQDDISNQIRNAIRDYAYEHNYSFFNLRSQEGMLRNLMIRTSSTGELMVLLQCKIVEESEM
DLMKQLLAFVAEHFPQITSLLYVVNNKCNDTINDLEVMVFKGNDHIFEEMEGLRFKIGAKSFYQTNSGQAYNLYKVARNF
AGLTGKELVYDLYTGTGTIANFVSRQAKKVIGIEYVPEAIEDAKVNSAINGIDNTLFYAGDMKDILTQEFINQHGRPDVI
ITDPPRAGMHNDVINTILFAEPQRIVYVSCNPATQARDLSLLDAKYKVMAVQPVDMFPHTHHVENVVLLEKRG
>Mature_472_residues
ARKKKELPLLEKITIIDVAAEGKALAKVNDLVVFVPYVVPGDVVDLQVKRKKNHYAEAVAVKFHEYSPVRAVPFCQHYGI
CGGCKWQCLPYTEQIKYKQKQVTDNLTRIGKIELPEISPIMGSEKTEFYRNKLEFTFSNKRWLTEEEVKEDVKYDQMNAV
GFHIPGAFDKVLAIEKCWLQDDISNQIRNAIRDYAYEHNYSFFNLRSQEGMLRNLMIRTSSTGELMVLLQCKIVEESEMD
LMKQLLAFVAEHFPQITSLLYVVNNKCNDTINDLEVMVFKGNDHIFEEMEGLRFKIGAKSFYQTNSGQAYNLYKVARNFA
GLTGKELVYDLYTGTGTIANFVSRQAKKVIGIEYVPEAIEDAKVNSAINGIDNTLFYAGDMKDILTQEFINQHGRPDVII
TDPPRAGMHNDVINTILFAEPQRIVYVSCNPATQARDLSLLDAKYKVMAVQPVDMFPHTHHVENVVLLEKRG

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI34222389, Length=424, Percent_Identity=30.4245283018868, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI51173878, Length=424, Percent_Identity=30.4245283018868, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI269784680, Length=288, Percent_Identity=28.8194444444444, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI269784676, Length=288, Percent_Identity=28.8194444444444, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI20149688, Length=288, Percent_Identity=28.8194444444444, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI269784678, Length=288, Percent_Identity=28.8194444444444, Blast_Score=122, Evalue=6e-28,
Organism=Escherichia coli, GI1789148, Length=465, Percent_Identity=26.0215053763441, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1787083, Length=403, Percent_Identity=24.5657568238213, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1790403, Length=205, Percent_Identity=27.8048780487805, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71997438, Length=168, Percent_Identity=35.1190476190476, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6322909, Length=424, Percent_Identity=21.6981132075472, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24666579, Length=441, Percent_Identity=31.2925170068027, Blast_Score=170, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280 [H]

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr [H]

EC number: NA

Molecular weight: Translated: 54008; Mature: 53877

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS50926 TRAM ; PS01230 TRMA_1 ; PS01231 TRMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKKKELPLLEKITIIDVAAEGKALAKVNDLVVFVPYVVPGDVVDLQVKRKKNHYAEAV
CCCCCCCCCHHHEEEEEEEECCCCHHEEECCEEEEEEEECCCCEEEEEEHHCCCHHHHEE
AVKFHEYSPVRAVPFCQHYGICGGCKWQCLPYTEQIKYKQKQVTDNLTRIGKIELPEISP
EEEEECCCCCCCCCHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCEECCCCCC
IMGSEKTEFYRNKLEFTFSNKRWLTEEEVKEDVKYDQMNAVGFHIPGAFDKVLAIEKCWL
CCCCCHHHHHHCCEEEEECCCCCCCHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHH
QDDISNQIRNAIRDYAYEHNYSFFNLRSQEGMLRNLMIRTSSTGELMVLLQCKIVEESEM
HHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHEEEECCCCCEEEEEEEEECCHHHH
DLMKQLLAFVAEHFPQITSLLYVVNNKCNDTINDLEVMVFKGNDHIFEEMEGLRFKIGAK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHCCCEEEECCH
SFYQTNSGQAYNLYKVARNFAGLTGKELVYDLYTGTGTIANFVSRQAKKVIGIEYVPEAI
HHEECCCCCEEHHHHHHHHHCCCCHHHHEEEEECCCHHHHHHHHHHHHHHHCHHHHHHHH
EDAKVNSAINGIDNTLFYAGDMKDILTQEFINQHGRPDVIITDPPRAGMHNDVINTILFA
HHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHEE
EPQRIVYVSCNPATQARDLSLLDAKYKVMAVQPVDMFPHTHHVENVVLLEKRG
CCCEEEEEECCCCCCCCCCCEECCCEEEEEEECHHHCCCCCCCCEEEEEEECC
>Mature Secondary Structure 
ARKKKELPLLEKITIIDVAAEGKALAKVNDLVVFVPYVVPGDVVDLQVKRKKNHYAEAV
CCCCCCCCHHHEEEEEEEECCCCHHEEECCEEEEEEEECCCCEEEEEEHHCCCHHHHEE
AVKFHEYSPVRAVPFCQHYGICGGCKWQCLPYTEQIKYKQKQVTDNLTRIGKIELPEISP
EEEEECCCCCCCCCHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCEECCCCCC
IMGSEKTEFYRNKLEFTFSNKRWLTEEEVKEDVKYDQMNAVGFHIPGAFDKVLAIEKCWL
CCCCCHHHHHHCCEEEEECCCCCCCHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHH
QDDISNQIRNAIRDYAYEHNYSFFNLRSQEGMLRNLMIRTSSTGELMVLLQCKIVEESEM
HHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHEEEECCCCCEEEEEEEEECCHHHH
DLMKQLLAFVAEHFPQITSLLYVVNNKCNDTINDLEVMVFKGNDHIFEEMEGLRFKIGAK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHCCCEEEECCH
SFYQTNSGQAYNLYKVARNFAGLTGKELVYDLYTGTGTIANFVSRQAKKVIGIEYVPEAI
HHEECCCCCEEHHHHHHHHHCCCCHHHHEEEEECCCHHHHHHHHHHHHHHHCHHHHHHHH
EDAKVNSAINGIDNTLFYAGDMKDILTQEFINQHGRPDVIITDPPRAGMHNDVINTILFA
HHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHEE
EPQRIVYVSCNPATQARDLSLLDAKYKVMAVQPVDMFPHTHHVENVVLLEKRG
CCCEEEEEECCCCCCCCCCCEECCCEEEEEEECHHHCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]