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The map label for this gene is srrB [H]

Identifier: 150005758

GI number: 150005758

Start: 4080158

End: 4081627

Strand: Reverse

Name: srrB [H]

Synonym: BVU_3251

Alternate gene names: 150005758

Gene position: 4081627-4080158 (Counterclockwise)

Preceding gene: 150005759

Following gene: 150005755

Centisome position: 79.05

GC content: 40.54

Gene sequence:

>1470_bases
ATGAATATAAAGTCGAAACTAACCCTCGCCATAGGGATATTGGTGGCAATGATTGTACTGTTGGTTGTACTTTCTGTTGT
GAATTTGCAAATACTGACTGCCACGGAACCTGACAGTCCGGCAGCAGGTCCCGGATTACAGCGGGCTTTATTGTGGATAT
ATGTTGTTGGTGCCGCATGTATATGTATTGGTATTGGTATGTGGTTGCGTCTTCCCGCATCAATTGATAATCCTATTAAA
GAGCTGACCAACGCTATACAGGAAATTGCAAACCATAATTATGAGAAACGTTTGGAATTGAACAGCAGTGAAGAATTTTC
AGAAGTATCTAAAAATTTCAACCGCATGGCCAAACGTCTGGAAGATTATCATGCAAGTACTTTATCCGATATGATGGCAT
CTAAAAAATATATGGAGACTATCATCAACAGTATCAACGAGCCTATTATCGGTTTAAATAATGATATGGAAATCCTGTTC
ATCAATGACGAAGCATTGAATGTGATCAACCTGAAGCGTGAAGAAGTTATTAAACATTCTGCACAGGATATTTCCCTGCG
CAATGATTTGTTGCGCCGCCTGATTCGTGAATTGGTGGAAATTCCTGGGGAACCAGTCAAAGACAAGGAAAAAGAAAAGA
AAGAACCTCTGAAGATTTATGCGGACAATAAAGAGAGTTTTTTCCAAGTAAAATACATGAGTATTTCCCAACCGGGGAAA
GATGGGGTTACTATGGAAAAAAAAGGATATGTCATTATGTTGAAGAATATAACCGAATTTAAGGAACTGGATTCGGCCAA
GACCACATTTATCTCTACAATCTCACATGAATTGAAGACTCCTATCTCGGCTATTATGATGAGTCTGCAATTATTAGAAG
ACCAGCGTATCGGAGCTTTAAATGAAGAACAGGAAGATTTGGCAAACAGTATCAAGGAAAATAGCGAACGGCTGCTTAAT
ATCACCGGCGAATTGCTGAATATGACGCAGGTAGAATCAGGAAAACTACAGTTGAAGCCTAAGATAACCAAACCTATAGA
GTTGATAGAATATGCAATAAAGGCAAACCGTGTGCAAGCCGAGAAGTTCAACATTCAAATAGAAGTGGAGTACCCTGAAG
ACAAAATAGGTAAACTGTTTGTCGACAGTGAGAAGATAGCTTGGGTGCTGACCAACCTTCTTTCCAATGCCATCCGGTAT
TCACCGGAAAACGGTCGTGTAGTAATAGGGGCACGTCAGACAGATGATGGATTCATTGAGATGTTTGTACGGGATTTCGG
GAAAGGGATTGATCCACGTTATCATAAAAGCATCTTTGACCATTATTTCCGGGTTCCCGGAACTAAAGTACAAGGAAGCG
GCTTAGGTCTGTCTATTTCCCGGGATTTTGTCGAGGCCCATAATGGTACGCTTACAGTAGACAGTAAGTTGGGAGAAGGA
AGTACGTTTGTTATGCGGTTAAAAGCATGA

Upstream 100 bases:

>100_bases
GCCCGGTGCATTATTCAGTCTTTCCAAATATCGAAAATTTCTACACTCTTTAGCAGAAATGGACATAGATTTGATTATAC
TTGCATAAAAAATAAAAGTT

Downstream 100 bases:

>100_bases
TCACAGCACAGGGGAGAGAATCTTTCAATAAGCGCTCTCCCCTGCTGCTTTTGAACCAAGCCGGAAAAGCTTACTCCAGC
CTATGAACGGTAATATCGCT

Product: two-component system sensor histidine kinase, FrrD

Products: NA

Alternate protein names: Staphylococcal respiratory response protein B [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MNIKSKLTLAIGILVAMIVLLVVLSVVNLQILTATEPDSPAAGPGLQRALLWIYVVGAACICIGIGMWLRLPASIDNPIK
ELTNAIQEIANHNYEKRLELNSSEEFSEVSKNFNRMAKRLEDYHASTLSDMMASKKYMETIINSINEPIIGLNNDMEILF
INDEALNVINLKREEVIKHSAQDISLRNDLLRRLIRELVEIPGEPVKDKEKEKKEPLKIYADNKESFFQVKYMSISQPGK
DGVTMEKKGYVIMLKNITEFKELDSAKTTFISTISHELKTPISAIMMSLQLLEDQRIGALNEEQEDLANSIKENSERLLN
ITGELLNMTQVESGKLQLKPKITKPIELIEYAIKANRVQAEKFNIQIEVEYPEDKIGKLFVDSEKIAWVLTNLLSNAIRY
SPENGRVVIGARQTDDGFIEMFVRDFGKGIDPRYHKSIFDHYFRVPGTKVQGSGLGLSISRDFVEAHNGTLTVDSKLGEG
STFVMRLKA

Sequences:

>Translated_489_residues
MNIKSKLTLAIGILVAMIVLLVVLSVVNLQILTATEPDSPAAGPGLQRALLWIYVVGAACICIGIGMWLRLPASIDNPIK
ELTNAIQEIANHNYEKRLELNSSEEFSEVSKNFNRMAKRLEDYHASTLSDMMASKKYMETIINSINEPIIGLNNDMEILF
INDEALNVINLKREEVIKHSAQDISLRNDLLRRLIRELVEIPGEPVKDKEKEKKEPLKIYADNKESFFQVKYMSISQPGK
DGVTMEKKGYVIMLKNITEFKELDSAKTTFISTISHELKTPISAIMMSLQLLEDQRIGALNEEQEDLANSIKENSERLLN
ITGELLNMTQVESGKLQLKPKITKPIELIEYAIKANRVQAEKFNIQIEVEYPEDKIGKLFVDSEKIAWVLTNLLSNAIRY
SPENGRVVIGARQTDDGFIEMFVRDFGKGIDPRYHKSIFDHYFRVPGTKVQGSGLGLSISRDFVEAHNGTLTVDSKLGEG
STFVMRLKA
>Mature_489_residues
MNIKSKLTLAIGILVAMIVLLVVLSVVNLQILTATEPDSPAAGPGLQRALLWIYVVGAACICIGIGMWLRLPASIDNPIK
ELTNAIQEIANHNYEKRLELNSSEEFSEVSKNFNRMAKRLEDYHASTLSDMMASKKYMETIINSINEPIIGLNNDMEILF
INDEALNVINLKREEVIKHSAQDISLRNDLLRRLIRELVEIPGEPVKDKEKEKKEPLKIYADNKESFFQVKYMSISQPGK
DGVTMEKKGYVIMLKNITEFKELDSAKTTFISTISHELKTPISAIMMSLQLLEDQRIGALNEEQEDLANSIKENSERLLN
ITGELLNMTQVESGKLQLKPKITKPIELIEYAIKANRVQAEKFNIQIEVEYPEDKIGKLFVDSEKIAWVLTNLLSNAIRY
SPENGRVVIGARQTDDGFIEMFVRDFGKGIDPRYHKSIFDHYFRVPGTKVQGSGLGLSISRDFVEAHNGTLTVDSKLGEG
STFVMRLKA

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. Probably phosphorylates srrA [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87081816, Length=232, Percent_Identity=32.3275862068966, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI48994928, Length=289, Percent_Identity=29.0657439446367, Blast_Score=112, Evalue=8e-26,
Organism=Escherichia coli, GI145693157, Length=234, Percent_Identity=32.0512820512821, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1788713, Length=259, Percent_Identity=29.7297297297297, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786600, Length=241, Percent_Identity=24.896265560166, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786783, Length=243, Percent_Identity=27.9835390946502, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790436, Length=235, Percent_Identity=28.5106382978723, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1789149, Length=235, Percent_Identity=27.6595744680851, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI87082128, Length=241, Percent_Identity=28.2157676348548, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1788393, Length=208, Percent_Identity=27.8846153846154, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1786912, Length=232, Percent_Identity=28.0172413793103, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788549, Length=446, Percent_Identity=23.9910313901345, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790346, Length=226, Percent_Identity=26.5486725663717, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1788279, Length=291, Percent_Identity=24.0549828178694, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55119; Mature: 55119

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIKSKLTLAIGILVAMIVLLVVLSVVNLQILTATEPDSPAAGPGLQRALLWIYVVGAAC
CCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
ICIGIGMWLRLPASIDNPIKELTNAIQEIANHNYEKRLELNSSEEFSEVSKNFNRMAKRL
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHEECCCCCHHHHHHHHHHHHHHHHH
EDYHASTLSDMMASKKYMETIINSINEPIIGLNNDMEILFINDEALNVINLKREEVIKHS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEECCCCCCHHHCCHHHHHHHH
AQDISLRNDLLRRLIRELVEIPGEPVKDKEKEKKEPLKIYADNKESFFQVKYMSISQPGK
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCEEEEECCCCCEEEEEEEEECCCCC
DGVTMEKKGYVIMLKNITEFKELDSAKTTFISTISHELKTPISAIMMSLQLLEDQRIGAL
CCCEEECCCCEEEECCCHHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCC
NEEQEDLANSIKENSERLLNITGELLNMTQVESGKLQLKPKITKPIELIEYAIKANRVQA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEECCCCCCHHHHHHHHHHHCCEEE
EKFNIQIEVEYPEDKIGKLFVDSEKIAWVLTNLLSNAIRYSPENGRVVIGARQTDDGFIE
EEEEEEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHH
MFVRDFGKGIDPRYHKSIFDHYFRVPGTKVQGSGLGLSISRDFVEAHNGTLTVDSKLGEG
HHHHHHCCCCCHHHHHHHHHHHHCCCCCEECCCCCEEEEEHHHHHHCCCEEEEECCCCCC
STFVMRLKA
CEEEEEECC
>Mature Secondary Structure
MNIKSKLTLAIGILVAMIVLLVVLSVVNLQILTATEPDSPAAGPGLQRALLWIYVVGAAC
CCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
ICIGIGMWLRLPASIDNPIKELTNAIQEIANHNYEKRLELNSSEEFSEVSKNFNRMAKRL
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHEECCCCCHHHHHHHHHHHHHHHHH
EDYHASTLSDMMASKKYMETIINSINEPIIGLNNDMEILFINDEALNVINLKREEVIKHS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEECCCCCCHHHCCHHHHHHHH
AQDISLRNDLLRRLIRELVEIPGEPVKDKEKEKKEPLKIYADNKESFFQVKYMSISQPGK
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCEEEEECCCCCEEEEEEEEECCCCC
DGVTMEKKGYVIMLKNITEFKELDSAKTTFISTISHELKTPISAIMMSLQLLEDQRIGAL
CCCEEECCCCEEEECCCHHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCC
NEEQEDLANSIKENSERLLNITGELLNMTQVESGKLQLKPKITKPIELIEYAIKANRVQA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEECCCCCCHHHHHHHHHHHCCEEE
EKFNIQIEVEYPEDKIGKLFVDSEKIAWVLTNLLSNAIRYSPENGRVVIGARQTDDGFIE
EEEEEEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHH
MFVRDFGKGIDPRYHKSIFDHYFRVPGTKVQGSGLGLSISRDFVEAHNGTLTVDSKLGEG
HHHHHHCCCCCHHHHHHHHHHHHCCCCCEECCCCCEEEEEHHHHHHCCCEEEEECCCCCC
STFVMRLKA
CEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA