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The map label for this gene is hmuU [H]

Identifier: 150005590

GI number: 150005590

Start: 3890859

End: 3891896

Strand: Direct

Name: hmuU [H]

Synonym: BVU_3078

Alternate gene names: 150005590

Gene position: 3890859-3891896 (Clockwise)

Preceding gene: 150005589

Following gene: 150005591

Centisome position: 75.36

GC content: 46.15

Gene sequence:

>1038_bases
ATGAAACGACCTGTTGCATTTTATATGCTGTTAATTATGGCTTCTATTTTTCTGTTTTTCTTCCTGAATCTGGTATTAGG
TTCTGTTTCCATACCGCTTCGTGCTGTGTGGAATATCCTTTGGGGAACAGGGAATGAGTCTGTTATATGGCAAAATATTA
TTTGGAAATCACGGGTACCACAGGCGCTTACCGCATTGGCGGCGGGGGCGGGGCTCTCTGTCAGCGGTTTACAGATGCAG
ACTGTTTTCCGCAATCCTTTGGCCGGTCCGTCGGTACTGGGCATCAGTTCGGGAGCCAGTATGGGAGTTGCTTTTGTGGT
GCTTCTTTCGGGCAGTTTGGGTGGTGTTGCTTTGAGCAAGCTAGGCTTTATGGGGGAAATAGCCCTTACCATAGCAGCTA
TTGCAGGTTCACTTTCCATTATGGCACTTATTGTTTTCGTTTCCCAAAAAGTAAGGGGCAATGTTACTTTGCTGATTATC
GGTGTGATGATTGGTTACATAGCCAATGCGGTGATCGGTGTGCTGAAATTTTTCAGTGTGGAGGAGGATATTCGTGCATA
TGTCATTTGGGGGTTGGGAAGTTTTGCCCGTGTATCGGGAGATCAGATGACTTTATTTATATGTATCATGGTGGTATTGT
TGCCACTTTCCTTCCTGCTTGTCAAAACATTGAATCTTTTGCTGCTGGGAGATGCATACGCACGGAATCTCGGATTGAAT
ATAAAACGTGCCCGTCTGCTTGTCATTACTTGTTCGGGAGTATTGGTAGCTATTGTTACCGCATATTGCGGCCCGATTAT
TTTTCTGGGGCTGGCCGTTCCGCATCTTTGCAGGGGAATGTTCCGCACATCCGATCATCGTATTCTGATGCCTGCTTCTT
TACTGGCAGGTGCGTCATTGGCATTGGTATGTAATCTGATTGCCCGTATGCCCGGTTTCGAAGGTGCATTGCCGGTAAAT
TCGGTGACGGCTTTGGTAGGTGCTCCGGTAGTGATGTCGGTTTTATTCAATAAACGTCGCAATGAAATGAATGAGTAA

Upstream 100 bases:

>100_bases
CGGAAGTTGTTCTGGCAGATTTGATTCAAATCTTTCATCCGCAGCTTTTGTCCGGTCACCAACCGGGATATTATGAATTG
CTTAAATAGGAAAATAGTAT

Downstream 100 bases:

>100_bases
TGATGAATCAAGAAACTATACATATTCGGAAACTGACTACCGGTTATCCCGGTAAGGGGGGAACCAAGATTGTAGCGAAG
GACATTGATGCTACTATCCG

Product: iron(III) ABC transporter putative permease protein

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MKRPVAFYMLLIMASIFLFFFLNLVLGSVSIPLRAVWNILWGTGNESVIWQNIIWKSRVPQALTALAAGAGLSVSGLQMQ
TVFRNPLAGPSVLGISSGASMGVAFVVLLSGSLGGVALSKLGFMGEIALTIAAIAGSLSIMALIVFVSQKVRGNVTLLII
GVMIGYIANAVIGVLKFFSVEEDIRAYVIWGLGSFARVSGDQMTLFICIMVVLLPLSFLLVKTLNLLLLGDAYARNLGLN
IKRARLLVITCSGVLVAIVTAYCGPIIFLGLAVPHLCRGMFRTSDHRILMPASLLAGASLALVCNLIARMPGFEGALPVN
SVTALVGAPVVMSVLFNKRRNEMNE

Sequences:

>Translated_345_residues
MKRPVAFYMLLIMASIFLFFFLNLVLGSVSIPLRAVWNILWGTGNESVIWQNIIWKSRVPQALTALAAGAGLSVSGLQMQ
TVFRNPLAGPSVLGISSGASMGVAFVVLLSGSLGGVALSKLGFMGEIALTIAAIAGSLSIMALIVFVSQKVRGNVTLLII
GVMIGYIANAVIGVLKFFSVEEDIRAYVIWGLGSFARVSGDQMTLFICIMVVLLPLSFLLVKTLNLLLLGDAYARNLGLN
IKRARLLVITCSGVLVAIVTAYCGPIIFLGLAVPHLCRGMFRTSDHRILMPASLLAGASLALVCNLIARMPGFEGALPVN
SVTALVGAPVVMSVLFNKRRNEMNE
>Mature_345_residues
MKRPVAFYMLLIMASIFLFFFLNLVLGSVSIPLRAVWNILWGTGNESVIWQNIIWKSRVPQALTALAAGAGLSVSGLQMQ
TVFRNPLAGPSVLGISSGASMGVAFVVLLSGSLGGVALSKLGFMGEIALTIAAIAGSLSIMALIVFVSQKVRGNVTLLII
GVMIGYIANAVIGVLKFFSVEEDIRAYVIWGLGSFARVSGDQMTLFICIMVVLLPLSFLLVKTLNLLLLGDAYARNLGLN
IKRARLLVITCSGVLVAIVTAYCGPIIFLGLAVPHLCRGMFRTSDHRILMPASLLAGASLALVCNLIARMPGFEGALPVN
SVTALVGAPVVMSVLFNKRRNEMNE

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=287, Percent_Identity=35.191637630662, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1790740, Length=321, Percent_Identity=32.398753894081, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1790741, Length=350, Percent_Identity=30.8571428571429, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786805, Length=330, Percent_Identity=31.2121212121212, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1786347, Length=287, Percent_Identity=27.5261324041812, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786804, Length=253, Percent_Identity=30.0395256916996, Blast_Score=78, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36700; Mature: 36700

Theoretical pI: Translated: 10.59; Mature: 10.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRPVAFYMLLIMASIFLFFFLNLVLGSVSIPLRAVWNILWGTGNESVIWQNIIWKSRVP
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEHHHHHHHHCCH
QALTALAAGAGLSVSGLQMQTVFRNPLAGPSVLGISSGASMGVAFVVLLSGSLGGVALSK
HHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHCCCCCHHHHHH
LGFMGEIALTIAAIAGSLSIMALIVFVSQKVRGNVTLLIIGVMIGYIANAVIGVLKFFSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
EEDIRAYVIWGLGSFARVSGDQMTLFICIMVVLLPLSFLLVKTLNLLLLGDAYARNLGLN
CHHHHEEEEECCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCC
IKRARLLVITCSGVLVAIVTAYCGPIIFLGLAVPHLCRGMFRTSDHRILMPASLLAGASL
EEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHCHHH
ALVCNLIARMPGFEGALPVNSVTALVGAPVVMSVLFNKRRNEMNE
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKRPVAFYMLLIMASIFLFFFLNLVLGSVSIPLRAVWNILWGTGNESVIWQNIIWKSRVP
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEHHHHHHHHCCH
QALTALAAGAGLSVSGLQMQTVFRNPLAGPSVLGISSGASMGVAFVVLLSGSLGGVALSK
HHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHCCCCCHHHHHH
LGFMGEIALTIAAIAGSLSIMALIVFVSQKVRGNVTLLIIGVMIGYIANAVIGVLKFFSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
EEDIRAYVIWGLGSFARVSGDQMTLFICIMVVLLPLSFLLVKTLNLLLLGDAYARNLGLN
CHHHHEEEEECCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCC
IKRARLLVITCSGVLVAIVTAYCGPIIFLGLAVPHLCRGMFRTSDHRILMPASLLAGASL
EEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHCHHH
ALVCNLIARMPGFEGALPVNSVTALVGAPVVMSVLFNKRRNEMNE
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]