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The map label for this gene is fhs

Identifier: 150005532

GI number: 150005532

Start: 3818795

End: 3820462

Strand: Direct

Name: fhs

Synonym: BVU_3016

Alternate gene names: 150005532

Gene position: 3818795-3820462 (Clockwise)

Preceding gene: 150005525

Following gene: 150005533

Centisome position: 73.96

GC content: 44.54

Gene sequence:

>1668_bases
ATGAAAACGGACATTGAAATAGCACGCAGCATTGAGCTGGTCAAGATTAAACAAGTGGCTCGGGAAACCGGTATTCCTGT
AGAGCACATCAGTAACTACGGGCGCTATATTGCCAAAGTGGATGAAAGTCAGATAAACGAAGAAAAGGTGCAGCAGAGTA
ACCTTATTCTAGTTACTGCCATCACTCCTACCAAAGCCGGTATTGGTAAGACCACTGTTTCCATCGGATTGGCTTTGGGA
CTGAATAAAATAGGAAAGAAAACAATTGTTGCCTTGCGCGAGCCGTCGCTAGGTCCTTGTTTCGGAATGAAAGGGGGAGC
TGCCGGAGGAGGATATGCCCAAGTTTTGCCGATGGATAAGATTAATCTTCATTTTACAGGTGATTTTCATGCCATCACTT
CCGCTCACAATATGATTTCGGCCTTGTTGGACAATTACCTTTATCAGAATCGTGATAATGGTTTCGGATTGAAGGAAGTG
CTGTGGCGTCGTGTGTTGGATGTGAATGACCGTTCCCTCCGTTATATTGTTACAGGACTAGGACCGAAGACCAACGGAAT
TACCCAGGAGTCAGGTTTTGATATTACTCCTGCATCTGAAATTATGGCTATTCTGTGTCTGGCCAAGGATGAAAAGGACC
TGCGTCGTCGCATTGAAAATATTTTATTAGGTTTTACGTATGACAACAAGCCTTTTACTGTAAAAGATTTAGGAGTTGCC
GGAGCCATTACAGTTCTTTTGAAAGATGCTCTTTCTCCTAATCTGGTACAAACTACGGAACATACTGCTGCCTTTGTTCA
TGGGGGGCCGTTTGCCAATATCGCTCACGGTTGCAACTCTATTCTGGCAACCAAGATGGCAATGACTTTTAGTGATTATA
CTATTACCGAAGCCGGATTCGGGGCTGACCTGGGAGCGGAGAAGTTCTATGATATTAAGTGCCGTAAAGCAGGTGTCACA
CCTAAACTGACCGTCTTGGTGGTTACTGCCCGTGCATTGAAAATGCATGGCGGCGTATCACAGGATAAGATAAAGGAACC
TAATCTGGAAGCTTTGAAGCAGGGTGTGGCCAATATGGATAAGCATTTGCGTAATTTGAGATATTTCGGTCAGACAGTTG
TCGTTGCGTTTAACCGTTATGGGGATGATTCGGAGGAAGAAGTGGATTATATCCGTACCCATTGCGAGAAGAAAGGTGTG
GGCTTTGCAGTGAACAACGCCTTTACTGATGGTGGCGAAGGGGCAGTAGAATTGGCGGAACTGGTTGTGAAAACCATTGA
GGAACAACCTTCCGAGCCTTTGCAATATGCCTATGATGATGAGGATAGTGTAGAAACTAAAATATCGAAGGTGGCTTGTA
ATTTATACGGTGCCAGCATTATTACGTATAGTGCCGCTGCCCGTAAGAAACTGAAGCATATTGTAGAATTGGGATATGGA
AATTTCCCTATCTGCATTGCCAAGACGCAGTATTCATTCTCTACCGACCCCAAAATTTACGGTGCGGTAGACAATTTTGA
ATTCCATGTACAAGATATTGTGATGAATGCCGGAGCTGAGATGCTGGTAGTCATTGCCGGAGAAATAATGCGTATGCCGG
GATTGCCGAAGGAACCGCAGGCATTGCATATTGATATCGTGAATGGTGAAATAGAGGGGTTGTCGTAA

Upstream 100 bases:

>100_bases
AAAATTGTTCATTTGCTTACTCCTTATATTATTTTGTTGTTTGAAACCAAAACAAAGTTAAGGAAATATATTACCTTTGC
CGCCTAAATTTAGTAAAAAG

Downstream 100 bases:

>100_bases
CCCCTCTTTTTTTTACTGAACTTATACTGTTTTACATTGACGAGATTAAACACCAGGTGTAAATGGAAAGTCCGATACCT
GTTACCAATCCTACAGATGA

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MKTDIEIARSIELVKIKQVARETGIPVEHISNYGRYIAKVDESQINEEKVQQSNLILVTAITPTKAGIGKTTVSIGLALG
LNKIGKKTIVALREPSLGPCFGMKGGAAGGGYAQVLPMDKINLHFTGDFHAITSAHNMISALLDNYLYQNRDNGFGLKEV
LWRRVLDVNDRSLRYIVTGLGPKTNGITQESGFDITPASEIMAILCLAKDEKDLRRRIENILLGFTYDNKPFTVKDLGVA
GAITVLLKDALSPNLVQTTEHTAAFVHGGPFANIAHGCNSILATKMAMTFSDYTITEAGFGADLGAEKFYDIKCRKAGVT
PKLTVLVVTARALKMHGGVSQDKIKEPNLEALKQGVANMDKHLRNLRYFGQTVVVAFNRYGDDSEEEVDYIRTHCEKKGV
GFAVNNAFTDGGEGAVELAELVVKTIEEQPSEPLQYAYDDEDSVETKISKVACNLYGASIITYSAAARKKLKHIVELGYG
NFPICIAKTQYSFSTDPKIYGAVDNFEFHVQDIVMNAGAEMLVVIAGEIMRMPGLPKEPQALHIDIVNGEIEGLS

Sequences:

>Translated_555_residues
MKTDIEIARSIELVKIKQVARETGIPVEHISNYGRYIAKVDESQINEEKVQQSNLILVTAITPTKAGIGKTTVSIGLALG
LNKIGKKTIVALREPSLGPCFGMKGGAAGGGYAQVLPMDKINLHFTGDFHAITSAHNMISALLDNYLYQNRDNGFGLKEV
LWRRVLDVNDRSLRYIVTGLGPKTNGITQESGFDITPASEIMAILCLAKDEKDLRRRIENILLGFTYDNKPFTVKDLGVA
GAITVLLKDALSPNLVQTTEHTAAFVHGGPFANIAHGCNSILATKMAMTFSDYTITEAGFGADLGAEKFYDIKCRKAGVT
PKLTVLVVTARALKMHGGVSQDKIKEPNLEALKQGVANMDKHLRNLRYFGQTVVVAFNRYGDDSEEEVDYIRTHCEKKGV
GFAVNNAFTDGGEGAVELAELVVKTIEEQPSEPLQYAYDDEDSVETKISKVACNLYGASIITYSAAARKKLKHIVELGYG
NFPICIAKTQYSFSTDPKIYGAVDNFEFHVQDIVMNAGAEMLVVIAGEIMRMPGLPKEPQALHIDIVNGEIEGLS
>Mature_555_residues
MKTDIEIARSIELVKIKQVARETGIPVEHISNYGRYIAKVDESQINEEKVQQSNLILVTAITPTKAGIGKTTVSIGLALG
LNKIGKKTIVALREPSLGPCFGMKGGAAGGGYAQVLPMDKINLHFTGDFHAITSAHNMISALLDNYLYQNRDNGFGLKEV
LWRRVLDVNDRSLRYIVTGLGPKTNGITQESGFDITPASEIMAILCLAKDEKDLRRRIENILLGFTYDNKPFTVKDLGVA
GAITVLLKDALSPNLVQTTEHTAAFVHGGPFANIAHGCNSILATKMAMTFSDYTITEAGFGADLGAEKFYDIKCRKAGVT
PKLTVLVVTARALKMHGGVSQDKIKEPNLEALKQGVANMDKHLRNLRYFGQTVVVAFNRYGDDSEEEVDYIRTHCEKKGV
GFAVNNAFTDGGEGAVELAELVVKTIEEQPSEPLQYAYDDEDSVETKISKVACNLYGASIITYSAAARKKLKHIVELGYG
NFPICIAKTQYSFSTDPKIYGAVDNFEFHVQDIVMNAGAEMLVVIAGEIMRMPGLPKEPQALHIDIVNGEIEGLS

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=612, Percent_Identity=38.8888888888889, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI36796743, Length=609, Percent_Identity=37.9310344827586, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17568737, Length=624, Percent_Identity=38.7820512820513, Blast_Score=375, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17568739, Length=624, Percent_Identity=38.7820512820513, Blast_Score=375, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6319558, Length=631, Percent_Identity=39.3026941362916, Blast_Score=404, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=38.4984025559105, Blast_Score=393, Evalue=1e-110,
Organism=Drosophila melanogaster, GI62472483, Length=620, Percent_Identity=39.3548387096774, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI45551871, Length=620, Percent_Identity=39.3548387096774, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24645718, Length=620, Percent_Identity=39.3548387096774, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI17137370, Length=620, Percent_Identity=39.3548387096774, Blast_Score=419, Evalue=1e-117,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_BACV8 (A6L4P0)

Other databases:

- EMBL:   CP000139
- RefSeq:   YP_001300276.1
- ProteinModelPortal:   A6L4P0
- SMR:   A6L4P0
- STRING:   A6L4P0
- GeneID:   5303977
- GenomeReviews:   CP000139_GR
- KEGG:   bvu:BVU_3016
- NMPDR:   fig|435590.6.peg.2824
- eggNOG:   COG2759
- HOGENOM:   HBG677721
- OMA:   EIMAVLC
- ProtClustDB:   PRK13505
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 60525; Mature: 60525

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTDIEIARSIELVKIKQVARETGIPVEHISNYGRYIAKVDESQINEEKVQQSNLILVTA
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHEEEECCHHHCCHHHHHCCCEEEEEE
ITPTKAGIGKTTVSIGLALGLNKIGKKTIVALREPSLGPCFGMKGGAAGGGYAQVLPMDK
ECCCCCCCCCHHHHHHHHHCHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCC
INLHFTGDFHAITSAHNMISALLDNYLYQNRDNGFGLKEVLWRRVLDVNDRSLRYIVTGL
EEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEC
GPKTNGITQESGFDITPASEIMAILCLAKDEKDLRRRIENILLGFTYDNKPFTVKDLGVA
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHEEEEEEECCCCEEEECCCHH
GAITVLLKDALSPNLVQTTEHTAAFVHGGPFANIAHGCNSILATKMAMTFSDYTITEAGF
HHHHHHHHHHCCCCCEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHEECCCEEECCCC
GADLGAEKFYDIKCRKAGVTPKLTVLVVTARALKMHGGVSQDKIKEPNLEALKQGVANMD
CCCCCCCCEEEEEEECCCCCCCEEEEEEEHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHH
KHLRNLRYFGQTVVVAFNRYGDDSEEEVDYIRTHCEKKGVGFAVNNAFTDGGEGAVELAE
HHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHH
LVVKTIEEQPSEPLQYAYDDEDSVETKISKVACNLYGASIITYSAAARKKLKHIVELGYG
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCC
NFPICIAKTQYSFSTDPKIYGAVDNFEFHVQDIVMNAGAEMLVVIAGEIMRMPGLPKEPQ
CCCEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEHHHHHHCCCCCCCCC
ALHIDIVNGEIEGLS
EEEEEEECCCCCCCC
>Mature Secondary Structure
MKTDIEIARSIELVKIKQVARETGIPVEHISNYGRYIAKVDESQINEEKVQQSNLILVTA
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHEEEECCHHHCCHHHHHCCCEEEEEE
ITPTKAGIGKTTVSIGLALGLNKIGKKTIVALREPSLGPCFGMKGGAAGGGYAQVLPMDK
ECCCCCCCCCHHHHHHHHHCHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCC
INLHFTGDFHAITSAHNMISALLDNYLYQNRDNGFGLKEVLWRRVLDVNDRSLRYIVTGL
EEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEC
GPKTNGITQESGFDITPASEIMAILCLAKDEKDLRRRIENILLGFTYDNKPFTVKDLGVA
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHEEEEEEECCCCEEEECCCHH
GAITVLLKDALSPNLVQTTEHTAAFVHGGPFANIAHGCNSILATKMAMTFSDYTITEAGF
HHHHHHHHHHCCCCCEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHEECCCEEECCCC
GADLGAEKFYDIKCRKAGVTPKLTVLVVTARALKMHGGVSQDKIKEPNLEALKQGVANMD
CCCCCCCCEEEEEEECCCCCCCEEEEEEEHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHH
KHLRNLRYFGQTVVVAFNRYGDDSEEEVDYIRTHCEKKGVGFAVNNAFTDGGEGAVELAE
HHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHH
LVVKTIEEQPSEPLQYAYDDEDSVETKISKVACNLYGASIITYSAAARKKLKHIVELGYG
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCC
NFPICIAKTQYSFSTDPKIYGAVDNFEFHVQDIVMNAGAEMLVVIAGEIMRMPGLPKEPQ
CCCEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEHHHHHHCCCCCCCCC
ALHIDIVNGEIEGLS
EEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA