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The map label for this gene is mutS2 [H]

Identifier: 150004986

GI number: 150004986

Start: 3149818

End: 3152328

Strand: Reverse

Name: mutS2 [H]

Synonym: BVU_2450

Alternate gene names: 150004986

Gene position: 3152328-3149818 (Counterclockwise)

Preceding gene: 150004999

Following gene: 150004985

Centisome position: 61.05

GC content: 41.34

Gene sequence:

>2511_bases
ATGATATACCCTCAGAATTTCGAACAGAAAATAGGTTTCGATTCCATCCGTCATTTACTAAAAGAGAAATGTCTCAGCAC
ATTAGGTCAAGAAAGAGTAGATGAAATGAACTTCTCAGAATCCTTTAAGGATATTAATGAATGGCTGGAACAGGTGATGG
AATTCATGCGCATCATACAAGAGGAAGACAGTTTTCCCGACCAATATTTTTTTGATGTACGACCATCACTAAAACGTATC
CGCGTAGAAGGTATGTATTTGGATGAGCAAGAACTGTTTGATTTACGCCGTTCTTTAGAAACAATTCGTGATATCATCCA
TTTTCTGACACTGACCTCGAATGACGAAGAACAAGAAAAAGAAAACTCCCCCTACCCTGCCCTACAAAAACTGGCAGGAG
ATATTATCGTGTTTCCTCAACTCATTACGCGTATAAACAACATCTTAGACAAATTCGGAAAAATCAAAGACAACGCTTCT
TCCGAATTATTACGCATCCGCAGAGAGTTGGCCTCGACAGCCGGAAGCATATCACGCAGTTTGAATGCAATTCTACGCAA
CGCTCAAGCAGAAGGTTATGTTGATAAAGATGTAACTCCTACCATGCGTGACGGAAGACTCGTCATCCCTGTCGCACCGG
GATTAAAACGGAAAATCAAGGGAATTGTACACGATGAATCATCCACCGGCAAAACAGTTTTCATAGAACCGGCCGAAGTA
GTGGAAGCAAACAATAGAATACGGGAATTGGAAGGAGAAGAACGCCGGGAAATCATCCGTATCCTGACAGATTTCTCTAT
CATAATCCGCCCACAGGTCCCCGCCATCCTCCAGTCATACGAGTTTTTGGCAGAAATTGATTTCATCCGTGCCAAAGCCC
ATTTTTCCATTCAGACGAACGCCACCAAACCATCATTGGAAGACAAACAGATTTTGGACTGGACCATGGCCATACACCCA
CTATTGCAACTCTCGCTGGCCAAGCATAATAAAAAGGTTGTTCCTCTAGATATAGAACTAACTAAAAATCAACGCATTCT
AATTATATCCGGACCGAATGCCGGAGGTAAATCCGTTTGTCTGAAGACTGTGGGATTACTACAATATATGTTACAATGTG
GTATGCCGGTTCCGATGCATGAACGTAGCCATGCCGGATTATTCGGCAGTATCTTTATAGACATAGGTGACGAACAAAGT
ATCGAAGACGATCTGAGTACCTACTCCTCACACCTTACCAACATGAAAACAATGATGAAAAGCTGTAACGAACGCAGCCT
TATCCTCATTGATGAATTCGGCGGAGGTACAGAACCACAAATTGGAGGAGCCATAGCTGAAGCTGTGTTGAAACGTTTCA
ATGAAAAGGGCACATTCGGCGTTATCACCACTCATTATCAAAATTTGAAACATTTTGCCGAAGATCACGAAGGAGTGGTT
AATGGTGCCATGTTATATGACAGGCATTTAATGCAAGCTTTATTCCAATTACAAATAGGAAATCCGGGAAGTTCATTTGC
AGTAGAAATAGCTAGGAAAATAGGTTTACCGGAAGAAGTTATAGCCGACGCATCCGAAATTGTAGGGAGTGAATATATCA
ATGCTGATAAATATCTACAAGATATCGTACGTGACAAACGTTATTGGGAAACTAAGCGTCAGAACATCCGCAAACGAGAA
AAACAGATGGAAGAAACCATCGCCAAATACGAAGAAGAACTACAGGAACTGGAGAAAAGTCGTAAAGAGATTTTGCGAAA
GGCCAAAGAAGATGCGGAAAAATTGATACAGGAATCAAATGCCCGAATTGAAAATACCATCCGTATCATCAAGGAAGCAC
AAGCCGACAAAGAACGTACACAATCGGCACGTCAGGAACTGACTGATTTTAAAAATCAGATAGAAGATATCGAGAAAAAG
AACAAGGAAGATGAAATCATCCGGAAAATGGAAAAACTCCGTGAAAAACAAGAGCGGAAAAAAAACAAAAAGGATAAAGC
CAAGACGGAATCTTCCCAACTGTCAATGCCCAAAGAACAGCCTATCACTGTAGGTAGCACTGTAAAGATCAAAGGTCAAT
CCAGTGTCGGAGAAGTACTAGGAATTAATGGCAAAAATGCAATAGTTATGTTCGGAATGATAAAAACCAATGTAAAACTG
GATAAGCTGGAACGTAGCACACCAATACAGCCCACCCAGAAAACAATGGTAAAAAGTACCTTCGTCAGCAGTGAAACACA
AGATCGGGTATATGAAAAGAAACTAAATTTCAAACAAGATATTGATGTACGCGGTATGCGTGGCGATGAAGCGATACAGG
CAGTAACTTATTTTATCGATGATGCCATACTATTGGGAATAGACCGTGTACGTATCCTTCACGGAACAGGTACAGGCATA
CTGCGCACCCTGATTCGCAGCTATTTGGGAAGTGTTCCAGGAGTAGCACACTATCAAGACGAACACGTACAATTTGGTGG
GGCAGGTATTACTGTAGTAGACTTAAAATAA

Upstream 100 bases:

>100_bases
ACGACTTTATTTTAAATAAGCAAATAGTTTACCAGTTTTTTTGCTATAAAATTTTCAAATCGTATTTTTGCATACGAATA
ATAAACGAAAGAAATAAATC

Downstream 100 bases:

>100_bases
TATTTTAATAGAATAAGAGGCTGTTTTTAATTAATTTTCTCTATATTCGCACTAAAATTAGAGAAAATTAAAAGCAAAGG
TGGCAGCGGGAACTTCTCAT

Product: DNA mismatch repair protein MutS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 836; Mature: 836

Protein sequence:

>836_residues
MIYPQNFEQKIGFDSIRHLLKEKCLSTLGQERVDEMNFSESFKDINEWLEQVMEFMRIIQEEDSFPDQYFFDVRPSLKRI
RVEGMYLDEQELFDLRRSLETIRDIIHFLTLTSNDEEQEKENSPYPALQKLAGDIIVFPQLITRINNILDKFGKIKDNAS
SELLRIRRELASTAGSISRSLNAILRNAQAEGYVDKDVTPTMRDGRLVIPVAPGLKRKIKGIVHDESSTGKTVFIEPAEV
VEANNRIRELEGEERREIIRILTDFSIIIRPQVPAILQSYEFLAEIDFIRAKAHFSIQTNATKPSLEDKQILDWTMAIHP
LLQLSLAKHNKKVVPLDIELTKNQRILIISGPNAGGKSVCLKTVGLLQYMLQCGMPVPMHERSHAGLFGSIFIDIGDEQS
IEDDLSTYSSHLTNMKTMMKSCNERSLILIDEFGGGTEPQIGGAIAEAVLKRFNEKGTFGVITTHYQNLKHFAEDHEGVV
NGAMLYDRHLMQALFQLQIGNPGSSFAVEIARKIGLPEEVIADASEIVGSEYINADKYLQDIVRDKRYWETKRQNIRKRE
KQMEETIAKYEEELQELEKSRKEILRKAKEDAEKLIQESNARIENTIRIIKEAQADKERTQSARQELTDFKNQIEDIEKK
NKEDEIIRKMEKLREKQERKKNKKDKAKTESSQLSMPKEQPITVGSTVKIKGQSSVGEVLGINGKNAIVMFGMIKTNVKL
DKLERSTPIQPTQKTMVKSTFVSSETQDRVYEKKLNFKQDIDVRGMRGDEAIQAVTYFIDDAILLGIDRVRILHGTGTGI
LRTLIRSYLGSVPGVAHYQDEHVQFGGAGITVVDLK

Sequences:

>Translated_836_residues
MIYPQNFEQKIGFDSIRHLLKEKCLSTLGQERVDEMNFSESFKDINEWLEQVMEFMRIIQEEDSFPDQYFFDVRPSLKRI
RVEGMYLDEQELFDLRRSLETIRDIIHFLTLTSNDEEQEKENSPYPALQKLAGDIIVFPQLITRINNILDKFGKIKDNAS
SELLRIRRELASTAGSISRSLNAILRNAQAEGYVDKDVTPTMRDGRLVIPVAPGLKRKIKGIVHDESSTGKTVFIEPAEV
VEANNRIRELEGEERREIIRILTDFSIIIRPQVPAILQSYEFLAEIDFIRAKAHFSIQTNATKPSLEDKQILDWTMAIHP
LLQLSLAKHNKKVVPLDIELTKNQRILIISGPNAGGKSVCLKTVGLLQYMLQCGMPVPMHERSHAGLFGSIFIDIGDEQS
IEDDLSTYSSHLTNMKTMMKSCNERSLILIDEFGGGTEPQIGGAIAEAVLKRFNEKGTFGVITTHYQNLKHFAEDHEGVV
NGAMLYDRHLMQALFQLQIGNPGSSFAVEIARKIGLPEEVIADASEIVGSEYINADKYLQDIVRDKRYWETKRQNIRKRE
KQMEETIAKYEEELQELEKSRKEILRKAKEDAEKLIQESNARIENTIRIIKEAQADKERTQSARQELTDFKNQIEDIEKK
NKEDEIIRKMEKLREKQERKKNKKDKAKTESSQLSMPKEQPITVGSTVKIKGQSSVGEVLGINGKNAIVMFGMIKTNVKL
DKLERSTPIQPTQKTMVKSTFVSSETQDRVYEKKLNFKQDIDVRGMRGDEAIQAVTYFIDDAILLGIDRVRILHGTGTGI
LRTLIRSYLGSVPGVAHYQDEHVQFGGAGITVVDLK
>Mature_836_residues
MIYPQNFEQKIGFDSIRHLLKEKCLSTLGQERVDEMNFSESFKDINEWLEQVMEFMRIIQEEDSFPDQYFFDVRPSLKRI
RVEGMYLDEQELFDLRRSLETIRDIIHFLTLTSNDEEQEKENSPYPALQKLAGDIIVFPQLITRINNILDKFGKIKDNAS
SELLRIRRELASTAGSISRSLNAILRNAQAEGYVDKDVTPTMRDGRLVIPVAPGLKRKIKGIVHDESSTGKTVFIEPAEV
VEANNRIRELEGEERREIIRILTDFSIIIRPQVPAILQSYEFLAEIDFIRAKAHFSIQTNATKPSLEDKQILDWTMAIHP
LLQLSLAKHNKKVVPLDIELTKNQRILIISGPNAGGKSVCLKTVGLLQYMLQCGMPVPMHERSHAGLFGSIFIDIGDEQS
IEDDLSTYSSHLTNMKTMMKSCNERSLILIDEFGGGTEPQIGGAIAEAVLKRFNEKGTFGVITTHYQNLKHFAEDHEGVV
NGAMLYDRHLMQALFQLQIGNPGSSFAVEIARKIGLPEEVIADASEIVGSEYINADKYLQDIVRDKRYWETKRQNIRKRE
KQMEETIAKYEEELQELEKSRKEILRKAKEDAEKLIQESNARIENTIRIIKEAQADKERTQSARQELTDFKNQIEDIEKK
NKEDEIIRKMEKLREKQERKKNKKDKAKTESSQLSMPKEQPITVGSTVKIKGQSSVGEVLGINGKNAIVMFGMIKTNVKL
DKLERSTPIQPTQKTMVKSTFVSSETQDRVYEKKLNFKQDIDVRGMRGDEAIQAVTYFIDDAILLGIDRVRILHGTGTGI
LRTLIRSYLGSVPGVAHYQDEHVQFGGAGITVVDLK

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=270, Percent_Identity=26.6666666666667, Blast_Score=101, Evalue=3e-21,
Organism=Homo sapiens, GI36949366, Length=310, Percent_Identity=26.4516129032258, Blast_Score=94, Evalue=6e-19,
Organism=Homo sapiens, GI26638666, Length=232, Percent_Identity=29.3103448275862, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI4505253, Length=232, Percent_Identity=29.3103448275862, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI4557761, Length=197, Percent_Identity=28.4263959390863, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI26638664, Length=233, Percent_Identity=29.1845493562232, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI4504191, Length=186, Percent_Identity=30.1075268817204, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI262231786, Length=141, Percent_Identity=36.1702127659575, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI1789089, Length=262, Percent_Identity=29.0076335877863, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17534743, Length=370, Percent_Identity=23.5135135135135, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17508445, Length=312, Percent_Identity=24.0384615384615, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17539736, Length=266, Percent_Identity=24.812030075188, Blast_Score=87, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17508447, Length=325, Percent_Identity=23.6923076923077, Blast_Score=77, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319935, Length=275, Percent_Identity=30.5454545454545, Blast_Score=98, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6324482, Length=378, Percent_Identity=25.1322751322751, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320302, Length=212, Percent_Identity=30.6603773584906, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320047, Length=270, Percent_Identity=28.8888888888889, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321912, Length=259, Percent_Identity=25.0965250965251, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24584320, Length=213, Percent_Identity=28.169014084507, Blast_Score=91, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24664545, Length=227, Percent_Identity=28.1938325991189, Blast_Score=82, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF05192 MutS_III; PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 95374; Mature: 95374

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS50828 SMR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYPQNFEQKIGFDSIRHLLKEKCLSTLGQERVDEMNFSESFKDINEWLEQVMEFMRIIQ
CCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
EEDSFPDQYFFDVRPSLKRIRVEGMYLDEQELFDLRRSLETIRDIIHFLTLTSNDEEQEK
HCCCCCCCEEECCCCCHHHEEECCEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
ENSPYPALQKLAGDIIVFPQLITRINNILDKFGKIKDNASSELLRIRRELASTAGSISRS
CCCCCHHHHHHCCCEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
LNAILRNAQAEGYVDKDVTPTMRDGRLVIPVAPGLKRKIKGIVHDESSTGKTVFIEPAEV
HHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHEECCCCCCCEEEECCHHH
VEANNRIRELEGEERREIIRILTDFSIIIRPQVPAILQSYEFLAEIDFIRAKAHFSIQTN
HHHHHHHHHCCCHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHEEEEEEEC
ATKPSLEDKQILDWTMAIHPLLQLSLAKHNKKVVPLDIELTKNQRILIISGPNAGGKSVC
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCEEEEEECCCCCCHHHH
LKTVGLLQYMLQCGMPVPMHERSHAGLFGSIFIDIGDEQSIEDDLSTYSSHLTNMKTMMK
HHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
SCNERSLILIDEFGGGTEPQIGGAIAEAVLKRFNEKGTFGVITTHYQNLKHFAEDHEGVV
CCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHCHHH
NGAMLYDRHLMQALFQLQIGNPGSSFAVEIARKIGLPEEVIADASEIVGSEYINADKYLQ
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHH
DIVRDKRYWETKRQNIRKREKQMEETIAKYEEELQELEKSRKEILRKAKEDAEKLIQESN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ARIENTIRIIKEAQADKERTQSARQELTDFKNQIEDIEKKNKEDEIIRKMEKLREKQERK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
KNKKDKAKTESSQLSMPKEQPITVGSTVKIKGQSSVGEVLGINGKNAIVMFGMIKTNVKL
HCHHHHHHCCHHHCCCCCCCCEECCCEEEECCCCCCCHHEECCCCCEEEEEEEHCCCCCH
DKLERSTPIQPTQKTMVKSTFVSSETQDRVYEKKLNFKQDIDVRGMRGDEAIQAVTYFID
HHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
DAILLGIDRVRILHGTGTGILRTLIRSYLGSVPGVAHYQDEHVQFGGAGITVVDLK
HHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCEEEEECC
>Mature Secondary Structure
MIYPQNFEQKIGFDSIRHLLKEKCLSTLGQERVDEMNFSESFKDINEWLEQVMEFMRIIQ
CCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
EEDSFPDQYFFDVRPSLKRIRVEGMYLDEQELFDLRRSLETIRDIIHFLTLTSNDEEQEK
HCCCCCCCEEECCCCCHHHEEECCEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
ENSPYPALQKLAGDIIVFPQLITRINNILDKFGKIKDNASSELLRIRRELASTAGSISRS
CCCCCHHHHHHCCCEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
LNAILRNAQAEGYVDKDVTPTMRDGRLVIPVAPGLKRKIKGIVHDESSTGKTVFIEPAEV
HHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHEECCCCCCCEEEECCHHH
VEANNRIRELEGEERREIIRILTDFSIIIRPQVPAILQSYEFLAEIDFIRAKAHFSIQTN
HHHHHHHHHCCCHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHEEEEEEEC
ATKPSLEDKQILDWTMAIHPLLQLSLAKHNKKVVPLDIELTKNQRILIISGPNAGGKSVC
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCEEEEEECCCCCCHHHH
LKTVGLLQYMLQCGMPVPMHERSHAGLFGSIFIDIGDEQSIEDDLSTYSSHLTNMKTMMK
HHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
SCNERSLILIDEFGGGTEPQIGGAIAEAVLKRFNEKGTFGVITTHYQNLKHFAEDHEGVV
CCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHCHHH
NGAMLYDRHLMQALFQLQIGNPGSSFAVEIARKIGLPEEVIADASEIVGSEYINADKYLQ
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHH
DIVRDKRYWETKRQNIRKREKQMEETIAKYEEELQELEKSRKEILRKAKEDAEKLIQESN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ARIENTIRIIKEAQADKERTQSARQELTDFKNQIEDIEKKNKEDEIIRKMEKLREKQERK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
KNKKDKAKTESSQLSMPKEQPITVGSTVKIKGQSSVGEVLGINGKNAIVMFGMIKTNVKL
HCHHHHHHCCHHHCCCCCCCCEECCCEEEECCCCCCCHHEECCCCCEEEEEEEHCCCCCH
DKLERSTPIQPTQKTMVKSTFVSSETQDRVYEKKLNFKQDIDVRGMRGDEAIQAVTYFID
HHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
DAILLGIDRVRILHGTGTGILRTLIRSYLGSVPGVAHYQDEHVQFGGAGITVVDLK
HHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA