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The map label for this gene is nadC [H]

Identifier: 150004912

GI number: 150004912

Start: 3053131

End: 3053982

Strand: Direct

Name: nadC [H]

Synonym: BVU_2375

Alternate gene names: 150004912

Gene position: 3053131-3053982 (Clockwise)

Preceding gene: 150004910

Following gene: 150004913

Centisome position: 59.13

GC content: 42.84

Gene sequence:

>852_bases
ATGGACGAATTAGTAGTAAAAGACTTAATAGACAGACTGATAGACCTGTCTTTTGCTGAAGATATAGGTGATGGGGATCA
TACTACCTTGTCATGTATTCCCGCAGATGCAATGGGAAAATCAAAGTTGTTGATTAAGGAAGAAGGTATTTTAGCAGGCA
TTGAAGTGGCTAAAGAAGTATTTCGCCGTTTTGATCCCACAATGAAGGTGGAGGTGTTCATTCAAGATGGAACTCACGTG
AAACCGGGTGATGTGGCTATGGTGGTGGAAGGTAAAGTTCAGTCACTTCTTCAGACAGAACGCTTGATGCTGAATATCAT
GCAACGCATGAGTGGCATTGCTACTATGACCAATAAATATGTGAAGAAACTGGAAGGTACGAAAACTCGTGTACTTGATA
CCCGTAAGACAACTCCGGGTATGCGTATCATGGAGAAGATGGCTGTAAAGATAGGAGGAGGATGCAATCACCGTATCGGT
TTGTTTGATATGATTCTGCTGAAAGACAACCATGTAGATTTCGCAGGCGGCATACACAATGCGGTGTCCCGTGCCAAAGA
ATATTGTAAGGCAAAGGGTAAGAACTTGAAGATTGAATTGGAAGTGCGTAACTTTGACGAATTGAATCAGGCGTTGGCAG
AAGGTGTGGATCGTATTATGTTTGATAACTTTACACCTGAAGATACTCGTAAGGCTGTAGAGATAGTAGGAGGTCGTTGC
GAAACCGAGTCTTCCGGTGGTATTACTTACGATACTATGTTGCCTTATGCGCAGGCAGGAGTGGATTTCATTTCTTTTGG
TGCGCTGACCCATTCTGTAAAAGGATTGGATATGAGCTTCAAGGCCTGTTAA

Upstream 100 bases:

>100_bases
ACTAATAATGTAAATTTCATACGTTCTTTTCTGGTTTACTTTGCAAAAATACGGAAAATCTCTACCTTTGCCTATCAATT
CATAAAAAAACGATAACATT

Downstream 100 bases:

>100_bases
GGAAATGTTTTATGATAAGAGAGAATTCTAAATTTTGGACTTCTTTTTGAAATGTGAATGACGCAAGTGGTACGAATAAA
ATTAAAATGAATTCGCACAT

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: General stress protein 70; GSP70; Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MDELVVKDLIDRLIDLSFAEDIGDGDHTTLSCIPADAMGKSKLLIKEEGILAGIEVAKEVFRRFDPTMKVEVFIQDGTHV
KPGDVAMVVEGKVQSLLQTERLMLNIMQRMSGIATMTNKYVKKLEGTKTRVLDTRKTTPGMRIMEKMAVKIGGGCNHRIG
LFDMILLKDNHVDFAGGIHNAVSRAKEYCKAKGKNLKIELEVRNFDELNQALAEGVDRIMFDNFTPEDTRKAVEIVGGRC
ETESSGGITYDTMLPYAQAGVDFISFGALTHSVKGLDMSFKAC

Sequences:

>Translated_283_residues
MDELVVKDLIDRLIDLSFAEDIGDGDHTTLSCIPADAMGKSKLLIKEEGILAGIEVAKEVFRRFDPTMKVEVFIQDGTHV
KPGDVAMVVEGKVQSLLQTERLMLNIMQRMSGIATMTNKYVKKLEGTKTRVLDTRKTTPGMRIMEKMAVKIGGGCNHRIG
LFDMILLKDNHVDFAGGIHNAVSRAKEYCKAKGKNLKIELEVRNFDELNQALAEGVDRIMFDNFTPEDTRKAVEIVGGRC
ETESSGGITYDTMLPYAQAGVDFISFGALTHSVKGLDMSFKAC
>Mature_283_residues
MDELVVKDLIDRLIDLSFAEDIGDGDHTTLSCIPADAMGKSKLLIKEEGILAGIEVAKEVFRRFDPTMKVEVFIQDGTHV
KPGDVAMVVEGKVQSLLQTERLMLNIMQRMSGIATMTNKYVKKLEGTKTRVLDTRKTTPGMRIMEKMAVKIGGGCNHRIG
LFDMILLKDNHVDFAGGIHNAVSRAKEYCKAKGKNLKIELEVRNFDELNQALAEGVDRIMFDNFTPEDTRKAVEIVGGRC
ETESSGGITYDTMLPYAQAGVDFISFGALTHSVKGLDMSFKAC

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=274, Percent_Identity=32.8467153284672, Blast_Score=141, Evalue=6e-34,
Organism=Escherichia coli, GI1786299, Length=270, Percent_Identity=35.9259259259259, Blast_Score=163, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6321162, Length=258, Percent_Identity=32.5581395348837, Blast_Score=138, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31271; Mature: 31271

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDELVVKDLIDRLIDLSFAEDIGDGDHTTLSCIPADAMGKSKLLIKEEGILAGIEVAKEV
CCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEECCCCCHHHHHHHHH
FRRFDPTMKVEVFIQDGTHVKPGDVAMVVEGKVQSLLQTERLMLNIMQRMSGIATMTNKY
HHHCCCCEEEEEEEECCCEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKKLEGTKTRVLDTRKTTPGMRIMEKMAVKIGGGCNHRIGLFDMILLKDNHVDFAGGIHN
HHHHCCCHHEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCHHCHHHH
AVSRAKEYCKAKGKNLKIELEVRNFDELNQALAEGVDRIMFDNFTPEDTRKAVEIVGGRC
HHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
ETESSGGITYDTMLPYAQAGVDFISFGALTHSVKGLDMSFKAC
CCCCCCCEEEHHHCCHHHHCCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MDELVVKDLIDRLIDLSFAEDIGDGDHTTLSCIPADAMGKSKLLIKEEGILAGIEVAKEV
CCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEECCCCCHHHHHHHHH
FRRFDPTMKVEVFIQDGTHVKPGDVAMVVEGKVQSLLQTERLMLNIMQRMSGIATMTNKY
HHHCCCCEEEEEEEECCCEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKKLEGTKTRVLDTRKTTPGMRIMEKMAVKIGGGCNHRIGLFDMILLKDNHVDFAGGIHN
HHHHCCCHHEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCHHCHHHH
AVSRAKEYCKAKGKNLKIELEVRNFDELNQALAEGVDRIMFDNFTPEDTRKAVEIVGGRC
HHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
ETESSGGITYDTMLPYAQAGVDFISFGALTHSVKGLDMSFKAC
CCCCCCCEEEHHHCCHHHHCCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 8444804; 9298659 [H]