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The map label for this gene is capA [H]

Identifier: 150004755

GI number: 150004755

Start: 2863199

End: 2864272

Strand: Direct

Name: capA [H]

Synonym: BVU_2216

Alternate gene names: 150004755

Gene position: 2863199-2864272 (Clockwise)

Preceding gene: 150004754

Following gene: 150004756

Centisome position: 55.45

GC content: 38.27

Gene sequence:

>1074_bases
ATGAAACAGATCTTCATTCTTTTTTTGCTATGGTTTGGTTTGTCGCTATCGGCGCAAGATCAGATCTCTTTGTTGTTTGT
CGGTGATTTGATGCAACATCAGGCTCAAATTGATGCAGCCAGGCAAGGAGACGGGTATAATTATAATGATTGCTTCCGTC
ATGTGAAGAAAGAAATAAGTGAGGCGGATATGGCTATAGGGAACTTAGAGGTGACATTGGGAGGAAAGCCTTATAGAGGG
TATCCGGCGTTCAGTGCTCCGGATGAATATCTTCATGCTATAAAGGAAGCCGGATTTGATGTATTGCTGACCGCTAACAA
TCATTGTCTGGATAAGGGGAAGTTGGGGTTGGAACGTACTATTCTGATGTTGGATTCTTTGAAAATACATCATGCTGGAA
CCTATAGGAACCCGGAAGAACGTCATAAGAACTACCCGTTATTGATTGAGAAGAATGGTTTTAGAATTGTATTGTTGAAC
TATACTTATGGAACGAATGGCTTGAAGACTGATGCTCCGAATGTGGTGAATTATATTAATCGGGAACAAATAAAAAAAGA
TATTCTTGATGCACGCAGAAAACTTCCTGATGTTATTATAGCCTGTATGCATTGGGGAGTGGAATATTGTTCGTTCCCTG
AACGATCGGAGTGTGAATTGGCTAACTGGTTGATTGAACAAGGAGTTGATCATGTAATAGGTTCGCATCCGCATGTACTC
CAGCCTATGGAAATTGTAAAAGACCCCCGGACTCCTGCCCGGCATGTCATTGTTTATTCATTAGGTAATTTTATCTCAAA
TATGTCGAAAGAAAAAACGGATGGAGGAGCTATGGTAAGATTGAAGTTGCAACGGATTTTTCGAATAACCCGTTTAGCGG
ATTGTGAATATGCATTGGTTTGGACTTCAAGACCTGTTTTAAGTAAAAAAAAGAACTTTGAATTATATCCTGTTACTTTT
ATTAATAAATCCATTAATAATGAGGAACTTAATGTGATGAAACGTTTCTTGAAAGGAACTGAAAATTTATTAGGAAAATC
GAATGGAGGCATAAAAGAGTATTTTTTTGAATAA

Upstream 100 bases:

>100_bases
TTGCTCCTACGGAATTCAAGCGTATGAAAACTGTAAATTAGTGTAGAACTTTGTTCTTTACGAATTTTTTCCTATCTTGT
ACCCTTTAATGTTAGAATAG

Downstream 100 bases:

>100_bases
TTTTTCCTCAAAAAGTTTGCAGATATAAAAAAAAGCAGTACCTTTGCATCGCTTTCGAAAGGAAAGCCTAACATGGTGAC
TATAGTTCAGTCGGTTAGAG

Product: capsule biosynthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MKQIFILFLLWFGLSLSAQDQISLLFVGDLMQHQAQIDAARQGDGYNYNDCFRHVKKEISEADMAIGNLEVTLGGKPYRG
YPAFSAPDEYLHAIKEAGFDVLLTANNHCLDKGKLGLERTILMLDSLKIHHAGTYRNPEERHKNYPLLIEKNGFRIVLLN
YTYGTNGLKTDAPNVVNYINREQIKKDILDARRKLPDVIIACMHWGVEYCSFPERSECELANWLIEQGVDHVIGSHPHVL
QPMEIVKDPRTPARHVIVYSLGNFISNMSKEKTDGGAMVRLKLQRIFRITRLADCEYALVWTSRPVLSKKKNFELYPVTF
INKSINNEELNVMKRFLKGTENLLGKSNGGIKEYFFE

Sequences:

>Translated_357_residues
MKQIFILFLLWFGLSLSAQDQISLLFVGDLMQHQAQIDAARQGDGYNYNDCFRHVKKEISEADMAIGNLEVTLGGKPYRG
YPAFSAPDEYLHAIKEAGFDVLLTANNHCLDKGKLGLERTILMLDSLKIHHAGTYRNPEERHKNYPLLIEKNGFRIVLLN
YTYGTNGLKTDAPNVVNYINREQIKKDILDARRKLPDVIIACMHWGVEYCSFPERSECELANWLIEQGVDHVIGSHPHVL
QPMEIVKDPRTPARHVIVYSLGNFISNMSKEKTDGGAMVRLKLQRIFRITRLADCEYALVWTSRPVLSKKKNFELYPVTF
INKSINNEELNVMKRFLKGTENLLGKSNGGIKEYFFE
>Mature_357_residues
MKQIFILFLLWFGLSLSAQDQISLLFVGDLMQHQAQIDAARQGDGYNYNDCFRHVKKEISEADMAIGNLEVTLGGKPYRG
YPAFSAPDEYLHAIKEAGFDVLLTANNHCLDKGKLGLERTILMLDSLKIHHAGTYRNPEERHKNYPLLIEKNGFRIVLLN
YTYGTNGLKTDAPNVVNYINREQIKKDILDARRKLPDVIIACMHWGVEYCSFPERSECELANWLIEQGVDHVIGSHPHVL
QPMEIVKDPRTPARHVIVYSLGNFISNMSKEKTDGGAMVRLKLQRIFRITRLADCEYALVWTSRPVLSKKKNFELYPVTF
INKSINNEELNVMKRFLKGTENLLGKSNGGIKEYFFE

Specific function: Essential for the synthesis of the polyglutamate capsule of B.anthracis which is one of the principal virulence factors during anthrax infection. May form a polyglutamyl synthetase complex together with proteins CapB and CapC [H]

COG id: COG2843

COG function: function code M; Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation)

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CapA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019079 [H]

Pfam domain/function: PF09587 PGA_cap [H]

EC number: NA

Molecular weight: Translated: 40882; Mature: 40882

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQIFILFLLWFGLSLSAQDQISLLFVGDLMQHQAQIDAARQGDGYNYNDCFRHVKKEIS
CHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
EADMAIGNLEVTLGGKPYRGYPAFSAPDEYLHAIKEAGFDVLLTANNHCLDKGKLGLERT
HHHHEECCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHH
ILMLDSLKIHHAGTYRNPEERHKNYPLLIEKNGFRIVLLNYTYGTNGLKTDAPNVVNYIN
HHHHHCEEEECCCCCCCHHHHCCCCCEEEECCCCEEEEEEEEECCCCCCCCCCHHHHHHH
REQIKKDILDARRKLPDVIIACMHWGVEYCSFPERSECELANWLIEQGVDHVIGSHPHVL
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHCHHHHHCCCCCCC
QPMEIVKDPRTPARHVIVYSLGNFISNMSKEKTDGGAMVRLKLQRIFRITRLADCEYALV
CCHHHHCCCCCCHHHEEHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCCCEEEE
WTSRPVLSKKKNFELYPVTFINKSINNEELNVMKRFLKGTENLLGKSNGGIKEYFFE
ECCCCHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCC
>Mature Secondary Structure
MKQIFILFLLWFGLSLSAQDQISLLFVGDLMQHQAQIDAARQGDGYNYNDCFRHVKKEIS
CHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
EADMAIGNLEVTLGGKPYRGYPAFSAPDEYLHAIKEAGFDVLLTANNHCLDKGKLGLERT
HHHHEECCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHH
ILMLDSLKIHHAGTYRNPEERHKNYPLLIEKNGFRIVLLNYTYGTNGLKTDAPNVVNYIN
HHHHHCEEEECCCCCCCHHHHCCCCCEEEECCCCEEEEEEEEECCCCCCCCCCHHHHHHH
REQIKKDILDARRKLPDVIIACMHWGVEYCSFPERSECELANWLIEQGVDHVIGSHPHVL
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHCHHHHHCCCCCCC
QPMEIVKDPRTPARHVIVYSLGNFISNMSKEKTDGGAMVRLKLQRIFRITRLADCEYALV
CCHHHHCCCCCCHHHEEHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCCCEEEE
WTSRPVLSKKKNFELYPVTFINKSINNEELNVMKRFLKGTENLLGKSNGGIKEYFFE
ECCCCHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2536679; 10475962; 12004073 [H]