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The map label for this gene is cirA [H]

Identifier: 150004732

GI number: 150004732

Start: 2827181

End: 2829337

Strand: Direct

Name: cirA [H]

Synonym: BVU_2193

Alternate gene names: 150004732

Gene position: 2827181-2829337 (Clockwise)

Preceding gene: 150004731

Following gene: 150004733

Centisome position: 54.76

GC content: 39.5

Gene sequence:

>2157_bases
ATGCATAGACTACTCAGAAACGTGTGCTTGATACTGTGTTGGCTGATGGCGGTATCAGTATCAGCACAACGAATTATTTC
GGGAACTGTATTTGATGAAAATAAAGAACCTCTGACGGGAGCAACAGTTTCCGTAAAAGAAAAAGTAACTTTGGGAACCA
CTACGGATACACAGGGAAAATACATGTTGAAATTACCCGATAATAGAGAATATACTCTACAGGTTTCATACATGGGGTAT
ATCTCGCAGACTCATAAAGTGTCTGTCAGTAAAACAGGTAAAGTTGATTTTATACTGAAAGAAGATGCTGTAAATATGGA
AACTGTAGTTGTAACGGGAACCCGTACTCCGAAACTCCTGAAAGATGTTCCCATTGTAACTCGTGTCATTACTGCCGATG
AAATAAAAAAAGTAGATGCTACCCATATTGGAGATTTACTTCAGGCAGAACTGCCGGGAATTGAATTCTCTTATTCCATG
GACCAGCAAGTTTCTCTCAATATGCAAGGATTTGGTGGAAATGCTGTACTTTTTCTGGTTGATGGTGAGCGTCTGGCAGG
TGAGACTTTGGATAATATAGACTACAACCGATTGAATATGAGCAATGTGGAGCGTATTGAAATTGTAAAAGGTGCGGCTT
CTTCACTCTATGGTTCGAATGCGGTAGGAGGAGTGGTAAACATCATAAGTAAAGTGCCTGCGGAGCCTTGGACTGTGAAT
CTCAATGGACGTTACGGGGCTTATAATGAGCAGCGTTATGGAGGAACAATAGGTTTCAATGTTGGAAAATTCAATAGTGT
GACTAATGTACAGCATACCCAAGTAGATGAAAAAGATTTGGCAGATGGAAAAACAAATGAGGAAACGGAGGATTGGGCAT
TTAAAAAGGTGTATGGTGATAAAACTTGGAATTTCAAAGAACGTTTGGTCTATACTGCTAATGACCATCTGAAACTGACG
GCACGTGCCGGATATTTTTTTCGTGAACGTGAGAAGTCACAGACTAGTAAAGACCGTTATCGAGACTTCAGTGGTGGGGT
GAAAGGAAATTATGTATTGGATAAAGATAAGGATCTGGAAATAGCTTATTCTTTCGACCAGTATGATAAGAGCGACTACT
TGCCGCAAGACGCTAATGATGTACGTGATTATAGTAATGTACAACATTCGGTTCATACTTTTTATAATCATACTTTTGTC
GGTAAGCATATTCTCACCGTGGGTGGTGATTATATGCGTGATTATTTAATGTCCTATCAGTTTGCCAATAATGGAAGTAA
ACATCAGTATACAGTGGACGGCTTTGCACAGTTTGACTGGAACCCGACGAAATATTTCAATGTCATCACAGGATTACGTT
TTGATTATTATTCAGATTCCGATATTAATCATTTCTCTCCCAAATTAGGACTGATGTATAAAATAGGAAACTGTTCATTG
AGAGGTTCCTATGCCGGTGGTTTCCGAGCTCCTACTTTGAAAGAAATGTATATGAATTTTGATATGGCAAGTATTTTTAT
GATTTATGGTAATCCTGACTTGAAGCCTGAAACCAGCCATAATTTTTCTCTTTCGGCAGAATATATGAAAGGTCGTTATA
ATTTGACGGTGACAGGTTTCTATAATGTAGTTGATAATCGTATCACTACGGCGTGGAGTGAGGCGTTGAAAGGGCAGGTA
TATACCAATATATCAAATATCAGGATATCCGGTGCCGAGGCAAATGCTTCCGTCAAATATCCTTGTGGACTGTCGGCACG
TTTATCTTACGCCTATACACACGAGAATATAAAGAAAGGGCAACCTGTCATTTCAAGTACTCGCCCGCATACGGCTACTG
TCCGTCTTGAGTATGACAAGCATTGGAAGAACTATGCGTTTAATGTTGCTTTGAACGGACGCTTTCTGTCCAAGGTGAAT
ACGGAGGAATATACTTCGAACACTTCTTATGAAGAAACTGAGAAGGTGACTTATCCGGCGTATACAATGTGGAAGCTTAC
GTTGTCTCAGAAAGTATGGAAAGGTGTTGATATGACTTTGGCGGTAGACAACCTGTTTAATTATGTCCCTTTCCGTTATT
ATAATAATTCGCCTGCTACTAAAGGAACAACTTTTTCAGCCGGTTTGTCATTGGATATAGAACAATTGTTCAAATGA

Upstream 100 bases:

>100_bases
GCGGCTGTTCGTCTCACAAATTATATGAATGCTAGTGGTGTAAAAGGCTTCATGACTATTGATTATATTTATCCGTTTGA
ATTGTAAACCGACATACGAT

Downstream 100 bases:

>100_bases
AATTTGGCTGCTAATACTAAATAAACTATGTGATTTAAATAAAGATATGAAGAAGAAACAATTATTGATTGGCGGAGGGA
TAGCAGTCATCTTGCTGCTT

Product: TonB-dependent receptor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 718; Mature: 718

Protein sequence:

>718_residues
MHRLLRNVCLILCWLMAVSVSAQRIISGTVFDENKEPLTGATVSVKEKVTLGTTTDTQGKYMLKLPDNREYTLQVSYMGY
ISQTHKVSVSKTGKVDFILKEDAVNMETVVVTGTRTPKLLKDVPIVTRVITADEIKKVDATHIGDLLQAELPGIEFSYSM
DQQVSLNMQGFGGNAVLFLVDGERLAGETLDNIDYNRLNMSNVERIEIVKGAASSLYGSNAVGGVVNIISKVPAEPWTVN
LNGRYGAYNEQRYGGTIGFNVGKFNSVTNVQHTQVDEKDLADGKTNEETEDWAFKKVYGDKTWNFKERLVYTANDHLKLT
ARAGYFFREREKSQTSKDRYRDFSGGVKGNYVLDKDKDLEIAYSFDQYDKSDYLPQDANDVRDYSNVQHSVHTFYNHTFV
GKHILTVGGDYMRDYLMSYQFANNGSKHQYTVDGFAQFDWNPTKYFNVITGLRFDYYSDSDINHFSPKLGLMYKIGNCSL
RGSYAGGFRAPTLKEMYMNFDMASIFMIYGNPDLKPETSHNFSLSAEYMKGRYNLTVTGFYNVVDNRITTAWSEALKGQV
YTNISNIRISGAEANASVKYPCGLSARLSYAYTHENIKKGQPVISSTRPHTATVRLEYDKHWKNYAFNVALNGRFLSKVN
TEEYTSNTSYEETEKVTYPAYTMWKLTLSQKVWKGVDMTLAVDNLFNYVPFRYYNNSPATKGTTFSAGLSLDIEQLFK

Sequences:

>Translated_718_residues
MHRLLRNVCLILCWLMAVSVSAQRIISGTVFDENKEPLTGATVSVKEKVTLGTTTDTQGKYMLKLPDNREYTLQVSYMGY
ISQTHKVSVSKTGKVDFILKEDAVNMETVVVTGTRTPKLLKDVPIVTRVITADEIKKVDATHIGDLLQAELPGIEFSYSM
DQQVSLNMQGFGGNAVLFLVDGERLAGETLDNIDYNRLNMSNVERIEIVKGAASSLYGSNAVGGVVNIISKVPAEPWTVN
LNGRYGAYNEQRYGGTIGFNVGKFNSVTNVQHTQVDEKDLADGKTNEETEDWAFKKVYGDKTWNFKERLVYTANDHLKLT
ARAGYFFREREKSQTSKDRYRDFSGGVKGNYVLDKDKDLEIAYSFDQYDKSDYLPQDANDVRDYSNVQHSVHTFYNHTFV
GKHILTVGGDYMRDYLMSYQFANNGSKHQYTVDGFAQFDWNPTKYFNVITGLRFDYYSDSDINHFSPKLGLMYKIGNCSL
RGSYAGGFRAPTLKEMYMNFDMASIFMIYGNPDLKPETSHNFSLSAEYMKGRYNLTVTGFYNVVDNRITTAWSEALKGQV
YTNISNIRISGAEANASVKYPCGLSARLSYAYTHENIKKGQPVISSTRPHTATVRLEYDKHWKNYAFNVALNGRFLSKVN
TEEYTSNTSYEETEKVTYPAYTMWKLTLSQKVWKGVDMTLAVDNLFNYVPFRYYNNSPATKGTTFSAGLSLDIEQLFK
>Mature_718_residues
MHRLLRNVCLILCWLMAVSVSAQRIISGTVFDENKEPLTGATVSVKEKVTLGTTTDTQGKYMLKLPDNREYTLQVSYMGY
ISQTHKVSVSKTGKVDFILKEDAVNMETVVVTGTRTPKLLKDVPIVTRVITADEIKKVDATHIGDLLQAELPGIEFSYSM
DQQVSLNMQGFGGNAVLFLVDGERLAGETLDNIDYNRLNMSNVERIEIVKGAASSLYGSNAVGGVVNIISKVPAEPWTVN
LNGRYGAYNEQRYGGTIGFNVGKFNSVTNVQHTQVDEKDLADGKTNEETEDWAFKKVYGDKTWNFKERLVYTANDHLKLT
ARAGYFFREREKSQTSKDRYRDFSGGVKGNYVLDKDKDLEIAYSFDQYDKSDYLPQDANDVRDYSNVQHSVHTFYNHTFV
GKHILTVGGDYMRDYLMSYQFANNGSKHQYTVDGFAQFDWNPTKYFNVITGLRFDYYSDSDINHFSPKLGLMYKIGNCSL
RGSYAGGFRAPTLKEMYMNFDMASIFMIYGNPDLKPETSHNFSLSAEYMKGRYNLTVTGFYNVVDNRITTAWSEALKGQV
YTNISNIRISGAEANASVKYPCGLSARLSYAYTHENIKKGQPVISSTRPHTATVRLEYDKHWKNYAFNVALNGRFLSKVN
TEEYTSNTSYEETEKVTYPAYTMWKLTLSQKVWKGVDMTLAVDNLFNYVPFRYYNNSPATKGTTFSAGLSLDIEQLFK

Specific function: Not yet known. Postulated to participate in iron transport. Outer membrane receptor for colicins IA and IB [H]

COG id: COG4771

COG function: function code P; Outer membrane receptor for ferrienterochelin and colicins

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1788478, Length=628, Percent_Identity=24.8407643312102, Blast_Score=150, Evalue=4e-37,
Organism=Escherichia coli, GI1790405, Length=627, Percent_Identity=23.444976076555, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1786798, Length=670, Percent_Identity=22.8358208955224, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR010917 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 81333; Mature: 81333

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRLLRNVCLILCWLMAVSVSAQRIISGTVFDENKEPLTGATVSVKEKVTLGTTTDTQGK
CHHHHHHHHHHHHHHHHHHHCHHHHEEEEEECCCCCCCCCCEEEEEEEEEECCCCCCCCE
YMLKLPDNREYTLQVSYMGYISQTHKVSVSKTGKVDFILKEDAVNMETVVVTGTRTPKLL
EEEECCCCCCEEEEEEEEEEECCCEEEEEECCCCEEEEEECCCCCEEEEEEECCCCCHHH
KDVPIVTRVITADEIKKVDATHIGDLLQAELPGIEFSYSMDQQVSLNMQGFGGNAVLFLV
HCCCHHHEEECHHHHHHCCHHHHHHHHHHHCCCEEEEECCCCEEEEEEECCCCCEEEEEE
DGERLAGETLDNIDYNRLNMSNVERIEIVKGAASSLYGSNAVGGVVNIISKVPAEPWTVN
CCCHHCCCCCCCCCCCCCCCCCCCEEEEECCCHHHCCCCCCHHHHHHHHHHCCCCCEEEE
LNGRYGAYNEQRYGGTIGFNVGKFNSVTNVQHTQVDEKDLADGKTNEETEDWAFKKVYGD
ECCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHEEEHHCCC
KTWNFKERLVYTANDHLKLTARAGYFFREREKSQTSKDRYRDFSGGVKGNYVLDKDKDLE
CCCCCCCEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCEE
IAYSFDQYDKSDYLPQDANDVRDYSNVQHSVHTFYNHTFVGKHILTVGGDYMRDYLMSYQ
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEECCCEEEECCHHHHHHHHHHHH
FANNGSKHQYTVDGFAQFDWNPTKYFNVITGLRFDYYSDSDINHFSPKLGLMYKIGNCSL
CCCCCCCEEEEECCEEEECCCHHHHHHHHHCEEEEECCCCCCCCCCCCCEEEEEECCEEE
RGSYAGGFRAPTLKEMYMNFDMASIFMIYGNPDLKPETSHNFSLSAEYMKGRYNLTVTGF
ECCCCCCCCCCCHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEEEEHHHCCEEEEEEEEE
YNVVDNRITTAWSEALKGQVYTNISNIRISGAEANASVKYPCGLSARLSYAYTHENIKKG
EEHHCCHHHHHHHHHHCCEEEEEEEEEEEECCCCCCEEECCCCCCCEEEEEEECCCHHCC
QPVISSTRPHTATVRLEYDKHWKNYAFNVALNGRFLSKVNTEEYTSNTSYEETEKVTYPA
CCCCCCCCCCEEEEEEEECCCCCCEEEEEEECCEEEECCCCHHHCCCCCCCCCCCEECCC
YTMWKLTLSQKVWKGVDMTLAVDNLFNYVPFRYYNNSPATKGTTFSAGLSLDIEQLFK
EEEEEEEHHHHHHCCCCEEEEHHHHHCCCCEEEECCCCCCCCCEEECCCEECHHHHCC
>Mature Secondary Structure
MHRLLRNVCLILCWLMAVSVSAQRIISGTVFDENKEPLTGATVSVKEKVTLGTTTDTQGK
CHHHHHHHHHHHHHHHHHHHCHHHHEEEEEECCCCCCCCCCEEEEEEEEEECCCCCCCCE
YMLKLPDNREYTLQVSYMGYISQTHKVSVSKTGKVDFILKEDAVNMETVVVTGTRTPKLL
EEEECCCCCCEEEEEEEEEEECCCEEEEEECCCCEEEEEECCCCCEEEEEEECCCCCHHH
KDVPIVTRVITADEIKKVDATHIGDLLQAELPGIEFSYSMDQQVSLNMQGFGGNAVLFLV
HCCCHHHEEECHHHHHHCCHHHHHHHHHHHCCCEEEEECCCCEEEEEEECCCCCEEEEEE
DGERLAGETLDNIDYNRLNMSNVERIEIVKGAASSLYGSNAVGGVVNIISKVPAEPWTVN
CCCHHCCCCCCCCCCCCCCCCCCCEEEEECCCHHHCCCCCCHHHHHHHHHHCCCCCEEEE
LNGRYGAYNEQRYGGTIGFNVGKFNSVTNVQHTQVDEKDLADGKTNEETEDWAFKKVYGD
ECCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHEEEHHCCC
KTWNFKERLVYTANDHLKLTARAGYFFREREKSQTSKDRYRDFSGGVKGNYVLDKDKDLE
CCCCCCCEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCEE
IAYSFDQYDKSDYLPQDANDVRDYSNVQHSVHTFYNHTFVGKHILTVGGDYMRDYLMSYQ
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEECCCEEEECCHHHHHHHHHHHH
FANNGSKHQYTVDGFAQFDWNPTKYFNVITGLRFDYYSDSDINHFSPKLGLMYKIGNCSL
CCCCCCCEEEEECCEEEECCCHHHHHHHHHCEEEEECCCCCCCCCCCCCEEEEEECCEEE
RGSYAGGFRAPTLKEMYMNFDMASIFMIYGNPDLKPETSHNFSLSAEYMKGRYNLTVTGF
ECCCCCCCCCCCHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEEEEHHHCCEEEEEEEEE
YNVVDNRITTAWSEALKGQVYTNISNIRISGAEANASVKYPCGLSARLSYAYTHENIKKG
EEHHCCHHHHHHHHHHCCEEEEEEEEEEEECCCCCCEEECCCCCCCEEEEEEECCCHHCC
QPVISSTRPHTATVRLEYDKHWKNYAFNVALNGRFLSKVNTEEYTSNTSYEETEKVTYPA
CCCCCCCCCCEEEEEEEECCCCCCEEEEEEECCEEEECCCCHHHCCCCCCCCCCCEECCC
YTMWKLTLSQKVWKGVDMTLAVDNLFNYVPFRYYNNSPATKGTTFSAGLSLDIEQLFK
EEEEEEEHHHHHHCCCCEEEEHHHHHCCCCEEEECCCCCCCCCEEECCCEECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2644220; 9278503; 3316180; 1315732; 2160948 [H]