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The map label for this gene is ltrA [H]

Identifier: 150004670

GI number: 150004670

Start: 2745951

End: 2747606

Strand: Direct

Name: ltrA [H]

Synonym: BVU_2131

Alternate gene names: 150004670

Gene position: 2745951-2747606 (Clockwise)

Preceding gene: 150004668

Following gene: 150004671

Centisome position: 53.18

GC content: 42.63

Gene sequence:

>1656_bases
ATGAACGCAAAGAAATTGGCGTGTGCGCCCGAAGACATAGACATTCACGAACTCTGGTCGAAAATCGACTGGGACAAATG
TGAGCGTTTTGTCCAAAAGCTGCAAGCACGTATTGTAAAGGCTCAAAGGGAAGGCAGAAATAACAAGGTGAAAGCCCTGC
AATGGATGCTTACCCACTCGTTCTACGCCAAAGCATTGGCGGTAAAACGAGTTACGACTAACAAAGGAAAATCTACTTCC
GGCGTTGACAAGATTACATGGTCTTCTCCATTGGCGAAAGCCAAAGCCATATTCACTCTGAAAAGACATGGCTACAAGCC
ACAACCTTTAAAACGTGTAAATATCAAAAAGAAGAACGGGAAATTACGCCCACTCGGAATACCAACGATGAAAGACCGTG
CGATGCAGGCATTGTACCTAATGGCACTTGACCCGATAGCGGAAACCACTGGCGACAGCCATTCCTACGGATTCCGCAGA
CATCGCTGTACACATGATGCCATCGAGCAATGCTACATCGTTCTTTCTCGTTCGGTCGCTCCCGAATGGATTCTTGAGGG
GGACATCAAAGGATGCTTCGACCATATCAGCCATGCGTGGTTAATCAACAATATCCCTATGGATAAGGAGATACTACGCA
AATGGCTCGAATGCGGATATGTGTTCAATGGAGAACTCTTTCCTACGGAAGAGGGAACCCCACAAGGTGGCATAATATCC
CCAACTCTTGCAAACATGGCACTTGACGGACTGCAAGATTTGTTGGAAAAGAGTGTCAAGAAATATCAGGTGAACTACAA
AAAGATAGTTCCTAAGATACATCTTGTACGATATGCAGATGATTTCATTGTAACGGCAAAGGATAAGGAAACGATAGAAC
AGGTTATACTTCCATTAGTACGTAAGTTCCTTGCGGAAAGAGGTCTGACACTATCAGAAGAAAAGACAAAAATCACACAT
ATAAATGAGGGATTTGACTTTCTCGGTTTCAATATCCGAAAGTTCCGCAATAATACGCTGCTGACAACTCCATCCAAAGA
TGCGCAAAAGAGGTTTTGCGAAAAAATCCGCAAGACGATAGAAGCCAACAAGTGTGTAAAACAGAAGTCACTTATTATGA
TGCTGAATCCAATCATAAAAGGTTGGGGTAATTATTATAAATATGGTACTTCTGCGAATGTATTCCACCGAATGGATTGG
GAAATCTTCAAGAAAATATGGCAATGGGCAAGACGCAGACATCCGCAGAAATGTAAAGGATGGGTAAAGGATAAGTATTT
CAGAACACTAAATGGGCACTCGTGGAGATTTGCGGCAGATATGGGCAAGAAAGATAAGATTGATTATCTCGAACTGACCT
ATCTACCAACCATCCACCATGAGAAATTCGTCAAGGTTCGGCATTATGCCAATCCGTATGACCCATCAGATAAATCGTAC
TACGAATGGAGAGAAACCTACCGAATGAAGCAAACGCTGAAAGGCAGGCAATCTCTAATAAACATTTGGAAACGACAGAA
TAAAGTATGTCCTGTATGTGGAGAGCGTATTGACAGGGAAAGACCTTGGAGTATCACTGAACAAATAGTCAGTGGACGAA
AGGTAAGAACTCTTGTACATACCAGTTGTAAACGTAAAATGCAAAGTAGATTATGA

Upstream 100 bases:

>100_bases
TTGGTAAAGGTAACATCATCCGACACGAAAGTGGGCAGACTTCCGCCTATGGTGACACTTTACAAGATAGTTTACAGAAC
TTTTAAAGAAAGGAAAGCAA

Downstream 100 bases:

>100_bases
ATATGAAAGTCGAAAATGAGATGGCTCTACCGATAACAAAGTCGGTAACGGTCATGTTGCTTGAGCCGTATGCGGGGAAA
CTCGCACGTACGGTTCTTAG

Product: putative reverse transcriptase

Products: NA

Alternate protein names: Reverse-transcriptase; RNA maturase; DNA endonuclease [H]

Number of amino acids: Translated: 551; Mature: 551

Protein sequence:

>551_residues
MNAKKLACAPEDIDIHELWSKIDWDKCERFVQKLQARIVKAQREGRNNKVKALQWMLTHSFYAKALAVKRVTTNKGKSTS
GVDKITWSSPLAKAKAIFTLKRHGYKPQPLKRVNIKKKNGKLRPLGIPTMKDRAMQALYLMALDPIAETTGDSHSYGFRR
HRCTHDAIEQCYIVLSRSVAPEWILEGDIKGCFDHISHAWLINNIPMDKEILRKWLECGYVFNGELFPTEEGTPQGGIIS
PTLANMALDGLQDLLEKSVKKYQVNYKKIVPKIHLVRYADDFIVTAKDKETIEQVILPLVRKFLAERGLTLSEEKTKITH
INEGFDFLGFNIRKFRNNTLLTTPSKDAQKRFCEKIRKTIEANKCVKQKSLIMMLNPIIKGWGNYYKYGTSANVFHRMDW
EIFKKIWQWARRRHPQKCKGWVKDKYFRTLNGHSWRFAADMGKKDKIDYLELTYLPTIHHEKFVKVRHYANPYDPSDKSY
YEWRETYRMKQTLKGRQSLINIWKRQNKVCPVCGERIDRERPWSITEQIVSGRKVRTLVHTSCKRKMQSRL

Sequences:

>Translated_551_residues
MNAKKLACAPEDIDIHELWSKIDWDKCERFVQKLQARIVKAQREGRNNKVKALQWMLTHSFYAKALAVKRVTTNKGKSTS
GVDKITWSSPLAKAKAIFTLKRHGYKPQPLKRVNIKKKNGKLRPLGIPTMKDRAMQALYLMALDPIAETTGDSHSYGFRR
HRCTHDAIEQCYIVLSRSVAPEWILEGDIKGCFDHISHAWLINNIPMDKEILRKWLECGYVFNGELFPTEEGTPQGGIIS
PTLANMALDGLQDLLEKSVKKYQVNYKKIVPKIHLVRYADDFIVTAKDKETIEQVILPLVRKFLAERGLTLSEEKTKITH
INEGFDFLGFNIRKFRNNTLLTTPSKDAQKRFCEKIRKTIEANKCVKQKSLIMMLNPIIKGWGNYYKYGTSANVFHRMDW
EIFKKIWQWARRRHPQKCKGWVKDKYFRTLNGHSWRFAADMGKKDKIDYLELTYLPTIHHEKFVKVRHYANPYDPSDKSY
YEWRETYRMKQTLKGRQSLINIWKRQNKVCPVCGERIDRERPWSITEQIVSGRKVRTLVHTSCKRKMQSRL
>Mature_551_residues
MNAKKLACAPEDIDIHELWSKIDWDKCERFVQKLQARIVKAQREGRNNKVKALQWMLTHSFYAKALAVKRVTTNKGKSTS
GVDKITWSSPLAKAKAIFTLKRHGYKPQPLKRVNIKKKNGKLRPLGIPTMKDRAMQALYLMALDPIAETTGDSHSYGFRR
HRCTHDAIEQCYIVLSRSVAPEWILEGDIKGCFDHISHAWLINNIPMDKEILRKWLECGYVFNGELFPTEEGTPQGGIIS
PTLANMALDGLQDLLEKSVKKYQVNYKKIVPKIHLVRYADDFIVTAKDKETIEQVILPLVRKFLAERGLTLSEEKTKITH
INEGFDFLGFNIRKFRNNTLLTTPSKDAQKRFCEKIRKTIEANKCVKQKSLIMMLNPIIKGWGNYYKYGTSANVFHRMDW
EIFKKIWQWARRRHPQKCKGWVKDKYFRTLNGHSWRFAADMGKKDKIDYLELTYLPTIHHEKFVKVRHYANPYDPSDKSY
YEWRETYRMKQTLKGRQSLINIWKRQNKVCPVCGERIDRERPWSITEQIVSGRKVRTLVHTSCKRKMQSRL

Specific function: Multifunctional protein that promotes group II intron splicing and mobility by acting both on RNA and DNA. It has three activities:reverse transcriptase (RT) for intron duplication, maturase to promote splicing, and DNA endonuclease for site- specific cle

COG id: COG3344

COG function: function code L; Retron-type reverse transcriptase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 reverse transcriptase domain [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6226520, Length=317, Percent_Identity=28.7066246056782, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6226521, Length=323, Percent_Identity=27.5541795665635, Blast_Score=104, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003615
- InterPro:   IPR002866
- InterPro:   IPR000477 [H]

Pfam domain/function: PF01348 Intron_maturas2; PF00078 RVT_1 [H]

EC number: =2.7.7.49 [H]

Molecular weight: Translated: 64595; Mature: 64595

Theoretical pI: Translated: 10.46; Mature: 10.46

Prosite motif: PS50878 RT_POL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAKKLACAPEDIDIHELWSKIDWDKCERFVQKLQARIVKAQREGRNNKVKALQWMLTHS
CCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
FYAKALAVKRVTTNKGKSTSGVDKITWSSPLAKAKAIFTLKRHGYKPQPLKRVNIKKKNG
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEECCCC
KLRPLGIPTMKDRAMQALYLMALDPIAETTGDSHSYGFRRHRCTHDAIEQCYIVLSRSVA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCHHHHHHHHHHHHHCCC
PEWILEGDIKGCFDHISHAWLINNIPMDKEILRKWLECGYVFNGELFPTEEGTPQGGIIS
CCCEECCCHHHHHHHHHHHHEECCCCCCHHHHHHHHHCCEEECCEEECCCCCCCCCCCCC
PTLANMALDGLQDLLEKSVKKYQVNYKKIVPKIHLVRYADDFIVTAKDKETIEQVILPLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEECCCEEEECCCHHHHHHHHHHHH
RKFLAERGLTLSEEKTKITHINEGFDFLGFNIRKFRNNTLLTTPSKDAQKRFCEKIRKTI
HHHHHHCCCCCCCCCCEEEEECCCCHHHCCCHHHHCCCEEEECCCHHHHHHHHHHHHHHH
EANKCVKQKSLIMMLNPIIKGWGNYYKYGTSANVFHRMDWEIFKKIWQWARRRHPQKCKG
HHHHHHHHHHHHHHHHHHHHHCHHHEECCCCCCHHHHCCHHHHHHHHHHHHHCCCHHHHH
WVKDKYFRTLNGHSWRFAADMGKKDKIDYLELTYLPTIHHEKFVKVRHYANPYDPSDKSY
HHHHHHHHHCCCCCEEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCHH
YEWRETYRMKQTLKGRQSLINIWKRQNKVCPVCGERIDRERPWSITEQIVSGRKVRTLVH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCHHHHHHHCCCHHHHHHH
TSCKRKMQSRL
HHHHHHHHHCC
>Mature Secondary Structure
MNAKKLACAPEDIDIHELWSKIDWDKCERFVQKLQARIVKAQREGRNNKVKALQWMLTHS
CCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
FYAKALAVKRVTTNKGKSTSGVDKITWSSPLAKAKAIFTLKRHGYKPQPLKRVNIKKKNG
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEECCCC
KLRPLGIPTMKDRAMQALYLMALDPIAETTGDSHSYGFRRHRCTHDAIEQCYIVLSRSVA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCHHHHHHHHHHHHHCCC
PEWILEGDIKGCFDHISHAWLINNIPMDKEILRKWLECGYVFNGELFPTEEGTPQGGIIS
CCCEECCCHHHHHHHHHHHHEECCCCCCHHHHHHHHHCCEEECCEEECCCCCCCCCCCCC
PTLANMALDGLQDLLEKSVKKYQVNYKKIVPKIHLVRYADDFIVTAKDKETIEQVILPLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEECCCEEEECCCHHHHHHHHHHHH
RKFLAERGLTLSEEKTKITHINEGFDFLGFNIRKFRNNTLLTTPSKDAQKRFCEKIRKTI
HHHHHHCCCCCCCCCCEEEEECCCCHHHCCCHHHHCCCEEEECCCHHHHHHHHHHHHHHH
EANKCVKQKSLIMMLNPIIKGWGNYYKYGTSANVFHRMDWEIFKKIWQWARRRHPQKCKG
HHHHHHHHHHHHHHHHHHHHHCHHHEECCCCCCHHHHCCHHHHHHHHHHHHHCCCHHHHH
WVKDKYFRTLNGHSWRFAADMGKKDKIDYLELTYLPTIHHEKFVKVRHYANPYDPSDKSY
HHHHHHHHHCCCCCEEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCHH
YEWRETYRMKQTLKGRQSLINIWKRQNKVCPVCGERIDRERPWSITEQIVSGRKVRTLVH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCHHHHHHHCCCHHHHHHH
TSCKRKMQSRL
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655550; 11157264; 10488339; 9353259; 10413481; 11731786 [H]