Click here to switch to the map view.

The map label for this gene is msrA [H]

Identifier: 150004555

GI number: 150004555

Start: 2600935

End: 2601420

Strand: Reverse

Name: msrA [H]

Synonym: BVU_2010

Alternate gene names: 150004555

Gene position: 2601420-2600935 (Counterclockwise)

Preceding gene: 150004557

Following gene: 150004546

Centisome position: 50.38

GC content: 43.0

Gene sequence:

>486_bases
ATGAAAGTAGAAAAAGCGATATTCGCCGCCGGATGCTTCTGGGGCGTACAACATCAGTTCGAACGTATTCCGGGTGTACT
AAACACTACAGTCGGTTATACAGGTGGTCCGGAAGCCAACCCCACATATACTCAGGTAAAAGCCCACATGACCCACCATG
TAGAAGCTATTTTTGTAGATTATGACGCCGACATGGTTTCTTATGTGGATTTGTGCAAACTTTTTTTTGAAATACATGAT
CCTTCACAAACCGATGGAATAGGTCCCGACCTCGGACCGCAATATCGGAGTATGATTTTCTACATGGATGAAAAACAAAA
ATCCGAAGCTGAAGAGGTCATCGAACTGCTTCGCTCGAAAGGTCATAGAGTCAATACCAAATTACGCCCTGCCGAGAAAT
TTTGGGAAGCAGAAGACTATCATCAGCACTATTACGATAAAACGGGAGGAGAACCTTACTGTCATATACGCGTAAAAAAA
TTCTAA

Upstream 100 bases:

>100_bases
ACGATATTCCTTTAGTTTAATTAAAAAAAGCATAAGGTAGGTTTCTCGTTTTAAAGGGTATTCCGTATATTTGGCATACA
ATTTTAAAAGAATAAAGAAC

Downstream 100 bases:

>100_bases
ATTAAACAACAGAGGTGTGTTCAAATAATGGCACACCTCTGTTATTCATAATTATCCGGAACCTTTCATCATTTCATCAA
TGCGTCCAGATACATATAAA

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 161; Mature: 161

Protein sequence:

>161_residues
MKVEKAIFAAGCFWGVQHQFERIPGVLNTTVGYTGGPEANPTYTQVKAHMTHHVEAIFVDYDADMVSYVDLCKLFFEIHD
PSQTDGIGPDLGPQYRSMIFYMDEKQKSEAEEVIELLRSKGHRVNTKLRPAEKFWEAEDYHQHYYDKTGGEPYCHIRVKK
F

Sequences:

>Translated_161_residues
MKVEKAIFAAGCFWGVQHQFERIPGVLNTTVGYTGGPEANPTYTQVKAHMTHHVEAIFVDYDADMVSYVDLCKLFFEIHD
PSQTDGIGPDLGPQYRSMIFYMDEKQKSEAEEVIELLRSKGHRVNTKLRPAEKFWEAEDYHQHYYDKTGGEPYCHIRVKK
F
>Mature_161_residues
MKVEKAIFAAGCFWGVQHQFERIPGVLNTTVGYTGGPEANPTYTQVKAHMTHHVEAIFVDYDADMVSYVDLCKLFFEIHD
PSQTDGIGPDLGPQYRSMIFYMDEKQKSEAEEVIELLRSKGHRVNTKLRPAEKFWEAEDYHQHYYDKTGGEPYCHIRVKK
F

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI208609995, Length=151, Percent_Identity=39.0728476821192, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI6912516, Length=151, Percent_Identity=39.0728476821192, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI208609993, Length=103, Percent_Identity=37.8640776699029, Blast_Score=64, Evalue=5e-11,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=41.4473684210526, Blast_Score=115, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17533973, Length=143, Percent_Identity=34.965034965035, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320881, Length=150, Percent_Identity=32.6666666666667, Blast_Score=93, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24664627, Length=141, Percent_Identity=37.5886524822695, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45553131, Length=136, Percent_Identity=37.5, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24664631, Length=141, Percent_Identity=36.1702127659575, Blast_Score=86, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 18624; Mature: 18624

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVEKAIFAAGCFWGVQHQFERIPGVLNTTVGYTGGPEANPTYTQVKAHMTHHVEAIFVD
CCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHCEEEEEEE
YDADMVSYVDLCKLFFEIHDPSQTDGIGPDLGPQYRSMIFYMDEKQKSEAEEVIELLRSK
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHEEEEECCCCHHHHHHHHHHHHHC
GHRVNTKLRPAEKFWEAEDYHQHYYDKTGGEPYCHIRVKKF
CCCCCCCCCCHHHHCCHHHHHHHHHCCCCCCCEEEEEEECC
>Mature Secondary Structure
MKVEKAIFAAGCFWGVQHQFERIPGVLNTTVGYTGGPEANPTYTQVKAHMTHHVEAIFVD
CCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHCEEEEEEE
YDADMVSYVDLCKLFFEIHDPSQTDGIGPDLGPQYRSMIFYMDEKQKSEAEEVIELLRSK
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHEEEEECCCCHHHHHHHHHHHHHC
GHRVNTKLRPAEKFWEAEDYHQHYYDKTGGEPYCHIRVKKF
CCCCCCCCCCHHHHCCHHHHHHHHHCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA