Click here to switch to the map view.

The map label for this gene is ispH

Identifier: 150004487

GI number: 150004487

Start: 2518188

End: 2519054

Strand: Reverse

Name: ispH

Synonym: BVU_1936

Alternate gene names: 150004487

Gene position: 2519054-2518188 (Counterclockwise)

Preceding gene: 150004488

Following gene: 150004486

Centisome position: 48.79

GC content: 44.87

Gene sequence:

>867_bases
ATGGTTAACATAGAGATAGACGAAGGATCTGGGTTCTGCTTCGGAGTCACCACAGCTATCCGTAAAGCAGAAGAAGAACT
GGCAAAAGGAAACACTCTTTATTGTCTGGGAGACATTGTACACAACGGACAGGAATGTGAACGCCTAAAAAAAATGGGGC
TTATCACAATAAACCACGAAGAGTTTGCCCAATTACACGATGCCAAAGTACTGTTGCGCGCACATGGAGAACCTCCTGAA
ACATACGCTATAGCCCGTACCAACAACATCGAGATCATTGACGCCACCTGTCCGGTAGTATTACGCCTCCAAAAGCGCAT
CAAACAGGAGTATGACAATGTTCCGGCAAGTCAAGACACACAAATCGTGATTTATGGCAAGAACGGTCATGCCGAAGTAC
TGGGGCTGGTAGGTCAAACTCATGGAAAAGCAATTGTCATAGAAACACCTGCTGAAGCTGCTCATCTGGACTTCACCAAA
GACATACGCTTGTACTCCCAGACAACCAAGTCTTTGGAAGAATTCTGGCAAATCATAGAATATATCAAGGAGCATATCTC
ACCCGATGCCACTTTTGAATATTACGACACAATCTGCCGGCAAGTGGCCAACCGGATGCCTAACATCCGCAAATTTGCAG
CAGCGCATGATCTGATCTTTTTTGTCTGCGGACGAAAAAGCTCAAACGGAAAGATCTTATATCAAGAATGCAAAAAGATC
AATCCGAATTCATACCTCATTGACCAGCCGGAAGAAATAGACCGGAACTTGCTCGAGGACGTCCGTTCCATCGGCATTTG
TGGAGCGACTTCCACCCCCAAATGGTTGATGGAAGAATGTAAAAAAGCAATCTTAAACGAAAAATAG

Upstream 100 bases:

>100_bases
CCGTTACGGCAAGCGGATGACGCTATCTTGTTGGACAACAGCCACATGAGCATTGCCGAACAGAAAAAGTGGCTGACCGA
AAAATTTCAAGCAGCGATAA

Downstream 100 bases:

>100_bases
ACCAATAAAAAATAGAAAATTATCGTTGTCCAACTGATAATTTGTTAACTTTGCGACATAAAAATATTAAAATGGGTATT
TATGGGAACGATTAAAAGTA

Product: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MVNIEIDEGSGFCFGVTTAIRKAEEELAKGNTLYCLGDIVHNGQECERLKKMGLITINHEEFAQLHDAKVLLRAHGEPPE
TYAIARTNNIEIIDATCPVVLRLQKRIKQEYDNVPASQDTQIVIYGKNGHAEVLGLVGQTHGKAIVIETPAEAAHLDFTK
DIRLYSQTTKSLEEFWQIIEYIKEHISPDATFEYYDTICRQVANRMPNIRKFAAAHDLIFFVCGRKSSNGKILYQECKKI
NPNSYLIDQPEEIDRNLLEDVRSIGICGATSTPKWLMEECKKAILNEK

Sequences:

>Translated_288_residues
MVNIEIDEGSGFCFGVTTAIRKAEEELAKGNTLYCLGDIVHNGQECERLKKMGLITINHEEFAQLHDAKVLLRAHGEPPE
TYAIARTNNIEIIDATCPVVLRLQKRIKQEYDNVPASQDTQIVIYGKNGHAEVLGLVGQTHGKAIVIETPAEAAHLDFTK
DIRLYSQTTKSLEEFWQIIEYIKEHISPDATFEYYDTICRQVANRMPNIRKFAAAHDLIFFVCGRKSSNGKILYQECKKI
NPNSYLIDQPEEIDRNLLEDVRSIGICGATSTPKWLMEECKKAILNEK
>Mature_288_residues
MVNIEIDEGSGFCFGVTTAIRKAEEELAKGNTLYCLGDIVHNGQECERLKKMGLITINHEEFAQLHDAKVLLRAHGEPPE
TYAIARTNNIEIIDATCPVVLRLQKRIKQEYDNVPASQDTQIVIYGKNGHAEVLGLVGQTHGKAIVIETPAEAAHLDFTK
DIRLYSQTTKSLEEFWQIIEYIKEHISPDATFEYYDTICRQVANRMPNIRKFAAAHDLIFFVCGRKSSNGKILYQECKKI
NPNSYLIDQPEEIDRNLLEDVRSIGICGATSTPKWLMEECKKAILNEK

Specific function: Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP)

COG id: COG0761

COG function: function code IM; Penicillin tolerance protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispH family

Homologues:

Organism=Escherichia coli, GI1786212, Length=275, Percent_Identity=26.1818181818182, Blast_Score=109, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPH_BACV8 (A6L1P5)

Other databases:

- EMBL:   CP000139
- RefSeq:   YP_001299231.1
- STRING:   A6L1P5
- GeneID:   5302902
- GenomeReviews:   CP000139_GR
- KEGG:   bvu:BVU_1936
- NMPDR:   fig|435590.6.peg.1820
- eggNOG:   COG0761
- HOGENOM:   HBG335228
- OMA:   AAIHFKR
- ProtClustDB:   PRK01045
- HAMAP:   MF_00191
- InterPro:   IPR003451
- TIGRFAMs:   TIGR00216

Pfam domain/function: PF02401 LYTB

EC number: =1.17.1.2

Molecular weight: Translated: 32599; Mature: 32599

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNIEIDEGSGFCFGVTTAIRKAEEELAKGNTLYCLGDIVHNGQECERLKKMGLITINHE
CEEEEEECCCCEEEHHHHHHHHHHHHHHCCCEEEEEHHHHHCCHHHHHHHHCCEEEECHH
EFAQLHDAKVLLRAHGEPPETYAIARTNNIEIIDATCPVVLRLQKRIKQEYDNVPASQDT
HHHHHHHHHHEEEECCCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCC
QIVIYGKNGHAEVLGLVGQTHGKAIVIETPAEAAHLDFTKDIRLYSQTTKSLEEFWQIIE
EEEEECCCCCCHHHEEHCCCCCCEEEEECCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHH
YIKEHISPDATFEYYDTICRQVANRMPNIRKFAAAHDLIFFVCGRKSSNGKILYQECKKI
HHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHEEEEEECCCCCCCCEEEHHHCCC
NPNSYLIDQPEEIDRNLLEDVRSIGICGATSTPKWLMEECKKAILNEK
CCCCEECCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVNIEIDEGSGFCFGVTTAIRKAEEELAKGNTLYCLGDIVHNGQECERLKKMGLITINHE
CEEEEEECCCCEEEHHHHHHHHHHHHHHCCCEEEEEHHHHHCCHHHHHHHHCCEEEECHH
EFAQLHDAKVLLRAHGEPPETYAIARTNNIEIIDATCPVVLRLQKRIKQEYDNVPASQDT
HHHHHHHHHHEEEECCCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCC
QIVIYGKNGHAEVLGLVGQTHGKAIVIETPAEAAHLDFTKDIRLYSQTTKSLEEFWQIIE
EEEEECCCCCCHHHEEHCCCCCCEEEEECCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHH
YIKEHISPDATFEYYDTICRQVANRMPNIRKFAAAHDLIFFVCGRKSSNGKILYQECKKI
HHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHEEEEEECCCCCCCCEEEHHHCCC
NPNSYLIDQPEEIDRNLLEDVRSIGICGATSTPKWLMEECKKAILNEK
CCCCEECCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA