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The map label for this gene is pepD [H]

Identifier: 150004478

GI number: 150004478

Start: 2504955

End: 2506415

Strand: Direct

Name: pepD [H]

Synonym: BVU_1927

Alternate gene names: 150004478

Gene position: 2504955-2506415 (Clockwise)

Preceding gene: 150004477

Following gene: 150004480

Centisome position: 48.52

GC content: 47.02

Gene sequence:

>1461_bases
ATGAGTACAATTCTCTCTCTCGCTCCGCAGAATGTGTGGAAGCATTTCTATTCATTGACTCAGGTTCCCCGCCCTTCGGG
TTACTTGAAGAAAGTGCAAGAGTTCTTGCTGAACTTTGGAAAAAGTGTAGGCGTAGAGTCATTCCAGGACGAAGCCGGTA
ATATCATTTACCGTAAGCCTGCCACTCCGGGGATGGAAAACCGTAAGAAGGTGATTCTTCAGGCTCACATGGACATGGTT
CCTCAGAAGAATAACGATACAGTGCATGATTTTGAAAATGATCCTATCGAGACTTACATTGACGGAGATTGGGTGAAAGC
TAAAGGCACGACTTTGGGAGCCGATGATGGCATGGGTGTTGCCGCTATCATGGCTATCATGGAAGACAAGACGCTGAAAC
ATGGTCCGTTGGAAGCACTGATTACTGCCGACGAAGAAACCGGTATGTTCGGTGCGTTCGGTTTGAAGCCGGGAACGGTA
GACGGTGATATTCTGTTGAATCTGGATTCGGAAGAAGAAGGAGAATTGTATATCGGTTGTGCAGGCGGTGAAGACCTGAC
AGCAGTGTTGGAATATAAAGAAGTGGAAACAGATCCGGCTGACATTGCTTTGAAAGTTACCTTGAAAGGGCTGCGCGGTG
GTCATTCAGGATTGGAAATAAATGAAGGACGTGCCAATGCCAACAAGCTGATGGCTCGTTTCATGAACCAGGTGATAACT
TACGATGAGGCTTGCCTGGTGTCCTGGCAAGGTGGCAATATGCGTAATGCCATTCCTCGTGAATGTGAAGTGGTCATTAC
GGTTCCGGCTGAAGAAGAAGCGGACGTACTGGAATTTGTGCAGGAGTGCGAAGCATTGTGGAATGAAGAATATCATGTAC
ACGAAACACCGATCAGCTTCAAGGCAGAACGGGTGGAATTGCCTGCGATGATGGTTCCCGATGAAATTAAAGATAATCTG
GTGGATGCCATTTATGCTTGTCAGAATGGAGTGATGCGTATGATTCCTACTATCCCCGATACCGTGGAAACCTCTTCCAA
TCTGGCTATCGTTTCTATAGGTGGTGGCAAGGCGGAGATAAAAATCCTGGCCCGCAGTTCACGCGATTCAATGAAGGATT
ATCTGAATACTGCATTGGAAAGCTGTTTCTCTATGGCAGGTATGGAAGTAACCCGTTCAGGTGGTTATTCAGGCTGGGAA
CCCAATGTGGATTCTCCTATTCTGAAAGCCATGAAGGAGTCTTATAAGGCACAATTCGGTACGGAACCTGCTGTGAAAGT
GATTCATGCCGGCTTGGAATGCGGTATCATCGGTGCGGTGGTTCCGGGATTGGATATGATTTCTTTCGGTCCTACCTTGC
GTTCTCCTCACTCACCGGATGAACGCTGCTTTATTCCTTCTGTAGGCAAGTTCTATGATTTCGTAGTAGCTACGTTGGAA
AATACGCCGGTAAAAGAATAG

Upstream 100 bases:

>100_bases
TTTTTGCCTTATTAGTGCATGGAATACAAACTTTTTTATTAATTTTGTTGGGTATATATGGATTAGCGGCTTTGCCGTTC
ACAAATAAAACTAAGAAGTT

Downstream 100 bases:

>100_bases
TCTTTAATATCTTATAAAGATTTCGGGCGCGGATGATAGGGATTTCGTCCGCGCCTTTCTATTAATACTCCACTTTGTCA
CTTTTCTCTGTCCATTGTTG

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MSTILSLAPQNVWKHFYSLTQVPRPSGYLKKVQEFLLNFGKSVGVESFQDEAGNIIYRKPATPGMENRKKVILQAHMDMV
PQKNNDTVHDFENDPIETYIDGDWVKAKGTTLGADDGMGVAAIMAIMEDKTLKHGPLEALITADEETGMFGAFGLKPGTV
DGDILLNLDSEEEGELYIGCAGGEDLTAVLEYKEVETDPADIALKVTLKGLRGGHSGLEINEGRANANKLMARFMNQVIT
YDEACLVSWQGGNMRNAIPRECEVVITVPAEEEADVLEFVQECEALWNEEYHVHETPISFKAERVELPAMMVPDEIKDNL
VDAIYACQNGVMRMIPTIPDTVETSSNLAIVSIGGGKAEIKILARSSRDSMKDYLNTALESCFSMAGMEVTRSGGYSGWE
PNVDSPILKAMKESYKAQFGTEPAVKVIHAGLECGIIGAVVPGLDMISFGPTLRSPHSPDERCFIPSVGKFYDFVVATLE
NTPVKE

Sequences:

>Translated_486_residues
MSTILSLAPQNVWKHFYSLTQVPRPSGYLKKVQEFLLNFGKSVGVESFQDEAGNIIYRKPATPGMENRKKVILQAHMDMV
PQKNNDTVHDFENDPIETYIDGDWVKAKGTTLGADDGMGVAAIMAIMEDKTLKHGPLEALITADEETGMFGAFGLKPGTV
DGDILLNLDSEEEGELYIGCAGGEDLTAVLEYKEVETDPADIALKVTLKGLRGGHSGLEINEGRANANKLMARFMNQVIT
YDEACLVSWQGGNMRNAIPRECEVVITVPAEEEADVLEFVQECEALWNEEYHVHETPISFKAERVELPAMMVPDEIKDNL
VDAIYACQNGVMRMIPTIPDTVETSSNLAIVSIGGGKAEIKILARSSRDSMKDYLNTALESCFSMAGMEVTRSGGYSGWE
PNVDSPILKAMKESYKAQFGTEPAVKVIHAGLECGIIGAVVPGLDMISFGPTLRSPHSPDERCFIPSVGKFYDFVVATLE
NTPVKE
>Mature_485_residues
STILSLAPQNVWKHFYSLTQVPRPSGYLKKVQEFLLNFGKSVGVESFQDEAGNIIYRKPATPGMENRKKVILQAHMDMVP
QKNNDTVHDFENDPIETYIDGDWVKAKGTTLGADDGMGVAAIMAIMEDKTLKHGPLEALITADEETGMFGAFGLKPGTVD
GDILLNLDSEEEGELYIGCAGGEDLTAVLEYKEVETDPADIALKVTLKGLRGGHSGLEINEGRANANKLMARFMNQVITY
DEACLVSWQGGNMRNAIPRECEVVITVPAEEEADVLEFVQECEALWNEEYHVHETPISFKAERVELPAMMVPDEIKDNLV
DAIYACQNGVMRMIPTIPDTVETSSNLAIVSIGGGKAEIKILARSSRDSMKDYLNTALESCFSMAGMEVTRSGGYSGWEP
NVDSPILKAMKESYKAQFGTEPAVKVIHAGLECGIIGAVVPGLDMISFGPTLRSPHSPDERCFIPSVGKFYDFVVATLEN
TPVKE

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=487, Percent_Identity=44.1478439425051, Blast_Score=421, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 53171; Mature: 53040

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTILSLAPQNVWKHFYSLTQVPRPSGYLKKVQEFLLNFGKSVGVESFQDEAGNIIYRKP
CCCHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEECC
ATPGMENRKKVILQAHMDMVPQKNNDTVHDFENDPIETYIDGDWVKAKGTTLGADDGMGV
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCEEEECCCEECCCCCCHH
AAIMAIMEDKTLKHGPLEALITADEETGMFGAFGLKPGTVDGDILLNLDSEEEGELYIGC
HHHHHHHHCCCCCCCCCEEEEECCCCCCCEEEECCCCCCCCCEEEEEECCCCCCCEEEEE
AGGEDLTAVLEYKEVETDPADIALKVTLKGLRGGHSGLEINEGRANANKLMARFMNQVIT
CCCCCEEEHEEHHHCCCCCCCEEEEEEEEECCCCCCCCEECCCCCCHHHHHHHHHHHHHC
YDEACLVSWQGGNMRNAIPRECEVVITVPAEEEADVLEFVQECEALWNEEYHVHETPISF
CCCEEEEEECCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCC
KAERVELPAMMVPDEIKDNLVDAIYACQNGVMRMIPTIPDTVETSSNLAIVSIGGGKAEI
CHHHCCCCCEECCHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCEEEEEECCCCEEE
KILARSSRDSMKDYLNTALESCFSMAGMEVTRSGGYSGWEPNVDSPILKAMKESYKAQFG
EEEECCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCC
TEPAVKVIHAGLECGIIGAVVPGLDMISFGPTLRSPHSPDERCFIPSVGKFYDFVVATLE
CCHHHHHHHCCCCCCCHHHHHCCCCCEECCCCCCCCCCCCCEEECCCHHHHHHHHHHHHC
NTPVKE
CCCCCC
>Mature Secondary Structure 
STILSLAPQNVWKHFYSLTQVPRPSGYLKKVQEFLLNFGKSVGVESFQDEAGNIIYRKP
CCHHHHCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEECC
ATPGMENRKKVILQAHMDMVPQKNNDTVHDFENDPIETYIDGDWVKAKGTTLGADDGMGV
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCEEEECCCEECCCCCCHH
AAIMAIMEDKTLKHGPLEALITADEETGMFGAFGLKPGTVDGDILLNLDSEEEGELYIGC
HHHHHHHHCCCCCCCCCEEEEECCCCCCCEEEECCCCCCCCCEEEEEECCCCCCCEEEEE
AGGEDLTAVLEYKEVETDPADIALKVTLKGLRGGHSGLEINEGRANANKLMARFMNQVIT
CCCCCEEEHEEHHHCCCCCCCEEEEEEEEECCCCCCCCEECCCCCCHHHHHHHHHHHHHC
YDEACLVSWQGGNMRNAIPRECEVVITVPAEEEADVLEFVQECEALWNEEYHVHETPISF
CCCEEEEEECCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCC
KAERVELPAMMVPDEIKDNLVDAIYACQNGVMRMIPTIPDTVETSSNLAIVSIGGGKAEI
CHHHCCCCCEECCHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCEEEEEECCCCEEE
KILARSSRDSMKDYLNTALESCFSMAGMEVTRSGGYSGWEPNVDSPILKAMKESYKAQFG
EEEECCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCC
TEPAVKVIHAGLECGIIGAVVPGLDMISFGPTLRSPHSPDERCFIPSVGKFYDFVVATLE
CCHHHHHHHCCCCCCCHHHHHCCCCCEECCCCCCCCCCCCCEEECCCHHHHHHHHHHHHC
NTPVKE
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]