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The map label for this gene is lpxB [H]

Identifier: 150004469

GI number: 150004469

Start: 2493721

End: 2494860

Strand: Direct

Name: lpxB [H]

Synonym: BVU_1917

Alternate gene names: 150004469

Gene position: 2493721-2494860 (Clockwise)

Preceding gene: 150004468

Following gene: 150004470

Centisome position: 48.3

GC content: 44.3

Gene sequence:

>1140_bases
ATGAAATACTATTTGATAGTAGGCGAGGCATCAGGCGATTTGCACGCATCTAATTTGATGCGTGCCTTGATACAGGAAGA
TCCGGAAGCAGAATTCCGTTTCTTTGGCGGGGACTTGATGACGGCTGTTGGTGGAACGCGGGTGAAACATTACAAAGAAC
TGGCTTATATGGGTTTTATCCCGGTGTTGTTGCATTTGCGTACTATCTTTCGGAATATGAAAGAATGTAAGCAGGACATT
GTTCGTTGGACTCCTGATGTAGTGATTCTGGTGGATTATCCCGGCTTTAACCTGAAAATAGCCGAGTTTATAAAGAAGCA
GACGAAAATACCTGTCTACTATTATATTTCTCCTAAAATATGGGCTTGGAAAGAGTATAGGATTAAAAATATCAAGCGGG
ATGTGGACGAACTGTTTTCCATCCTGCCTTTTGAGGTTGAGTTTTTTGCCGGACATCAGTACCCTGTTCATTATGTGGGT
AATCCTTGTGTAGATGCAGTGGATGCTTATTGTAAGGAACATCCGGATGGATTTCCGGAATTTGTGGCGGATAATGGCTT
GTCCGAAAAGCCTGTTATCGCATTGTTGGCGGGCAGCCGGAAACAGGAAATCAAAGACAACCTGCCGATGATGCTGGAGG
CTGCTGCTCCGTTTACCAAAGATTATCAATTGGTGCTGGCAGGGGCTCCGGGGATGGACCCTGCCTATTATTCGGATTAT
ATAAATCCGAATGTACCGGTTAAAATCATTTTCGGACAGACCTACAGGTTGTTGCAGCACGCGCAGGCGGCATTGGTGAC
TTCGGGTACTGCAACTTTGGAAACAGCTCTTTTCCGTGTTCCTCAAGTGGTGTGTTACTATACTCCGGTAGGGAAATTTA
TCGCTTTTCTTCGCCGGCATATTCTAAAAGTGAAATATATTTCGTTGGTTAATCTGGTAGCCGACAAGGAAGTGGTTCGT
GAACTGGTGGCGGATACGATGACGGTGGATAACGTGCGTTCAGAGTTAGAATCTCTTTTATATAATAAGGTATACAGAAA
TAAGGTGTTGGAAGAGTATGATCGTATTATTCAGATTTTAGGTCCGGCAGGAGCTTCGGGGACAGCAGCCCGTGAAATGG
TAGCTTTGTTGAAGAAATAA

Upstream 100 bases:

>100_bases
ACTGGGCATTAGGGCATGGGTATGTGGCGGTAACTCCGACCCAAATTGATGTGACTGCTTATGGGATGATGAATGAGTTG
AAAAACTGGAATCTGGAAGT

Downstream 100 bases:

>100_bases
ACTTTTCACGATCTCTTTTTGTTCTTTCGGGTAAACAACTTAAACCTTGGAAGTATATGAAATATTTTTTTCAATCTATG
TTAGGGGCGATGCTTCTTTT

Product: glycosyltransferase family lipid-alpha-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MKYYLIVGEASGDLHASNLMRALIQEDPEAEFRFFGGDLMTAVGGTRVKHYKELAYMGFIPVLLHLRTIFRNMKECKQDI
VRWTPDVVILVDYPGFNLKIAEFIKKQTKIPVYYYISPKIWAWKEYRIKNIKRDVDELFSILPFEVEFFAGHQYPVHYVG
NPCVDAVDAYCKEHPDGFPEFVADNGLSEKPVIALLAGSRKQEIKDNLPMMLEAAAPFTKDYQLVLAGAPGMDPAYYSDY
INPNVPVKIIFGQTYRLLQHAQAALVTSGTATLETALFRVPQVVCYYTPVGKFIAFLRRHILKVKYISLVNLVADKEVVR
ELVADTMTVDNVRSELESLLYNKVYRNKVLEEYDRIIQILGPAGASGTAAREMVALLKK

Sequences:

>Translated_379_residues
MKYYLIVGEASGDLHASNLMRALIQEDPEAEFRFFGGDLMTAVGGTRVKHYKELAYMGFIPVLLHLRTIFRNMKECKQDI
VRWTPDVVILVDYPGFNLKIAEFIKKQTKIPVYYYISPKIWAWKEYRIKNIKRDVDELFSILPFEVEFFAGHQYPVHYVG
NPCVDAVDAYCKEHPDGFPEFVADNGLSEKPVIALLAGSRKQEIKDNLPMMLEAAAPFTKDYQLVLAGAPGMDPAYYSDY
INPNVPVKIIFGQTYRLLQHAQAALVTSGTATLETALFRVPQVVCYYTPVGKFIAFLRRHILKVKYISLVNLVADKEVVR
ELVADTMTVDNVRSELESLLYNKVYRNKVLEEYDRIIQILGPAGASGTAAREMVALLKK
>Mature_379_residues
MKYYLIVGEASGDLHASNLMRALIQEDPEAEFRFFGGDLMTAVGGTRVKHYKELAYMGFIPVLLHLRTIFRNMKECKQDI
VRWTPDVVILVDYPGFNLKIAEFIKKQTKIPVYYYISPKIWAWKEYRIKNIKRDVDELFSILPFEVEFFAGHQYPVHYVG
NPCVDAVDAYCKEHPDGFPEFVADNGLSEKPVIALLAGSRKQEIKDNLPMMLEAAAPFTKDYQLVLAGAPGMDPAYYSDY
INPNVPVKIIFGQTYRLLQHAQAALVTSGTATLETALFRVPQVVCYYTPVGKFIAFLRRHILKVKYISLVNLVADKEVVR
ELVADTMTVDNVRSELESLLYNKVYRNKVLEEYDRIIQILGPAGASGTAAREMVALLKK

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=338, Percent_Identity=31.0650887573964, Blast_Score=149, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 43096; Mature: 43096

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYYLIVGEASGDLHASNLMRALIQEDPEAEFRFFGGDLMTAVGGTRVKHYKELAYMGFI
CEEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEECCHHHHHHCCHHHHHHHHHHHHHHH
PVLLHLRTIFRNMKECKQDIVRWTPDVVILVDYPGFNLKIAEFIKKQTKIPVYYYISPKI
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCE
WAWKEYRIKNIKRDVDELFSILPFEVEFFAGHQYPVHYVGNPCVDAVDAYCKEHPDGFPE
EEHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEECCCHHHHHHHHHHHHCCCCCHH
FVADNGLSEKPVIALLAGSRKQEIKDNLPMMLEAAAPFTKDYQLVLAGAPGMDPAYYSDY
HHHCCCCCCCCEEEEECCCCHHHHHCCCCEEEECCCCCCCCCEEEEECCCCCCCHHHHHC
INPNVPVKIIFGQTYRLLQHAQAALVTSGTATLETALFRVPQVVCYYTPVGKFIAFLRRH
CCCCCCEEEEECHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEECCHHHHHHHHHHH
ILKVKYISLVNLVADKEVVRELVADTMTVDNVRSELESLLYNKVYRNKVLEEYDRIIQIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GPAGASGTAAREMVALLKK
CCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MKYYLIVGEASGDLHASNLMRALIQEDPEAEFRFFGGDLMTAVGGTRVKHYKELAYMGFI
CEEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEECCHHHHHHCCHHHHHHHHHHHHHHH
PVLLHLRTIFRNMKECKQDIVRWTPDVVILVDYPGFNLKIAEFIKKQTKIPVYYYISPKI
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCE
WAWKEYRIKNIKRDVDELFSILPFEVEFFAGHQYPVHYVGNPCVDAVDAYCKEHPDGFPE
EEHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEECCCHHHHHHHHHHHHCCCCCHH
FVADNGLSEKPVIALLAGSRKQEIKDNLPMMLEAAAPFTKDYQLVLAGAPGMDPAYYSDY
HHHCCCCCCCCEEEEECCCCHHHHHCCCCEEEECCCCCCCCCEEEEECCCCCCCHHHHHC
INPNVPVKIIFGQTYRLLQHAQAALVTSGTATLETALFRVPQVVCYYTPVGKFIAFLRRH
CCCCCCEEEEECHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEECCHHHHHHHHHHH
ILKVKYISLVNLVADKEVVRELVADTMTVDNVRSELESLLYNKVYRNKVLEEYDRIIQIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GPAGASGTAAREMVALLKK
CCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA