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The map label for this gene is trxA [C]

Identifier: 150004439

GI number: 150004439

Start: 2460963

End: 2461277

Strand: Direct

Name: trxA [C]

Synonym: BVU_1886

Alternate gene names: 150004439

Gene position: 2460963-2461277 (Clockwise)

Preceding gene: 150004438

Following gene: 150004440

Centisome position: 47.66

GC content: 40.0

Gene sequence:

>315_bases
ATGGCACTAGAAATTAAAGATAGCAATTTTGAAGAATTGCTGGCATCAGGCAAGCCTGTAGTAGTGGACTTTTGGGCAAC
ATGGTGTGGTCCTTGTAAAAAAATAGCTCCGGATGTTGAAGCTTTGGCAGAAGAATATAAGGATCAGGTAATAATTGGAA
AGTGCGACGTGGATGATAACGACGAACTGACCGGTAAATTTGGTGTACGTAACATTCCTACTGTTCTTTTTATCAAGGAC
GGTGAAGTGAAAGATAAGACTGTAGGTGCAGTGACCAAAGCTCAGCTGGAAGAAAAAATAAAAGCTTTACTGTAA

Upstream 100 bases:

>100_bases
AAAAAGAGATCATGACTTATTTAAAGAGCCAACCACAGCTCTCTTACAAAATTAATTAGTATATTTGCGCTAACATTTTA
AATAACTAAGTATAATAATT

Downstream 100 bases:

>100_bases
TAAAAAGAATATTCACCCCTTTAATATATACGACTATGGGAATGGAAGACGATTTCTTATTGGAAGATGAGGATGATCAA
AAAACGATAGAGTTTATCAA

Product: thioredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 104; Mature: 103

Protein sequence:

>104_residues
MALEIKDSNFEELLASGKPVVVDFWATWCGPCKKIAPDVEALAEEYKDQVIIGKCDVDDNDELTGKFGVRNIPTVLFIKD
GEVKDKTVGAVTKAQLEEKIKALL

Sequences:

>Translated_104_residues
MALEIKDSNFEELLASGKPVVVDFWATWCGPCKKIAPDVEALAEEYKDQVIIGKCDVDDNDELTGKFGVRNIPTVLFIKD
GEVKDKTVGAVTKAQLEEKIKALL
>Mature_103_residues
ALEIKDSNFEELLASGKPVVVDFWATWCGPCKKIAPDVEALAEEYKDQVIIGKCDVDDNDELTGKFGVRNIPTVLFIKDG
EVKDKTVGAVTKAQLEEKIKALL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=94, Percent_Identity=41.4893617021277, Blast_Score=80, Evalue=3e-16,
Organism=Homo sapiens, GI20070125, Length=93, Percent_Identity=35.4838709677419, Blast_Score=67, Evalue=2e-12,
Organism=Homo sapiens, GI50592994, Length=103, Percent_Identity=42.7184466019417, Blast_Score=67, Evalue=4e-12,
Organism=Homo sapiens, GI21361657, Length=83, Percent_Identity=39.7590361445783, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI87082331, Length=103, Percent_Identity=41.747572815534, Blast_Score=95, Evalue=1e-21,
Organism=Escherichia coli, GI1788936, Length=95, Percent_Identity=41.0526315789474, Blast_Score=85, Evalue=1e-18,
Organism=Escherichia coli, GI87081747, Length=102, Percent_Identity=35.2941176470588, Blast_Score=69, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17509965, Length=107, Percent_Identity=42.9906542056075, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71980565, Length=92, Percent_Identity=42.3913043478261, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71980562, Length=86, Percent_Identity=41.8604651162791, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=94, Percent_Identity=35.1063829787234, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17556044, Length=78, Percent_Identity=39.7435897435897, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71998175, Length=86, Percent_Identity=40.6976744186046, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=102, Percent_Identity=36.2745098039216, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=88, Percent_Identity=42.0454545454545, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI25144092, Length=80, Percent_Identity=38.75, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17549970, Length=81, Percent_Identity=35.8024691358025, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=92, Percent_Identity=46.7391304347826, Blast_Score=79, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323072, Length=95, Percent_Identity=44.2105263157895, Blast_Score=74, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=96, Percent_Identity=39.5833333333333, Blast_Score=71, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24639826, Length=89, Percent_Identity=46.0674157303371, Blast_Score=86, Evalue=6e-18,
Organism=Drosophila melanogaster, GI17648013, Length=88, Percent_Identity=43.1818181818182, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24583090, Length=88, Percent_Identity=43.1818181818182, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17530795, Length=76, Percent_Identity=40.7894736842105, Blast_Score=75, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28573567, Length=88, Percent_Identity=35.2272727272727, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24664269, Length=76, Percent_Identity=42.1052631578947, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11454; Mature: 11323

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALEIKDSNFEELLASGKPVVVDFWATWCGPCKKIAPDVEALAEEYKDQVIIGKCDVDDN
CEEEECCCCHHHHHHCCCCEEEEEHHHHCCCHHHCCCCHHHHHHHHCCCEEEEECCCCCC
DELTGKFGVRNIPTVLFIKDGEVKDKTVGAVTKAQLEEKIKALL
CCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ALEIKDSNFEELLASGKPVVVDFWATWCGPCKKIAPDVEALAEEYKDQVIIGKCDVDDN
EEEECCCCHHHHHHCCCCEEEEEHHHHCCCHHHCCCCHHHHHHHHCCCEEEEECCCCCC
DELTGKFGVRNIPTVLFIKDGEVKDKTVGAVTKAQLEEKIKALL
CCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7021558 [H]