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The map label for this gene is menA [H]

Identifier: 150004199

GI number: 150004199

Start: 2123840

End: 2124730

Strand: Reverse

Name: menA [H]

Synonym: BVU_1640

Alternate gene names: 150004199

Gene position: 2124730-2123840 (Counterclockwise)

Preceding gene: 150004202

Following gene: 150004195

Centisome position: 41.15

GC content: 45.34

Gene sequence:

>891_bases
ATGGAAATTGTTCAAGTTAACTCAATAAAAGCATGGCTTCTAGCCGCCCGCCCTAAAACATTGGCAGGAGCCGCCACTCC
GGTTTTACTGGGATGTGCCTTGGCCTATGCAGACAGCTGCTTCCAAATGACACCAGCATTGCTTTGCTTTGCCTTCGCTT
TTCTGATGCAGATAGACGCCAACTTCATTAATGATTACTTTGATTACCTGAAAGGCAGTGACCGTGAAGACCGTTTGGGT
CCTGAACGTGCCTGCGCGCAAGGATGGATCACACTGAACGCCATGAGAAAGGGAATCGCCCTGACCACAGCAACAGCTTG
TTTAGCAGGGTTATGCCTATTAGCTTATGGAGGGATTGAAATGATTCCAGTAGGAATTTTATGTGTTTTATTCGCTTTTC
TTTATACAGCAGGACCTTATCCGCTAGCTTATCACGGATGGGGAGACATACTTGTCATTGTCTTTTTCGGATTTGTACCG
GTAGGCTGCACTTACTATGTGATGTGCCGTGACTGGACTTGGAATGTGACACTCGCCTCTCTAGCTTGCGGACTGATTAT
AGATACCTTGTTGATGGTGAATAATTACCGTGACCGCGATCAGGATGCAAAAAGCGGAAAGAAAACAATCGTAGTACGCT
GGGGAGCCAATGCAGGGCAACAATTATACTTATTTTTGGGATTGGCTGCCGCATGGCTTTGTTTATTGTTTATCCCGACC
GGGCACATTTGGGCTGCATTATTACCCCAAATTTATCTGTTACCTCACTTCATGGCATGGCAAAGAATGGTAAAAATCAA
CAGGGGAAAAGAATTAAACAGCATATTGGGAGAAACCTCCCGCAATATGCTGCTATTCGGCGTATTACTAGCATTCGGCC
TTATCCTATAA

Upstream 100 bases:

>100_bases
AAGCAAAAAAAGAAACTGTTTCTTCATAATCCTTTCTATTTGGAGACAAAGATACAGAATTAATTGTTTTATCTTTGCAC
AACCTTAATTATAAATAGAA

Downstream 100 bases:

>100_bases
TCTTCCAGCAAGATCTTGCCAGAAGATATTTCCCAATAAAGCGCAACAAATCATTCCGCTTTCTCTATCAATACAGTGGC
ATAAGCGGAAATGCCCTCCT

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MEIVQVNSIKAWLLAARPKTLAGAATPVLLGCALAYADSCFQMTPALLCFAFAFLMQIDANFINDYFDYLKGSDREDRLG
PERACAQGWITLNAMRKGIALTTATACLAGLCLLAYGGIEMIPVGILCVLFAFLYTAGPYPLAYHGWGDILVIVFFGFVP
VGCTYYVMCRDWTWNVTLASLACGLIIDTLLMVNNYRDRDQDAKSGKKTIVVRWGANAGQQLYLFLGLAAAWLCLLFIPT
GHIWAALLPQIYLLPHFMAWQRMVKINRGKELNSILGETSRNMLLFGVLLAFGLIL

Sequences:

>Translated_296_residues
MEIVQVNSIKAWLLAARPKTLAGAATPVLLGCALAYADSCFQMTPALLCFAFAFLMQIDANFINDYFDYLKGSDREDRLG
PERACAQGWITLNAMRKGIALTTATACLAGLCLLAYGGIEMIPVGILCVLFAFLYTAGPYPLAYHGWGDILVIVFFGFVP
VGCTYYVMCRDWTWNVTLASLACGLIIDTLLMVNNYRDRDQDAKSGKKTIVVRWGANAGQQLYLFLGLAAAWLCLLFIPT
GHIWAALLPQIYLLPHFMAWQRMVKINRGKELNSILGETSRNMLLFGVLLAFGLIL
>Mature_296_residues
MEIVQVNSIKAWLLAARPKTLAGAATPVLLGCALAYADSCFQMTPALLCFAFAFLMQIDANFINDYFDYLKGSDREDRLG
PERACAQGWITLNAMRKGIALTTATACLAGLCLLAYGGIEMIPVGILCVLFAFLYTAGPYPLAYHGWGDILVIVFFGFVP
VGCTYYVMCRDWTWNVTLASLACGLIIDTLLMVNNYRDRDQDAKSGKKTIVVRWGANAGQQLYLFLGLAAAWLCLLFIPT
GHIWAALLPQIYLLPHFMAWQRMVKINRGKELNSILGETSRNMLLFGVLLAFGLIL

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=295, Percent_Identity=27.7966101694915, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1790365, Length=217, Percent_Identity=38.7096774193548, Blast_Score=147, Evalue=7e-37,
Organism=Drosophila melanogaster, GI17737429, Length=296, Percent_Identity=27.027027027027, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 32691; Mature: 32691

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIVQVNSIKAWLLAARPKTLAGAATPVLLGCALAYADSCFQMTPALLCFAFAFLMQIDA
CCEEEECCHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NFINDYFDYLKGSDREDRLGPERACAQGWITLNAMRKGIALTTATACLAGLCLLAYGGIE
HHHHHHHHHHCCCCCCCCCCHHHHHHHCCEEHHHHHCCHHHHHHHHHHHHHHHHHHCCHH
MIPVGILCVLFAFLYTAGPYPLAYHGWGDILVIVFFGFVPVGCTYYVMCRDWTWNVTLAS
HHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHH
LACGLIIDTLLMVNNYRDRDQDAKSGKKTIVVRWGANAGQQLYLFLGLAAAWLCLLFIPT
HHHHHHHHHHHHHCCCCCCCCHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCC
GHIWAALLPQIYLLPHFMAWQRMVKINRGKELNSILGETSRNMLLFGVLLAFGLIL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHC
>Mature Secondary Structure
MEIVQVNSIKAWLLAARPKTLAGAATPVLLGCALAYADSCFQMTPALLCFAFAFLMQIDA
CCEEEECCHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NFINDYFDYLKGSDREDRLGPERACAQGWITLNAMRKGIALTTATACLAGLCLLAYGGIE
HHHHHHHHHHCCCCCCCCCCHHHHHHHCCEEHHHHHCCHHHHHHHHHHHHHHHHHHCCHH
MIPVGILCVLFAFLYTAGPYPLAYHGWGDILVIVFFGFVPVGCTYYVMCRDWTWNVTLAS
HHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHH
LACGLIIDTLLMVNNYRDRDQDAKSGKKTIVVRWGANAGQQLYLFLGLAAAWLCLLFIPT
HHHHHHHHHHHHHCCCCCCCCHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCC
GHIWAALLPQIYLLPHFMAWQRMVKINRGKELNSILGETSRNMLLFGVLLAFGLIL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]