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The map label for this gene is pccB [H]

Identifier: 150004030

GI number: 150004030

Start: 1943365

End: 1944897

Strand: Direct

Name: pccB [H]

Synonym: BVU_1465

Alternate gene names: 150004030

Gene position: 1943365-1944897 (Clockwise)

Preceding gene: 150004029

Following gene: 150004032

Centisome position: 37.64

GC content: 51.47

Gene sequence:

>1533_bases
ATGACAAGAGAAGAAATATACAGCCGGTTTGAAGAGCTGGACAAACGCGCGTCGCTGGGCGGCGGTGTGGACAAGATCGA
GAAACAACACGCCCAAGGGAAGATGACCGCTCGCGAGCGTATCGGAATGTTGCTGGACAAAGGTACGTTCAATGAACTGG
ACAAGCTGGTGAATCACCGTTGTACCAACTTCGGCATGGAGAAGAAGCAGATTGCCGGAGATGGTATGGTTACCGGTTAC
GGAAAGATAGACGGCCGTCCGGTGTTTGTCTATGCATACGATTTCACCGCGCACGGCGGTTCGCTGAGCGAAACCAATGC
GGCCAAGATTGTAAAGGTTCAGCAACTGGCTTTGAAGACGGGAGCTCCCGTTATCGCTTTGAACGATTCGGGGGGTGCAC
GCATACAGGAAGGGGTGAACAGCTTGGCCGGATATGCCTCCATCTTTTATCAGAATACCATTGCATCAGGTGTTATCCCC
CAGATTTCCGCCATTTTGGGGCCTTGTGCCGGAGGCGCCTGCTATTCCCCGGCACTGACCGACTTTATCTTTATGGTGAA
GGAGCAGAGCCACATGTTTATCACGGGTCCGGATGTGGTGAAGACCGTGACTAACGAGGAGGTGGGCAAGGAGGAACTGG
GTGGTGCCCAGACTCACAGCGGCAAAAGCGGTGTGACCCATTTTATGTGCGATAATGAGGAGGAAACGCTGATGAGTATC
CGCGAATTGCTGAGTTTCCTGCCTTCCAACAATATGGAGGATGCGCCGCTGGTTCCCTGCAACGATGACATCCATCGTCA
GGTGGAGGCGTTGCAGACTGTCATTCCCGAAGATCCGAACATGCCTTATGATATAAAGGATATCATCGAACCGGTGCTGG
ATAACCAGTATTTCTTCGAGGTGATGCCTCACTTTGCTAAAAATGTGGTGGTGGGGTTTGGTCGCCTGGGAGGTCGTTCC
GTAGGTATTGTTGCCAATCAGCCCGCCTGGCTGGCCGGCGTCCTTGACATTGACGCCAGCGACAAGGCTGCCCGTTTTAT
CCGTTTCTGTGACTGCTTTAATATTCCTCTGATCACTTTCGAGGATGTTCCCGGCTTCCTGCCCGGAACGGTACAGGAAC
ACAACGGCATCATCCGCCACGGTGCGAAGATAGTCTATGCATACGCTGAAGCTACAGTGCCCAAGGTTACTTTAATTACC
CGTAAAGCTTATGGAGGTGCCTACATTGTCATGTCCAGCAAGCCGACGGGAGCCGATGTGAACCTGGCTTACCCACAGGC
GGAAATAGCCGTCATGGGTGCAGAAGGGGCAGTGAATATCCTTTACCGCAAGTCTGCTCCGGAAGAGAAAGCTGAGATCA
TCAAGGAATACGAAGATAAATTCTCCAATCCTTATCGTGCGGCAGAACGTGGTCTGATTGATGAGGTGATTATGCCCCGT
GACACTCGTTACAAACTTATTCAAGCTTTGGAAATGTGTCACAATAAAAACCAAAGCAATCCGCCTAAGAAACATGGCAA
TATGCCTTTATGA

Upstream 100 bases:

>100_bases
CCTCGGACTGTACGGTAAGGGATATCCTGGTCAATGAGGGGGATTCCGTCAATGCTAACCAGGTATTAATAGTATTGGAT
ATAATAAAAGAAGATTGATC

Downstream 100 bases:

>100_bases
TAAAATCAAGATTCCGTCACAGATTGATCAGATTGACATCGGTCCAATTTAAGCAGTGGGTCCTCAATGGAAATAACCGG
TGACAATCTGCGTAACCTGT

Product: propionyl-CoA carboxylase beta chain

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MTREEIYSRFEELDKRASLGGGVDKIEKQHAQGKMTARERIGMLLDKGTFNELDKLVNHRCTNFGMEKKQIAGDGMVTGY
GKIDGRPVFVYAYDFTAHGGSLSETNAAKIVKVQQLALKTGAPVIALNDSGGARIQEGVNSLAGYASIFYQNTIASGVIP
QISAILGPCAGGACYSPALTDFIFMVKEQSHMFITGPDVVKTVTNEEVGKEELGGAQTHSGKSGVTHFMCDNEEETLMSI
RELLSFLPSNNMEDAPLVPCNDDIHRQVEALQTVIPEDPNMPYDIKDIIEPVLDNQYFFEVMPHFAKNVVVGFGRLGGRS
VGIVANQPAWLAGVLDIDASDKAARFIRFCDCFNIPLITFEDVPGFLPGTVQEHNGIIRHGAKIVYAYAEATVPKVTLIT
RKAYGGAYIVMSSKPTGADVNLAYPQAEIAVMGAEGAVNILYRKSAPEEKAEIIKEYEDKFSNPYRAAERGLIDEVIMPR
DTRYKLIQALEMCHNKNQSNPPKKHGNMPL

Sequences:

>Translated_510_residues
MTREEIYSRFEELDKRASLGGGVDKIEKQHAQGKMTARERIGMLLDKGTFNELDKLVNHRCTNFGMEKKQIAGDGMVTGY
GKIDGRPVFVYAYDFTAHGGSLSETNAAKIVKVQQLALKTGAPVIALNDSGGARIQEGVNSLAGYASIFYQNTIASGVIP
QISAILGPCAGGACYSPALTDFIFMVKEQSHMFITGPDVVKTVTNEEVGKEELGGAQTHSGKSGVTHFMCDNEEETLMSI
RELLSFLPSNNMEDAPLVPCNDDIHRQVEALQTVIPEDPNMPYDIKDIIEPVLDNQYFFEVMPHFAKNVVVGFGRLGGRS
VGIVANQPAWLAGVLDIDASDKAARFIRFCDCFNIPLITFEDVPGFLPGTVQEHNGIIRHGAKIVYAYAEATVPKVTLIT
RKAYGGAYIVMSSKPTGADVNLAYPQAEIAVMGAEGAVNILYRKSAPEEKAEIIKEYEDKFSNPYRAAERGLIDEVIMPR
DTRYKLIQALEMCHNKNQSNPPKKHGNMPL
>Mature_509_residues
TREEIYSRFEELDKRASLGGGVDKIEKQHAQGKMTARERIGMLLDKGTFNELDKLVNHRCTNFGMEKKQIAGDGMVTGYG
KIDGRPVFVYAYDFTAHGGSLSETNAAKIVKVQQLALKTGAPVIALNDSGGARIQEGVNSLAGYASIFYQNTIASGVIPQ
ISAILGPCAGGACYSPALTDFIFMVKEQSHMFITGPDVVKTVTNEEVGKEELGGAQTHSGKSGVTHFMCDNEEETLMSIR
ELLSFLPSNNMEDAPLVPCNDDIHRQVEALQTVIPEDPNMPYDIKDIIEPVLDNQYFFEVMPHFAKNVVVGFGRLGGRSV
GIVANQPAWLAGVLDIDASDKAARFIRFCDCFNIPLITFEDVPGFLPGTVQEHNGIIRHGAKIVYAYAEATVPKVTLITR
KAYGGAYIVMSSKPTGADVNLAYPQAEIAVMGAEGAVNILYRKSAPEEKAEIIKEYEDKFSNPYRAAERGLIDEVIMPRD
TRYKLIQALEMCHNKNQSNPPKKHGNMPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=508, Percent_Identity=56.6929133858268, Blast_Score=593, Evalue=1e-169,
Organism=Homo sapiens, GI295821216, Length=528, Percent_Identity=54.7348484848485, Blast_Score=582, Evalue=1e-166,
Organism=Homo sapiens, GI11545863, Length=502, Percent_Identity=31.2749003984064, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI134142062, Length=342, Percent_Identity=26.9005847953216, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI38679971, Length=340, Percent_Identity=27.3529411764706, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI38679977, Length=340, Percent_Identity=27.3529411764706, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI38679967, Length=340, Percent_Identity=27.3529411764706, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI38679960, Length=340, Percent_Identity=27.3529411764706, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI38679974, Length=340, Percent_Identity=27.3529411764706, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1788655, Length=207, Percent_Identity=29.4685990338164, Blast_Score=75, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI25147362, Length=506, Percent_Identity=57.5098814229249, Blast_Score=615, Evalue=1e-176,
Organism=Caenorhabditis elegans, GI25147359, Length=506, Percent_Identity=57.5098814229249, Blast_Score=615, Evalue=1e-176,
Organism=Caenorhabditis elegans, GI17552936, Length=502, Percent_Identity=32.6693227091633, Blast_Score=250, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI71997163, Length=392, Percent_Identity=25.765306122449, Blast_Score=93, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6323863, Length=359, Percent_Identity=22.5626740947075, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24586065, Length=516, Percent_Identity=33.5271317829457, Blast_Score=245, Evalue=6e-65,
Organism=Drosophila melanogaster, GI24586458, Length=390, Percent_Identity=26.9230769230769, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI161076407, Length=390, Percent_Identity=26.9230769230769, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24586460, Length=390, Percent_Identity=26.9230769230769, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI161076409, Length=390, Percent_Identity=26.9230769230769, Blast_Score=86, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 55879; Mature: 55747

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTREEIYSRFEELDKRASLGGGVDKIEKQHAQGKMTARERIGMLLDKGTFNELDKLVNHR
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHH
CTNFGMEKKQIAGDGMVTGYGKIDGRPVFVYAYDFTAHGGSLSETNAAKIVKVQQLALKT
HHCCCCCHHHHCCCCEEEEECCCCCEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHC
GAPVIALNDSGGARIQEGVNSLAGYASIFYQNTIASGVIPQISAILGPCAGGACYSPALT
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCHHHH
DFIFMVKEQSHMFITGPDVVKTVTNEEVGKEELGGAQTHSGKSGVTHFMCDNEEETLMSI
HHHHHEECCCEEEEECCHHHHHHCCHHCCHHHCCCCCCCCCCCCCEEEEECCCHHHHHHH
RELLSFLPSNNMEDAPLVPCNDDIHRQVEALQTVIPEDPNMPYDIKDIIEPVLDNQYFFE
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHH
VMPHFAKNVVVGFGRLGGRSVGIVANQPAWLAGVLDIDASDKAARFIRFCDCFNIPLITF
HHHHHHHHHEEECCCCCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEE
EDVPGFLPGTVQEHNGIIRHGAKIVYAYAEATVPKVTLITRKAYGGAYIVMSSKPTGADV
CCCCCCCCCCHHHCCCHHHCCCEEEEEEECCCCCEEEEEEEECCCCEEEEEECCCCCCCE
NLAYPQAEIAVMGAEGAVNILYRKSAPEEKAEIIKEYEDKFSNPYRAAERGLIDEVIMPR
EEECCCEEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHCCC
DTRYKLIQALEMCHNKNQSNPPKKHGNMPL
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TREEIYSRFEELDKRASLGGGVDKIEKQHAQGKMTARERIGMLLDKGTFNELDKLVNHR
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHH
CTNFGMEKKQIAGDGMVTGYGKIDGRPVFVYAYDFTAHGGSLSETNAAKIVKVQQLALKT
HHCCCCCHHHHCCCCEEEEECCCCCEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHC
GAPVIALNDSGGARIQEGVNSLAGYASIFYQNTIASGVIPQISAILGPCAGGACYSPALT
CCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCHHHH
DFIFMVKEQSHMFITGPDVVKTVTNEEVGKEELGGAQTHSGKSGVTHFMCDNEEETLMSI
HHHHHEECCCEEEEECCHHHHHHCCHHCCHHHCCCCCCCCCCCCCEEEEECCCHHHHHHH
RELLSFLPSNNMEDAPLVPCNDDIHRQVEALQTVIPEDPNMPYDIKDIIEPVLDNQYFFE
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHH
VMPHFAKNVVVGFGRLGGRSVGIVANQPAWLAGVLDIDASDKAARFIRFCDCFNIPLITF
HHHHHHHHHEEECCCCCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEE
EDVPGFLPGTVQEHNGIIRHGAKIVYAYAEATVPKVTLITRKAYGGAYIVMSSKPTGADV
CCCCCCCCCCHHHCCCHHHCCCEEEEEEECCCCCEEEEEEEECCCCEEEEEECCCCCCCE
NLAYPQAEIAVMGAEGAVNILYRKSAPEEKAEIIKEYEDKFSNPYRAAERGLIDEVIMPR
EEECCCEEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHCCC
DTRYKLIQALEMCHNKNQSNPPKKHGNMPL
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]