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The map label for this gene is accC [H]

Identifier: 150004028

GI number: 150004028

Start: 1941311

End: 1942822

Strand: Direct

Name: accC [H]

Synonym: BVU_1463

Alternate gene names: 150004028

Gene position: 1941311-1942822 (Clockwise)

Preceding gene: 150004027

Following gene: 150004029

Centisome position: 37.6

GC content: 50.53

Gene sequence:

>1512_bases
ATGATACAAAAGGTTCTAATTGCCAACCGTGGCGAGATAGCCGTGCGCGTTATGCGCTCTTGCAAAGAGATGGGTATCCG
CACTGTGGCTGTTTTCTCGGAAGCCGACCGTACGGCGCGTCATGTGATGTATGCAGACGAAGCCTGTCTGATAGGGCCTG
CCGCTTCCAAAGAAAGTTATCTGAATATAGATAATATCATTAAAGCTGCAAGGCAACATCATGCCGATGCCATTCATCCC
GGTTATGGTTTTTTGTCCGAGAATGCTGATTTTGCCCGCCGGTGCAAAGAGGAGGGGATCATCTTTATCGGCCCTGCCGC
CGAGACGATGGAAGCGATGGGTGACAAGATTGCCGCCCGTAAGCGTATGATTGCCGCAGGTGTTCCCGTGGTCCCCGGTA
CGGAACAGCCGTTGCAAAGTGCCGAAGAGGCGGTACGTATCTGTAATGAAATAGGCTATCCTGTCATGTTGAAGGCTTCT
ATGGGAGGCGGCGGTAAAGGGATGAGGCTGATACACAGTGAAGATGAAGTGGTGGAGGCATATAACACCGCCCGTTCCGA
GTCCATGTCTTCTTTCGGGGATGATACGGTTTATCTGGAAAAATTTGTGGAGGAACCCCATCATATAGAATTTCAAATAC
TGGGTGACAATCATGGCAATGTAATCCATCTGTTTGACCGCGAGTGTTCTGTTCAGCGTCGCAACCAAAAGATTGTAGAG
GAGAGTCCGTCTCCGTTCCTTACTCCGGAACTCCGTCAGGAGATGGGGGAAAAGGCGGTGGCTGCTGCCAGGGCAGTGAA
CTATTCGGGAGCCGGAACTATCGAGTTTCTGGTGGACAAGAACCGCAATTTCTATTTTCTGGAGATGAACACCCGTCTCC
AGGTGGAGCATCCCATTACCGAAGAAGTGGTGGGCGTGGACTTGGTGAAAGAGCAGATCCGCATTGCCAATGATGAAGTG
CTGCATTTGAAACAGGAAGAGCTGTATCAGCGCGGTCATGCCATCGAATGTCGTATCTGTGCGGAAGACACGGAGAACAA
CTTCATGCCTTCGCCGGGTATCATCAAACAGCTGACGGAGCCTAACGGCATCGGCGTACGCATTGACAGCTACGTGTACG
AAGGGTACGAGATTCCTGTCTTTTACGACCCGATGATAGGCAAGTTGATCGTGTGGGCTACAACTCGCCAGTATGCCATA
GAGCGTATGCGCCGTGTGCTTTACGAGTACAAGATTACGGGCTTGAAGACCAACCTCAGTTATCTGAAACGCATCATGCA
TACCCCCGACTTTGTGAAGGGTGAGTATAATACCTTATTTATAGAGAAGAACTCCCGTATGCTGCTCCGTGGCAACGGCA
ACAATGAGGAGATTGAAAACATGGCCATGATCGCCTCTTATATTGACTATCTGATGAATCTGGAAGAGAACAAGAGTCCC
CAGCTGTCTGATGCCCGTCCCATCAGCCGTTGGCGTGAGTTCGGCTTGCAGAAAGGAGTGTTGAGAATCTGA

Upstream 100 bases:

>100_bases
AATCAATACTAATGAGAGATGCCACCCATGTAAGATGTGTTCATGTATAATGAATGCATCTGTAATTTTGTGTGACATTT
CGGGTAAAAAGAGAAAGATT

Downstream 100 bases:

>100_bases
TTCTTCATTTAATTAAGCAAAAGTATGGAAATACATATTGGAGACCGCGTAGCCGATGTGACGTTGGTGAGCAAGGAAGG
AAACAAGGTACAGTTTATGA

Product: pyruvate carboxylase subunit A

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MIQKVLIANRGEIAVRVMRSCKEMGIRTVAVFSEADRTARHVMYADEACLIGPAASKESYLNIDNIIKAARQHHADAIHP
GYGFLSENADFARRCKEEGIIFIGPAAETMEAMGDKIAARKRMIAAGVPVVPGTEQPLQSAEEAVRICNEIGYPVMLKAS
MGGGGKGMRLIHSEDEVVEAYNTARSESMSSFGDDTVYLEKFVEEPHHIEFQILGDNHGNVIHLFDRECSVQRRNQKIVE
ESPSPFLTPELRQEMGEKAVAAARAVNYSGAGTIEFLVDKNRNFYFLEMNTRLQVEHPITEEVVGVDLVKEQIRIANDEV
LHLKQEELYQRGHAIECRICAEDTENNFMPSPGIIKQLTEPNGIGVRIDSYVYEGYEIPVFYDPMIGKLIVWATTRQYAI
ERMRRVLYEYKITGLKTNLSYLKRIMHTPDFVKGEYNTLFIEKNSRMLLRGNGNNEEIENMAMIASYIDYLMNLEENKSP
QLSDARPISRWREFGLQKGVLRI

Sequences:

>Translated_503_residues
MIQKVLIANRGEIAVRVMRSCKEMGIRTVAVFSEADRTARHVMYADEACLIGPAASKESYLNIDNIIKAARQHHADAIHP
GYGFLSENADFARRCKEEGIIFIGPAAETMEAMGDKIAARKRMIAAGVPVVPGTEQPLQSAEEAVRICNEIGYPVMLKAS
MGGGGKGMRLIHSEDEVVEAYNTARSESMSSFGDDTVYLEKFVEEPHHIEFQILGDNHGNVIHLFDRECSVQRRNQKIVE
ESPSPFLTPELRQEMGEKAVAAARAVNYSGAGTIEFLVDKNRNFYFLEMNTRLQVEHPITEEVVGVDLVKEQIRIANDEV
LHLKQEELYQRGHAIECRICAEDTENNFMPSPGIIKQLTEPNGIGVRIDSYVYEGYEIPVFYDPMIGKLIVWATTRQYAI
ERMRRVLYEYKITGLKTNLSYLKRIMHTPDFVKGEYNTLFIEKNSRMLLRGNGNNEEIENMAMIASYIDYLMNLEENKSP
QLSDARPISRWREFGLQKGVLRI
>Mature_503_residues
MIQKVLIANRGEIAVRVMRSCKEMGIRTVAVFSEADRTARHVMYADEACLIGPAASKESYLNIDNIIKAARQHHADAIHP
GYGFLSENADFARRCKEEGIIFIGPAAETMEAMGDKIAARKRMIAAGVPVVPGTEQPLQSAEEAVRICNEIGYPVMLKAS
MGGGGKGMRLIHSEDEVVEAYNTARSESMSSFGDDTVYLEKFVEEPHHIEFQILGDNHGNVIHLFDRECSVQRRNQKIVE
ESPSPFLTPELRQEMGEKAVAAARAVNYSGAGTIEFLVDKNRNFYFLEMNTRLQVEHPITEEVVGVDLVKEQIRIANDEV
LHLKQEELYQRGHAIECRICAEDTENNFMPSPGIIKQLTEPNGIGVRIDSYVYEGYEIPVFYDPMIGKLIVWATTRQYAI
ERMRRVLYEYKITGLKTNLSYLKRIMHTPDFVKGEYNTLFIEKNSRMLLRGNGNNEEIENMAMIASYIDYLMNLEENKSP
QLSDARPISRWREFGLQKGVLRI

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=449, Percent_Identity=53.2293986636971, Blast_Score=486, Evalue=1e-137,
Organism=Homo sapiens, GI189095269, Length=440, Percent_Identity=52.2727272727273, Blast_Score=460, Evalue=1e-129,
Organism=Homo sapiens, GI65506442, Length=440, Percent_Identity=52.2727272727273, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI295821183, Length=440, Percent_Identity=52.2727272727273, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI106049528, Length=452, Percent_Identity=46.4601769911504, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI106049295, Length=452, Percent_Identity=46.4601769911504, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI106049292, Length=452, Percent_Identity=46.4601769911504, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI38679960, Length=503, Percent_Identity=32.4055666003976, Blast_Score=249, Evalue=5e-66,
Organism=Homo sapiens, GI38679977, Length=503, Percent_Identity=32.4055666003976, Blast_Score=249, Evalue=6e-66,
Organism=Homo sapiens, GI38679967, Length=503, Percent_Identity=32.4055666003976, Blast_Score=249, Evalue=6e-66,
Organism=Homo sapiens, GI38679974, Length=503, Percent_Identity=32.4055666003976, Blast_Score=248, Evalue=7e-66,
Organism=Homo sapiens, GI38679971, Length=503, Percent_Identity=32.4055666003976, Blast_Score=248, Evalue=7e-66,
Organism=Homo sapiens, GI134142062, Length=503, Percent_Identity=31.8091451292247, Blast_Score=234, Evalue=1e-61,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=53.3783783783784, Blast_Score=466, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI71987519, Length=449, Percent_Identity=49.8886414253898, Blast_Score=436, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17567343, Length=440, Percent_Identity=47.7272727272727, Blast_Score=414, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17562816, Length=491, Percent_Identity=43.7881873727088, Blast_Score=411, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI71997168, Length=450, Percent_Identity=32.6666666666667, Blast_Score=228, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI71997163, Length=450, Percent_Identity=32.6666666666667, Blast_Score=228, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI133931226, Length=487, Percent_Identity=30.3901437371663, Blast_Score=224, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6319695, Length=523, Percent_Identity=41.8738049713193, Blast_Score=402, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6321376, Length=523, Percent_Identity=42.4474187380497, Blast_Score=391, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6319685, Length=439, Percent_Identity=42.5968109339408, Blast_Score=376, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6324343, Length=510, Percent_Identity=30.5882352941176, Blast_Score=232, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6323863, Length=453, Percent_Identity=32.6710816777042, Blast_Score=230, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24651757, Length=450, Percent_Identity=48.8888888888889, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI281363050, Length=452, Percent_Identity=46.0176991150442, Blast_Score=417, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24652224, Length=452, Percent_Identity=46.0176991150442, Blast_Score=417, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24652222, Length=452, Percent_Identity=46.0176991150442, Blast_Score=417, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24652220, Length=452, Percent_Identity=46.0176991150442, Blast_Score=417, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24652218, Length=452, Percent_Identity=46.0176991150442, Blast_Score=417, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24652212, Length=452, Percent_Identity=46.0176991150442, Blast_Score=417, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24652210, Length=452, Percent_Identity=46.0176991150442, Blast_Score=417, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24652214, Length=452, Percent_Identity=46.0176991150442, Blast_Score=417, Evalue=1e-116,
Organism=Drosophila melanogaster, GI19921944, Length=452, Percent_Identity=46.0176991150442, Blast_Score=417, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24652216, Length=452, Percent_Identity=46.0176991150442, Blast_Score=417, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24651759, Length=411, Percent_Identity=48.1751824817518, Blast_Score=400, Evalue=1e-111,
Organism=Drosophila melanogaster, GI161076409, Length=497, Percent_Identity=31.9919517102616, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24586458, Length=497, Percent_Identity=31.9919517102616, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI161076407, Length=497, Percent_Identity=31.9919517102616, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24586460, Length=497, Percent_Identity=31.9919517102616, Blast_Score=240, Evalue=2e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 57011; Mature: 57011

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQKVLIANRGEIAVRVMRSCKEMGIRTVAVFSEADRTARHVMYADEACLIGPAASKESY
CCCEEEECCCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHEEECCCEEECCCCCCCCC
LNIDNIIKAARQHHADAIHPGYGFLSENADFARRCKEEGIIFIGPAAETMEAMGDKIAAR
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHHHHHHHH
KRMIAAGVPVVPGTEQPLQSAEEAVRICNEIGYPVMLKASMGGGGKGMRLIHSEDEVVEA
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCHHHHHH
YNTARSESMSSFGDDTVYLEKFVEEPHHIEFQILGDNHGNVIHLFDRECSVQRRNQKIVE
HHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHH
ESPSPFLTPELRQEMGEKAVAAARAVNYSGAGTIEFLVDKNRNFYFLEMNTRLQVEHPIT
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCEEEECCCCH
EEVVGVDLVKEQIRIANDEVLHLKQEELYQRGHAIECRICAEDTENNFMPSPGIIKQLTE
HHHHHHHHHHHHHHHCCCHHEEECHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHCCC
PNGIGVRIDSYVYEGYEIPVFYDPMIGKLIVWATTRQYAIERMRRVLYEYKITGLKTNLS
CCCCEEEEECEEECCEECEEEECCCCCCEEEEECHHHHHHHHHHHHHHHHHHCCEECCHH
YLKRIMHTPDFVKGEYNTLFIEKNSRMLLRGNGNNEEIENMAMIASYIDYLMNLEENKSP
HHHHHHCCCCCCCCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCC
QLSDARPISRWREFGLQKGVLRI
CCCCCCHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MIQKVLIANRGEIAVRVMRSCKEMGIRTVAVFSEADRTARHVMYADEACLIGPAASKESY
CCCEEEECCCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHEEECCCEEECCCCCCCCC
LNIDNIIKAARQHHADAIHPGYGFLSENADFARRCKEEGIIFIGPAAETMEAMGDKIAAR
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHHHHHHHH
KRMIAAGVPVVPGTEQPLQSAEEAVRICNEIGYPVMLKASMGGGGKGMRLIHSEDEVVEA
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCHHHHHH
YNTARSESMSSFGDDTVYLEKFVEEPHHIEFQILGDNHGNVIHLFDRECSVQRRNQKIVE
HHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHH
ESPSPFLTPELRQEMGEKAVAAARAVNYSGAGTIEFLVDKNRNFYFLEMNTRLQVEHPIT
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCEEEECCCCH
EEVVGVDLVKEQIRIANDEVLHLKQEELYQRGHAIECRICAEDTENNFMPSPGIIKQLTE
HHHHHHHHHHHHHHHCCCHHEEECHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHCCC
PNGIGVRIDSYVYEGYEIPVFYDPMIGKLIVWATTRQYAIERMRRVLYEYKITGLKTNLS
CCCCEEEEECEEECCEECEEEECCCCCCEEEEECHHHHHHHHHHHHHHHHHHCCEECCHH
YLKRIMHTPDFVKGEYNTLFIEKNSRMLLRGNGNNEEIENMAMIASYIDYLMNLEENKSP
HHHHHHCCCCCCCCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCC
QLSDARPISRWREFGLQKGVLRI
CCCCCCHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]