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The map label for this gene is manC [H]

Identifier: 150004001

GI number: 150004001

Start: 1915149

End: 1916192

Strand: Reverse

Name: manC [H]

Synonym: BVU_1435

Alternate gene names: 150004001

Gene position: 1916192-1915149 (Counterclockwise)

Preceding gene: 150004002

Following gene: 150003997

Centisome position: 37.11

GC content: 37.36

Gene sequence:

>1044_bases
ATGACAAACAGCAATAATTATTGTGTCATCATGGGGGGAGGTATAGGTAGTCGGTTCTGGCCATATAGCCGCAAAAACCT
TCCTAAACAATTCCTTGATTTCTTCGGGACCGGACGTTCTCTAATACAGCAAACGTTTGATCGTTATAAAAAAATAGTCC
CTATAGAAAACATTTTTATTACAACCAATGTATTGTATAAAGAACTGATCCAAGAACAACTCCCAGAATTGGACAAATCA
CAAATTTTATTGGAACCCACCCGCAGAAACACTGCTCCATGTATAGCTTGGGCTTCCTATCATATAAAAAAACTCAATCC
AAATGCCAATGTCATTGTCGCACCGTCCGACCACCTGATTTTAAAAGAAGATGAGTTCAAAGCTGCAATTTTGAAAGGTC
TGGAATTTGTTTCAAACTCTCCTCAATTACTAACATTAGGTATCAAACCTAACAGACCGGAAACCGGCTATGGCTATATT
CAGATTGAGGAAGAAAAACAAGGAGAATTCTTTAAAGTAAAAACATTCATTGAAAAGCCCCAATTGGAATTTGCCAAAGT
ATTCGTAGAAAGTGGAGAATTCTATTGGAACTCAGGAATATTCTTATGGAATATCAATACAATTTTAAAAGCCTTCAATG
AGATTATGCCCGAAGTTTGTACCAAACTGACTAACGGAGAAGAAGATTTTGCCTCCTGTCCCAATATCTCCATTGACTAT
GGAATCATGGAGAAAGCCAACAATGTTTTCGTCCAATTGTGCGACTTCGGATGGGCAGATTTAGGTACATGGGACTCCTT
GTATGATATATCATCCAAGGACCAAGAAGGTAACGTCGTAGTAAACGGAAACTCCTTATTATATAACAGCTATAATAATG
TAATAGTAGTGCCAGAAGGGAAATTAGCCGTAATACAGGATCTAGAAGGTTATTTAGTAGCCGCAAGAGACAATGTATTA
CTCATATGCAAAAAAGATGACGAAAGCGCTATCCGAAAATTCGTAAATGACGTACAAATCAAACTAGGAGATCAGTTTGT
ATAA

Upstream 100 bases:

>100_bases
TTCAAAAAAAGATAAATATACTACGATTTATGGGATAACGGACAATGGTTTTCTAAAAATAAGCCCTATATTAGCGGAAA
CTTTAAAACGATTTTATATC

Downstream 100 bases:

>100_bases
AAACAGGTAACCGGAGTTTAATCATAAAAGAAAGCGGGAAACAGAATATCCGTTTCCCGCTCTTTATATTTACTAAGAAA
GAAAAAGATTACTTGTCACC

Product: putative mannose-1-phosphate guanylyltransferase

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP [H]

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MTNSNNYCVIMGGGIGSRFWPYSRKNLPKQFLDFFGTGRSLIQQTFDRYKKIVPIENIFITTNVLYKELIQEQLPELDKS
QILLEPTRRNTAPCIAWASYHIKKLNPNANVIVAPSDHLILKEDEFKAAILKGLEFVSNSPQLLTLGIKPNRPETGYGYI
QIEEEKQGEFFKVKTFIEKPQLEFAKVFVESGEFYWNSGIFLWNINTILKAFNEIMPEVCTKLTNGEEDFASCPNISIDY
GIMEKANNVFVQLCDFGWADLGTWDSLYDISSKDQEGNVVVNGNSLLYNSYNNVIVVPEGKLAVIQDLEGYLVAARDNVL
LICKKDDESAIRKFVNDVQIKLGDQFV

Sequences:

>Translated_347_residues
MTNSNNYCVIMGGGIGSRFWPYSRKNLPKQFLDFFGTGRSLIQQTFDRYKKIVPIENIFITTNVLYKELIQEQLPELDKS
QILLEPTRRNTAPCIAWASYHIKKLNPNANVIVAPSDHLILKEDEFKAAILKGLEFVSNSPQLLTLGIKPNRPETGYGYI
QIEEEKQGEFFKVKTFIEKPQLEFAKVFVESGEFYWNSGIFLWNINTILKAFNEIMPEVCTKLTNGEEDFASCPNISIDY
GIMEKANNVFVQLCDFGWADLGTWDSLYDISSKDQEGNVVVNGNSLLYNSYNNVIVVPEGKLAVIQDLEGYLVAARDNVL
LICKKDDESAIRKFVNDVQIKLGDQFV
>Mature_346_residues
TNSNNYCVIMGGGIGSRFWPYSRKNLPKQFLDFFGTGRSLIQQTFDRYKKIVPIENIFITTNVLYKELIQEQLPELDKSQ
ILLEPTRRNTAPCIAWASYHIKKLNPNANVIVAPSDHLILKEDEFKAAILKGLEFVSNSPQLLTLGIKPNRPETGYGYIQ
IEEEKQGEFFKVKTFIEKPQLEFAKVFVESGEFYWNSGIFLWNINTILKAFNEIMPEVCTKLTNGEEDFASCPNISIDYG
IMEKANNVFVQLCDFGWADLGTWDSLYDISSKDQEGNVVVNGNSLLYNSYNNVIVVPEGKLAVIQDLEGYLVAARDNVLL
ICKKDDESAIRKFVNDVQIKLGDQFV

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O antigen [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=348, Percent_Identity=38.2183908045977, Blast_Score=209, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR018247
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 39477; Mature: 39345

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNSNNYCVIMGGGIGSRFWPYSRKNLPKQFLDFFGTGRSLIQQTFDRYKKIVPIENIFI
CCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEE
TTNVLYKELIQEQLPELDKSQILLEPTRRNTAPCIAWASYHIKKLNPNANVIVAPSDHLI
EHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCEEEEEEEEEEEECCCCCEEECCCCCEE
LKEDEFKAAILKGLEFVSNSPQLLTLGIKPNRPETGYGYIQIEEEKQGEFFKVKTFIEKP
EECCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEEEECCCCCEEEEEEHHCCC
QLEFAKVFVESGEFYWNSGIFLWNINTILKAFNEIMPEVCTKLTNGEEDFASCPNISIDY
CHHHHHHHHHCCCEEEECCEEEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEC
GIMEKANNVFVQLCDFGWADLGTWDSLYDISSKDQEGNVVVNGNSLLYNSYNNVIVVPEG
HHHHCCCCEEEEEECCCCCCCCCCCHHHCCCCCCCCCCEEECCCEEEEECCCCEEEEECC
KLAVIQDLEGYLVAARDNVLLICKKDDESAIRKFVNDVQIKLGDQFV
CEEEEECCCCEEEEECCCEEEEEECCCHHHHHHHHHHHEEEECCCCC
>Mature Secondary Structure 
TNSNNYCVIMGGGIGSRFWPYSRKNLPKQFLDFFGTGRSLIQQTFDRYKKIVPIENIFI
CCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEE
TTNVLYKELIQEQLPELDKSQILLEPTRRNTAPCIAWASYHIKKLNPNANVIVAPSDHLI
EHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCEEEEEEEEEEEECCCCCEEECCCCCEE
LKEDEFKAAILKGLEFVSNSPQLLTLGIKPNRPETGYGYIQIEEEKQGEFFKVKTFIEKP
EECCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEEEECCCCCEEEEEEHHCCC
QLEFAKVFVESGEFYWNSGIFLWNINTILKAFNEIMPEVCTKLTNGEEDFASCPNISIDY
CHHHHHHHHHCCCEEEECCEEEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEC
GIMEKANNVFVQLCDFGWADLGTWDSLYDISSKDQEGNVVVNGNSLLYNSYNNVIVVPEG
HHHHCCCCEEEEEECCCCCCCCCCCHHHCCCCCCCCCCEEECCCEEEEECCCCEEEEECC
KLAVIQDLEGYLVAARDNVLLICKKDDESAIRKFVNDVQIKLGDQFV
CEEEEECCCCEEEEECCCEEEEEECCCHHHHHHHHHHHEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1383393 [H]